ATE131830T1 - Immunologische komponente, verfahren zur synthese und verwendung in anit-malaria-impfstoff- zusammensetzungen - Google Patents

Immunologische komponente, verfahren zur synthese und verwendung in anit-malaria-impfstoff- zusammensetzungen

Info

Publication number: ATE131830T1
Authority: AT; Austria
Prior art keywords: amino acid; lysine; acid residue; chem; direct bond
Prior art date: 1990-04-02

Application number

AT91200727T

Other languages

English (en)

Inventor

Antonello Pessi

Elisabetta Bianchi

Giampietro Corradin

Original Assignee

Eniricerche Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-04-02

Filing date

1991-03-28

Publication date

1996-01-15

1991-03-28 Application filed by Eniricerche Spa filed Critical Eniricerche Spa

1996-01-15 Application granted granted Critical

1996-01-15 Publication of ATE131830T1 publication Critical patent/ATE131830T1/de

Links

230000015572 biosynthetic process Effects 0.000 title 1
230000001900 immune effect Effects 0.000 title 1
229940124735 malaria vaccine Drugs 0.000 title 1
238000000034 method Methods 0.000 title 1
239000000203 mixture Substances 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1
KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 5
235000019766 L-Lysine Nutrition 0.000 abstract 3
239000004472 Lysine Substances 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 3
-1 poly(L-lysine) Polymers 0.000 abstract 3
WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 2
239000002671 adjuvant Substances 0.000 abstract 2
125000000539 amino acid group Chemical group 0.000 abstract 2
239000008280 blood Substances 0.000 abstract 2
210000004369 blood Anatomy 0.000 abstract 2
102000004196 processed proteins & peptides Human genes 0.000 abstract 2
108090000765 processed proteins & peptides Proteins 0.000 abstract 2
125000006239 protecting group Chemical group 0.000 abstract 2
MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 abstract 1
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 1
XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 abstract 1
ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 abstract 1
QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 abstract 1
ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 abstract 1
DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 abstract 1
CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 abstract 1
ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 abstract 1
HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 abstract 1
ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 abstract 1
FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 abstract 1
COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 abstract 1
AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 abstract 1
QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 abstract 1
OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 abstract 1
KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 abstract 1
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
150000001408 amides Chemical class 0.000 abstract 1
150000001413 amino acids Chemical group 0.000 abstract 1
230000000078 anti-malarial effect Effects 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
230000002163 immunogen Effects 0.000 abstract 1
229940124280 l-arginine Drugs 0.000 abstract 1
229920000729 poly(L-lysine) polymer Polymers 0.000 abstract 1
229920001184 polypeptide Polymers 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
210000002966 serum Anatomy 0.000 abstract 1
229960005486 vaccine Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
- C07K14/445—Plasmodium
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Biophysics (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Biochemistry (AREA)
Toxicology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Tropical Medicine & Parasitology (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Peptides Or Proteins (AREA)

AT91200727T 1990-04-02 1991-03-28 Immunologische komponente, verfahren zur synthese und verwendung in anit-malaria-impfstoff- zusammensetzungen ATE131830T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT19914A IT1241395B (it)	1990-04-02	1990-04-02	Composti immunogenici,il procedimento per la loro sintesi e loro impiego per la preparazione di vaccini antimalaria

Publications (1)

Publication Number	Publication Date
ATE131830T1 true ATE131830T1 (de)	1996-01-15

Family

ID=11162291

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91200727T ATE131830T1 (de)	1990-04-02	1991-03-28	Immunologische komponente, verfahren zur synthese und verwendung in anit-malaria-impfstoff- zusammensetzungen

Country Status (7)

Country	Link
EP (1)	EP0450715B1 (de)
AT (1)	ATE131830T1 (de)
DE (1)	DE69115539T2 (de)
DK (1)	DK0450715T3 (de)
ES (1)	ES2082109T3 (de)
GR (1)	GR3018750T3 (de)
IT (1)	IT1241395B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9107434D0 (en) *	1991-04-09	1991-05-22	Medical Res Council	Peptide-based assay
US5869451A (en) *	1995-06-07	1999-02-09	Glaxo Group Limited	Peptides and compounds that bind to a receptor
US6251864B1 (en)	1995-06-07	2001-06-26	Glaxo Group Limited	Peptides and compounds that bind to a receptor
US7091311B2 (en)	1996-06-07	2006-08-15	Smithkline Beecham Corporation	Peptides and compounds that bind to a receptor
ES2781475T3 (es)	2002-09-18	2020-09-02	Janssen Pharmaceuticals Inc	Métodos para aumentar la producción de células madre hematopoyéticas y plaquetas
US7723295B2 (en)	2003-08-28	2010-05-25	Ortho-Mcneil Pharmaceutical, Inc.	Peptides and compounds that bind to a receptor
SG131110A1 (en)	2003-08-28	2007-04-26	Ortho Mcneil Pharm Inc	Peptides and compounds that bind to thrombopoietin receptors
CN102153654B (zh) *	2009-12-31	2012-10-10	中国疾病预防控制中心病毒病预防控制所	以免疫活性肽为载体的分支多肽及其衍生物与应用
US10450343B2 (en)	2013-03-21	2019-10-22	Sanofi-Aventis Deutschland Gmbh	Synthesis of cyclic imide containing peptide products
CA2907454C (en)	2013-03-21	2021-05-04	Sanofi-Aventis Deutschland Gmbh	Synthesis of hydantoin containing peptide products
WO2016084944A1 (ja) *	2014-11-28	2016-06-02	国立大学法人群馬大学	熱帯熱マラリア原虫のエノラーゼタンパク質の部分配列を用いた人工抗原とその製造方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1187710B (it) *	1985-07-25	1987-12-23	Eniricerche Spa	Composizione peptidica utile per la preparazione di vaccini per la malaria e di kit diagnostici per la determinazione di affezioni malariche
EP0253190B1 (de) *	1986-07-16	1992-12-30	ENIRICERCHE S.p.A.	Teilweise retro-invertierte Analoge des Tuftsin, Methode zu ihrer Herstellung und pharmazeutische Zusammensetzungen, die sie enthalten
IT1216908B (it) *	1987-03-19	1990-03-14	Eniricerche Spa	Analoghi retro-inversi della timopentina e dei suoi frammenti, il metodo per la loro sintesi ed il loro impiego per la preparazionedi composizioni farmaceutiche.
GB8812214D0 (en) *	1988-05-24	1988-06-29	Hoffmann La Roche	Use of peptide from circumsporozoite protein of p falciparum as universally recognized t-cell epitope
CA2006700A1 (en) *	1989-01-17	1990-07-17	Antonello Pessi	Synthetic peptides and their use as universal carriers for the preparation of immunogenic conjugates suitable for the development of synthetic vaccines
CA2031197A1 (en) *	1989-04-12	1990-10-13	James P. Tam	Dendritic polymer of multiple antigen peptide system useful as anti-malarial vaccine

1990
- 1990-04-02 IT IT19914A patent/IT1241395B/it active IP Right Grant
1991
- 1991-03-28 DK DK91200727.5T patent/DK0450715T3/da active
- 1991-03-28 EP EP91200727A patent/EP0450715B1/de not_active Expired - Lifetime
- 1991-03-28 ES ES91200727T patent/ES2082109T3/es not_active Expired - Lifetime
- 1991-03-28 DE DE69115539T patent/DE69115539T2/de not_active Expired - Fee Related
- 1991-03-28 AT AT91200727T patent/ATE131830T1/de not_active IP Right Cessation
1996
- 1996-01-19 GR GR960400139T patent/GR3018750T3/el unknown

Also Published As

Publication number	Publication date
IT9019914A0 (it)	1990-04-02
GR3018750T3 (en)	1996-04-30
DE69115539D1 (de)	1996-02-01
IT9019914A1 (it)	1991-10-02
IT1241395B (it)	1994-01-10
ES2082109T3 (es)	1996-03-16
DK0450715T3 (da)	1996-02-26
EP0450715B1 (de)	1995-12-20
DE69115539T2 (de)	1996-08-01
EP0450715A1 (de)	1991-10-09

Legal Events

Date	Code	Title	Description
1996-06-15	UEP	Publication of translation of european patent specification
1998-12-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE131830T1 (de)	1996-01-15	Immunologische komponente, verfahren zur synthese und verwendung in anit-malaria-impfstoff- zusammensetzungen
Adam et al.	1976	Correlation of structure and adjuvant activity of N-acetyl muramyl-L-alanyl-D-isoglutamine (MDP), its derivatives and analogues. Anti-adjuvant and competition properties of stereoisomers
AU2020210919B2 (en)	2026-01-29	Glycoside-containing peptide linkers for antibody-drug conjugates
EP0409607A2 (de)	1991-01-23	Antikörper gegen menschlichen Interleukin-6-Rezeptor
MY162525A (en)	2017-06-15	Process for concentration of antibodies and therapeutic products thereof
DE3484691D1 (de)	1991-07-18	Konjugierte vinblastin-verbindungen und ihre derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
US5693325A (en)	1997-12-02	Peptide vaccines and methods relating thereto
CY1108538T1 (el)	2014-04-09	Χιμαιρικα πεπτιδια β-αμυλοειδους
JP2013009682A5 (de)	2013-10-24
CN1177982A (zh)	1998-04-01	作为融合蛋白的异源抗原的表达系统
AU2025204146A9 (en)	2026-03-19	Adjuvant effect of the TLR1/2 agonist diprovocim synergizes with checkpoint-inhibiting antibodies to eliminate disease
US20250345444A1 (en)	2025-11-13	Cleavable fragment directed by affinity fragment, design and synthesis thereof, and use thereof in preparation of site-directed drug conjugate
CA2176024A1 (en)	1995-05-18	Therapy
CY1111431T1 (el)	2015-08-05	Μεταλλαγμενες πρωτεϊνες πλακουντιου αυξητικου παραγοντα τυπου 1, μεθοδος παρασκευης και εφαρμογες αυτων
CA2554195A1 (en)	2005-08-04	Peptide originating in epidermal growth factor receptor (egfr)
Ramasamy et al.	1990	Characterisation of an inhibitory monoclonal antibody-defined epitope on a malaria vaccine candidate antigen
CA2003211A1 (en)	1990-05-17	Monoclonal antibodies
DE69014150D1 (de)	1994-12-22	Immunogen-Verbindungen und deren Benutzung in der Herstellung von genetisch unbeschränkten synthetischen Impfstoffen und bei der immunoenzymatischer Bestimmung von antisporozoiden Antikörpern von Plasmodium malariae.
IT1241081B (it)	1993-12-29	Composti immunogenici e loro impiego per la preparazione di vaccini sintetici geneticamente non ristretti per la determinazione immunoenzimatica di anticorpi anti-sporozoita di plasmodium malariae
Young et al.	1977	The binding of analogs of phosphorylcholine by the murine myeloma proteins McPC 603, MOPC 167 and S107
Babic et al.	2006	Epoxide opening with amino acids: improved synthesis of hydroxyethylamine dipeptide isosters
US20250367166A1 (en)	2025-12-04	Next generation diprovocims that activate the innate and adaptive immune response
Aoki et al.	2024	Chemical Synthesis of Interleukin-6 for Mirror-Image Screening
Toyota et al.	1999	Application of Schiff base copper (II) and iron (III) chelates to site-specific cleavage of a trypsin
US6639075B2 (en)	2003-10-28	Lactam-aldehyde compound and process of preparing same