ATE132974T1 - Test, indikatoren, immunogene und antikörper für benzodiazepine - Google Patents

Test, indikatoren, immunogene und antikörper für benzodiazepine

Info

Publication number
ATE132974T1
ATE132974T1 AT87114982T AT87114982T ATE132974T1 AT E132974 T1 ATE132974 T1 AT E132974T1 AT 87114982 T AT87114982 T AT 87114982T AT 87114982 T AT87114982 T AT 87114982T AT E132974 T1 ATE132974 T1 AT E132974T1
Authority
AT
Austria
Prior art keywords
benzodiazepines
antibodies
assay
immunogenic
indicators
Prior art date
Application number
AT87114982T
Other languages
English (en)
Inventor
Nai-Yi Wang
Candace Linda Keegan
Daniel Fuelner Heiman
Charles Arthur Flentge
Philip Pei Wang
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Application granted granted Critical
Publication of ATE132974T1 publication Critical patent/ATE132974T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/948—Sedatives, e.g. cannabinoids, barbiturates

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Anesthesiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT87114982T 1986-10-24 1987-10-14 Test, indikatoren, immunogene und antikörper für benzodiazepine ATE132974T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US92259586A 1986-10-24 1986-10-24

Publications (1)

Publication Number Publication Date
ATE132974T1 true ATE132974T1 (de) 1996-01-15

Family

ID=25447288

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87114982T ATE132974T1 (de) 1986-10-24 1987-10-14 Test, indikatoren, immunogene und antikörper für benzodiazepine

Country Status (9)

Country Link
EP (1) EP0264797B1 (de)
JP (1) JPH0660166B2 (de)
KR (1) KR880005101A (de)
AT (1) ATE132974T1 (de)
AU (1) AU604766B2 (de)
CA (1) CA1339439C (de)
DE (1) DE3751673T2 (de)
ES (1) ES2084577T3 (de)
GR (1) GR3019283T3 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5352803A (en) * 1992-03-30 1994-10-04 Abbott Laboratories 5(6)-methyl substituted fluorescein derivatives
EP0649533B1 (de) * 1992-03-30 2000-05-10 Abbott Laboratories Reagenzien und verfahren zum nachweis und zur quantifizierung von thyroxin in flüssigen proben
AU678503B2 (en) * 1993-09-24 1997-05-29 Takeda Chemical Industries Ltd. Condensed heterocyclic compounds and their use as squalene synthetase inhibitors
US5492841A (en) * 1994-02-18 1996-02-20 E. I. Du Pont De Nemours And Company Quaternary ammonium immunogenic conjugates and immunoassay reagents
DE19503320A1 (de) * 1995-02-02 1996-08-08 Boehringer Mannheim Gmbh Neue Benzodiazepinkonjugate
EP0934527B1 (de) * 1996-10-25 2002-07-24 Elimo B.V. Nicht-radioaktives rezeptorassay zur quantitativen und qualitativen analyse von spurenmengen eines rezeptorbindierendenanalytes
US7160880B1 (en) 1999-05-14 2007-01-09 Cenes Limited Short-acting benzodiazepines
GB9911152D0 (en) * 1999-05-14 1999-07-14 Glaxo Group Ltd Short-acting benzodiazepines
AU6420700A (en) * 1999-08-05 2001-03-05 Prescient Neuropharma Inc. Novel 1,4-benzodiazepine compounds and derivatives thereof
US7026166B2 (en) 2002-01-22 2006-04-11 Chiron Corporation Fluorogenic dyes
US7029918B2 (en) * 2002-01-25 2006-04-18 Roche Diagnostics Operations, Inc. Water-soluble derivatives of lipophilic drugs
US7704756B2 (en) 2003-01-21 2010-04-27 Novartis Vaccines And Diagnostics, Inc. Fluorogenic dyes
BRPI0714886B8 (pt) 2006-07-10 2021-05-25 Paion Uk Ltd sais de benzodiazepina, seus usos e seus processos de preparação, e composição farmacêutica
EP2450039A1 (de) 2010-11-08 2012-05-09 PAION UK Ltd. Dosierschema zur Sedierung mit CNS 7056 (Remimazolam)
AR094963A1 (es) 2013-03-04 2015-09-09 Ono Pharmaceutical Co Reacción de oxidación excelente en el índice de conversión

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL37230A0 (en) * 1970-07-29 1971-10-20 Sparamedica Ag Benzodiazepine derivatives,their manufacture and pharmaceutical compositions containing them
CH566324A5 (en) * 1970-10-07 1975-09-15 Hoffmann La Roche 1-Carbamoylalkyl substd. 1,4-benzodiazepin-2-ones prodn - from corresp acids or derivs by reacting with amines, useful as CNS depressants
CH538492A (de) * 1970-10-07 1973-06-30 Hoffmann La Roche Verfahren zur Herstellung von Benzodiazepin-Derivaten
US4243654A (en) * 1978-09-11 1981-01-06 Syva Company Oxazepam derivatives for immunoassay reagents
AT361492B (de) * 1978-12-18 1981-03-10 Gerot Pharmazeutika Verfahren zur herstellung von neuen 3-hydroxy- 1,4-benzodiazepin-2-onen
US4318846A (en) * 1979-09-07 1982-03-09 Syva Company Novel ether substituted fluorescein polyamino acid compounds as fluorescers and quenchers
EP0218010A3 (de) * 1985-07-10 1988-01-07 Abbott Laboratories Verfahren zur Bestimmung von Liganden und substituierte Carboxyfluoreszein-Markers zur Durchführung desselben

Also Published As

Publication number Publication date
JPH0660166B2 (ja) 1994-08-10
KR880005101A (ko) 1988-06-28
CA1339439C (en) 1997-09-02
ES2084577T3 (es) 1996-05-16
EP0264797A3 (en) 1990-02-07
AU7997587A (en) 1988-04-28
DE3751673D1 (de) 1996-02-22
JPS63246666A (ja) 1988-10-13
GR3019283T3 (en) 1996-06-30
DE3751673T2 (de) 1996-08-01
AU604766B2 (en) 1991-01-03
EP0264797A2 (de) 1988-04-27
EP0264797B1 (de) 1996-01-10

Similar Documents

Publication Publication Date Title
DE69113114D1 (de) Test für Phencyclidin und Phencyclidin-Metaboliten, Tracer, Immunogene, Antikörper und Reagenzsatz dafür.
EP0254120A3 (de) Immunoassay für Opiatalkaloide und ihre Metaboliten; Tracer, Immunogene und Antikörper
DE3751673D1 (de) Test, Indikatoren, Immunogene und Antikörper für Benzodiazepine
ES2079390T3 (es) Reactivos, metodo y kits para un ensayo inmunologico de polarizacion de fluorescencia de anfetaminas.
ES456694A1 (es) Procedimiento para preparar colorantes que contienen un sis-tema cromoforico.
FI101575B1 (fi) Menetelmä reagenssin pitoisuuden mittaamiseksi reaktioseoksessa
EP0148551A3 (de) Verfahren zur Messung von Membranschmelzung
DK422583D0 (da) Fremgangsmade til fremstilling af diazobicyclo-(3,3,1)-nonaner
ATE74662T1 (de) Immunoanalysetestverfahren fuer cholesterolepoxide.
FI954029A0 (fi) Kemiluminesoiva reagenssi ja analyysimenetelmä, jossa käytetään substituoitua asetanilidia valon muodostukseen
NO163920C (no) Fremgangsmaate for bestemmelse av pivka-ii i fysiologiske proever.
DE69126915D1 (de) Test für Barbiturate, Tracer, Immunogene, Antikörper und Testsatz dafür
GB1484579A (en) Biological staining technique and mixture thereof
SE7904890L (sv) Komposition, testanordning och forfarande for bestemning av nervaro av urobilinogen i ett prov
ES2035452T3 (es) Procedimiento para la obtencion conjunta de 3-dialquil-aminopropionitrilos, bis-(2-cianoetil)-eteres y en caso deseado etilencianhidrina.
ES522722A1 (es) Procedimiento de inmunoanalisis para determinar propanolol en una muestra
ES2061686T3 (es) Progreso de epoxidos.
PL195632A1 (pl) Sposob wytwarzania antygenu,sposob przygotowania odczynnika antygenowego oraz zestaw do wykonywania testu
EP0252405A3 (de) Fluoreszenz-Polarisationsimmunoassay zur Bestimmung von 3-Methoxy-4-hydroxyphenylglykol
EP0201633A3 (de) Substituierte Anilid-Verbindungen und ihre Verwendung
EP0373508A3 (de) Test, Indikatoren, Immunogene und Antikörper für Barbiturate
FI87021B (fi) Foerfarande foer stabilisering av prostataspecifik antigen i naturella matriser och foerfarande foer framstaellning av matriser.
ES2147731T3 (es) Haptenos, trazadores, inmunogenos y anticuerpos para inmunoanalisis de deteccion de propoxifeno.
JPS51129288A (en) Sample cell for fluorescence detector
AT377612B (de) Anordnung zur optischen messung von stoffkonzentrationen