ATE133183T1 - Peptide, die von der faktor viii-bindungsdomäne des von willebrand-faktors abgeleitet sind - Google Patents

Peptide, die von der faktor viii-bindungsdomäne des von willebrand-faktors abgeleitet sind

Info

Publication number
ATE133183T1
ATE133183T1 AT88303796T AT88303796T ATE133183T1 AT E133183 T1 ATE133183 T1 AT E133183T1 AT 88303796 T AT88303796 T AT 88303796T AT 88303796 T AT88303796 T AT 88303796T AT E133183 T1 ATE133183 T1 AT E133183T1
Authority
AT
Austria
Prior art keywords
factor
von willebrand
binding domain
factor viii
peptides derived
Prior art date
Application number
AT88303796T
Other languages
English (en)
Inventor
Theodore S Zimmerman
Carol A Fulcher
Paul A Foster
Original Assignee
Scripps Clinic Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Clinic Res filed Critical Scripps Clinic Res
Application granted granted Critical
Publication of ATE133183T1 publication Critical patent/ATE133183T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT88303796T 1987-05-01 1988-04-27 Peptide, die von der faktor viii-bindungsdomäne des von willebrand-faktors abgeleitet sind ATE133183T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07045032 US5043429B1 (en) 1987-05-01 1987-05-01 Protein fragments containing factor VIII binding domain of von willebrand factor

Publications (1)

Publication Number Publication Date
ATE133183T1 true ATE133183T1 (de) 1996-02-15

Family

ID=21935641

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88303796T ATE133183T1 (de) 1987-05-01 1988-04-27 Peptide, die von der faktor viii-bindungsdomäne des von willebrand-faktors abgeleitet sind

Country Status (9)

Country Link
US (3) US5043429B1 (de)
EP (1) EP0294025B1 (de)
JP (1) JP2631127B2 (de)
AT (1) ATE133183T1 (de)
AU (1) AU626255B2 (de)
CA (1) CA1341097C (de)
DE (1) DE3854904T2 (de)
ES (1) ES2081804T3 (de)
GR (1) GR3018870T3 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5043429B1 (en) * 1987-05-01 1997-10-14 Scripps Research Inst Protein fragments containing factor VIII binding domain of von willebrand factor
FR2632309B1 (fr) * 1988-06-07 1990-08-24 Lille Transfusion Sanguine Procede de purification par voie chromatographique de proteines, notamment de facteur viii, et les produits obtenus
US5849536A (en) * 1990-03-02 1998-12-15 Bio-Technology General Corp. Cloning and production of human von willebrand factor GPIb binding domain polypeptides and methods of using same
US6008193A (en) * 1990-03-02 1999-12-28 Bio-Technology General Corp. Methods of using human von Willebrand factor GPIb binding domain polypeptides
US5530100A (en) * 1990-05-07 1996-06-25 Rhone-Poulenc Rorer Pharmaceuticals Inc. Methods for purification of recombinantly produced proteins
US5629287A (en) * 1991-01-18 1997-05-13 University College London Depot formulations
US5610148A (en) * 1991-01-18 1997-03-11 University College London Macroscopically oriented cell adhesion protein for wound treatment
ATE283864T1 (de) * 1991-06-20 2004-12-15 Aventis Behring L L C Ein verfahren zur herstellung therapeutisch wirksamer bruchstücke von von willebrand-faktor
US5847086A (en) * 1991-06-20 1998-12-08 Centeon L.L.C. Therapeutic fragments of von Willebrand factor
CA2117780A1 (en) * 1992-04-10 1993-10-28 Paul F. Goetinck Cartillage matrix protein and methods for use
US6005077A (en) * 1995-11-10 1999-12-21 Immuno Aktiengesellschaft Use of von willebrand factor and pharmaceutical formulation
DE19740310A1 (de) * 1997-09-13 1999-04-01 Octapharma Ag Peptid mit Affinität zu Gerinnungsfaktor VIII
KR100398058B1 (ko) * 2001-05-18 2003-09-19 주식회사 경동도시가스 수식된 θ-알루미나에 담지되어 이루어진 니켈계 개질촉매및 이를 이용한 천연가스로부터 합성가스의 제조방법
KR20070101227A (ko) * 2004-09-07 2007-10-16 아케믹스 코포레이션 폰 빌레브란트 인자에 대한 앱타머 및 이의 혈전증치료제로서의 용도
US7566701B2 (en) * 2004-09-07 2009-07-28 Archemix Corp. Aptamers to von Willebrand Factor and their use as thrombotic disease therapeutics
CA2578046A1 (en) * 2004-09-07 2006-03-16 Archemix Corp. Aptamer medicinal chemistry
US20090203766A1 (en) * 2007-06-01 2009-08-13 Archemix Corp. vWF aptamer formulations and methods for use
HUE029454T2 (en) 2009-11-13 2017-03-28 Grifols Therapeutics Inc Von willebrand factor (vwf)-containing preparations, and methods, kits, and uses related thereto
AU2011343813B2 (en) 2010-12-15 2015-05-21 Takeda Pharmaceutical Company Limited Eluate collection using conductivity gradient
WO2013093760A2 (en) 2011-12-19 2013-06-27 Grifols, S.A. Compositions, methods, and kits for preparing sialylated recombinant proteins
NL2013007B1 (en) 2014-06-16 2016-07-05 Ablynx Nv Methods of treating TTP with immunoglobulin single variable domains and uses thereof.
EP3476937A4 (de) 2016-06-24 2019-12-04 Mogam Institute for Biomedical Research Chimäres protein mit fviii- und vwf-faktoren sowie verwendung davon
MY204220A (en) 2018-02-06 2024-08-16 Ablynx Nv Methods of treating initial episode of ttp with immunoglobulin single variable domains

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4361509A (en) * 1981-12-14 1982-11-30 Scripps Clinic And Research Foundation Ultrapurification of factor VIII using monoclonal antibodies
US4661471A (en) * 1984-04-10 1987-04-28 New England Deaconess Hospital Method of inhibiting and inducing human platelet aggregation
US4683291A (en) * 1985-10-28 1987-07-28 Scripps Clinic And Research Foundation Platelet binding inhibitors
WO1987004187A1 (en) * 1986-01-03 1987-07-16 Genetics Institute, Inc. METHOD FOR PRODUCING FACTOR VIII:c-TYPE PROTEINS
US5198349A (en) * 1986-01-03 1993-03-30 Genetics Institute, Inc. Method for producing factor VIII:C and analogs
US5043429B1 (en) * 1987-05-01 1997-10-14 Scripps Research Inst Protein fragments containing factor VIII binding domain of von willebrand factor

Also Published As

Publication number Publication date
EP0294025A3 (en) 1989-11-08
US5260274B1 (en) 1998-01-20
JPS6456697A (en) 1989-03-03
US5597711A (en) 1997-01-28
DE3854904D1 (de) 1996-02-29
AU1527188A (en) 1988-11-03
US5043429B1 (en) 1997-10-14
ES2081804T3 (es) 1996-03-16
US5260274A (en) 1993-11-09
EP0294025B1 (de) 1996-01-17
EP0294025A2 (de) 1988-12-07
DE3854904T2 (de) 1996-07-04
AU626255B2 (en) 1992-07-30
US5043429A (en) 1991-08-27
JP2631127B2 (ja) 1997-07-16
GR3018870T3 (en) 1996-05-31
CA1341097C (en) 2000-09-12

Similar Documents

Publication Publication Date Title
ATE133183T1 (de) Peptide, die von der faktor viii-bindungsdomäne des von willebrand-faktors abgeleitet sind
DE59209129D1 (de) Verwendung von Antikörper enthaltenden Präparationen zur Immunsuppression
DK0397633T3 (da) Fibronectinbindende protein samt fremstilling deraf
DE3486030D1 (de) Monoklonale antikoerper, spezifisch von in vivo von fibrinogen abgeleiteten derivatstuecken.
DK564989A (da) Bindingsproteiner
DD133563A5 (de) Verfahren zur herstellung von trisubstituierten 1-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepinen
ATE177758T1 (de) Synthetische peptide, antikörper dagegen und ihre verwendung
ES8801729A1 (es) Un ensayo inmunometrio para proteina p21ras humana
FI953525L (fi) Kemiallinen syntetointimenetelmä fibronektiiniä sitovan proteiinin tai polypeptidin valmistamiseksi
ES2123582T3 (es) Proteina con capacidad de formacion de huesos y procedimiento para su produccion.
DE3888736D1 (de) Verfahren zur Epitaxieabscheidung von Silizium.
ATE50458T1 (de) Bestimmung von fibrin mit fibrin-spezifischen antikoerpern.
DE69023532D1 (de) Verfahren zur Synthese von Acylamino-Organosilicium-Verbindungen.
ATE66669T1 (de) Verfahren zur gewinnung von 2-methylbutanal.
DE69011719D1 (de) Verfahren zur Synthese von Acylamino-organosilicium-Verbindungen.
DE59104538D1 (de) Verfahren zur Herstellung von Peptiden mittels Festphasensynthese.
DE69109510D1 (de) Verfahren zur Herstellung von Glycin.
DE69006888D1 (de) Verfahren zur Synthese von Acylamino-Organosilicon-Verbindungen.
DE59004279D1 (de) Verfahren zur C-terminalen Modifizierung von Proteinen.
DE69019839D1 (de) Verfahren zur Synthese von cis-Olefinen.
IT7924191A0 (it) Procedimento per preparare peptidi ciclici contenenti legami di bisolfuro.
ATE48128T1 (de) Verfahren zur synthese von olefinen aus paraffinen.
ATE7030T1 (de) Verfahren zur gewinnung von faktor viii.
ATE41310T1 (de) Verwendung von hexamethylcyclotrisiloxan als riechstofftraegermaterial.

Legal Events

Date Code Title Description
EELA Cancelled due to lapse of time