ATE132746T1 - Verwendung der ester von acyl-l-carnitin mit gamma-hydroxy-buttersäure zur herstellung von pharmazeutischen zusammensetzungen zur behandlung von lebererkrankungen - Google Patents

Verwendung der ester von acyl-l-carnitin mit gamma-hydroxy-buttersäure zur herstellung von pharmazeutischen zusammensetzungen zur behandlung von lebererkrankungen

Info

Publication number: ATE132746T1
Authority: AT; Austria
Prior art keywords: carnitine; gamma; esters; acyl; pharmaceutical compositions
Prior art date: 1991-05-15

Application number

AT92830220T

Other languages

English (en)

Inventor

Fabio Zezza

Original Assignee

Sigma Tau Ind Farmaceuti

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-05-15

Filing date

1992-05-12

Publication date

1996-01-15

1992-05-12 Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti

1996-01-15 Application granted granted Critical

1996-01-15 Publication of ATE132746T1 publication Critical patent/ATE132746T1/de

Links

239000002253 acid Substances 0.000 title abstract 2
208000019423 liver disease Diseases 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title abstract 2
150000003839 salts Chemical class 0.000 abstract 2
SJZRECIVHVDYJC-UHFFFAOYSA-N 4-hydroxybutyric acid Chemical compound OCCCC(O)=O SJZRECIVHVDYJC-UHFFFAOYSA-N 0.000 abstract 1
-1 acyl L-carnitine Chemical compound 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
150000001450 anions Chemical class 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

Landscapes

Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Emergency Medicine (AREA)
Gastroenterology & Hepatology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT92830220T 1991-05-15 1992-05-12 Verwendung der ester von acyl-l-carnitin mit gamma-hydroxy-buttersäure zur herstellung von pharmazeutischen zusammensetzungen zur behandlung von lebererkrankungen ATE132746T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
ITRM910327A IT1248321B (it)	1991-05-15	1991-05-15	Uso di esteri di acil l-carnitine con l'acido gamma-idrossibutirrico per produrre composizioni farmaceutiche per il trattamento di epatopatie

Publications (1)

Publication Number	Publication Date
ATE132746T1 true ATE132746T1 (de)	1996-01-15

Family

ID=11400141

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92830220T ATE132746T1 (de)	1991-05-15	1992-05-12	Verwendung der ester von acyl-l-carnitin mit gamma-hydroxy-buttersäure zur herstellung von pharmazeutischen zusammensetzungen zur behandlung von lebererkrankungen

Country Status (7)

Country	Link
US (1)	US5246967A (de)
EP (1)	EP0514357B1 (de)
JP (1)	JP3406614B2 (de)
AT (1)	ATE132746T1 (de)
DE (1)	DE69207479T2 (de)
DK (1)	DK0514357T3 (de)
IT (1)	IT1248321B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5607691A (en) *	1992-06-12	1997-03-04	Affymax Technologies N.V.	Compositions and methods for enhanced drug delivery
IT1263013B (it) *	1992-10-20	1996-07-23	Avantgarde Spa	Esteri della l-carnitina e di alcanoil l-carnitine con l'acido glicolico o suoi esteri e composizioni farmaceutiche contenenti tali per il trattamento di affezioni cutanee.
IT1261432B (it) *	1993-03-26	1996-05-23	Sigma Tau Ind Farmaceuti	Uso di acil l- carnitina gammaidrossibutirrato per il trattamento dell'alcolismo.
IT1261984B (it) *	1993-06-22	1996-06-11	Avantgarde Spa	Uso di esteri della l-carnitina o di acil l- carnitine con idrossiacidi per produrre composizioni farmaceutiche per il trattamento di affezioni cutanee.
IT1261485B (it) *	1993-06-24	1996-05-23	Sigma Tau Ind Farmaceuti	Uso di acil l-carnitine gamma-idrossibutirrato per il trattamento di tossicodipendenze.
IT1261828B (it) *	1993-07-14	1996-06-03	Sigma Tau Ind Farmaceuti	Esteri di acil l-carnitine e composizioni farmaceutiche che li contengono per il trattamento dello shock endotossico.
IT1277898B1 (it) *	1995-08-03	1997-11-12	Mendes Srl	Uso di amminoacidi basici, di acil derivati di amminoacidi basici e di loro sali farmaceuticamente accettabili per la profilassi di malattie
IT1306129B1 (it) *	1999-04-13	2001-05-30	Sigma Tau Ind Farmaceuti	Esteri della l-carnitina o di alcanoil l-carnitine utilizzabili comelipidi cationici per l'immissione intracellulare di composti
US20050232911A1 (en) *	2004-04-19	2005-10-20	Schreiber Brian D	Prevention and treatment of metabolic abnormalities associated with excess intramyocellular lipid
US20200114015A1 (en) *	2017-04-11	2020-04-16	John K. Thottathil	Novel Alpha-Hydroxy Carboxylic Acid And Derivatives And Other GRAS- Based Prodrugs Of Gamma-Hydroxybutyrate (GHB) And Uses Thereof
GB201710229D0 (en) *	2017-06-27	2017-08-09	Tdeltas Ltd	Compounds for new use

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2903579A1 (de) *	1978-02-03	1979-08-09	Sigma Tau Ind Farmaceuti	Verwendung von acetylcarnitin und anderen acylderivaten des carnitins zur behandlung der hyperlipoproteinaemie und hyperlimpidaemie sowie arzneimittel
IT1147079B (it) *	1980-05-30	1986-11-19	Sigma Tau Ind Farmacuetiche Ri	Esteri di alcossi-acil derivati della carnitina procedimento per la loro preparatione e composizioni farmaceutiche che li contengono
DE3166142D1 (en) *	1980-06-09	1984-10-25	Leopold & Co Chem Pharm	Infusion solution for the protection of the liver and the improvement of its functioning, and process for its production
IT1208753B (it) *	1986-07-02	1989-07-10	Sigma Tau Ind Farmaceuti	L-amminoacil derivati della l-carnitina, procedimento per la loro preparazione e composizioni farmaceutiche ad attivita' epatoprotettrice che li contengono
IT1240760B (it) *	1990-02-12	1993-12-17	Sigma Tau Ind Farmaceuti	Esteri di acil-l-carnitine con l'acido gamma-idrossibutirrico e composizioni farmaceutiche che li contengono per l'inibizione della degenerazione neuronale e nel trattamento del coma.
IT1240775B (it) *	1990-02-23	1993-12-17	Sigma Tau Ind Farmaceuti	Esteri della l-carnitina e di acil-l-carnitine con l'acido beta-idrossibutirrico e composizioni farmaceutiche che li contengono per la inibizione della degenerazione neuronale, della proteolisi epatica e nel trattamento del coma.

1991
- 1991-05-15 IT ITRM910327A patent/IT1248321B/it active IP Right Grant
1992
- 1992-05-12 DK DK92830220.7T patent/DK0514357T3/da active
- 1992-05-12 DE DE69207479T patent/DE69207479T2/de not_active Expired - Fee Related
- 1992-05-12 EP EP92830220A patent/EP0514357B1/de not_active Expired - Lifetime
- 1992-05-12 AT AT92830220T patent/ATE132746T1/de not_active IP Right Cessation
- 1992-05-15 US US07/883,673 patent/US5246967A/en not_active Expired - Lifetime
- 1992-05-15 JP JP12355292A patent/JP3406614B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
ITRM910327A0 (it)	1991-05-15
JP3406614B2 (ja)	2003-05-12
DK0514357T3 (da)	1996-02-26
HK1005848A1 (en)	1999-01-29
JPH05163141A (ja)	1993-06-29
EP0514357A1 (de)	1992-11-19
EP0514357B1 (de)	1996-01-10
US5246967A (en)	1993-09-21
IT1248321B (it)	1995-01-05
ITRM910327A1 (it)	1992-11-15
DE69207479D1 (de)	1996-02-22
DE69207479T2 (de)	1996-05-23

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Legal Events

Date	Code	Title	Description
1996-07-15	UEP	Publication of translation of european patent specification
2007-02-15	REN	Ceased due to non-payment of the annual fee