ATE132149T1 - Konjugate von difluoroglutaminsäure mit fölaten und antifölaten für die behandlung von neoplastischen krankheiten - Google Patents

Konjugate von difluoroglutaminsäure mit fölaten und antifölaten für die behandlung von neoplastischen krankheiten

Info

Publication number: ATE132149T1
Authority: AT; Austria
Prior art keywords: antifolates; treatment; conjugates; acid; neoplastic diseases
Prior art date: 1990-04-12

Application number

AT91105768T

Other languages

English (en)

Inventor

Philippe Bey

James K Coward

John J Mcguire

Original Assignee

Health Research Inc

Merrell Dow Pharma

Univ Michigan

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-04-12

Filing date

1991-04-11

Publication date

1996-01-15

1991-04-11 Application filed by Health Research Inc, Merrell Dow Pharma, Univ Michigan filed Critical Health Research Inc

1996-01-15 Application granted granted Critical

1996-01-15 Publication of ATE132149T1 publication Critical patent/ATE132149T1/de

Links

229940127074 antifolate Drugs 0.000 title abstract 2
201000010099 disease Diseases 0.000 title abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
239000004052 folic acid antagonist Substances 0.000 title abstract 2
230000001613 neoplastic effect Effects 0.000 title abstract 2
DSNSKNAHYTUBEF-VKHMYHEASA-N (2s)-5-amino-2-(difluoroamino)-5-oxopentanoic acid Chemical compound NC(=O)CC[C@H](N(F)F)C(O)=O DSNSKNAHYTUBEF-VKHMYHEASA-N 0.000 title 1
COKJHIVDQXTJKI-VKHMYHEASA-N (2s)-2-(difluoroamino)pentanedioic acid Chemical compound OC(=O)CC[C@H](N(F)F)C(O)=O COKJHIVDQXTJKI-VKHMYHEASA-N 0.000 abstract 1
201000009030 Carcinoma Diseases 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
206010039491 Sarcoma Diseases 0.000 abstract 1
230000003432 anti-folate effect Effects 0.000 abstract 1
235000019152 folic acid Nutrition 0.000 abstract 1
150000002224 folic acids Chemical class 0.000 abstract 1
208000032839 leukemia Diseases 0.000 abstract 1
201000001441 melanoma Diseases 0.000 abstract 1
230000009826 neoplastic cell growth Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
- C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Hematology (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Peptides Or Proteins (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT91105768T 1990-04-12 1991-04-11 Konjugate von difluoroglutaminsäure mit fölaten und antifölaten für die behandlung von neoplastischen krankheiten ATE132149T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/508,873 US5286726A (en)	1990-04-12	1990-04-12	Difluoroglutamic acid conjugates with folates and anti-folates for the treatment of neoplastic diseases

Publications (1)

Publication Number	Publication Date
ATE132149T1 true ATE132149T1 (de)	1996-01-15

Family

ID=24024425

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91105768T ATE132149T1 (de)	1990-04-12	1991-04-11	Konjugate von difluoroglutaminsäure mit fölaten und antifölaten für die behandlung von neoplastischen krankheiten

Country Status (17)

Country	Link
US (1)	US5286726A (de)
EP (1)	EP0451836B1 (de)
JP (1)	JP2894576B2 (de)
KR (1)	KR910018383A (de)
CN (1)	CN1057653A (de)
AT (1)	ATE132149T1 (de)
AU (1)	AU631055B2 (de)
CA (1)	CA2039855C (de)
DE (1)	DE69115744T2 (de)
ES (1)	ES2082029T3 (de)
FI (1)	FI911788L (de)
HU (1)	HUT57793A (de)
IE (1)	IE911234A1 (de)
IL (1)	IL97815A0 (de)
NO (1)	NO911415L (de)
PT (1)	PT97337B (de)
ZA (1)	ZA912555B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
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GB9205907D0 (en) *	1992-03-18	1992-04-29	Cancer Res Inst Royal	Anti-cancer compounds
WO1993020075A1 (en) *	1992-04-01	1993-10-14	The University Of Sydney	8-substituted-n5-deazapterins as antifolates
EP0638079B1 (de) *	1992-04-29	1999-12-15	Sri International	Deazaaminopterine für behandlung von entzündungen
US5547954A (en) *	1994-05-26	1996-08-20	Fmc Corporation	2,4-Diamino-5,6-disubstituted-and 5,6,7-trisubstituted-5-deazapteridines as insecticides
US6323205B1 (en) *	1996-07-17	2001-11-27	Sloan-Kettering Institute For Cancer Research	Combinations of 10-propargyl-10-deazaaminopterin and taxols and methods of using same in the treatment of tumors
DE19830599A1 (de) *	1998-07-09	2000-01-13	Basf Ag	Verfahren zur stereoselektiven Herstellung von Grignardverbindungen und deren Verwendung
AU2008237932C1 (en) *	2007-04-11	2014-04-24	Merck & Cie	18 F-labelled folates
PT2146944E (pt) *	2007-04-11	2014-03-11	Merck & Cie	Processo para a preparação de folatos marcados com 18f
US20100248249A1 (en) *	2007-08-17	2010-09-30	Allos Therapeutics, Inc.	Methods for Assessing Cancer for Increased Sensitivity to 10-Propargyl-10-Deazaaminopterin by Assessing Egfr Levels
WO2009026234A1 (en) *	2007-08-17	2009-02-26	Allos Therapeutics, Inc.	Combination of 10-propargyl-10-deazaaminopterin and erlotinib for the treatment of non-small cell lung cancer
US9901578B2 (en)	2007-08-17	2018-02-27	Allos Therapeutics, Inc.	Combination of 10-propargyl-10-deazaaminopterin and erlotinib for the treatment of non-small cell lung cancer
CA2736861C (en)	2008-10-10	2017-11-14	Roger Schibli	18f-labelled folates as pet radiotracers
US20110190305A1 (en)	2010-02-02	2011-08-04	Allos Therapeutics, Inc.	Optically Pure Diastereomers of 10-Propargyl-10-Deazaaminopterin and Methods of Using Same

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2520392A (en) *	1947-06-27	1950-08-29	Flenghi Louis	Disk and pin game
US4393064A (en) *	1976-03-05	1983-07-12	Sri International	Process and composition for treatment of leukemia and process for preparing the same
DE3069468D1 (en) *	1979-12-19	1984-11-22	Nat Res Dev	Quinazoline derivatives, processes for their preparation, compositions containing them and their use as anti-cancer agents
US4853221A (en) *	1980-11-13	1989-08-01	Warner-Lambert Company	Method for treating non-small cell lung cancer, head and neck cancers and breast cancer
US4628089A (en) *	1982-01-11	1986-12-09	Southern Research Institute	Pyrido(2,3-D)pyrimidines
US4460591A (en) *	1982-08-26	1984-07-17	Sri International	8,10-Dideazaminopterins
US4628090A (en) *	1984-08-21	1986-12-09	Rensselaer Polytechnic Institute	Fluorine-containing antifolates incapable of polyglutanayte formation related compounds
US4584375A (en) *	1984-08-21	1986-04-22	Rensselaer Polytechnic Institute	Fluorine-containing antifolates incapable of polyglutamate formation
US5026851A (en) *	1985-03-08	1991-06-25	The Trustees Of Princeton University	Pyrido[2,3-]pyrimidine derivatives
GB8513754D0 (en) *	1985-05-31	1985-07-03	Jones T R	Anti-cancer quinazoline derivatives
JPS6281385A (ja) *	1985-10-02	1987-04-14	Shionogi & Co Ltd	新規メトトレキサ−ト誘導体
GB8607683D0 (en) *	1986-03-27	1986-04-30	Ici Plc	Anti-tumor agents
US5223620A (en) *	1988-04-01	1993-06-29	Takeda Chemical Industries, Ltd.	Pyrido[2,3-d]pyrimidine compounds useful as intermediates
GB8809978D0 (en) *	1988-04-27	1988-06-02	Ici Plc	Anti-tumour agents
US4882333A (en) *	1988-05-25	1989-11-21	The Trustess Of Princeton University	N-(5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-yl-alkanoyl)-glutamic acid derivatives
AU3843189A (en) *	1988-07-01	1990-01-23	Sloan-Kettering Institute For Cancer Research	5-deaza-5,7-disubstituted-aminopterin analogues
JPH03501490A (ja) *	1988-09-16	1991-04-04	エス・アール・アイ・インターナシヨナル	８，１０‐ジデアザテトラヒドロ葉酸誘導体
CA2001458A1 (en) *	1989-08-14	1991-02-14	James R. Piper	5-methyl-5-deaza-10-propargylaminopterin
US4996207A (en) *	1990-01-18	1991-02-26	Nair Madhavan G	Three new non-polyglutamatable deazaaminopterins
US5066828A (en) *	1990-04-12	1991-11-19	Merrell Dow Pharmaceuticals Inc.	Difluoroglutamic acid conjugates with folates and anti-folates for the treatment of neoplastic diseases

1990
- 1990-04-12 US US07/508,873 patent/US5286726A/en not_active Expired - Lifetime
1991
- 1991-04-05 CA CA002039855A patent/CA2039855C/en not_active Expired - Fee Related
- 1991-04-05 ZA ZA912555A patent/ZA912555B/xx unknown
- 1991-04-09 AU AU74175/91A patent/AU631055B2/en not_active Ceased
- 1991-04-10 IL IL97815A patent/IL97815A0/xx unknown
- 1991-04-11 KR KR1019910005788A patent/KR910018383A/ko not_active Withdrawn
- 1991-04-11 EP EP91105768A patent/EP0451836B1/de not_active Expired - Lifetime
- 1991-04-11 DE DE69115744T patent/DE69115744T2/de not_active Expired - Fee Related
- 1991-04-11 ES ES91105768T patent/ES2082029T3/es not_active Expired - Lifetime
- 1991-04-11 AT AT91105768T patent/ATE132149T1/de not_active IP Right Cessation
- 1991-04-11 PT PT97337A patent/PT97337B/pt not_active IP Right Cessation
- 1991-04-11 HU HU911193A patent/HUT57793A/hu unknown
- 1991-04-11 NO NO91911415A patent/NO911415L/no unknown
- 1991-04-11 CN CN91102295A patent/CN1057653A/zh active Pending
- 1991-04-11 IE IE123491A patent/IE911234A1/en unknown
- 1991-04-12 JP JP3106389A patent/JP2894576B2/ja not_active Expired - Fee Related
- 1991-04-12 FI FI911788A patent/FI911788L/fi not_active Application Discontinuation

Also Published As

Publication number	Publication date
JP2894576B2 (ja)	1999-05-24
EP0451836B1 (de)	1995-12-27
JPH04234854A (ja)	1992-08-24
IE911234A1 (en)	1991-10-23
HU911193D0 (en)	1991-10-28
ES2082029T3 (es)	1996-03-16
AU631055B2 (en)	1992-11-12
FI911788A7 (fi)	1991-10-13
CA2039855A1 (en)	1991-10-13
PT97337A (pt)	1992-01-31
IL97815A0 (en)	1992-06-21
US5286726A (en)	1994-02-15
DE69115744T2 (de)	1996-05-30
ZA912555B (en)	1992-04-29
AU7417591A (en)	1991-10-17
NO911415L (no)	1991-10-14
DE69115744D1 (de)	1996-02-08
FI911788L (fi)	1991-10-13
HUT57793A (en)	1991-12-30
CA2039855C (en)	2001-08-21
EP0451836A2 (de)	1991-10-16
NO911415D0 (no)	1991-04-11
FI911788A0 (fi)	1991-04-12
PT97337B (pt)	1998-08-31
EP0451836A3 (en)	1992-07-01
KR910018383A (ko)	1991-11-30
CN1057653A (zh)	1992-01-08

Legal Events

Date	Code	Title
1996-06-15	UEP	Publication of translation of european patent specification
1997-04-15	EEFA	Change of the company name
2005-01-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69115744D1 (de)	1996-02-08	Konjugate von Difluoroglutaminsäure mit Fölaten und Antifölaten für die Behandlung von neoplastischen Krankheiten
EP0335901A4 (en)	1990-11-28	Methods and compositions for the treatment of non-ige-mediated diseases
ATE32730T1 (de)	1988-03-15	Indikatormarkierte konjugate von metallothionein und zielsuchenden, biologisch aktiven molekuelen.
PL342078A1 (en)	2001-05-21	Inhibition of raf kinase using symmetrical and dissymmetrical substituted dimethylureas
ATE255896T1 (de)	2003-12-15	Tetrahydropteridine und pyridylpiperazine zur behandlung von neurologischen störungen
ATE250566T1 (de)	2003-10-15	24-hydroxy vitamin d, deren analogen und verwendungen
DE69523654D1 (de)	2001-12-13	Verwendung von Ascorbyl-gamma-Linolenat und von Ascorbyl-dihomo-gamma-linolenat zur Behandlung von Asthma, Krebs, kardiovaskulären und inflammatorischen Erkrankungen
BG100930A (bg)	1997-07-31	Фармацевтични състави и лекарствени средства за профилактика и лечение на ендотелиални нарушения
DE69112885D1 (de)	1995-10-19	Zwischenprodukte für Difluoroglutamsäurekonjugate mit Folaten und Antifolaten zur Behandlung von neoplastischen Krankheiten.
ATE82857T1 (de)	1992-12-15	Interleukin-2-zusammensetzungen.
PT88275A (pt)	1989-06-30	Processo para a preparacao de composicoes farmaceuticas contendo 5-amino ou amino substituido-1,2,3-triazois uteis como agentes antiproliferativos
DE69520832D1 (de)	2001-06-07	Neurotrophische und antiproliferative verbindungen
DK0510913T3 (da)	2000-10-16	Farmaceutiske sammensætninger indeholdende calcitonin
TR199701605A2 (xx)	1998-07-21	S�lfonamid-substit�e edilmi� bile�ikler
ATE121935T1 (de)	1995-05-15	D-asparaginsäure-beta-hydroxamat zur behandlung viraler infektionen und tumoren.
DE3373907D1 (en)	1987-11-05	N-acyl derivatives of dipeptides, their manufacture and use in treating diseases, and means therefor
RO84903B1 (ro)	1984-09-30	Solutie medicamentoasa pentru tratamentul afectiunilor otice
UA40656C2 (uk)	2001-08-15	Засіб "феррофол" для лікування залізодефіцитної анемії