ATE133711T1 - Produktion von cystinreste enthaltenden aktiven proteinen - Google Patents

Produktion von cystinreste enthaltenden aktiven proteinen

Info

Publication number: ATE133711T1
Authority: AT; Austria
Prior art keywords: cystin; residue; production; proteins containing; nucleotide sequence
Prior art date: 1985-11-01

Application number

AT86115148T

Other languages

English (en)

Inventor

Robert T Garvin

Eric James

Original Assignee

Cangene Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-11-01

Filing date

1986-10-31

Publication date

1996-02-15

1986-10-31 Application filed by Cangene Corp filed Critical Cangene Corp

1996-02-15 Application granted granted Critical

1996-02-15 Publication of ATE133711T1 publication Critical patent/ATE133711T1/de

Links

102000004169 proteins and genes Human genes 0.000 title abstract 5
108090000623 proteins and genes Proteins 0.000 title abstract 5
LEVWYRKDKASIDU-IMJSIDKUSA-N L-cystine Chemical group [O-]C(=O)[C@@H]([NH3+])CSSC[C@H]([NH3+])C([O-])=O LEVWYRKDKASIDU-IMJSIDKUSA-N 0.000 title abstract 2
239000002773 nucleotide Substances 0.000 abstract 3
125000003729 nucleotide group Chemical group 0.000 abstract 3
LEVWYRKDKASIDU-QWWZWVQMSA-N D-cystine Chemical compound OC(=O)[C@H](N)CSSC[C@@H](N)C(O)=O LEVWYRKDKASIDU-QWWZWVQMSA-N 0.000 abstract 1
108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
229960003067 cystine Drugs 0.000 abstract 1
244000005700 microbiome Species 0.000 abstract 1
230000001105 regulatory effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6478—Aspartic endopeptidases (3.4.23)
- C12N9/6481—Pepsins (3.4.23.1; 3.4.23.2; 3.4.23.3)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/76—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Actinomyces; for Streptomyces
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
- C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Biomedical Technology (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Microbiology (AREA)
Biophysics (AREA)
Physics & Mathematics (AREA)
Plant Pathology (AREA)
Medicinal Chemistry (AREA)
Endocrinology (AREA)
Toxicology (AREA)
Gastroenterology & Hepatology (AREA)
Diabetes (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Enzymes And Modification Thereof (AREA)

AT86115148T 1985-11-01 1986-10-31 Produktion von cystinreste enthaltenden aktiven proteinen ATE133711T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CA000494456A CA1295563C (en)	1985-11-01	1985-11-01	Production of active proteins containing cystine residues

Publications (1)

Publication Number	Publication Date
ATE133711T1 true ATE133711T1 (de)	1996-02-15

Family

ID=4131785

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT86115148T ATE133711T1 (de)	1985-11-01	1986-10-31	Produktion von cystinreste enthaltenden aktiven proteinen

Country Status (5)

Country	Link
EP (1)	EP0222279B1 (de)
AT (1)	ATE133711T1 (de)
CA (1)	CA1295563C (de)
DE (1)	DE3650477T2 (de)
ES (1)	ES2083352T3 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1295566C (en) *	1987-07-21	1992-02-11	Robert T. Garvin	Characterization and structure of genes for protease a and protease b from streptomyces griseus
CA1295567C (en) *	1988-07-25	1992-02-11	Lawrence T. Malek	Expression system for the secretion of bioactive human granulocyte, macrophage-colony stimulating factor (gm-csf) and other heterologous proteins from streptomyces
AU1299988A (en) *	1987-03-09	1988-10-10	Cetus Corporation	Expression of heterologous genes in streptomyces species
US5610034A (en) *	1987-04-29	1997-03-11	Alko Group Ltd.	Immunoglobulin production by trichoderma
DE3908813A1 (de) *	1989-03-17	1990-09-20	Roehm Gmbh	Verfahren zur expression eines aus aspergillus niger stammenden gens in einem aspergillus
GB9106185D0 (en) *	1991-03-22	1991-05-08	Wellcome Found	Biological control agents
FR2686899B1 (fr)	1992-01-31	1995-09-01	Rhone Poulenc Rorer Sa	Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
EP2213743A1 (de)	2000-04-12	2010-08-04	Human Genome Sciences, Inc.	Albuminfusionsproteine
WO2005003296A2 (en)	2003-01-22	2005-01-13	Human Genome Sciences, Inc.	Albumin fusion proteins
AU2002364586A1 (en)	2001-12-21	2003-07-30	Delta Biotechnology Limited	Albumin fusion proteins

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3418274A1 (de) *	1984-05-17	1985-11-21	Hoechst Ag, 6230 Frankfurt	Signalpeptid fuer die exkretion von peptiden in streptomyceten
US4745056A (en) *	1984-10-23	1988-05-17	Biotechnica International, Inc.	Streptomyces secretion vector

1985
- 1985-11-01 CA CA000494456A patent/CA1295563C/en not_active Expired - Lifetime
1986
- 1986-10-31 DE DE3650477T patent/DE3650477T2/de not_active Expired - Fee Related
- 1986-10-31 EP EP86115148A patent/EP0222279B1/de not_active Expired - Lifetime
- 1986-10-31 AT AT86115148T patent/ATE133711T1/de not_active IP Right Cessation
- 1986-10-31 ES ES86115148T patent/ES2083352T3/es not_active Expired - Lifetime

Also Published As

Publication number	Publication date
ES2083352T3 (es)	1996-04-16
CA1295563C (en)	1992-02-11
EP0222279B1 (de)	1996-01-31
EP0222279A3 (en)	1988-11-09
DE3650477D1 (de)	1996-03-14
DE3650477T2 (de)	1996-10-31
EP0222279A2 (de)	1987-05-20

Legal Events

Date	Code	Title	Description
1996-07-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE3669175D1 (de)	1990-04-05	Fusionsproteine, verfahren zu ihrer herstellung und ihre verwendung.
GB2197324B (en)	1990-04-11	Process for the production of a polypeptide
FI104261B1 (fi)	1999-12-15	Menetelmä yhdistelmä ihmisen erytropoietiinin tuottamiseksi
IE820069L (en)	1983-06-01	Recombinant dna encoding a polypeptide
GB2160206B (en)	1987-11-11	Dna sequence coding for an enzyme cleavage site
DE3751269D1 (de)	1995-06-01	Expression des biologisch aktiven Faktors XIII.
ATE90944T1 (de)	1993-07-15	Fuer ein hirudinaehnliches protein kodierende dns- sequenz und verfahren zur herstellung eines solchen proteins.
JPS6485096A (en)	1989-03-30	Hybrid human protein c and biotechnological synthesis thereof
ATE81673T1 (de)	1992-11-15	Verfahren zur beseitigung von nendaminos\|ureresten aus eukaryotpolypeptidanlagen und so erzeugte polypeptide.
ATE133711T1 (de)	1996-02-15	Produktion von cystinreste enthaltenden aktiven proteinen
ATE364703T1 (de)	2007-07-15	Herstellung von proteinen aus pro-proteinen durch fusionsproteine abgeleitet von furin oder furinanalogen
PT83968A (de)	1987-01-01	Verfahren zur verbesserung des expression von eukaryontenprotein
AU1090688A (en)	1988-08-04	Synthetic porcine growth hormone
ATE119938T1 (de)	1995-04-15	Produktion von menschlichen nervenwachstumsfaktoren.
DE58909692D1 (de)	1996-07-25	Verfahren zur selektiven Spaltung von Fusionsproteinen
EP0213085A3 (en)	1988-03-16	Vector for the expression and secretion of heterologous gene products in bacillus subtilis