ATE131174T1 - Antivirale peptide, die eine 2- ketoalkylaminosäureseitenkette enthalten. - Google Patents

Antivirale peptide, die eine 2- ketoalkylaminosäureseitenkette enthalten.

Info

Publication number: ATE131174T1
Authority: AT; Austria
Prior art keywords: ketoalkylaminosic; side chain; acid side; peptides containing; alkyl
Prior art date: 1989-07-07

Application number

AT90112644T

Other languages

English (en)

Inventor

Pierre Louis Beaulieu

Robert Deziel

Pierre Lavallee

Original Assignee

Bio Mega Boehringer Ingelheim

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-07-07

Filing date

1990-07-03

Publication date

1995-12-15

1990-07-03 Application filed by Bio Mega Boehringer Ingelheim filed Critical Bio Mega Boehringer Ingelheim

1995-12-15 Application granted granted Critical

1995-12-15 Publication of ATE131174T1 publication Critical patent/ATE131174T1/de

Links

108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
239000002253 acid Substances 0.000 title 1
230000000840 anti-viral effect Effects 0.000 title 1
102000004196 processed proteins & peptides Human genes 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 3
125000000753 cycloalkyl group Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
206010019973 Herpes virus infection Diseases 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000000539 amino acid group Chemical group 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
125000001589 carboacyl group Chemical group 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 1
125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
125000003884 phenylalkyl group Chemical group 0.000 abstract 1
150000003254 radicals Chemical class 0.000 abstract 1
125000000464 thioxo group Chemical group S=* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
- C12N2710/16622—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Virology (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Communicable Diseases (AREA)
Gastroenterology & Hepatology (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Cosmetics (AREA)

AT90112644T 1989-07-07 1990-07-03 Antivirale peptide, die eine 2- ketoalkylaminosäureseitenkette enthalten. ATE131174T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CA000605062A CA1340682C (en)	1989-07-07	1989-07-07	Antiviral peptides having a 2-oxoalkyl amino acid side chain

Publications (1)

Publication Number	Publication Date
ATE131174T1 true ATE131174T1 (de)	1995-12-15

Family

ID=4140313

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90112644T ATE131174T1 (de)	1989-07-07	1990-07-03	Antivirale peptide, die eine 2- ketoalkylaminosäureseitenkette enthalten.

Country Status (8)

Country	Link
US (1)	US5700780A (de)
EP (1)	EP0411332B1 (de)
JP (1)	JP2877910B2 (de)
AT (1)	ATE131174T1 (de)
AU (1)	AU643448B2 (de)
CA (1)	CA1340682C (de)
DE (1)	DE69023977T2 (de)
IL (1)	IL94981A (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU643636B2 (en) *	1989-07-07	1993-11-18	Bio-Mega/Boehringer Ingelheim Research Inc.	Antiherpes pentapeptide derivatives having a substituted aspartic acid side chain
EP0411333B1 (de) *	1989-07-07	1995-05-31	Bio-Mega/Boehringer Ingelheim Research Inc.	Antiherpes-Tetrapeptid-Derivate mit einer substituierten Seitenkette aus Asparaginsäure
CA1340681C (en) *	1989-07-07	1999-07-27	Robert Deziel	Antiherpes tetrapeptides having a substituted aspartic acid side chain
US5846941A (en) *	1992-03-12	1998-12-08	Boehringer Ingelheim (Canada) Ltd.	Isosteric antiherpes peptide derivatives II
ATE169931T1 (de)	1992-03-12	1998-09-15	Boehringer Ingelheim Ca Ltd	Isosterische peptidderivate gegen herpes
US6465612B1 (en) *	1998-09-23	2002-10-15	The Regents Of The University Of California	Synthetic peptides, conjugation reagents and methods
WO2001057072A2 (en)	2000-02-07	2001-08-09	Wisconsin Alumni Research Foundation	Pharmacologically active antiviral peptides and methods of their use
WO2005060541A2 (en) *	2003-12-01	2005-07-07	Wisconsin Alumni Research Foundation	Peptides and methods for inducing cellular resistance to infection

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4795740A (en) *	1986-05-20	1989-01-03	Cohen Eric A	Antiviral peptides and means for treating herpes infections
EP0292255A3 (de) *	1987-05-22	1990-08-22	Merck & Co. Inc.	Hemmungsstoff für Ribonukleotid-Reduktase
US4845195A (en) *	1987-05-22	1989-07-04	Merck & Co., Inc.	Inhibitor of ribonucleotide reductase
US4814432A (en) *	1987-05-22	1989-03-21	Merck & Co., Inc.	Inhibitor of ribonucleotide reductase
US4837304A (en) *	1987-05-22	1989-06-06	Merck & Co., Inc.	Inhibitor of ribonucleotide reductase
IL90872A0 (en) *	1988-07-08	1990-02-09	Smithkline Beckman Corp	Retroviral protease binding peptides
EP0357332A3 (de) *	1988-08-24	1991-07-31	Merck & Co. Inc.	Renin-Inhibitoren zur Behandlung von AIDS durch Hemmung der HIV-Protease
EP0374097A3 (de) *	1988-12-15	1991-06-12	Ciba-Geigy Ag	Verwendung von Peptidisosteren als retrovirale Proteasehemmer
AU643636B2 (en) *	1989-07-07	1993-11-18	Bio-Mega/Boehringer Ingelheim Research Inc.	Antiherpes pentapeptide derivatives having a substituted aspartic acid side chain
EP0411333B1 (de) *	1989-07-07	1995-05-31	Bio-Mega/Boehringer Ingelheim Research Inc.	Antiherpes-Tetrapeptid-Derivate mit einer substituierten Seitenkette aus Asparaginsäure
CA1340684C (en) *	1989-07-07	1999-07-27	Pierre Louis Beaulieu	Antiherpes pentapeptides
CA1340683C (en) *	1989-07-07	1999-07-27	Pierre Louis Beaulieu	Antiherpes pentapeptides having a substituted aspartic acid side chain

1989
- 1989-07-07 CA CA000605062A patent/CA1340682C/en not_active Expired - Fee Related
1990
- 1990-07-03 EP EP90112644A patent/EP0411332B1/de not_active Expired - Lifetime
- 1990-07-03 DE DE69023977T patent/DE69023977T2/de not_active Expired - Fee Related
- 1990-07-03 AT AT90112644T patent/ATE131174T1/de active
- 1990-07-05 IL IL9498190A patent/IL94981A/en unknown
- 1990-07-06 JP JP2179374A patent/JP2877910B2/ja not_active Expired - Lifetime
- 1990-07-06 AU AU58777/90A patent/AU643448B2/en not_active Ceased
1995
- 1995-10-11 US US08/540,862 patent/US5700780A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE69023977D1 (de)	1996-01-18
DE69023977T2 (de)	1996-05-15
IL94981A (en)	1995-03-15
EP0411332A1 (de)	1991-02-06
EP0411332B1 (de)	1995-12-06
JP2877910B2 (ja)	1999-04-05
AU643448B2 (en)	1993-11-18
AU5877790A (en)	1991-01-10
US5700780A (en)	1997-12-23
IL94981A0 (en)	1991-06-10
CA1340682C (en)	1999-07-27
JPH03115296A (ja)	1991-05-16

Publication	Publication Date	Title
NZ236327A (en)	1993-05-26	Substituted pyrrolidines and piperidines, and use thereof for preparing amino acid derivatives
ATE131174T1 (de)	1995-12-15	Antivirale peptide, die eine 2- ketoalkylaminosäureseitenkette enthalten.
ATE116995T1 (de)	1995-01-15	Enzyminhibitoren.
DE69015451D1 (de)	1995-02-09	Enzym-inhibierende Peptid-Derivate.
DE69017113D1 (de)	1995-03-30	Pentapeptidderivate, wirksam gegen Herpes, die eine ersetzte Asparaginsäureseitenkette enthalten.
FI944187A0 (fi)	1994-09-12	Isosteeriset antiherpespeptidijohdannaiset
ATE144534T1 (de)	1996-11-15	Antiherpes-pentapeptide
AU643403B2 (en)	1993-11-11	Antiherpes tetrapeptide derivatives having a substituted aspartic acid side chain
CA2019005A1 (en)	1991-12-14	Antiherpes pentapeptide derivatives having a cycloalkyl substituted aspartic acid side chain
HU9300697D0 (en)	1993-05-28	Method for producing polypeptide derivatives of anti-herpetic effect and phamaceutical preparatives containing them
CA2019006A1 (en)	1991-12-14	Antiherpes tetrapeptide derivatives having a cycloalkyl substituted aspartic acid side chain