ATE132744T1 - Selbst-agglomerierendes diketopiperazin- arzneistoffabgabesystem - Google Patents

Selbst-agglomerierendes diketopiperazin- arzneistoffabgabesystem

Info

Publication number: ATE132744T1
Authority: AT; Austria
Prior art keywords: microparticles; drug delivery; diketopiperazine; stable; agglomering
Prior art date: 1992-03-11

Application number

AT93920574T

Other languages

English (en)

Inventor

Robert Feldstein

John Glass

Solomon S Steiner

Original Assignee

Pharmaceutical Discovery Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-03-11

Filing date

1993-03-11

Publication date

1996-01-15

1993-03-11 Application filed by Pharmaceutical Discovery Corp filed Critical Pharmaceutical Discovery Corp

1996-01-15 Application granted granted Critical

1996-01-15 Publication of ATE132744T1 publication Critical patent/ATE132744T1/de

Links

BXRNXXXXHLBUKK-UHFFFAOYSA-N piperazine-2,5-dione Chemical compound O=C1CNC(=O)CN1 BXRNXXXXHLBUKK-UHFFFAOYSA-N 0.000 title abstract 4
238000012377 drug delivery Methods 0.000 title abstract 3
239000011859 microparticle Substances 0.000 abstract 5
229940079593 drug Drugs 0.000 abstract 2
239000003814 drug Substances 0.000 abstract 2
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
230000007935 neutral effect Effects 0.000 abstract 2
102000055006 Calcitonin Human genes 0.000 abstract 1
108060001064 Calcitonin Proteins 0.000 abstract 1
HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 abstract 1
102000004877 Insulin Human genes 0.000 abstract 1
108090001061 Insulin Proteins 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 abstract 1
229960004015 calcitonin Drugs 0.000 abstract 1
238000006074 cyclodimerization reaction Methods 0.000 abstract 1
WKGXYQFOCVYPAC-UHFFFAOYSA-N felbamate Chemical compound NC(=O)OCC(COC(N)=O)C1=CC=CC=C1 WKGXYQFOCVYPAC-UHFFFAOYSA-N 0.000 abstract 1
229960003472 felbamate Drugs 0.000 abstract 1
229960002897 heparin Drugs 0.000 abstract 1
229920000669 heparin Polymers 0.000 abstract 1
229940125396 insulin Drugs 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
229940126701 oral medication Drugs 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Molecular Biology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Cephalosporin Compounds (AREA)
Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Saccharide Compounds (AREA)

AT93920574T 1992-03-11 1993-03-11 Selbst-agglomerierendes diketopiperazin- arzneistoffabgabesystem ATE132744T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/849,186 US5352461A (en)	1992-03-11	1992-03-11	Self assembling diketopiperazine drug delivery system

Publications (1)

Publication Number	Publication Date
ATE132744T1 true ATE132744T1 (de)	1996-01-15

Family

ID=25305266

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93920574T ATE132744T1 (de)	1992-03-11	1993-03-11	Selbst-agglomerierendes diketopiperazin- arzneistoffabgabesystem

Country Status (11)

Country	Link
US (2)	US5352461A (de)
EP (1)	EP0630236B1 (de)
JP (1)	JP2617273B2 (de)
AT (1)	ATE132744T1 (de)
AU (1)	AU680408B2 (de)
CA (1)	CA2131366C (de)
DE (1)	DE69301311T2 (de)
DK (1)	DK0630236T3 (de)
ES (1)	ES2089844T3 (de)
GR (1)	GR3019622T3 (de)
WO (1)	WO1993018754A1 (de)

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- 1993-03-11 DE DE69301311T patent/DE69301311T2/de not_active Expired - Lifetime
- 1993-03-11 AT AT93920574T patent/ATE132744T1/de active
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Publication number	Publication date
WO1993018754A1 (en)	1993-09-30
EP0630236A1 (de)	1994-12-28
JP2617273B2 (ja)	1997-06-04
JPH07506818A (ja)	1995-07-27
AU680408B2 (en)	1997-07-31
DE69301311D1 (de)	1996-02-22
CA2131366C (en)	2003-09-23
DE69301311T2 (de)	1996-08-22
CA2131366A1 (en)	1993-09-30
US5503852A (en)	1996-04-02
AU3804493A (en)	1993-10-21
US5352461A (en)	1994-10-04
EP0630236B1 (de)	1996-01-10
DK0630236T3 (da)	1996-06-03
ES2089844T3 (es)	1996-10-01
GR3019622T3 (en)	1996-07-31

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Date	Code	Title	Description
1996-09-15	UEP	Publication of translation of european patent specification
2005-05-15	EEFA	Change of the company name

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