ES2029171A6 - Un procedimiento para preparar un polipeptido virico de hepatitis no a y no b post-transfusional (pt-nanbh) - Google Patents

Un procedimiento para preparar un polipeptido virico de hepatitis no a y no b post-transfusional (pt-nanbh)

Info

Publication number
ES2029171A6
ES2029171A6 ES9003217A ES9003217A ES2029171A6 ES 2029171 A6 ES2029171 A6 ES 2029171A6 ES 9003217 A ES9003217 A ES 9003217A ES 9003217 A ES9003217 A ES 9003217A ES 2029171 A6 ES2029171 A6 ES 2029171A6
Authority
ES
Spain
Prior art keywords
viric
nanbh
polypeptide
vector
expression
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES9003217A
Other languages
English (en)
Inventor
Peter Edmund Highfield
Brian Colin Rodgers
Richard Seton Tedder
John Anthony J Barbara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898928562A external-priority patent/GB8928562D0/en
Priority claimed from GB909004414A external-priority patent/GB9004414D0/en
Priority claimed from GB909004814A external-priority patent/GB9004814D0/en
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Publication of ES2029171A6 publication Critical patent/ES2029171A6/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C07K16/116—Togaviridae (F); Matonaviridae (F); Flaviviridae (F)
    • C07K16/118—Hepatitis C virus; GB virus C [GBV-C]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/706—Specific hybridization probes for hepatitis
    • C12Q1/707—Specific hybridization probes for hepatitis non-A, non-B Hepatitis, excluding hepatitis D
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y10S530/826—Viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR UN POLIPEPTIDO VIRICO DE HEPATITIS NO A Y NO B POST-TRANSFUSIONAL (PT-NANBH). COMPRENDE CLONAR O SINTETIZAR UNA SECUENCIA DE ADN QUE CODIFICA UN ANTIGENO QUE TIENE UNA SECUENCIA DEFINIDA DE AMINOACIDOS QUE ES HOMOLOGA AL MENOS EN UN 90% CON UNA DE LAS SECUENCIAS DE AMINOACIDOS INDICADAS EN LA MEMORIA, O CON UN FRAGMENTO ANTIGENICO DE LA MISMA, INSERTAR LA SECUENCIA DE ADN EN UN VECTOR DE EXPRESION TAL QUE ESTA ES APTA PARA SER EXPRESADA EN UN HOSPEDANTE APROPIADO, TRANSFORMAR UNA CELULA HOSPEDANTE CON EL VECTOR DE EXPRESION, CULTIVAR LA CELULA HOSPEDANTE TRANSFORMADA Y AISLAR EL POLIPEPTIDO VIRICO. LOS POLIPEPTIDOS OBTENIDOS SON APLICABLES AL DIAGNOSTICO DE INFECCIONES POR VIRUS DE PT-NANBH Y A LA PRODUCCION DE LAS CORRESPONDIENTES VACUNAS.
ES9003217A 1989-12-18 1990-12-17 Un procedimiento para preparar un polipeptido virico de hepatitis no a y no b post-transfusional (pt-nanbh) Expired - Fee Related ES2029171A6 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB898928562A GB8928562D0 (en) 1989-12-18 1989-12-18 Viral agent
GB909004414A GB9004414D0 (en) 1990-02-27 1990-02-27 Viral agent
GB909004814A GB9004814D0 (en) 1990-03-03 1990-03-03 Viral agent

Publications (1)

Publication Number Publication Date
ES2029171A6 true ES2029171A6 (es) 1992-07-16

Family

ID=27264852

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9003217A Expired - Fee Related ES2029171A6 (es) 1989-12-18 1990-12-17 Un procedimiento para preparar un polipeptido virico de hepatitis no a y no b post-transfusional (pt-nanbh)

Country Status (24)

Country Link
US (1) US6210675B1 (es)
JP (1) JPH06107687A (es)
AR (1) AR243239A1 (es)
AT (1) AT400724B (es)
AU (1) AU642942B2 (es)
BE (1) BE1005485A5 (es)
BR (1) BR9006422A (es)
CA (1) CA2032381C (es)
CH (1) CH684594A5 (es)
DE (1) DE4040339C2 (es)
DK (1) DK298190A (es)
ES (1) ES2029171A6 (es)
FI (1) FI906208A7 (es)
FR (1) FR2655990A1 (es)
GB (1) GB2239245B (es)
GR (1) GR1001261B (es)
HU (1) HUT56883A (es)
IE (1) IE65172B1 (es)
IT (1) IT1242183B (es)
LU (1) LU87861A1 (es)
NL (1) NL9002779A (es)
NO (1) NO905438L (es)
NZ (1) NZ236491A (es)
SE (1) SE9004010D0 (es)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6861212B1 (en) 1987-11-18 2005-03-01 Chiron Corporation NANBV diagnostics and vaccines
US5712088A (en) * 1987-11-18 1998-01-27 Chiron Corporation Methods for detecting Hepatitis C virus using polynucleotides specific for same
US5683864A (en) * 1987-11-18 1997-11-04 Chiron Corporation Combinations of hepatitis C virus (HCV) antigens for use in immunoassays for anti-HCV antibodies
US5350671A (en) * 1987-11-18 1994-09-27 Chiron Corporation HCV immunoassays employing C domain antigens
US5714596A (en) * 1987-11-18 1998-02-03 Chiron Corporation NANBV diagnostics: polynucleotides useful for screening for hepatitis C virus
US6171782B1 (en) 1987-11-18 2001-01-09 Chiron Corporation Antibody compositions to HCV and uses thereof
US5698390A (en) * 1987-11-18 1997-12-16 Chiron Corporation Hepatitis C immunoassays
US6027729A (en) * 1989-04-20 2000-02-22 Chiron Corporation NANBV Diagnostics and vaccines
US5372928A (en) * 1989-09-15 1994-12-13 Chiron Corporation Hepatitis C virus isolates
US5712087A (en) * 1990-04-04 1998-01-27 Chiron Corporation Immunoassays for anti-HCV antibodies employing combinations of hepatitis C virus (HCV) antigens
KR100206150B1 (ko) * 1990-04-04 1999-07-01 로버트 피. 블랙버언 항-에이치씨브이 항체에 대한 면역분석용 씨형 간염 바이러스(에이치디브이)항원의 조합체
AU660925B2 (en) * 1990-04-06 1995-07-13 Genelabs Technologies, Inc. Hepatitis C virus epitopes
JP3549201B2 (ja) * 1990-10-24 2004-08-04 中外製薬株式会社 非ａ非ｂ型肝炎特異的遺伝子の検出方法及び検出用試薬組成物
EP0485209A1 (en) * 1990-11-08 1992-05-13 Immuno Japan Inc. Non A, non B hepatitis virus related antigen, antibody detection systems, polynucleotides and polypeptides
EP0516859A1 (en) * 1990-11-29 1992-12-09 Toray Industries, Inc. Non-a non-b hepatitis virus antigen protein
RU2155228C2 (ru) * 1991-05-08 2000-08-27 Чирон Корпорейшн Hcv геномные последовательности для диагностических и терапевтических целей
US6190864B1 (en) 1991-05-08 2001-02-20 Chiron Corporation HCV genomic sequences for diagnostics and therapeutics
KR0185426B1 (ko) * 1991-06-24 1999-04-01 로버트 피. 블랙버언 씨형 간염 바이러스 폴리펩티드
WO1993002193A1 (es) * 1991-07-19 1993-02-04 Bartolome Nebreda Fernando Jav cDNAS DERIVADOS DEL VIRUS C DE LA HEPATITIS
DK0529493T3 (da) * 1991-08-27 1998-08-24 Hoffmann La Roche Fremgangsmåder og reagenser til hepatitis C-detektion
GB9203803D0 (en) * 1992-02-21 1992-04-08 Wellcome Found A recombinant polypeptide
UA39944C2 (uk) * 1992-07-07 2001-07-16 Чірон Корпорейшн Спосіб визначення ранньої сероконверсії у ссавця-хазяїна до вірусу гепатиту с і набір для використання в способі
US6153378A (en) * 1992-10-16 2000-11-28 Bionova Corporation Diagnosis of, and vaccination against, a positive stranded RNA virus using an isolated, unprocessed polypeptide encoded by a substantially complete genome of such virus
US6762024B2 (en) 1993-04-27 2004-07-13 Innogenetics, S.A. Sequences of hepatitis C virus genotypes and their use as therapeutic and diagnostic agents
US7255997B1 (en) 1993-04-27 2007-08-14 N.V. Innogenetics S.A. Sequences of hepatitis C virus genotypes and their use as therapeutic and diagnostic agents
WO1995011918A1 (en) * 1993-10-29 1995-05-04 Srl, Inc. Antigen peptide compound and immunoassay method
DE69526973T3 (de) 1994-10-21 2010-01-07 Innogenetics N.V. Sequenzen von hepatitis-c-virus genotype 7, und deren verwendung als vorbeugende, therapeutische und diagnostische mittel
FR2775690B1 (fr) * 1998-03-09 2001-12-14 Bio Merieux Anticorps monoclonal et utilisations pour detecter des antigenes de la proteine core de vhc
US6071721A (en) * 1998-11-13 2000-06-06 Incyte Pharmaceuticals, Inc. Calcium binding protein
US7829085B2 (en) * 1999-07-14 2010-11-09 Life Sciences Research Partners Vzw Methods of treating hemostasis disorders using antibodies binding the C1 domain of factor VIII
US7067313B1 (en) * 1999-07-14 2006-06-27 D. Collen Research Foundation Ligands for use in therapeutic compositions for the treatment of hemostasis disorders
CU23244A1 (es) * 2001-07-16 2007-10-17 Ct Ingenieria Genetica Biotech Formulacion vacunal potenciada por la combinacion de un adn con un antigeno
US7196183B2 (en) 2001-08-31 2007-03-27 Innogenetics N.V. Hepatitis C virus genotype, and its use as prophylactic, therapeutic and diagnostic agent
ES2312806T3 (es) * 2002-09-09 2009-03-01 Novartis Vaccines And Diagnostics, Inc. Ensayo de vhc.
JP4422430B2 (ja) * 2003-05-14 2010-02-24 帝國製薬株式会社 エストロゲン及び／又はプロゲストゲン含有外用貼付剤
CA2535489C (en) * 2003-08-14 2014-09-30 D. Collen Research Foundation Vzw Antibodies against factor viii with modified glycosylation in the variable region
US8124747B2 (en) 2003-08-29 2012-02-28 Innogenetics HCV clade and prototype sequences thereof
ES2702278T3 (es) 2012-04-01 2019-02-28 Technion Res & Dev Foundation Péptidos de inductor de metaloproteinasa de matriz extracelular (emmprin) y anticuerpos de unión
EP3740224A4 (en) * 2018-01-18 2022-05-04 Adanate, Inc. ANTI-LILRB ANTIBODIES AND THEIR USES

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4356164A (en) 1979-05-21 1982-10-26 Govt. of the U.S., as represented by the Secretary, Dept. of Health & Human Services Detection of non-A, non-B hepatitis associated antigen
US4464474A (en) 1980-07-09 1984-08-07 Connaught Laboratories Limited Non-A, non-B hepatitis assay and vaccine
EP0071640B1 (en) 1981-02-11 1986-06-04 Connaught Laboratories Incorporated Non-a, non-b hepatitis virus
US4542016A (en) 1981-03-27 1985-09-17 Institut Merieux Non-a non-b hepatitis surface antigen useful for the preparation of vaccines and methods of use
JPS57198867A (en) 1981-06-02 1982-12-06 Eisai Co Ltd Non-a, non-b hepatitis related antigen and diagnostic therefor
JPS58183629A (ja) 1982-04-21 1983-10-26 Eisai Co Ltd 非ａ非ｂ型肝炎関連モノクロナ−ル抗体および診断薬
US4702909A (en) * 1982-05-05 1987-10-27 Louisiana State University A & M Non-A, non-B hepatitis antigen, antigen compositions, vaccine and diagnostic reagent
US4707439A (en) 1984-10-26 1987-11-17 The United States Of America As Represented By The Department Of Health And Human Services Screening test for reverse-transcriptase containing virus such as non-A, non-B hepatitis, NANBH
GB8431171D0 (en) 1984-12-11 1985-01-23 Technology Licence Co Ltd Monoclonal antibodies
JPS61176856A (ja) 1985-02-01 1986-08-08 Mitsubishi Chem Ind Ltd 非ａ非ｂ型肝炎抗原
US4673634A (en) 1985-03-08 1987-06-16 The United States Of America As Represented By The Department Of Health And Human Services Purified antigen from non-A, non-B hepatitis causing factor
FR2597606B1 (fr) 1986-04-16 1989-10-06 Pasteur Institut Nouveau reactif pour la detection d'hepatites virales non a non b et procede de diagnostic de telles hepatites par voie immunoenzymatique
JPS6391328A (ja) 1986-10-07 1988-04-22 Mitsubishi Kasei Corp 非ａ非ｂ型肝炎抗原
NZ222465A (en) 1986-11-07 1992-11-25 Pasteur Institut Nanb (non a, non b hepatitis viral) antigen
US5141867A (en) * 1987-02-02 1992-08-25 E. I. Du Pont De Nemours And Company Nucleotide sequence encoding a human immunodeficiency virus antigen
DE3744242A1 (de) 1987-02-20 1989-07-06 Seelig Renate Virusantigen, verfahren zu seiner gewinnung und anwendung in diagnose und therapie (impfstoff)
US5032511A (en) * 1987-03-31 1991-07-16 Mitsubishi Kasei Corporation DNA fragments coding for antigens specific to non-A non-B hepatitis, expression vectors containing said DNA fragments, transformants and process for producing said antigens
AU624105B2 (en) * 1987-11-18 1992-06-04 Novartis Vaccines And Diagnostics, Inc. Nanbv diagnostics and vaccines
WO1989004669A1 (en) * 1987-11-18 1989-06-01 Chiron Corporation Nanbv diagnostics and vaccines
YU48038B (sh) * 1987-11-18 1996-10-18 Chiron Corp. Postupak za dijagnostiku ne-a, ne-v hepatitisa
US5350671A (en) * 1987-11-18 1994-09-27 Chiron Corporation HCV immunoassays employing C domain antigens
AU632271B2 (en) 1988-03-30 1992-12-24 Abbott Laboratories Production of monoclonal antibodies specific for non-a, non-b hepatitis infected liver
AU3748489A (en) 1988-06-17 1990-01-12 Genelabs Incorporated Enterically transmitted non-a/non-b hepatitis viral agent
WO1990000597A1 (en) * 1988-07-06 1990-01-25 Genelabs Incorporated Post-transfusion, non-a, non-b hepatitis virus and antigens
IL91371A0 (en) 1988-08-24 1990-04-29 Us Commerce Clones or vectors bearing dna sequences of non-a and non-b hepatitis and a method for detecting these materials in blood
US5191064A (en) * 1988-09-30 1993-03-02 The Research Foundation For Microbial Diseases (Osaka University) Non-a, non-b hepatitis virus antigen peptide
JPH02167081A (ja) 1988-12-21 1990-06-27 Tetsuo Nakamura 非Ａ非Ｂ型肝炎ウイルスゲノムＲＮＡ、ｃＤＮＡおよびウイルス抗原蛋白質
HUT54896A (en) * 1989-03-17 1991-04-29 Chiron Corp Process for producing aquous diagnosticum and vaccine of nanbv
WO1990014436A1 (en) * 1989-05-18 1990-11-29 Chiron Corporation Nanbv diagnostics: polynucleotides useful for screening for hepatitis c virus
EP0416725A3 (en) * 1989-07-14 1991-03-20 Chugai Seiyaku Kabushiki Kaisha Blood-borne non-a, non-b hepatitis specific protein, dna encoding it, and process for its production
ATE161041T1 (de) 1989-08-25 1997-12-15 Chiron Corp Verfahren zur hcv-züchtung in zell-linien aus b- oder t-lymphozyten
WO1991004262A1 (en) 1989-09-15 1991-04-04 National Institute Of Health Of Japan New hcv isolates
US5372928A (en) 1989-09-15 1994-12-13 Chiron Corporation Hepatitis C virus isolates
US5106726A (en) * 1990-02-16 1992-04-21 United Biomedical, Inc. Synthetic peptides specific for the detection of antibodies to HCV
KR100206150B1 (ko) 1990-04-04 1999-07-01 로버트 피. 블랙버언 항-에이치씨브이 항체에 대한 면역분석용 씨형 간염 바이러스(에이치디브이)항원의 조합체
EP0933426A1 (en) * 1990-06-25 1999-08-04 The Research Foundation for Microbial Diseases of Osaka University Non-a, non-b hepatitis virus genomic cdna fragments and antigen polypeptides

Also Published As

Publication number Publication date
LU87861A1 (fr) 1991-10-08
HU908296D0 (en) 1991-06-28
GR1001261B (el) 1993-06-30
NL9002779A (nl) 1991-07-16
IE904540A1 (en) 1991-06-19
SE9004010L (es) 1991-06-19
US6210675B1 (en) 2001-04-03
CH684594A5 (fr) 1994-10-31
NZ236491A (en) 1993-10-26
DK298190A (da) 1991-06-19
AU642942B2 (en) 1993-11-04
FI906208L (fi) 1991-06-19
JPH06107687A (ja) 1994-04-19
GB9027250D0 (en) 1991-02-06
AT400724B (de) 1996-03-25
GB2239245A (en) 1991-06-26
AU6817590A (en) 1991-06-20
NO905438L (no) 1991-06-19
NO905438D0 (no) 1990-12-17
DE4040339A1 (de) 1991-06-20
FR2655990B1 (es) 1995-04-07
BR9006422A (pt) 1991-09-24
SE9004010D0 (sv) 1990-12-17
FI906208A0 (fi) 1990-12-17
IT9048588A1 (it) 1991-06-19
BE1005485A5 (fr) 1993-08-10
DE4040339C2 (de) 1999-07-08
FR2655990A1 (fr) 1991-06-21
DK298190D0 (da) 1990-12-17
GR900100868A (en) 1992-05-12
IE65172B1 (en) 1995-10-04
HUT56883A (en) 1991-10-28
CA2032381C (en) 2006-02-21
IT9048588A0 (it) 1990-12-17
AR243239A1 (es) 1993-07-30
FI906208A7 (fi) 1991-06-19
ATA257190A (de) 1995-07-15
IT1242183B (it) 1994-02-16
GB2239245B (en) 1993-11-10
CA2032381A1 (en) 1991-06-19

Similar Documents

Publication Publication Date Title
ES2059565T3 (es) Virus mva de la vacuna, recombinante.
SE9004010D0 (sv) Viralt medel
RU98117084A (ru) Hcv иммунореактивные полипептидные композиции
DK0419182T4 (da) Nyt HCV-isolat J 1
FI943591A7 (fi) Synteettinen hemofilus-influenssa yhdistelmärokote
ES2138784T3 (es) Antigenos sinteticos para la deteccion de anticuerpos contra el virus de la hepatitis c.
ES2061708T3 (es) Virus recombinante de la viruela de la gallina, vectores de expresion de proteinas heterologas y vacunas para aves de corral derivadas de este virus.
ES2127294T3 (es) Vacunas del virus de la inmunodeficiencia anti-felino (fiv).
ES2104156T3 (es) Peptido estimulante de linfocitos t citotoxicos especificos de virus de la hepatitis c.
ATE134195T1 (de) Peptidfragmente von hiv
ES2162125T3 (es) Proteinas de vertebrados eficaces contra bacterias, hongos y virus y sus preparados cosmeticos.
DK35891A (da) Praktisk taget rent, antigenisk peptid eller protein med en epitop af haemophilus influenzae, dets fremstilling og anvendelse
IT1249684B (it) Epitopi della proteina env del virus dell'epatite c.
KR920002629A (ko) B형 간염 코어 항원의 아미노산 잔기 서열
DE69106141D1 (de) Non-a non-b sequenzen.
ATE120800T1 (de) Antigen-protein der sporozoit- und hepatischen phase von p. falciparum.
DE69012989D1 (de) Peptiden von retinblastoma gen produkten und antikoerper dagegen.
DK43991A (da) Allele varianter af plasmodium falciparum merozoitoverfladeantigen
NO902491D0 (no) Proteiner, vaksiner og nukleinsyrer.
KR950704494A (ko) 수두-대상포진 바이러스(vzv)에 대한 백신(vaccines against varicellazoster virus(vzv))
PT96223A (pt) Processo para a preparacao de um agente viral responsavel pela hepatite nao-a bnao-b de pos-transfusao
MY106940A (en) Allelic variants of plasmodium falciparum merozoite surface antigen.
KR950000881A (ko) 새로운 한국형 씨(C)형 간염 바이러스 씨디엔에이(cDNA) 절편의 뉴클레오티드 서열 및 이로부터 유추된 아미노산 서열
GB2244273A (en) Allelic variants of plasmodium falciparum merozoite surface antigen.

Legal Events

Date Code Title Description
FD2A Announcement of lapse in spain

Effective date: 20110224