IT1216908B - Analoghi retro-inversi della timopentina e dei suoi frammenti, il metodo per la loro sintesi ed il loro impiego per la preparazionedi composizioni farmaceutiche. - Google Patents

Analoghi retro-inversi della timopentina e dei suoi frammenti, il metodo per la loro sintesi ed il loro impiego per la preparazionedi composizioni farmaceutiche.

Info

Publication number: IT1216908B
Authority: IT; Italy
Prior art keywords: thyopentine; analogues; fragments; synthesis; reverse
Prior art date: 1987-03-19

Application number

IT8719763A

Other languages

English (en)

Other versions

IT8719763A0 (it

Inventor

Alessandro Sisto

Antonio Silvio Verdini

Original Assignee

Eniricerche Spa

Sclavo Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-03-19

Filing date

1987-03-19

Publication date

1990-03-14

1987-03-19 Application filed by Eniricerche Spa, Sclavo Spa filed Critical Eniricerche Spa

1987-03-19 Publication of IT8719763A0 publication Critical patent/IT8719763A0/it

1987-03-19 Priority to IT8719763A priority Critical patent/IT1216908B/it

1988-03-09 Priority to DE88103699T priority patent/DE3887362T2/de

1988-03-09 Priority to EP88103699A priority patent/EP0282891B1/en

1988-03-09 Priority to AT88103699T priority patent/ATE100816T1/de

1988-03-09 Priority to ES88103699T priority patent/ES2061533T3/es

1988-03-11 Priority to CA000561269A priority patent/CA1315472C/en

1988-03-15 Priority to US07/168,237 priority patent/US5013723A/en

1988-03-18 Priority to JP63063716A priority patent/JPS63250360A/ja

1990-03-14 Application granted granted Critical

1990-03-14 Publication of IT1216908B publication Critical patent/IT1216908B/it

1991-01-31 Priority to US07/648,977 priority patent/US5200506A/en

1992-01-13 Priority to CA000616330A priority patent/CA1336738C/en

Links

239000012634 fragment Substances 0.000 title abstract 2
230000015572 biosynthetic process Effects 0.000 title 1
238000000034 method Methods 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
238000002360 preparation method Methods 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1
102400000160 Thymopentin Human genes 0.000 abstract 3
101800001703 Thymopentin Proteins 0.000 abstract 3
PSWFFKRAVBDQEG-YGQNSOCVSA-N thymopentin Chemical compound NC(N)=NCCC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](C(O)=O)CC1=CC=C(O)C=C1 PSWFFKRAVBDQEG-YGQNSOCVSA-N 0.000 abstract 3
229960004517 thymopentin Drugs 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
102000004190 Enzymes Human genes 0.000 abstract 1
108090000790 Enzymes Proteins 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
230000002519 immonomodulatory effect Effects 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0212—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -N-C-N-C(=0)-, e.g. retro-inverso peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Immunology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Saccharide Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

IT8719763A 1987-03-19 1987-03-19 Analoghi retro-inversi della timopentina e dei suoi frammenti, il metodo per la loro sintesi ed il loro impiego per la preparazionedi composizioni farmaceutiche. IT1216908B (it)

Priority Applications (10)

Application Number	Priority Date	Filing Date	Title
IT8719763A IT1216908B (it)	1987-03-19	1987-03-19	Analoghi retro-inversi della timopentina e dei suoi frammenti, il metodo per la loro sintesi ed il loro impiego per la preparazionedi composizioni farmaceutiche.
ES88103699T ES2061533T3 (es)	1987-03-19	1988-03-09	Nuevos analogos retroinversos de timopentina y sus fragmentos, un procedimiento de preparacion de los nuevos compuestos y los productos intermedios obtenidos.
EP88103699A EP0282891B1 (en)	1987-03-19	1988-03-09	New thymopentin retro-inverso analogs and fragments thereof, a process of preparation of the new compounds and the intermediates obtained therein
AT88103699T ATE100816T1 (de)	1987-03-19	1988-03-09	Thymopentin-retro-inverso-analoga und deren fragmente, verfahren zu deren herstellung und so erhaltene zwischenprodukte.
DE88103699T DE3887362T2 (de)	1987-03-19	1988-03-09	Thymopentin-Retro-Inverso-Analoga und deren Fragmente, Verfahren zu deren Herstellung und so erhaltene Zwischenprodukte.
CA000561269A CA1315472C (en)	1987-03-19	1988-03-11	Thymopentin retro-inverso analogs and fragments thereof, a process of preparation of the new compounds and the intermediates obtained therein
US07/168,237 US5013723A (en)	1987-03-19	1988-03-15	New thymopentin retro-inverso analogs and fragments thereof, a process of preparation of the new compounds and the intermediates obtained therein
JP63063716A JPS63250360A (ja)	1987-03-19	1988-03-18	サイモペンチンレトロ−インバーソ類似体及びそのフラグメント
US07/648,977 US5200506A (en)	1987-03-19	1991-01-31	Process for preparing new thymopentin retro-inverso analogs and fragments thereof and the intermediates obtained therein
CA000616330A CA1336738C (en)	1987-03-19	1992-01-13	Intermediates produced during the preparation of new thymopentin retroinverso analogs

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT8719763A IT1216908B (it)	1987-03-19	1987-03-19	Analoghi retro-inversi della timopentina e dei suoi frammenti, il metodo per la loro sintesi ed il loro impiego per la preparazionedi composizioni farmaceutiche.

Publications (2)

Publication Number	Publication Date
IT8719763A0 IT8719763A0 (it)	1987-03-19
IT1216908B true IT1216908B (it)	1990-03-14

Family

ID=11161024

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT8719763A IT1216908B (it)	1987-03-19	1987-03-19	Analoghi retro-inversi della timopentina e dei suoi frammenti, il metodo per la loro sintesi ed il loro impiego per la preparazionedi composizioni farmaceutiche.

Country Status (8)

Country	Link
US (1)	US5013723A (it)
EP (1)	EP0282891B1 (it)
JP (1)	JPS63250360A (it)
AT (1)	ATE100816T1 (it)
CA (1)	CA1315472C (it)
DE (1)	DE3887362T2 (it)
ES (1)	ES2061533T3 (it)
IT (1)	IT1216908B (it)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5200506A (en) *	1987-03-19	1993-04-06	Eniricerche S.P.A.	Process for preparing new thymopentin retro-inverso analogs and fragments thereof and the intermediates obtained therein
US5214052A (en) *	1987-07-28	1993-05-25	Mitsubishi Kasei Corporation	Method for dissolving arginineamides and pharmaceutical compositions containing them
GB8807427D0 (en) *	1988-03-28	1988-05-05	National Biological Standards Board	Peptides
NZ229004A (en) *	1988-05-19	1993-09-27	Immunobiology Res Inst Inc	Tetrapeptides having t cell helper acitivity
IT1227908B (it) *	1988-12-23	1991-05-14	Eniricerche S P A Milano Sclav	Nuovi analoghi retro-inversi della timopentina, il metodo per la loro sintesi ed il loro impiego per la preparazione di composizioni farmaceutiche
US5218089A (en) *	1988-12-23	1993-06-08	Sclavo S.P.A.	Retro-inverso analogues of thymopentin and the method for their synthesis
IT1241395B (it) *	1990-04-02	1994-01-10	Eniricerche Spa	Composti immunogenici,il procedimento per la loro sintesi e loro impiego per la preparazione di vaccini antimalaria
KR950702839A (ko)	1992-08-27	1995-08-23	스티븐 딕	레트로, 인버소-, 및 레트로- 인버소 합성 펩티드 유사체(retro-, inverso-, and retro-inverso synthetic peptide analogues)
US5639729A (en) *	1993-08-26	1997-06-17	Immunobiology Research Institute, Inc.	Tripeptides useful in immune and CNS therapy
IT1270882B (it) *	1993-10-05	1997-05-13	Isagro Srl	Oligopeptidi ad attivita' fungicida
AUPM411994A0 (en) *	1994-02-25	1994-03-24	Deakin Research Limited	Epitopes
RU2107692C1 (ru) *	1995-06-07	1998-03-27	Дейгин Владислав Исакович	Пептид и способ его получения
RU2107691C1 (ru) *	1995-03-02	1998-03-27	Дейгин Владислав Исакович	Пептид и способ его получения
US6159940A (en) *	1996-02-28	2000-12-12	Immunotech Developments Inc.	Method for modulating hemopoiesis
US11975051B1 (en)	2022-07-12	2024-05-07	Siobhan Ellison	Therapeutic peptides and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4505853A (en) *	1983-11-18	1985-03-19	Ortho Pharmaceutical Corporation	Enzyme-resistant immunomodulatory peptides
US4547489A (en) *	1984-06-11	1985-10-15	Ortho Pharmaceutical Corporation	Conformationally restricted thymopentin-like compounds
US4629723A (en) *	1984-06-27	1986-12-16	Ortho Pharmaceutical Corporation	Potent thymopentin analogs
HUT46044A (en) *	1986-11-21	1988-09-28	Richter Gedeon Vegyeszet	Process for producing immunstimulant peptides inhibiting multiplication of leukaemic cells and pharmaceutics comprising same

1987
- 1987-03-19 IT IT8719763A patent/IT1216908B/it active
1988
- 1988-03-09 AT AT88103699T patent/ATE100816T1/de not_active IP Right Cessation
- 1988-03-09 EP EP88103699A patent/EP0282891B1/en not_active Expired - Lifetime
- 1988-03-09 ES ES88103699T patent/ES2061533T3/es not_active Expired - Lifetime
- 1988-03-09 DE DE88103699T patent/DE3887362T2/de not_active Expired - Fee Related
- 1988-03-11 CA CA000561269A patent/CA1315472C/en not_active Expired - Fee Related
- 1988-03-15 US US07/168,237 patent/US5013723A/en not_active Expired - Fee Related
- 1988-03-18 JP JP63063716A patent/JPS63250360A/ja active Pending

Also Published As

Publication number	Publication date
US5013723A (en)	1991-05-07
DE3887362T2 (de)	1994-05-11
JPS63250360A (ja)	1988-10-18
EP0282891A2 (en)	1988-09-21
CA1315472C (en)	1993-03-30
ATE100816T1 (de)	1994-02-15
DE3887362D1 (de)	1994-03-10
EP0282891B1 (en)	1994-01-26
IT8719763A0 (it)	1987-03-19
ES2061533T3 (es)	1994-12-16
EP0282891A3 (en)	1990-05-23

Legal Events

Date	Code	Title	Description
1999-10-27	TA	Fee payment date (situation as of event date), data collected since 19931001	Effective date: 19940330

Publication	Publication Date	Title
ATE100816T1 (de)	1994-02-15	Thymopentin-retro-inverso-analoga und deren fragmente, verfahren zu deren herstellung und so erhaltene zwischenprodukte.
ATE199730T1 (de)	2001-03-15	Oberflächenaktives lungenprotein und verwandte polypeptide
NO974899L (no)	1997-10-23	Analogifremgangsmåte for fremstilling av en terapeutisk aktiv aprotinin-analog
HUT37780A (en)	1986-02-28	Process for producing n-/4-piperidyl/-substituted bicyclic condensed 2-imidazolyl-amine derivatives and pharmaceutical compositions containing them as active agents
DE3689508D1 (de)	1994-02-17	Peptide.
EP0358660B1 (en)	1994-05-25	Synthetic inhibitors of mammalian collagenase
FI824419A0 (fi)	1982-12-22	Cykliska oktapeptider och farmaceutiska preparat daerav, samt foerfarande foer deras framstaellning deras anvaendning
ES2071815T3 (es)	1995-07-01	Analogos de delecion de los peptidos conocidos como magaininas.
IL92240A0 (en)	1990-07-26	Serine analogs of bu-3608 antibodies,their preparation and pharmaceutical compositions containing them
ATE179169T1 (de)	1999-05-15	Prostaglandinanaloge
HUT46933A (en)	1988-12-28	Process for producing cyclic peptides of anticoagulant activity
HUT47136A (en)	1989-01-30	Process for producing cyclic peptides with anticoagulant effect
GR862021B (en)	1986-12-31	Process for obtaining aminoalcohols peptidic derivatives containing a tetrasubstituted carbon atom as inhibitors of renine and acid proteases
HUT51283A (en)	1990-04-28	Process for production of n-alkyl derivatives of bu-3608-antibiotics and medical compositions containing them as active substances
WO1995032954A1 (en)	1995-12-07	Epoxysuccinic acid derivatives, their production and use
HUT45518A (en)	1988-07-28	Process for producing 1,5-benzothiazepine derivatives and pharmaceutics comprising these compounds
IT1227908B (it)	1991-05-14	Nuovi analoghi retro-inversi della timopentina, il metodo per la loro sintesi ed il loro impiego per la preparazione di composizioni farmaceutiche
IT1230733B (it)	1991-10-29	Analoghi della timopentina retro invertita a tutti i legami, il metodo per la loro sintesi ed il loro impiego per la preparazione di composizioni farmaceutiche.
IT1217567B (it)	1990-03-30	Processo diastereoselettivo per la preparazione di intermedi utili per la sintesi di derivati peptidici
SE9800865D0 (sv)	1998-03-16	New Process
IT1229658B (it)	1991-09-06	Analoghi della timopentina retro-inversi ad uno o piu' legami, il metodo per la loro sintesi ed il loro impiego per la preparazione di composizioni farmaceutiche.
ATE46347T1 (de)	1989-09-15	Immunostimulierende peptide.