ATE176931T1 - Verfahren zur enzymatischen herstellung von optisch aktiven estern einer transglycidsäure - Google Patents

Verfahren zur enzymatischen herstellung von optisch aktiven estern einer transglycidsäure

Info

Publication number: ATE176931T1
Authority: AT; Austria
Prior art keywords: optically active; acid; ester; transglycid; trans
Prior art date: 1992-12-18

Application number

AT93203495T

Other languages

English (en)

Inventor

Joannes Gerardus Theo Kierkels

Wijnand Peter Helena Peeters

Original Assignee

Dsm Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-12-18

Filing date

1993-12-13

Publication date

1999-03-15

1993-12-13 Application filed by Dsm Nv filed Critical Dsm Nv

1999-03-15 Application granted granted Critical

1999-03-15 Publication of ATE176931T1 publication Critical patent/ATE176931T1/de

Links

239000002253 acid Substances 0.000 title abstract 2
230000002255 enzymatic effect Effects 0.000 title 1
150000002148 esters Chemical class 0.000 abstract 5
239000000203 mixture Substances 0.000 abstract 2
HALONVPKHYIEQU-JGVFFNPUSA-N (2r,3s)-3-phenyloxirane-2-carboxylic acid Chemical compound OC(=O)[C@@H]1O[C@H]1C1=CC=CC=C1 HALONVPKHYIEQU-JGVFFNPUSA-N 0.000 abstract 1
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
102000004190 Enzymes Human genes 0.000 abstract 1
108090000790 Enzymes Proteins 0.000 abstract 1
241001661345 Moesziomyces antarcticus Species 0.000 abstract 1
150000008038 benzoazepines Chemical class 0.000 abstract 1
150000007657 benzothiazepines Chemical class 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
239000011541 reaction mixture Substances 0.000 abstract 1
230000035484 reaction time Effects 0.000 abstract 1
-1 trans-3-phenylglycidic acid ester Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
- C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Health & Medical Sciences (AREA)
General Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Microbiology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Analytical Chemistry (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Epoxy Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT93203495T 1992-12-18 1993-12-13 Verfahren zur enzymatischen herstellung von optisch aktiven estern einer transglycidsäure ATE176931T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
NL9202208A NL9202208A (nl)	1992-12-18	1992-12-18	Werkwijze voor de enzymatische bereiding van optisch aktieve glycidezure esters.

Publications (1)

Publication Number	Publication Date
ATE176931T1 true ATE176931T1 (de)	1999-03-15

Family

ID=19861657

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93203495T ATE176931T1 (de)	1992-12-18	1993-12-13	Verfahren zur enzymatischen herstellung von optisch aktiven estern einer transglycidsäure

Country Status (11)

Country	Link
US (1)	US5407828A (de)
EP (1)	EP0602740B1 (de)
JP (1)	JP3781788B2 (de)
AT (1)	ATE176931T1 (de)
CA (1)	CA2111595C (de)
DE (1)	DE69323600T2 (de)
DK (1)	DK0602740T3 (de)
ES (1)	ES2129491T3 (de)
FI (1)	FI102974B (de)
IL (1)	IL108029A (de)
NL (1)	NL9202208A (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1249777B (it) *	1990-05-17	1995-03-18	Zambon Spa	Processo per la preparazione di intermedi per la sintesi del diltiazem
JP3610600B2 (ja) *	1994-08-22	2005-01-12	チッソ株式会社	光学活性エンド−２−ノルボルネオール類の製造方法
PT1054996E (pt)	1998-02-17	2004-05-31	Searle & Co	Processo para resolucao enzimatica de lactamas
IT1302261B1 (it)	1998-09-24	2000-09-05	Zambon Spa	Processo per la risoluzione cinetica enzimatica di 3-fenilglicidatiper transesterificazione con amminoalcoli
WO2006008170A1 (en) *	2004-07-23	2006-01-26	Dsm Ip Assets B.V.	Process for the preparation of (2r, 3r)-2-hydroxy-3-amino-3-aryl-propionamide and (2r, 3r)-2-hydroxy-3-amino-3-aryl-propionic acid alkyl ester
CN107446960A (zh) *	2017-09-30	2017-12-08	湖南理工学院	一种采用生物酶催化立体选择性拆分2,3‑二苯基丙酸对映体的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2628667B2 (ja) *	1986-10-17	1997-07-09	ノボノルディスクアクティーゼルスカブ	位置非特異性リパーゼ
US5273898A (en) *	1986-10-17	1993-12-28	Noro Nordisk A/S	Thermally stable and positionally non-specific lipase isolated from Candida
JP2641935B2 (ja) *	1987-09-28	1997-08-20	ノボ‐ノルディスクアクティーゼルスカブ	リパーゼの固定化方法
NL8801311A (nl) *	1988-05-20	1989-12-18	Stamicarbon	Fenylglycidaatstereoisomeren, omzettingsprodukten daarvan met 2-nitrothiofenol en de bereiding van diltiazem.
FI95931C (fi) *	1988-09-02	1996-04-10	Tanabe Seiyaku Co	Menetelmä (2R,3S)-3-(4-metoksifenyyli)glysidiinihapon alemman alkyyliesterin valmistamiseksi
US6521445B1 (en) *	1988-10-26	2003-02-18	Sepracor, Inc.	Process for preparing optically active glycidate esters
JPH088879B2 (ja) *	1989-09-13	1996-01-31	田辺製薬株式会社	光学活性３―フェニルグリシッド酸エステル類化合物の製法
FR2672600B1 (fr) *	1991-02-08	1994-10-14	Synthelabo	Procede de preparation du (-)-(2r,3s)-2,3-epoxy-3-(4-methoxyphenyl) propionate de methyle.

1992
- 1992-12-18 NL NL9202208A patent/NL9202208A/nl not_active Application Discontinuation
1993
- 1993-12-13 DK DK93203495T patent/DK0602740T3/da active
- 1993-12-13 ES ES93203495T patent/ES2129491T3/es not_active Expired - Lifetime
- 1993-12-13 EP EP93203495A patent/EP0602740B1/de not_active Expired - Lifetime
- 1993-12-13 DE DE69323600T patent/DE69323600T2/de not_active Expired - Lifetime
- 1993-12-13 US US08/165,344 patent/US5407828A/en not_active Expired - Lifetime
- 1993-12-13 AT AT93203495T patent/ATE176931T1/de active
- 1993-12-15 IL IL10802993A patent/IL108029A/en not_active IP Right Cessation
- 1993-12-16 CA CA002111595A patent/CA2111595C/en not_active Expired - Fee Related
- 1993-12-16 JP JP31669193A patent/JP3781788B2/ja not_active Expired - Fee Related
- 1993-12-17 FI FI935712A patent/FI102974B/fi active

Also Published As

Publication number	Publication date
US5407828A (en)	1995-04-18
DE69323600T2 (de)	1999-09-23
ES2129491T3 (es)	1999-06-16
EP0602740B1 (de)	1999-02-24
NL9202208A (nl)	1994-07-18
IL108029A0 (en)	1994-04-12
FI102974B1 (fi)	1999-03-31
JPH06335399A (ja)	1994-12-06
IL108029A (en)	1998-09-24
FI935712L (fi)	1994-06-19
DK0602740T3 (da)	1999-09-27
CA2111595C (en)	2004-12-14
DE69323600D1 (de)	1999-04-01
FI935712A0 (fi)	1993-12-17
JP3781788B2 (ja)	2006-05-31
CA2111595A1 (en)	1994-06-19
EP0602740A1 (de)	1994-06-22
FI102974B (fi)	1999-03-31

Legal Events

Date	Code	Title	Description
1999-09-15	UEP	Publication of translation of european patent specification

Publication	Publication Date	Title
ATE113661T1 (de)	1994-11-15	Verfahren zur herstellung von optisch aktiven 3- phenylglycidsäureestern.
DE69914458D1 (de)	2004-03-04	Verfahren zur enzymatischen auflösung von laktamen
DK0625571T3 (da)	2000-12-18	Mikroorganismer, deres anvendelse samt fremgangsmåde til fremstilling af L-alfa-aminosyrer
DE68906904D1 (de)	1993-07-15	Verfahren zur herstellung von optisch aktiven 2-arylalkansaeuren.
DE69323600D1 (de)	1999-04-01	Verfahren zur enzymatischen Herstellung von optisch aktiven Estern einer Transglycidsäure
ATE131209T1 (de)	1995-12-15	Verfahren zur herstellung von optisch aktiven 3- phenylglycidsäureestern.
DE3579663D1 (de)	1990-10-18	Verfahren zur herstellung aromatisch substituierter l-aminosaeuren.
ATE134610T1 (de)	1996-03-15	Verfahren zur herstellung von optisch aktiven 4- amino-3-hydroxycarbonsäuren
EP0350811A2 (de)	1990-01-17	Verfahren zur enzymatischen Auflösung
DE3679149D1 (de)	1991-06-13	Verfahren zur enzymatischen trennung von optisch aktiven isomeren des 2-aminobutanols.
DE3779785D1 (de)	1992-07-23	Verfahren zur enzymatischen auftrennung von racemischen 2-amino-1-alkanolen.
HUT63658A (en)	1993-09-28	Process for reducing the enantioselectivity of candida lipase and for producing immobilized candida lipase
US5861304A (en)	1999-01-19	Process for the enzymatic separation of enantiomers of rac-2-oxotricyclo 2.2.1.0 3,5! heptane-7-carboxylic acid and of rac-2-oxotricyclo 2.2.1.0 3,5! heptane-7-carboxylic esters
JPS6012992A (ja)	1985-01-23	光学活性カルボン酸の製造法
WO2002022849A3 (en)	2002-08-29	Enzymatic resolution of aryl- and thio-substituted acids
ATE161290T1 (de)	1998-01-15	Verfahren zur trennung von 1,2- isopropylidenglycerinbenzoylester-enantiomeren