IT1261432B - Uso di acil l- carnitina gammaidrossibutirrato per il trattamento dell'alcolismo. - Google Patents

Uso di acil l- carnitina gammaidrossibutirrato per il trattamento dell'alcolismo.

Info

Publication number
IT1261432B
IT1261432B ITRM930191A ITRM930191A IT1261432B IT 1261432 B IT1261432 B IT 1261432B IT RM930191 A ITRM930191 A IT RM930191A IT RM930191 A ITRM930191 A IT RM930191A IT 1261432 B IT1261432 B IT 1261432B
Authority
IT
Italy
Prior art keywords
gammaidrossibutirrato
carnitina
acil
alcoholism
treatment
Prior art date
Application number
ITRM930191A
Other languages
English (en)
Inventor
Claudio Cavazza
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Publication of ITRM930191A0 publication Critical patent/ITRM930191A0/it
Priority to ITRM930191A priority Critical patent/IT1261432B/it
Priority to EP94830122A priority patent/EP0616805B1/en
Priority to DE69410866T priority patent/DE69410866T2/de
Priority to DK94830122T priority patent/DK0616805T3/da
Priority to AT94830122T priority patent/ATE167056T1/de
Priority to ES94830122T priority patent/ES2118357T3/es
Priority to JP6055625A priority patent/JPH06321875A/ja
Publication of ITRM930191A1 publication Critical patent/ITRM930191A1/it
Application granted granted Critical
Publication of IT1261432B publication Critical patent/IT1261432B/it
Priority to HK98109956.6A priority patent/HK1009326B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Viene descritto l'uso di esteri di acil L-carnitine con l'acido gamma idrossibutirrico in cui R è acile lineare o ramificato avente da 2 a 5 atomi di carbonio, preferibilmente acetile, propionile, n-butirrile, isobutirrile e isovalerile, e X? è l'anione di un acido farmacologicamente accettabile o dei corrispondenti sali interni per produrre un farmaco per sopprimere negli alcolisti i sintomi della astinenza e il desiderio insaziabile ("craving") di consumare bevande alcoliche.
ITRM930191A 1993-03-26 1993-03-26 Uso di acil l- carnitina gammaidrossibutirrato per il trattamento dell'alcolismo. IT1261432B (it)

Priority Applications (8)

Application Number Priority Date Filing Date Title
ITRM930191A IT1261432B (it) 1993-03-26 1993-03-26 Uso di acil l- carnitina gammaidrossibutirrato per il trattamento dell'alcolismo.
AT94830122T ATE167056T1 (de) 1993-03-26 1994-03-21 Verwendung von ester von acyl-l-carnitin mit gammahydroxybuttersäure zur behandlung von alkoholismus
DE69410866T DE69410866T2 (de) 1993-03-26 1994-03-21 Verwendung von Ester von Acyl-L-Carnitin mit Gammahydroxybuttersäure zur Behandlung von Alkoholismus
DK94830122T DK0616805T3 (da) 1993-03-26 1994-03-21 Anvendelse af acyl L-carnitin-gamma-hydroxybutyrater til behandling af alkoholisme
EP94830122A EP0616805B1 (en) 1993-03-26 1994-03-21 Use of acyl L-carnitine gamma-hydroxybutyrate for the treatment of alcoholism
ES94830122T ES2118357T3 (es) 1993-03-26 1994-03-21 Empleo de gamma-hidroxibutirato de acil l-carnitina para el tratamiento de alcoholismo.
JP6055625A JPH06321875A (ja) 1993-03-26 1994-03-25 アルコール中毒症の処置のためのアシルｌ−カルニチンエステル
HK98109956.6A HK1009326B (en) 1993-03-26 1998-08-15 Use of acyl l-carnitine gamma-hydroxybutyrate for the treatment of alcoholism

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITRM930191A IT1261432B (it) 1993-03-26 1993-03-26 Uso di acil l- carnitina gammaidrossibutirrato per il trattamento dell'alcolismo.

Publications (3)

Publication Number Publication Date
ITRM930191A0 ITRM930191A0 (it) 1993-03-26
ITRM930191A1 ITRM930191A1 (it) 1994-09-26
IT1261432B true IT1261432B (it) 1996-05-23

Family

ID=11401655

Family Applications (1)

Application Number Title Priority Date Filing Date
ITRM930191A IT1261432B (it) 1993-03-26 1993-03-26 Uso di acil l- carnitina gammaidrossibutirrato per il trattamento dell'alcolismo.

Country Status (7)

Country Link
EP (1) EP0616805B1 (it)
JP (1) JPH06321875A (it)
AT (1) ATE167056T1 (it)
DE (1) DE69410866T2 (it)
DK (1) DK0616805T3 (it)
ES (1) ES2118357T3 (it)
IT (1) IT1261432B (it)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX9708147A (es) * 1995-04-21 1997-12-31 Neurosearch As Compuestos de bencimidazol y su uso como moduladores del complejo receptor de gabaa.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1217783B (it) * 1988-06-03 1990-03-30 Farmaceutico Ct S R L Lab Impiego di salo dell,acido gamma idrossi butirrico per la preparazione di composizioni farmaceutiche adatta ad essereimpiegate nella terapia dell,alcolismo e composizioni relative
IT1240760B (it) * 1990-02-12 1993-12-17 Sigma Tau Ind Farmaceuti Esteri di acil-l-carnitine con l'acido gamma-idrossibutirrico e composizioni farmaceutiche che li contengono per l'inibizione della degenerazione neuronale e nel trattamento del coma.
IT1248321B (it) * 1991-05-15 1995-01-05 Sigma Tau Ind Farmaceuti Uso di esteri di acil l-carnitine con l'acido gamma-idrossibutirrico per produrre composizioni farmaceutiche per il trattamento di epatopatie

Also Published As

Publication number Publication date
ITRM930191A1 (it) 1994-09-26
HK1009326A1 (en) 1999-05-28
ES2118357T3 (es) 1998-09-16
EP0616805A1 (en) 1994-09-28
DE69410866T2 (de) 1998-10-15
ITRM930191A0 (it) 1993-03-26
ATE167056T1 (de) 1998-06-15
DK0616805T3 (da) 1999-02-01
DE69410866D1 (de) 1998-07-16
JPH06321875A (ja) 1994-11-22
EP0616805B1 (en) 1998-06-10

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Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19960129