ATE72436T1 - 2-(methyl(4-piperidinyl)>-1,2,3,4-tetrahydro-9h pyrido(3,4-b>indolderivate, ihre herstellung und therapeutische verwendung. - Google Patents

2-(methyl(4-piperidinyl)>-1,2,3,4-tetrahydro-9h pyrido(3,4-b>indolderivate, ihre herstellung und therapeutische verwendung.

Info

Publication number
ATE72436T1
ATE72436T1 AT88402024T AT88402024T ATE72436T1 AT E72436 T1 ATE72436 T1 AT E72436T1 AT 88402024 T AT88402024 T AT 88402024T AT 88402024 T AT88402024 T AT 88402024T AT E72436 T1 ATE72436 T1 AT E72436T1
Authority
AT
Austria
Prior art keywords
group
denotes
formula
indolderivates
pyrido
Prior art date
Application number
AT88402024T
Other languages
English (en)
Inventor
Mireille Sevrin
Pascal George
Jacques Menin
Claude Morel
Dennis Bigg
Original Assignee
Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo filed Critical Synthelabo
Application granted granted Critical
Publication of ATE72436T1 publication Critical patent/ATE72436T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT88402024T 1987-08-07 1988-08-03 2-(methyl(4-piperidinyl)>-1,2,3,4-tetrahydro-9h pyrido(3,4-b>indolderivate, ihre herstellung und therapeutische verwendung. ATE72436T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8711291A FR2619111B1 (fr) 1987-08-07 1987-08-07 Derives de (piperidinyl-4)methyl-2 tetrahydro-1,2,3,4 9h-pyrido (3,4-b) indole, leur preparation et leur application en therapeutique
EP88402024A EP0302788B1 (de) 1987-08-07 1988-08-03 2-[Methyl(4-piperidinyl)]-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indolderivate, ihre Herstellung und therapeutische Verwendung

Publications (1)

Publication Number Publication Date
ATE72436T1 true ATE72436T1 (de) 1992-02-15

Family

ID=9354027

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88402024T ATE72436T1 (de) 1987-08-07 1988-08-03 2-(methyl(4-piperidinyl)>-1,2,3,4-tetrahydro-9h pyrido(3,4-b>indolderivate, ihre herstellung und therapeutische verwendung.

Country Status (17)

Country Link
US (1) US4977159A (de)
EP (1) EP0302788B1 (de)
JP (1) JPS6466185A (de)
KR (1) KR890003756A (de)
AT (1) ATE72436T1 (de)
AU (1) AU597188B2 (de)
DE (1) DE3868301D1 (de)
DK (1) DK437788A (de)
FI (1) FI883669A7 (de)
FR (1) FR2619111B1 (de)
GR (1) GR3003920T3 (de)
HU (1) HU198931B (de)
IL (1) IL87343A0 (de)
NO (1) NO166129C (de)
NZ (1) NZ225706A (de)
PT (1) PT88206B (de)
ZA (1) ZA885788B (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4978669A (en) * 1989-06-08 1990-12-18 Neurex Corporation Method of suppressing appetite by administration of tetrahydro-beta-carboline derivatives
US5102889B1 (en) * 1990-09-27 1993-05-11 2-(4-piperidinyl)-1h-pyrido(4,3-b)indol-1-ones and related compounds
US5229517A (en) * 1990-09-27 1993-07-20 Hoechst-Roussel Pharmaceuticals Incorporated 2-(4-Piperindinyl)-1H-pyrido[4,3-B]indol-1-ones and related compounds
US5455254A (en) * 1991-02-15 1995-10-03 Mondadori; Cesare Substituted benzofuranylpiperidine as a nootropic agent
RU2095339C1 (ru) * 1991-10-17 1997-11-10 Циба-Гейги АГ Производные гидрохинона в свободном виде или в виде соли, способы их получения, производные пиперидина и способы их получения
US5693807A (en) * 1992-10-14 1997-12-02 Ciba-Geigy Corporation Substituted hydroquinone derivatives
FR2715659B1 (fr) * 1994-02-03 1996-03-22 Synthelabo Dérivés de 3-(2-aminoéthyl)-4-[3-(trifluorométhyl)benzoyl]-3,4-dihydro-2H-1,4-benzoxazine, leur préparation et leur application en thérapeutique.
CN1109880A (zh) * 1994-02-03 1995-10-11 合成实验室公司 3-(2-氨基乙基)-4-[3-(三氟甲基)苯甲酰基]-3，4-二氢-2h-1，4-苯并噁嗪衍生物、制备及其应用
AU3831495A (en) * 1994-10-20 1996-05-15 American Home Products Corporation Indole derivatives useful as serotonergic agents
US6255302B1 (en) 1998-12-17 2001-07-03 American Home Products Corporation 1,4-piperazine derivatives
CO5180550A1 (es) 1999-04-19 2002-07-30 Smithkline Beecham Corp Inhibidores de fab i
AR024158A1 (es) 1999-06-01 2002-09-04 Smithkline Beecham Corp Compuestos antibacterianos
ES2231275T3 (es) 1999-10-08 2005-05-16 Affinium Pharmaceuticals, Inc. Inhibidores de fab i.
US6730684B1 (en) 1999-10-08 2004-05-04 Affinium Pharmaceuticals, Inc. Fab I inhibitors
US6762201B1 (en) 1999-10-08 2004-07-13 Affinium Pharmaceuticals, Inc. Fab I inhibitors
OA12118A (en) 1999-12-10 2006-05-04 Pfizer Prod Inc PyrroloÄ2,3-dÜpyrimidine compounds.
JP4387804B2 (ja) * 2001-04-06 2009-12-24 アフィニアム・ファーマシューティカルズ・インコーポレイテッド ＦａｂＩ阻害剤
US7812035B2 (en) * 2001-12-11 2010-10-12 Sepracor Inc. 4-substituted piperidines, and methods of use thereof
RS20050380A (sr) * 2002-11-21 2007-11-15 Pfizer Products Inc., Derivati 3-aminopiperidina i postupci njihove proizvodnje
PT1575951E (pt) 2002-12-06 2014-09-15 Debiopharm Int Sa Compostos heterocíclicos, métodos para os preparar e sua utilização em terapia
EP1608377B1 (de) 2003-03-17 2008-10-01 Affinium Pharmaceuticals, Inc. Pharmazeutische zusammensetzungen inhibitoren von fab i und weitere antibiotika enthaltend
ATE414082T1 (de) * 2003-04-29 2008-11-15 Oscient Pharmaceuticals Antibiotische tetrahydro-b-carbolinderivative
US8450307B2 (en) 2004-06-04 2013-05-28 Affinium Pharmaceuticals, Inc. Therapeutic agents, and methods of making and using the same
EP2054422B1 (de) 2006-07-20 2017-06-14 Debiopharm International SA Acrylamidderivate als fab-i-inhibitoren
WO2008098374A1 (en) 2007-02-16 2008-08-21 Affinium Pharmaceuticals, Inc. Salts, prodrugs and polymorphs of fab i inhibitors
EP2861608B8 (de) 2012-06-19 2019-06-19 Debiopharm International SA Prodrug-derivate von (e)-n-methyl-n-((3-methylbenzofuran-2-yl) methyl)-3- (7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylamid
DK3419628T3 (da) 2016-02-26 2021-01-11 Debiopharm Int Sa Medikament til behandling af diabetiske fodinfektioner
ES2944535T3 (es) 2019-02-14 2023-06-22 Debiopharm Int Sa Formulación de afabicina, método para preparar la misma
UA129222C2 (uk) 2019-06-14 2025-02-12 Дебіофарм Інтернешнл С.А. Лікарський засіб і його застосування для лікування бактеріальних інфекцій, пов'язаних з біоплівкою

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4539407A (en) * 1983-12-13 1985-09-03 American Home Products Corporation β-Carboline anticonvulsants
US4663456A (en) * 1985-09-16 1987-05-05 American Home Products Corporation 2-(substituted piperazinylalkyl)β-carbolines useful in treatment of psychological disorders

Also Published As

Publication number Publication date
PT88206A (pt) 1989-06-30
FI883669A0 (fi) 1988-08-05
NO883487L (no) 1989-02-08
AU597188B2 (en) 1990-05-24
DK437788A (da) 1989-02-07
KR890003756A (ko) 1989-04-17
HUT48242A (en) 1989-05-29
FR2619111B1 (fr) 1991-01-11
NO166129B (no) 1991-02-25
JPS6466185A (en) 1989-03-13
IL87343A0 (en) 1989-01-31
EP0302788A1 (de) 1989-02-08
HU198931B (en) 1989-12-28
NO883487D0 (no) 1988-08-05
FI883669A7 (fi) 1989-02-08
US4977159A (en) 1990-12-11
DK437788D0 (da) 1988-08-05
AU2044588A (en) 1989-02-09
ZA885788B (en) 1989-04-26
PT88206B (pt) 1995-05-04
NO166129C (no) 1991-06-05
FR2619111A1 (fr) 1989-02-10
GR3003920T3 (de) 1993-03-16
NZ225706A (en) 1990-04-26
EP0302788B1 (de) 1992-02-05
DE3868301D1 (de) 1992-03-19

Similar Documents

Publication Publication Date Title
DE3868301D1 (de) 2-(methyl(4-piperidinyl))-1,2,3,4-tetrahydro-9h-pyrido(3,4-b)indolderivate, ihre herstellung und therapeutische verwendung.
DE69530511D1 (de) Enantioselective herstellung von pharmazeutisch aktiven sulfoxiden durch bioreduktion
ATE165510T1 (de) Methode zur hemmung der proliferation weiche muskelzellen und der restenose
DK170188D0 (da) Carbinolderivater
ATE166648T1 (de) Benzoxazinderivate, deren herstellung und deren verwendung in therapie
DE3376749T2 (de)
ATE133939T1 (de) Indan-1,3-dion und indan-1,2,3-trionderivate, verfahren zu ihrer herstellung und ihrer therapeutische verwendung
DE69525633D1 (de) Chinoxalinderivate und ihre therapeutische verwendbarkeit
ATE24316T1 (de) 1,4-dihydropyridinderivate, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln.
ATE123025T1 (de) 2-amino-n-(((4-(aminocarbonyl)pyrimidin-2- yl>amino>alkyl>-pyrimidin-4- carbonsäureamidderivate, ihre herstellung und ihre anwendung in der therapeutica.
DE69837628D1 (de) Aminderivate, verfahren zu ihrer herstellung und ihre verwendung als antimykotische mittel
BR9812928A (pt) Novos derivados de 3-oxo-(2h) -1,2,4-triazina, processo de preparação de compostos quìmicos, e, composição farmacêutica
DK549789A (da) Fremgangsmaade til fremstilling af optisk aktive acyloxyazetidinoner
DE60312511D1 (de) Oxophenylcyclohexylpropanolaminderivate, deren herstellung und verwendung in therapeutika
NO941830D0 (no) Karboksamid-derivater, deres fremstilling og anvendelse som terapeutika
UY24465A1 (es) Antagonistas oxadiazol y tiadiazol del receptor muscarinico
PE20020513A1 (es) COMPUESTOS DE 2,4,8-TRISUSTITUIDA-8H-PIRIDO[2,3-d]PIRIMIDIN-7-ONA
PE20040557A1 (es) Amidas de acidos 2-heteroarilcarboxilicos

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee