ES2082474T3 - Derivados de tetrahidrobenzazepina que inhiben la lipoxigenasa. - Google Patents

Derivados de tetrahidrobenzazepina que inhiben la lipoxigenasa.

Info

Publication number
ES2082474T3
ES2082474T3 ES92911321T ES92911321T ES2082474T3 ES 2082474 T3 ES2082474 T3 ES 2082474T3 ES 92911321 T ES92911321 T ES 92911321T ES 92911321 T ES92911321 T ES 92911321T ES 2082474 T3 ES2082474 T3 ES 2082474T3
Authority
ES
Spain
Prior art keywords
alkilo
lipoxigenase
arilalkyl
treatment
states
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92911321T
Other languages
English (en)
Inventor
Takafumi Ikeda
Yoko Hoshino
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PFIZER
Pfizer Inc
Original Assignee
PFIZER
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PFIZER, Pfizer Inc filed Critical PFIZER
Application granted granted Critical
Publication of ES2082474T3 publication Critical patent/ES2082474T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

COMPUESTOS DE LA FORMULA (I) EN DONDE N ES DE 1 A 5 Y R ES HIDROGENO, ALKILO C1 A C4, ARILALKILO QUE TIENE DE UNO A CUATRO ATOMOS DE CARBONO EN LA UNIDAD DE ALKILO O ARILALKILO SUSTITUIDO POR UNO O MAS SUSTITUYENTES SELECCIONADOS INDEPENDIENTEMENTE DEL GRUPO QUE CONSISTE EN HALOGENO, NITRO, CIANO, ALKILO C1 A C6, ALCOXI C1 A C6, ALKILO HALOSUSTITUIDO C1 A C6, ALKILO HIDROXISUSTITUIDO C1 A C6, ALCOXICARBONILO C2 A C7 Y AMINOCARBONILO Y LAS SALES FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS, QUE INHIBEN LA LIPOXIGENESA DE LA ENZIMA Y SON UTILES PARA EL TRATAMIENTO DE ESTADOS ALERGICOS, INFLAMATORIOS Y CARDIOVASCULARES EN LOS QUE HA INTERVENIDO LA ACCION DE LA LIPOXIGENASA. ESTOS COMPUESTOS FORMAN EL INGREDIENTE ACTIVO DE LAS COMPOSICIONES FARMACEUTICAS PARA EL TRATAMIENTO DE TALES ESTADOS.
ES92911321T 1991-06-28 1992-05-27 Derivados de tetrahidrobenzazepina que inhiben la lipoxigenasa. Expired - Lifetime ES2082474T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3158832A JPH0717612B2 (ja) 1991-06-28 1991-06-28 新規なテトラヒドロベンズアゼピン誘導体

Publications (1)

Publication Number Publication Date
ES2082474T3 true ES2082474T3 (es) 1996-03-16

Family

ID=15680372

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92911321T Expired - Lifetime ES2082474T3 (es) 1991-06-28 1992-05-27 Derivados de tetrahidrobenzazepina que inhiben la lipoxigenasa.

Country Status (13)

Country Link
US (1) US5478822A (es)
EP (1) EP0591255B1 (es)
JP (1) JPH0717612B2 (es)
AT (1) ATE132857T1 (es)
CA (1) CA2111460C (es)
DE (1) DE69207597T2 (es)
DK (1) DK0591255T3 (es)
ES (1) ES2082474T3 (es)
FI (1) FI935867L (es)
GR (1) GR3019196T3 (es)
IE (1) IE70234B1 (es)
PT (1) PT100628A (es)
WO (1) WO1993000335A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0710233T3 (da) * 1993-07-20 2000-01-03 Pfizer Heteroarylcycloalkenylhydroxyurinstoffer
EP0920417A4 (en) * 1996-08-15 1999-12-29 Smithkline Beecham Corp IL-8 RECEPTOR ANTAGONISTS
US6476524B1 (en) 1998-02-13 2002-11-05 Kabushiki Kaisha Yaskawa Denki Linear motor
US7229986B2 (en) 2000-05-16 2007-06-12 Takeda Pharmaceutical Company Ltd. Melanin-concentrating hormone antagonist

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT82200B (pt) * 1985-03-16 1990-02-08 Wellcome Found Processo para a preparacao de novos derivados do acido hidroxamico e de composicoes farmaceuticas que os contem
DE3882732T2 (de) * 1987-02-10 1993-12-02 Abbott Lab Indol, Benzofuran, Benzothiophen enthaltende, Lipoxygenase hemmende Verbindungen.
CA1336099C (en) * 1987-04-24 1995-06-27 James B. Summers, Jr. Urea based lipoxygenase compounds
US4981865A (en) * 1989-05-26 1991-01-01 Warner-Lambert Co. N-hydroxyamide, N-hydroxythioamide, hydroxyurea, and N-hydroxythiourea derivatives of selected nsaids as antiinflammatory agents

Also Published As

Publication number Publication date
EP0591255B1 (en) 1996-01-10
FI935867A0 (fi) 1993-12-27
JPH059181A (ja) 1993-01-19
GR3019196T3 (en) 1996-06-30
CA2111460A1 (en) 1993-01-07
ATE132857T1 (de) 1996-01-15
IE70234B1 (en) 1996-11-13
WO1993000335A1 (en) 1993-01-07
JPH0717612B2 (ja) 1995-03-01
DK0591255T3 (da) 1996-02-12
US5478822A (en) 1995-12-26
PT100628A (pt) 1993-09-30
FI935867A7 (fi) 1993-12-27
IE922075A1 (en) 1992-12-30
FI935867L (fi) 1993-12-27
DE69207597D1 (de) 1996-02-22
EP0591255A1 (en) 1994-04-13
CA2111460C (en) 1996-11-19
DE69207597T2 (de) 1996-05-23

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