ATE132857T1 - Lipoxygenase inhibierende tetrahydrobenzazepinderivate - Google Patents

Lipoxygenase inhibierende tetrahydrobenzazepinderivate

Info

Publication number: ATE132857T1
Authority: AT; Austria
Prior art keywords: alkyl; pct; lipoxygenase; sec; arylalkyl
Prior art date: 1991-06-28

Application number

AT92911321T

Other languages

English (en)

Inventor

Takafumi Ikeda

Yoko Hoshino

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-06-28

Filing date

1992-05-27

Publication date

1996-01-15

1992-05-27 Application filed by Pfizer filed Critical Pfizer

1996-01-15 Application granted granted Critical

1996-01-15 Publication of ATE132857T1 publication Critical patent/ATE132857T1/de

Links

102000003820 Lipoxygenases Human genes 0.000 title abstract 3
108090000128 Lipoxygenases Proteins 0.000 title abstract 3
MZBVNYACSSGXID-UHFFFAOYSA-N 2,3,4,5-tetrahydro-1h-1-benzazepine Chemical class N1CCCCC2=CC=CC=C21 MZBVNYACSSGXID-UHFFFAOYSA-N 0.000 title 1
230000002401 inhibitory effect Effects 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 3
125000003710 aryl alkyl group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
206010020751 Hypersensitivity Diseases 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
208000026935 allergic disease Diseases 0.000 abstract 1
230000007815 allergy Effects 0.000 abstract 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
230000002526 effect on cardiovascular system Effects 0.000 abstract 1
125000001188 haloalkyl group Chemical group 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
230000002757 inflammatory effect Effects 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Immunology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Hydrogenated Pyridines (AREA)

AT92911321T 1991-06-28 1992-05-27 Lipoxygenase inhibierende tetrahydrobenzazepinderivate ATE132857T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP3158832A JPH0717612B2 (ja)	1991-06-28	1991-06-28	新規なテトラヒドロベンズアゼピン誘導体

Publications (1)

Publication Number	Publication Date
ATE132857T1 true ATE132857T1 (de)	1996-01-15

Family

ID=15680372

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92911321T ATE132857T1 (de)	1991-06-28	1992-05-27	Lipoxygenase inhibierende tetrahydrobenzazepinderivate

Country Status (13)

Country	Link
US (1)	US5478822A (de)
EP (1)	EP0591255B1 (de)
JP (1)	JPH0717612B2 (de)
AT (1)	ATE132857T1 (de)
CA (1)	CA2111460C (de)
DE (1)	DE69207597T2 (de)
DK (1)	DK0591255T3 (de)
ES (1)	ES2082474T3 (de)
FI (1)	FI935867A0 (de)
GR (1)	GR3019196T3 (de)
IE (1)	IE70234B1 (de)
PT (1)	PT100628A (de)
WO (1)	WO1993000335A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0710233B1 (de) *	1993-07-20	1999-10-13	Pfizer Inc.	Heteroaryl-cyloalkenyl-hydroxy-harnstoeffe
JP2001501172A (ja) *	1996-08-15	2001-01-30	スミスクライン・ビーチャム・コーポレイション	Ｉｌ―８レセプターアンタゴニスト
EP1056187A4 (de)	1998-02-13	2005-11-02	Yaskawa Denki Seisakusho Kk	Linearmotor
US7229986B2 (en)	2000-05-16	2007-06-12	Takeda Pharmaceutical Company Ltd.	Melanin-concentrating hormone antagonist

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT82200B (pt) *	1985-03-16	1990-02-08	Wellcome Found	Processo para a preparacao de novos derivados do acido hidroxamico e de composicoes farmaceuticas que os contem
ES2059408T3 (es) *	1987-02-10	1994-11-16	Abbott Lab	Un proceso para la preparacion de un compuesto.
EP0292699B1 (de) *	1987-04-24	1994-03-23	Abbott Laboratories	Harnstoff-Derivate mit lipoxygenasehemmender Wirkung
US4981865A (en) *	1989-05-26	1991-01-01	Warner-Lambert Co.	N-hydroxyamide, N-hydroxythioamide, hydroxyurea, and N-hydroxythiourea derivatives of selected nsaids as antiinflammatory agents

1991
- 1991-06-28 JP JP3158832A patent/JPH0717612B2/ja not_active Expired - Fee Related
1992
- 1992-05-27 AT AT92911321T patent/ATE132857T1/de not_active IP Right Cessation
- 1992-05-27 FI FI935867A patent/FI935867A0/fi unknown
- 1992-05-27 ES ES92911321T patent/ES2082474T3/es not_active Expired - Lifetime
- 1992-05-27 DE DE69207597T patent/DE69207597T2/de not_active Expired - Fee Related
- 1992-05-27 EP EP92911321A patent/EP0591255B1/de not_active Expired - Lifetime
- 1992-05-27 WO PCT/US1992/004197 patent/WO1993000335A1/en not_active Ceased
- 1992-05-27 CA CA002111460A patent/CA2111460C/en not_active Expired - Fee Related
- 1992-05-27 US US08/167,959 patent/US5478822A/en not_active Expired - Fee Related
- 1992-05-27 DK DK92911321.5T patent/DK0591255T3/da active
- 1992-06-26 PT PT100628A patent/PT100628A/pt not_active Application Discontinuation
- 1992-07-01 IE IE922075A patent/IE70234B1/en not_active IP Right Cessation
1996
- 1996-03-05 GR GR960400599T patent/GR3019196T3/el unknown

Also Published As

Publication number	Publication date
PT100628A (pt)	1993-09-30
FI935867L (fi)	1993-12-27
FI935867A7 (fi)	1993-12-27
DE69207597T2 (de)	1996-05-23
DE69207597D1 (de)	1996-02-22
JPH059181A (ja)	1993-01-19
EP0591255A1 (de)	1994-04-13
ES2082474T3 (es)	1996-03-16
EP0591255B1 (de)	1996-01-10
IE70234B1 (en)	1996-11-13
US5478822A (en)	1995-12-26
WO1993000335A1 (en)	1993-01-07
JPH0717612B2 (ja)	1995-03-01
FI935867A0 (fi)	1993-12-27
CA2111460C (en)	1996-11-19
CA2111460A1 (en)	1993-01-07
DK0591255T3 (da)	1996-02-12
GR3019196T3 (en)	1996-06-30
IE922075A1 (en)	1992-12-30

Legal Events

Date	Code	Title	Description
1996-07-15	UEP	Publication of translation of european patent specification
1998-02-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DK0620216T3 (da)	2003-05-05	Benzamidderivater og deres anvendelse som vasopressinantagonister
DK0794949T3 (da)	1999-05-03	Hidtil ukendte 3,5-dioxo-(2H,4H)-1,2,4-triazinderivater, fremstilling heraf og deres anvendelse som lægemidler
YU34896A (sh)	1999-09-27	Supstituisani n-(indol-2-karbonil)-glicinamidi, njihovi intermedijeri i farmaceutske kompozicije
YU48089B (sh)	1997-01-08	Novi derivati tetrazola i postupak za njihovo pripremanje
PT1044186E (pt)	2006-07-31	Composto 2-benzilamino-2-fenil-acetamida substituidos
ATE224372T1 (de)	2002-10-15	Substituierte 6-alkylphenanthridine
NZ334701A (en)	2001-01-26	Dihydropyrones and use in treating retrovirus infections and diseases
MX9400253A (es)	1994-08-31	Derivados de piperazina, proceso para su preparacion y composiciones farmaceuticas que los contienen.
HUT59124A (en)	1992-04-28	Process for producing 2-(aminoalkyl)-5-(arylalkyl)-1,3-dioxane derivatives and pharmaceutical compositions comprising such derivatives as active ingredient
DE69207597D1 (de)	1996-02-22	Lipoxygenase inhibierende tetrahydrobenzazepinderivate
DK0720598T3 (da)	1999-06-21	Phenoxyphenylcyclopentenyl-hydroxyurinstoffer
BG106152A (en)	2002-06-28	1-trifluoromethyl-4-hydroxy-7-piperidinyl-aminomethylchroman derivatives
DK0588850T3 (da)	1996-01-08	N-hydroxyureaderivater, som inhiberer lipoxygenase
DK0596917T3 (da)	1999-07-05	Benzimidazolanthelmintika
KR950702533A (ko)	1995-07-29	리폭시게나제 억제제로서의 인돌리닐 n-하이드록시우레아 및 n-하이드록삼산 유도체(indolinyl n-hydroxyurea and n-hydroxamic acid derivatives as lipoxygenase inhibitors)
FI942768A0 (fi)	1994-06-10	Syklopropyyli-N-hydroksiurea ja N-hydroksiasetamidit, jotka inhiboivat lipoksygenaasia
KR960034199A (ko)	1996-10-22	피라졸을 함유한 벤즈이미다졸 유도체