ATE132534T1 - Rekombinanter impfstoff - Google Patents

Rekombinanter impfstoff

Info

Publication number: ATE132534T1
Authority: AT; Austria
Prior art keywords: vaccine; antigenic polypeptide; vector; lymphokine; expressed
Prior art date: 1986-08-01

Application number

AT87905142T

Other languages

English (en)

Inventor

Ian Allister Ramshaw

David Bernard Boyle

Barbara Elizabeth Howie Coupar

Marion Elizabeth Andrew

Original Assignee

Commw Scient Ind Res Org

Univ Australian

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-08-01

Filing date

1987-07-31

Publication date

1996-01-15

1987-07-31 Application filed by Commw Scient Ind Res Org, Univ Australian filed Critical Commw Scient Ind Res Org

1996-01-15 Application granted granted Critical

1996-01-15 Publication of ATE132534T1 publication Critical patent/ATE132534T1/de

Links

108010008038 Synthetic Vaccines Proteins 0.000 title abstract 2
229940124551 recombinant vaccine Drugs 0.000 title abstract 2
239000013598 vector Substances 0.000 abstract 4
230000000890 antigenic effect Effects 0.000 abstract 3
229920001184 polypeptide Polymers 0.000 abstract 3
102000004196 processed proteins & peptides Human genes 0.000 abstract 3
108090000765 processed proteins & peptides Proteins 0.000 abstract 3
229960005486 vaccine Drugs 0.000 abstract 3
239000002773 nucleotide Substances 0.000 abstract 2
125000003729 nucleotide group Chemical group 0.000 abstract 2
102000008070 Interferon-gamma Human genes 0.000 abstract 1
108010074328 Interferon-gamma Proteins 0.000 abstract 1
102000015696 Interleukins Human genes 0.000 abstract 1
108010063738 Interleukins Proteins 0.000 abstract 1
230000002708 enhancing effect Effects 0.000 abstract 1
229940044627 gamma-interferon Drugs 0.000 abstract 1
230000028993 immune response Effects 0.000 abstract 1
241000701161 unidentified adenovirus Species 0.000 abstract 1
241001529453 unidentified herpesvirus Species 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/275—Poxviridae, e.g. avipoxvirus
- A61K39/285—Vaccinia virus or variola virus
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/525—Tumour necrosis factor [TNF]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/57—IFN-gamma
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24141—Use of virus, viral particle or viral elements as a vector
- C12N2710/24143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Wood Science & Technology (AREA)
Molecular Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Microbiology (AREA)
Physics & Mathematics (AREA)
Virology (AREA)
Plant Pathology (AREA)
Medicinal Chemistry (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Toxicology (AREA)
Mycology (AREA)
Immunology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

AT87905142T 1986-08-01 1987-07-31 Rekombinanter impfstoff ATE132534T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
AUPH721286		1986-08-01

Publications (1)

Publication Number	Publication Date
ATE132534T1 true ATE132534T1 (de)	1996-01-15

Family

ID=3771741

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT87905142T ATE132534T1 (de)	1986-08-01	1987-07-31	Rekombinanter impfstoff

Country Status (10)

Country	Link
EP (1)	EP0275300B1 (de)
JP (1)	JP2642113B2 (de)
KR (1)	KR970008217B1 (de)
AT (1)	ATE132534T1 (de)
AU (1)	AU612983B2 (de)
CA (1)	CA1339346C (de)
DE (1)	DE3751664T2 (de)
NZ (1)	NZ221298A (de)
WO (1)	WO1988000971A1 (de)
ZA (1)	ZA875681B (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5833975A (en) *	1989-03-08	1998-11-10	Virogenetics Corporation	Canarypox virus expressing cytokine and/or tumor-associated antigen DNA sequence
US5171568A (en) *	1984-04-06	1992-12-15	Chiron Corporation	Recombinant herpes simplex gb-gd vaccine
IL87394A0 (en) *	1987-08-12	1989-12-15	Natural Environment Res	Expression vectors for the synthesis of proteins and plasmid replicons and sequence cassettes for use in constructing said vectors
US6569679B1 (en) *	1988-03-21	2003-05-27	Chiron Corporation	Producer cell that generates adenoviral vectors encoding a cytokine and a conditionally lethal gene
US5662896A (en) *	1988-03-21	1997-09-02	Chiron Viagene, Inc.	Compositions and methods for cancer immunotherapy
DE69019609T2 (de) *	1989-07-07	1995-11-30	Takeda Chemical Industries Ltd	Proteine und deren Herstellung.
AU651949B2 (en) *	1989-07-14	1994-08-11	American Cyanamid Company	Cytokine and hormone carriers for conjugate vaccines
GR1001220B (el) *	1990-08-06	1993-06-21	Praxis Biolog Inc	Φορεις κυτοκινης και ορμονης για συζευγμενα εμβολια.
US5594107A (en) *	1990-08-22	1997-01-14	University Of Saskatchewan	Chimeric protein comprising an RTX-family cytotoxin and interferon-2 or interferon
US5238823A (en) *	1990-08-22	1993-08-24	Veterinary Infectious Disease Organization	Interleukin-2-leukotoxin gene fusions and uses thereof
US5273889A (en) *	1990-08-22	1993-12-28	University Of Saskatchewan	Gamma-iterferon-leukotoxin gene fusions and uses thereof
AU651152B2 (en) *	1990-08-29	1994-07-14	Genetics Institute, Llc	Multidomain hematopoiesis stimulators
JPH05502463A (ja) *	1990-09-28	1993-04-28	オーソ・フアーマシユーチカル・コーポレーシヨン	ハイブリツド成長因子
US5707652A (en) *	1990-12-04	1998-01-13	State Of Oregon	Methods of treating circadian rhythm phase disorders
DK0563254T3 (da) *	1990-12-19	1996-02-12	Schering Corp	Anvendelse af IL-4 til forstærkning af immunrespons på immunogener i vacciner
FR2681786A1 (fr) *	1991-09-27	1993-04-02	Centre Nat Rech Scient	Vecteurs recombinants d'origine virale, leur procede d'obtention et leur utilisation pour l'expression de polypeptides dans des cellules musculaires.
ATE219522T1 (de) *	1992-02-04	2002-07-15	Chiron Corp	Hepatistherapeutikum
US6297048B1 (en) *	1992-02-04	2001-10-02	Chiron Corporation	Hepatitis therapeutics
USRE39494E1 (en)	1992-02-27	2007-02-27	Intervet Inc.	Inactivated mycoplasma hyopneumoniae and uses therefor
FR2688514A1 (fr)	1992-03-16	1993-09-17	Centre Nat Rech Scient	Adenovirus recombinants defectifs exprimant des cytokines et medicaments antitumoraux les contenant.
WO1993019092A1 (fr) *	1992-03-19	1993-09-30	Centre National De La Recherche Scientifique	Adenovirus recombinants defectifs exprimant des proteines caracteristiques du virus epstein-barr
EP0609739A1 (de) *	1993-02-02	1994-08-10	American Cyanamid Company	Methode der Umkehrung der Immunsuppression in Vakzinen
KR960701988A (ko) *	1993-04-20	1996-03-28	윌리엄 에스. 로빈슨	세포내 감염원에 감염된 개체의 치료방법 및 치료물질(methods and materials for treatment of individuals infected with intracellular in-fectious agents)
KR960703172A (ko) *	1993-11-18	1996-06-19	스티븐 제이. 멘토	조건적으로 치사적인 유전자를 활용하기 위한 조성물 및 방법(Compositions and methods for utilizing conditionally lethal genes)
WO1995031105A1 (en) *	1994-05-13	1995-11-23	Thomas Jefferson University	A method of inducing an immune response using vaccinia virus recombinants
US6093700A (en)	1995-05-11	2000-07-25	Thomas Jefferson University	Method of inducing an immune response using vaccinia virus recombinants encoding GM-CSF
IL114576A0 (en) *	1994-07-22	1995-11-27	Merck & Co Inc	Polynucleotide herpes virus vaccine
US7094767B2 (en)	1994-07-22	2006-08-22	Merck & Co., Inc.	Polynucleotide herpes virus vaccine
FR2725213B1 (fr) *	1994-10-04	1996-11-08	Rhone Poulenc Rorer Sa	Vecteurs viraux et utilisation en therapie genique
WO1996040880A1 (en) *	1995-06-07	1996-12-19	Syntro Corporation	Recombinant fowlpox viruses and uses thereof
US6344445B1 (en)	1995-10-19	2002-02-05	Cantab Pharmaceutical Research Limited	Herpes virus vectors and their uses
CA2745736C (en) *	1996-10-23	2016-11-22	The Trustees Of The University Of Pennsylvania	Immunotherapy and improved vaccines
US6696423B1 (en)	1997-08-29	2004-02-24	Biogen, Inc.	Methods and compositions for therapies using genes encoding secreted proteins such as interferon-beta
AUPP700798A0 (en) *	1998-11-09	1998-12-03	Australian National University, The	Recombinant viral constructs and methods relating thereto
US7754201B2 (en)	2000-06-02	2010-07-13	GenPhar, Inc	Method of vaccination through serotype rotation
US6544780B1 (en)	2000-06-02	2003-04-08	Genphar, Inc.	Adenovirus vector with multiple expression cassettes
US7092633B2 (en)	2000-11-14	2006-08-15	University Of Texas System Board Of Regents	System and method for configuring optical circuits

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0088540A3 (de) *	1982-02-22	1984-10-17	Biogen, Inc.	DNS-Sequenzen, Rekombinante DNS-Moleküle und Verfahren zur Herstellung von dem immunen menschlichen Interferon ähnlichen Polypeptiden
US4695542A (en) *	1983-10-04	1987-09-22	Dnax Research Institute Of Molecular And Cellular Biology, Inc.	cDNA clones coding for polypeptides exhibiting multi-lineage cellular growth factor activity
US4855238A (en) *	1983-12-16	1989-08-08	Genentech, Inc.	Recombinant gamma interferons having enhanced stability and methods therefor
CA1282721C (en) *	1984-06-04	1991-04-09	Bernard Roizman	Herpes simplex virus as a vector
AU576907B2 (en) *	1984-11-01	1988-09-08	American Home Products Corporation	Oral vaccines comprising live recombinant adenoviruses
FR2583429B1 (fr) *	1985-06-18	1989-11-03	Transgene Sa	Vecteur d'expression de l'interferon u dans les cellules de mammifere, procede pour sa mise en oeuvre et produit obtenu et composition pharmaceutique contenant l'interferon u
FR2583770B1 (fr) *	1985-06-21	1988-08-19	Transgene Sa	Expression de l'il-2 humaine dans les cellules de mammiferes par un poxvirus recombine
AU603768B2 (en) *	1985-07-04	1990-11-29	Kanegafuchi Kagaku Kogyo Kabushiki Kaisha	Lymphotoxin dna, lymphotoxin expression vector, lymphotoxin resistant cell, transformant with lymphotoxin expression vector and process for preparing lymphotoxin

1987
- 1987-07-31 AU AU77899/87A patent/AU612983B2/en not_active Expired
- 1987-07-31 ZA ZA875681A patent/ZA875681B/xx unknown
- 1987-07-31 KR KR1019880700347A patent/KR970008217B1/ko not_active Expired - Lifetime
- 1987-07-31 AT AT87905142T patent/ATE132534T1/de not_active IP Right Cessation
- 1987-07-31 JP JP62504750A patent/JP2642113B2/ja not_active Expired - Fee Related
- 1987-07-31 CA CA000543498A patent/CA1339346C/en not_active Expired - Lifetime
- 1987-07-31 WO PCT/AU1987/000246 patent/WO1988000971A1/en not_active Ceased
- 1987-07-31 DE DE3751664T patent/DE3751664T2/de not_active Expired - Lifetime
- 1987-07-31 NZ NZ221298A patent/NZ221298A/xx unknown
- 1987-07-31 EP EP87905142A patent/EP0275300B1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
CA1339346C (en)	1997-08-26
AU7789987A (en)	1988-02-24
DE3751664T2 (de)	1996-06-05
DE3751664D1 (de)	1996-02-15
NZ221298A (en)	1990-07-26
EP0275300A4 (de)	1988-12-01
ZA875681B (en)	1988-04-27
AU612983B2 (en)	1991-07-25
JP2642113B2 (ja)	1997-08-20
EP0275300A1 (de)	1988-07-27
KR970008217B1 (ko)	1997-05-22
EP0275300B1 (de)	1996-01-03
KR880701775A (ko)	1988-11-05
JPH01500755A (ja)	1989-03-16
WO1988000971A1 (en)	1988-02-11

Legal Events

Date	Code	Title	Description
1996-07-15	UEP	Publication of translation of european patent specification
2007-10-15	EELA	Cancelled due to lapse of time

Publication	Publication Date	Title
DE3751664D1 (de)	1996-02-15	Rekombinanter impfstoff
MX9205131A (es)	1994-06-30	Vectores de virus recombinantes.
FI823528A0 (fi)	1982-10-15	Maenniskans immun-interferon
GB2303854B (en)	1998-10-21	Helicobacter proteins and vaccines
IL84154A0 (en)	1988-03-31	Polypeptides derived from the envelope gene of human immunodeficiency virus in recombinant baculovirus infected insect cells and vaccines against acquired immune deficiency syndrome containing the same
DK0596979T3 (da)	2002-05-13	Rekombinante nucleinsyrer fra plantevirus
EP1001032A3 (de)	2005-02-23	Rekombinante Retroviren um Vektorkonstruktionen an Zielzellen zu liefern
DE3786592D1 (de)	1993-08-26	Transformation von trichoderma.
ES2029171A6 (es)	1992-07-16	Un procedimiento para preparar un polipeptido virico de hepatitis no a y no b post-transfusional (pt-nanbh)
BR9202024A (pt)	1993-01-19	Virus de apivox recombinante,cultura de celulas eucariotica infectadas por um virus de avipox,vacina,sequencia de transferencia e plasmideo
DK0437604T3 (da)	2003-09-15	Rekombinant poxvirus- og streptokok M-proteinvaccine
EP0261940A3 (de)	1989-07-05	Pseudorabies-Impfstoffe und DNS-Vektoren zur Rekombination mit Poxviren
DE68920610D1 (de)	1995-03-02	Rekombinantes Virus der Marekschen Krankheit und Vakzin.
HUP9901035A2 (hu)	1999-07-28	Idegen DNS-t tartalmazó parapoxvírusok, előállításuk és alkalmazásuk vakcinákban
DK0586076T3 (da)	2003-10-20	Rekombinant adenovirus-vacciner
IE870507L (en)	1987-09-07	Bovine virus diarrhea and hog cholera vaccines
DE69432730D1 (de)	2003-07-03	Rekombinante Adenovirus-Vakzinen
NO964874L (no)	1996-11-15	Fusjonsglykoprotein fra HCMV og HSV
CA2012414A1 (en)	1990-09-19	Hog cholera virus vaccine and diagnostic
AU1948788A (en)	1989-01-04	Expression of immunologically active proteins of human b-lymphotropic virus
SE8700466D0 (sv)	1987-02-06	Vaccines against melanoma
ES2105984A1 (es)	1997-10-16	Adenovirus recombinantes que expresan antigenos del virus de la gastroenteritis porcina transmisible (vgpt) y su empleo en la formacion de vacunas.
ES2155436T3 (es)	2001-05-16	Proteinas recombinantes con la reactividad inmunologica del antigeno e del virus de la hepatitis b (hbeag), procedimiento para su preparacion y su utilizacion en analisis inmunologicos y en vacunas.
TH11952A (th)	1992-10-01	ไวรัสของโรคมาเรคที่ตัดต่อสารพันธุกรรมขึ้นใหม่และ?วัคซีน