ATE133938T1 - Indan-1,3-dion und indan-1,2,3-trionderivate, verfahren zu ihrer herstellung und ihre therapeutische verwendung - Google Patents

Indan-1,3-dion und indan-1,2,3-trionderivate, verfahren zu ihrer herstellung und ihre therapeutische verwendung

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Publication number
ATE133938T1
ATE133938T1 AT93400840T AT93400840T ATE133938T1 AT E133938 T1 ATE133938 T1 AT E133938T1 AT 93400840 T AT93400840 T AT 93400840T AT 93400840 T AT93400840 T AT 93400840T AT E133938 T1 ATE133938 T1 AT E133938T1
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Austria
Prior art keywords
indan
nhr5
trion
dione
derivatives
Prior art date
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AT93400840T
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English (en)
Inventor
De Sevricourt Michel Cugnon
Catherine Dacquet
Michel Finet
Marquer Florence Le
Max Robba
Norbert Olivier Tembo
Sylvie Yannic-Arnoult
Jean-Luc Torregrosa
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Innothera Lab Sa
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Publication of ATE133938T1 publication Critical patent/ATE133938T1/de

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/86—Hydrazides; Thio or imino analogues thereof
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

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  • General Chemical & Material Sciences (AREA)
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  • Engineering & Computer Science (AREA)
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  • Oncology (AREA)
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  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Pyrrole Compounds (AREA)
AT93400840T 1992-04-03 1993-04-01 Indan-1,3-dion und indan-1,2,3-trionderivate, verfahren zu ihrer herstellung und ihre therapeutische verwendung ATE133938T1 (de)

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FR9204071 1992-04-03

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ATE133938T1 true ATE133938T1 (de) 1996-02-15

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AT93400841T ATE133939T1 (de) 1992-04-03 1993-04-01 Indan-1,3-dion und indan-1,2,3-trionderivate, verfahren zu ihrer herstellung und ihrer therapeutische verwendung
AT93400840T ATE133938T1 (de) 1992-04-03 1993-04-01 Indan-1,3-dion und indan-1,2,3-trionderivate, verfahren zu ihrer herstellung und ihre therapeutische verwendung

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Country Link
US (2) US5648381A (de)
EP (2) EP0566445B1 (de)
JP (2) JPH06508374A (de)
AT (2) ATE133939T1 (de)
DE (2) DE69301494T2 (de)
ES (2) ES2084458T3 (de)
WO (2) WO1993020045A1 (de)

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Publication number Priority date Publication date Assignee Title
DE69301494T2 (de) * 1992-04-03 1996-10-17 Innothera Lab Sa Indan-1,3-Dion und Indan-1,2,3-Trionderivate, Verfahren zu ihrer Herstellung und ihrer therapeutische Verwendung
FR2710644B1 (fr) * 1993-10-01 1995-12-22 Innothera Lab Sa Dérivés d'indane cétoniques et de leurs analogues hétérocycliques et leur utilisation thérapeutique.
FR2710641B1 (fr) * 1993-10-01 1995-12-22 Innothera Lab Sa Dérivés d'indane triones et d'hydrazides et leur application thérapeutique.
FR2710639B1 (fr) * 1993-10-01 1995-12-22 Innothera Lab Sa Dérivés d'indane cétoniques, leur procédé d'obtention, leur application thérapeutique.
FR2738150B1 (fr) * 1995-09-01 1997-10-31 Synthelabo Utilisation de la sulphasalazine et de ses metabolites pour la fabrication d'un medicament utile dans le traitement de l'insuffisance veineuse et des ulceres veineux
FR2742151B1 (fr) * 1995-12-12 1998-03-06 Innothera Lab Sa Utilisation de derives de bicycles mono ou dicetoniques, nouveaux composes obtenus et leur application en therapeutique
US6013674A (en) * 1997-06-02 2000-01-11 Eli Lilly And Company Cell adhesion inhibitors
WO2015017549A1 (en) 2013-07-30 2015-02-05 University Of South Florida (A Florida Non-Profit Corporation) Treating an atypical protein kinase c enzyme abnormality
JP6328642B2 (ja) * 2013-09-02 2018-05-23 インサイト ハイ テクノロジー カンパニー リミテッドＩｎｓｉｇｈｔ Ｈｉｇｈ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏ．， Ｌｔｄ． シクロペンタンジオンオキシムエステルとその応用
CN104910053B (zh) * 2014-06-09 2017-09-12 北京英力科技发展有限公司 不对称二肟酯化合物及其制造方法与应用
WO2016082304A1 (zh) * 2014-11-28 2016-06-02 北京英力科技发展有限公司 一种光固化阻焊油墨
IT201900008301A1 (it) 2019-06-06 2020-12-06 Epi C S R L Modulatori di sirtuine
CN111991377B (zh) * 2020-09-23 2022-03-22 唐怡庭 一种茚酮衍生物在制备治疗脓毒症药物中的应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3280185A (en) * 1965-10-01 1966-10-18 American Home Prod 3-substituted 1, 2, 4-cyclopentanetrione, 1-thiosemicarbazones
DE2127982A1 (en) * 1971-06-05 1972-12-14 Boehringer Mannheim Gmbh, 6800 Mannheim Virustatic indane-1,3-dione-2,2-derivs - from indanedione and two reagents or from diethylphthalate and methylsulphones
FR2567754B1 (fr) * 1984-07-20 1987-05-29 Cortial Application therapeutique d'aminomethylene-2 indanediones-1,3 substituees sur l'azote
FR2593501B1 (fr) * 1986-01-29 1988-05-06 Panmedica Sa Nouveaux derives bis (r-oxyimino)-5,7 dihydro-6,7 (5h) dibenzo (a,c) cycloheptene, leurs procedes de preparation et leur application comme medicaments
AU645799B2 (en) * 1990-05-07 1994-01-27 Novartis Ag Hydrazones
DE69301494T2 (de) * 1992-04-03 1996-10-17 Innothera Lab Sa Indan-1,3-Dion und Indan-1,2,3-Trionderivate, Verfahren zu ihrer Herstellung und ihrer therapeutische Verwendung

Also Published As

Publication number Publication date
ES2084458T3 (es) 1996-05-01
EP0566446A1 (de) 1993-10-20
US5571843A (en) 1996-11-05
WO1993020046A1 (fr) 1993-10-14
US5648381A (en) 1997-07-15
EP0566445B1 (de) 1996-02-07
DE69301494D1 (de) 1996-03-21
JPH06508375A (ja) 1994-09-22
WO1993020045A1 (fr) 1993-10-14
EP0566446B1 (de) 1996-02-07
ATE133939T1 (de) 1996-02-15
JPH06508374A (ja) 1994-09-22
DE69301494T2 (de) 1996-10-17
ES2084459T3 (es) 1996-05-01
DE69301493D1 (de) 1996-03-21
DE69301493T2 (de) 1996-11-07
EP0566445A1 (de) 1993-10-20

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