ATE134620T1 - Verfahren zur herstellung von enantiomerenreinen substituierten (chinolin-2-yl-methoxy)phenyl- essigsäuren - Google Patents

Verfahren zur herstellung von enantiomerenreinen substituierten (chinolin-2-yl-methoxy)phenyl- essigsäuren

Info

Publication number: ATE134620T1
Authority: AT; Austria
Prior art keywords: methoxy; quinoline; phenyl; acetic acids; quinolin
Prior art date: 1991-04-17

Application number

AT92105894T

Other languages

English (en)

Inventor

Matthias Dr Decker

Klaus-Helmut Dr Mohrs

Siegfried Dr Raddatz

Original Assignee

Bayer Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-04-17

Filing date

1992-04-06

Publication date

1996-03-15

1992-04-06 Application filed by Bayer Ag filed Critical Bayer Ag

1996-03-15 Application granted granted Critical

1996-03-15 Publication of ATE134620T1 publication Critical patent/ATE134620T1/de

Links

-1 QUINOLINE-2-YL-METHOXY Chemical class 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
WLJVXDMOQOGPHL-UHFFFAOYSA-N phenylacetic acid Chemical class OC(=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-UHFFFAOYSA-N 0.000 title 1
OTAGHZZKFIMSMC-UHFFFAOYSA-N 2-phenyl-2-(quinolin-2-ylmethoxy)acetic acid Chemical class C=1C=C2C=CC=CC2=NC=1COC(C(=O)O)C1=CC=CC=C1 OTAGHZZKFIMSMC-UHFFFAOYSA-N 0.000 abstract 3
YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 1
150000007513 acids Chemical class 0.000 abstract 1
229940114079 arachidonic acid Drugs 0.000 abstract 1
235000021342 arachidonic acid Nutrition 0.000 abstract 1
238000011873 diastereoselective alkylation Methods 0.000 abstract 1
238000006911 enzymatic reaction Methods 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
230000004060 metabolic process Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Quinoline Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT92105894T 1991-04-17 1992-04-06 Verfahren zur herstellung von enantiomerenreinen substituierten (chinolin-2-yl-methoxy)phenyl- essigsäuren ATE134620T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE4112533A DE4112533A1 (de)	1991-04-17	1991-04-17	Verfahren zur herstellung von enantiomerenreinen substituierten (chinolin-2-yl-methoxy)phenyl-essigsaeuren

Publications (1)

Publication Number	Publication Date
ATE134620T1 true ATE134620T1 (de)	1996-03-15

Family

ID=6429785

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92105894T ATE134620T1 (de)	1991-04-17	1992-04-06	Verfahren zur herstellung von enantiomerenreinen substituierten (chinolin-2-yl-methoxy)phenyl- essigsäuren

Country Status (8)

Country	Link
US (2)	US5306820A (de)
EP (1)	EP0509359B1 (de)
JP (1)	JP3224271B2 (de)
AT (1)	ATE134620T1 (de)
DE (2)	DE4112533A1 (de)
DK (1)	DK0509359T3 (de)
ES (1)	ES2085510T3 (de)
GR (1)	GR3019414T3 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5304563A (en) *	1991-02-22	1994-04-19	Bayer Aktiengesellschaft	2-substituted quinolines, and their use in medicaments
DE4226649A1 (de) *	1992-08-12	1994-02-17	Bayer Ag	Neue isobutylsubstituierte Methansulfonyl-chinolylmethoxyphenyl-cycloalkylessigsäureaminole
US5358955A (en) *	1992-10-30	1994-10-25	Abbott Laboratories	Aryl and heteroarylmethoxyphenyl inhibitors of leukotriene biosynthesis
DE4435477A1 (de)	1994-10-04	1996-04-11	Bayer Ag	Cycloalkano-indol- und -azaindol-derivate
DE4443892A1 (de) *	1994-12-09	1996-06-13	Bayer Ag	4-(Chinolin-2-yl-methoxy)-phenyl-essigsäurederivate
DE4443891A1 (de) *	1994-12-09	1996-06-13	Bayer Ag	Heterocyclisch substituierte Oxy-phenyl-(phenyl)glycinolamide
DE19613550A1 (de) *	1996-04-04	1997-10-09	Bayer Ag	Neue Pyrimido[1,2-a]indole
DE19615265A1 (de) *	1996-04-18	1997-12-04	Bayer Ag	Neue Pyridazino-, Pyrimido-, Pyrazino- und Triazino-indole
GB2356138A (en) *	1999-11-15	2001-05-16	Bayer Ag	Use of substituted 4-(quinolin-2-yl-methoxy)phenyl-acetic acid derivatives for the treatment of diseases
US7851486B2 (en)	2002-10-17	2010-12-14	Decode Genetics Ehf.	Susceptibility gene for myocardial infarction, stroke, and PAOD; methods of treatment
CA2502357A1 (en) *	2002-10-17	2004-04-29	Decode Genetics Ehf.	Susceptibility gene for myocardial infarction; methods of treatment
US7507531B2 (en)	2002-10-17	2009-03-24	Decode Genetics Chf.	Use of 5-lipoxygenase activating protein (FLAP) gene to assess susceptibility for myocardial infarction
US20060019269A1 (en) *	2002-10-17	2006-01-26	Decode Genetics, Inc.	Susceptibility gene for myocardial infarction, stroke, and PAOD, methods of treatment
US20080293750A1 (en) *	2002-10-17	2008-11-27	Anna Helgadottir	Susceptibility Gene for Myocardial Infarction, Stroke, Paod and Methods of Treatment
WO2005027886A2 (en) *	2003-09-17	2005-03-31	Decode Genetics Ehf.	Methods of preventing or treating recurrence of myocardial infarction
AU2004298486A1 (en)	2003-12-12	2005-06-30	Wyeth	Quinolines useful in treating cardiovascular disease
US8158362B2 (en)	2005-03-30	2012-04-17	Decode Genetics Ehf.	Methods of diagnosing susceptibility to myocardial infarction and screening for an LTA4H haplotype
US20100216863A1 (en) *	2004-01-30	2010-08-26	Decode Genetics Ehf.	Susceptibility Gene for Myocardial Infarction, Stroke, and PAOD; Methods of Treatment
WO2016149126A1 (en)	2015-03-13	2016-09-22	The Board Of Trustees Of The Leland Stanford Junior University	Ltb4 inhibition to prevent and treat human lymphedema

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3814504A1 (de) *	1988-04-29	1989-11-09	Bayer Ag	(alpha)-substituierte 4-(chinolin-2-yl-methoxy)phenylessigsaeuren und -ester, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
DE3900261A1 (de) *	1988-05-31	1989-12-07	Bayer Ag	Substituierte 4-(chinolin-2-yl-methoxy) phenyl-essigsaeure-derivate
DE3916663A1 (de) *	1989-05-23	1990-11-29	Bayer Ag	Substituierte (chinolin-2-yl-methoxy)phenyl-acyl-sulfonamide und -cyanamide, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
DE4105551A1 (de) *	1991-02-22	1992-08-27	Bayer Ag	2-substituierte chinoline, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln

1991
- 1991-04-17 DE DE4112533A patent/DE4112533A1/de not_active Withdrawn
1992
- 1992-04-06 DK DK92105894.7T patent/DK0509359T3/da active
- 1992-04-06 EP EP92105894A patent/EP0509359B1/de not_active Expired - Lifetime
- 1992-04-06 DE DE59205422T patent/DE59205422D1/de not_active Expired - Lifetime
- 1992-04-06 AT AT92105894T patent/ATE134620T1/de active
- 1992-04-06 ES ES92105894T patent/ES2085510T3/es not_active Expired - Lifetime
- 1992-04-10 US US07/866,707 patent/US5306820A/en not_active Expired - Lifetime
- 1992-04-13 JP JP11849292A patent/JP3224271B2/ja not_active Expired - Lifetime
1993
- 1993-12-08 US US08/164,674 patent/US5473076A/en not_active Expired - Lifetime
1996
- 1996-03-26 GR GR960400794T patent/GR3019414T3/el unknown

Also Published As

Publication number	Publication date
EP0509359B1 (de)	1996-02-28
US5306820A (en)	1994-04-26
JPH05125051A (ja)	1993-05-21
JP3224271B2 (ja)	2001-10-29
DE4112533A1 (de)	1992-10-22
EP0509359A1 (de)	1992-10-21
GR3019414T3 (en)	1996-06-30
ES2085510T3 (es)	1996-06-01
DK0509359T3 (da)	1996-08-12
US5473076A (en)	1995-12-05
DE59205422D1 (de)	1996-04-04

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Legal Events

Date	Code	Title	Description
2010-03-15	EEIH	Change in the person of patent owner