|
US8597910B1
(en)
|
1985-04-11 |
2013-12-03 |
Children's Medical Center Corporation |
DNA encoding Von Willebrand Factor (VWF) and methods and cells for producing VFW, and VFW produced by the DNA, methods and cells
|
|
US5198349A
(en)
*
|
1986-01-03 |
1993-03-30 |
Genetics Institute, Inc. |
Method for producing factor VIII:C and analogs
|
|
US5451521A
(en)
*
|
1986-05-29 |
1995-09-19 |
Genetics Institute, Inc. |
Procoagulant proteins
|
|
US5576194A
(en)
*
|
1986-07-11 |
1996-11-19 |
Bayer Corporation |
Recombinant protein production
|
|
GR871029B
(en)
|
1986-07-14 |
1987-11-02 |
Genetics Inst |
Novel osteoinductive factors
|
|
WO1988005825A1
(en)
*
|
1987-01-30 |
1988-08-11 |
Biogen N.V. |
A method for producing factor viii in high yield
|
|
CA1331157C
(en)
*
|
1987-04-06 |
1994-08-02 |
Randal J. Kaufman |
Method for producing factor viii:c-type proteins
|
|
US5043429B1
(en)
*
|
1987-05-01 |
1997-10-14 |
Scripps Research Inst |
Protein fragments containing factor VIII binding domain of von willebrand factor
|
|
JPH0387173A
(ja)
*
|
1987-09-10 |
1991-04-11 |
Teijin Ltd |
ヒト活性化天然型ファクター8cの製造方法及びそれに用いる形質転換体
|
|
CA1340740C
(en)
*
|
1987-12-08 |
1999-09-14 |
Eileen R. Mulvihill |
Co-expression in eukaryotic cells
|
|
US5648254A
(en)
*
|
1988-01-15 |
1997-07-15 |
Zymogenetics, Inc. |
Co-expression in eukaryotic cells
|
|
US5811523A
(en)
|
1988-11-10 |
1998-09-22 |
Trinchieri; Giorgio |
Antibodies to natural killer stimulatory factor
|
|
ES2060942T3
(es)
*
|
1989-02-02 |
1994-12-01 |
Joel S Greenberger |
Terapia genetica utilizando celulas estromicas.
|
|
US7247475B2
(en)
|
1989-07-28 |
2007-07-24 |
Wyeth |
Method for producing monoclonal antibodies
|
|
US6475787B1
(en)
|
1989-07-28 |
2002-11-05 |
Wyeth |
Method for producing monoclonal antibodies
|
|
SE465222C5
(sv)
*
|
1989-12-15 |
1998-02-10 |
Pharmacia & Upjohn Ab |
Ett rekombinant, humant faktor VIII-derivat och förfarande för dess framställning
|
|
FR2657884B1
(fr)
|
1990-02-05 |
1994-09-02 |
Tm Innovation |
Procede pour la preparation du facteur viii humain et d'analogues du facteur viii.
|
|
US5661008A
(en)
*
|
1991-03-15 |
1997-08-26 |
Kabi Pharmacia Ab |
Recombinant human factor VIII derivatives
|
|
US5371198A
(en)
*
|
1991-12-16 |
1994-12-06 |
Novo Nordisk A/S |
Method for protection of proteolysis-susceptible protein during protein production in a fluid medium
|
|
DK53792D0
(da)
*
|
1992-04-24 |
1992-04-24 |
Novo Nordisk As |
Fremgangsmaade til fremstilling af proteiner
|
|
US5563045A
(en)
|
1992-11-13 |
1996-10-08 |
Genetics Institute, Inc. |
Chimeric procoagulant proteins
|
|
US5952198A
(en)
*
|
1995-05-04 |
1999-09-14 |
Bayer Corporation |
Production of recombinant Factor VIII in the presence of liposome-like substances of mixed composition
|
|
US5744326A
(en)
*
|
1996-03-11 |
1998-04-28 |
The Immune Response Corporation |
Use of viral CIS-acting post-transcriptional regulatory sequences to increase expression of intronless genes containing near-consensus splice sites
|
|
US8183344B2
(en)
|
1996-04-24 |
2012-05-22 |
University Of Michigan |
Inactivation resistant factor VIII
|
|
EP0910628B1
(de)
|
1996-04-24 |
2006-03-08 |
The Regents of The University of Michigan |
Gegen inaktivierung resistenter faktor viii
|
|
BR9711540A
(pt)
|
1996-09-24 |
2001-06-19 |
Protector & Gamble Company |
Inibidores de protease proteìnico estabilizados e variantes dos mesmos
|
|
JP4405668B2
(ja)
|
1998-03-12 |
2010-01-27 |
ジェネティクス インスティテュート,エルエルシー |
因子viii蛋白を製造するための改良された方法
|
|
US7820796B2
(en)
|
1998-03-12 |
2010-10-26 |
Genetics Institute, Llc. |
Methods for producing Factor VIII proteins
|
|
EP1038959A1
(de)
|
1999-03-17 |
2000-09-27 |
Aventis Behring Gesellschaft mit beschränkter Haftung |
Faktor VIII ohne B-Domän, der ein oder mehrere Insertionsstücke von verkürztem Intron I des Faktors IX enthält
|
|
DK1266006T3
(da)
*
|
2000-03-22 |
2006-01-16 |
Octagene Gmbh |
Fremstilling af rekombinante muteiner af blodkoagulationsfaktor VIII i humane cellelinier
|
|
EP1351986A2
(de)
|
2001-01-12 |
2003-10-15 |
The American National Red Cross |
Verfahren und zusammensetzungen zur verminderung von heparansulfatproteoglykan-vermittelter entfernung von faktor viii
|
|
EP1233064A1
(de)
|
2001-02-09 |
2002-08-21 |
Aventis Behring Gesellschaft mit beschränkter Haftung |
Modifizierte Faktor VIII cDNA und deren Verwendung bei der Produktion von Faktor VIII
|
|
TWI353991B
(en)
|
2003-05-06 |
2011-12-11 |
Syntonix Pharmaceuticals Inc |
Immunoglobulin chimeric monomer-dimer hybrids
|
|
US7211559B2
(en)
|
2003-10-31 |
2007-05-01 |
University Of Maryland, Baltimore |
Factor VIII compositions and methods
|
|
EP1707634A1
(de)
|
2005-03-29 |
2006-10-04 |
Octapharma AG |
Verfahren zur Isolierung von rekombinant hergestellten Proteinen
|
|
EP1739179A1
(de)
|
2005-06-30 |
2007-01-03 |
Octapharma AG |
Serumfreie stabile Transfektion und Produktion von rekombinanten humanen Proteinen in humanen Zelllinien
|
|
US7855279B2
(en)
|
2005-09-27 |
2010-12-21 |
Amunix Operating, Inc. |
Unstructured recombinant polymers and uses thereof
|
|
US20080070251A1
(en)
|
2006-06-30 |
2008-03-20 |
Kaufman Randal J |
Method of Producing Factor VIII Proteins by Recombinant Methods
|
|
EP1988101A1
(de)
|
2007-05-04 |
2008-11-05 |
Novo Nordisk A/S |
Verbesserung von Faktor-VIII-Polypeptid-Titern in Zellkulturen
|
|
SI2393828T1
(sl)
|
2009-02-03 |
2017-01-31 |
Amunix Operating Inc. |
Podaljšani rekombinantni polipetidi in sestavki, ki jih obsegajo
|
|
US20110046060A1
(en)
|
2009-08-24 |
2011-02-24 |
Amunix Operating, Inc., |
Coagulation factor IX compositions and methods of making and using same
|
|
BR112012013502A2
(pt)
|
2009-12-06 |
2017-01-10 |
Biogen Idec Hemophilia Inc |
"polipeptídeos quiméricos e híbridos de fator viii-fc, e métodos de uso dos mesmos".
|
|
WO2011095604A1
(en)
|
2010-02-04 |
2011-08-11 |
Octapharma Biopharmaceuticals Gmbh |
Half-life prolongation of proteins
|
|
ES2739503T3
(es)
|
2010-07-09 |
2020-01-31 |
Bioverativ Therapeutics Inc |
Moléculas de cadena simple procesables y polipéptidos producidos usándolas
|
|
US9611310B2
(en)
|
2010-07-09 |
2017-04-04 |
Bioverativ Therapeutics Inc. |
Systems for factor VIII processing and methods thereof
|
|
EP2957628A1
(de)
|
2010-10-05 |
2015-12-23 |
Novo Nordisk Health Care AG |
Verfahren zur proteinherstellung
|
|
ES2724778T3
(es)
|
2011-06-10 |
2019-09-16 |
Bioverativ Therapeutics Inc |
Compuestos procoagulantes y procedimientos de uso de los mismos
|
|
DK2729161T3
(en)
|
2011-07-08 |
2019-04-08 |
Bioverativ Therapeutics Inc |
FACTOR VIII CHEMICAL AND HYBRID POLYPEPTIDES AND PROCEDURES FOR USE THEREOF
|
|
WO2013016454A1
(en)
|
2011-07-25 |
2013-01-31 |
Biogen Idec Hemophilia Inc. |
Assays to monitor bleeding disorders
|
|
CN111499761A
(zh)
|
2012-01-12 |
2020-08-07 |
比奥贝拉蒂治疗公司 |
嵌合因子viii多肽及其用途
|
|
BR112014017111A8
(pt)
|
2012-01-12 |
2018-05-15 |
Biogen Idec Inc |
métodos de redução de imunogenicidade contra o fator viii em indivíduos submetidos à terapia de fator viii
|
|
CN111548418A
(zh)
|
2012-02-15 |
2020-08-18 |
比奥贝拉蒂治疗公司 |
因子viii组合物及其制备和使用方法
|
|
NZ628014A
(en)
|
2012-02-15 |
2016-09-30 |
Biogen Ma Inc |
Recombinant factor viii proteins
|
|
EP2858659B1
(de)
|
2012-06-08 |
2019-12-25 |
Bioverativ Therapeutics Inc. |
Prokoagulationsverbindungen
|
|
US10202595B2
(en)
|
2012-06-08 |
2019-02-12 |
Bioverativ Therapeutics Inc. |
Chimeric clotting factors
|
|
WO2014008480A2
(en)
|
2012-07-06 |
2014-01-09 |
Biogen Idec Ma Inc. |
Cell line expressing single chain factor viii polypeptides and uses thereof
|
|
AU2013290173B2
(en)
|
2012-07-11 |
2018-02-15 |
Bioverativ Therapeutics Inc. |
Factor VIII complex with XTEN and von Willebrand Factor protein, and uses thereof
|
|
EP3970738A1
(de)
|
2012-07-25 |
2022-03-23 |
Bioverativ Therapeutics Inc. |
Blutfaktorüberwachungstest und verwendungen davon
|
|
EP2908847B1
(de)
|
2012-10-18 |
2022-03-30 |
Bioverativ Therapeutics Inc. |
Verfahren zur verwendung einer festgelegten dosis eines blutgerinnungsfaktors
|
|
EP2914293A4
(de)
|
2012-10-30 |
2016-04-20 |
Biogen Ma Inc |
Verfahren zur verwendung von fviii-polypeptid
|
|
DK2956477T4
(da)
|
2013-02-15 |
2024-04-15 |
Bioverativ Therapeutics Inc |
Optimeret faktor viii-gen
|
|
EA037906B1
(ru)
|
2013-03-15 |
2021-06-04 |
Биовератив Терапьютикс Инк. |
Препараты полипептида фактора ix
|
|
EP3666283B1
(de)
|
2013-03-15 |
2022-06-08 |
Bioverativ Therapeutics Inc. |
Faktor-viii-polypeptidformulierungen
|
|
HK1223302A1
(zh)
|
2013-06-28 |
2017-07-28 |
Bioverativ Therapeutics Inc. |
具有xten的凝血酶可裂解连接子和其用途
|
|
EP3043813B1
(de)
|
2013-08-08 |
2021-01-13 |
Bioverativ Therapeutics Inc. |
Reinigung von chimären fviii-molekülen
|
|
US10548953B2
(en)
|
2013-08-14 |
2020-02-04 |
Bioverativ Therapeutics Inc. |
Factor VIII-XTEN fusions and uses thereof
|
|
US10584147B2
(en)
|
2013-11-08 |
2020-03-10 |
Biovertiv Therapeutics Inc. |
Procoagulant fusion compound
|
|
US10325687B2
(en)
|
2013-12-06 |
2019-06-18 |
Bioverativ Therapeutics Inc. |
Population pharmacokinetics tools and uses thereof
|
|
PH12016501323B1
(en)
|
2014-01-10 |
2022-04-29 |
Bioverativ Therapeutics Inc |
Factor viii chimeric proteins and uses thereof
|
|
KR102382402B1
(ko)
|
2014-02-04 |
2022-04-01 |
바이오젠 엠에이 인코포레이티드 |
번역 후 변형을 강화시키기 위한 통류 방식 양이온 교환 크로마토그래피의 용도
|
|
US11008561B2
(en)
|
2014-06-30 |
2021-05-18 |
Bioverativ Therapeutics Inc. |
Optimized factor IX gene
|
|
MA40864A
(fr)
|
2014-10-31 |
2017-09-05 |
Biogen Ma Inc |
Hypotaurine, gaba, bêta-alanine et choline pour la régulation de l'accumulation de sous-produits résiduaires dans des procédés de culture de cellules mammifères
|
|
CN104630131B
(zh)
*
|
2015-01-15 |
2017-08-15 |
上海交通大学 |
一种稳定表达人凝血八因子的cho细胞株及其应用
|
|
AU2016301303B2
(en)
|
2015-08-03 |
2021-10-07 |
Bioverativ Therapeutics Inc. |
Factor IX fusion proteins and methods of making and using same
|
|
KR20180118659A
(ko)
|
2016-02-01 |
2018-10-31 |
바이오버라티브 테라퓨틱스 인크. |
최적화된 viii 인자 유전자
|
|
CN110520149A
(zh)
|
2016-12-02 |
2019-11-29 |
比奥维拉迪维治疗股份有限公司 |
诱导对凝血因子的免疫耐受性的方法
|
|
WO2018102743A1
(en)
|
2016-12-02 |
2018-06-07 |
Bioverativ Therapeutics Inc. |
Methods of treating hemophilic arthropathy using chimeric clotting factors
|
|
TWI904068B
(zh)
|
2017-08-09 |
2025-11-11 |
美商生物化學醫療公司 |
核酸分子及其用途
|
|
AU2018338608B2
(en)
|
2017-09-27 |
2025-09-11 |
Sigilon Therapeutics, Inc. |
Methods, compositions, and implantable elements comprising active cells
|
|
SG11202007114VA
(en)
|
2018-02-01 |
2020-08-28 |
Bioverativ Therapeutics Inc |
Use of lentiviral vectors expressing factor viii
|
|
WO2019195056A1
(en)
|
2018-04-04 |
2019-10-10 |
Sigilon Therapeutics, Inc. |
Methods, compositions, and implantable elements comprising stem cells
|
|
MX2020010369A
(es)
|
2018-04-04 |
2020-10-22 |
Sigilon Therapeutics Inc |
Particulas implantables y metodos relacionados.
|
|
JP7763589B2
(ja)
|
2018-05-18 |
2025-11-04 |
バイオベラティブ セラピューティクス インコーポレイテッド |
血友病aを処置する方法
|
|
WO2020033863A1
(en)
|
2018-08-09 |
2020-02-13 |
Bioverativ Therapeutics Inc. |
Nucleic acid molecules and uses thereof for non-viral gene therapy
|
|
UY38389A
(es)
|
2018-09-27 |
2020-04-30 |
Sigilon Therapeutics Inc |
Dispositivos implantables para terapia celular y métodos relacionados
|
|
US10654911B1
(en)
*
|
2019-04-02 |
2020-05-19 |
Beijing Neoletix Biological Technology Co., Ltd. |
Vector co-expressing truncated von Willebrand factor and factor VIII
|
|
JP2022537200A
(ja)
|
2019-06-19 |
2022-08-24 |
バイオベラティブ セラピューティクス インコーポレイテッド |
血友病および低骨ミネラル密度を処置するための方法および組成物
|
|
TW202126284A
(zh)
|
2019-09-30 |
2021-07-16 |
美商百歐維拉提夫治療公司 |
慢病毒載體配製物
|
|
WO2021262963A1
(en)
|
2020-06-24 |
2021-12-30 |
Bioverativ Therapeutics Inc. |
Methods for the removal of free factor viii from preparations of lentiviral vectors modified to express said protein
|
|
KR20240049332A
(ko)
|
2021-08-23 |
2024-04-16 |
바이오버라티브 테라퓨틱스 인크. |
최적화된 인자 viii 유전자
|
|
EP4408874A1
(de)
|
2021-09-30 |
2024-08-07 |
Bioverativ Therapeutics Inc. |
Faktor viii polypeptid kodierende nukleinsäuren mit verminderter immunogenität
|
|
WO2024081309A1
(en)
|
2022-10-11 |
2024-04-18 |
Sigilon Therapeutics, Inc. |
Engineered cells and implantable elements for treatment of disease
|
|
CN120659872A
(zh)
|
2022-10-11 |
2025-09-16 |
西吉隆医疗股份有限公司 |
用于治疗疾病的经工程化的细胞和可植入元件
|