ATE134643T1 - Verfahren zur herstellung von zidovudine - Google Patents

Verfahren zur herstellung von zidovudine

Info

Publication number: ATE134643T1
Authority: AT; Austria
Prior art keywords: zidovudine; producing; azt; complex; deoxythymidine
Prior art date: 1991-06-21

Application number

AT92914161T

Other languages

English (en)

Inventor

Bruno Konrad Radatus

Khashayar Karimian

Original Assignee

Acic Canada Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-06-21

Filing date

1992-06-22

Publication date

1996-03-15

1992-06-22 Application filed by Acic Canada Inc filed Critical Acic Canada Inc

1996-03-15 Application granted granted Critical

1996-03-15 Publication of ATE134643T1 publication Critical patent/ATE134643T1/de

Links

HBOMLICNUCNMMY-XLPZGREQSA-N zidovudine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](N=[N+]=[N-])C1 HBOMLICNUCNMMY-XLPZGREQSA-N 0.000 title abstract 4
238000004519 manufacturing process Methods 0.000 title 1
229960002555 zidovudine Drugs 0.000 title 1
ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 abstract 2
CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 abstract 1
SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 abstract 1
238000000746 purification Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Life Sciences & Earth Sciences (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT92914161T 1991-06-21 1992-06-22 Verfahren zur herstellung von zidovudine ATE134643T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US71783191A	1991-06-21	1991-06-21

Publications (1)

Publication Number	Publication Date
ATE134643T1 true ATE134643T1 (de)	1996-03-15

Family

ID=24883679

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92914161T ATE134643T1 (de)	1991-06-21	1992-06-22	Verfahren zur herstellung von zidovudine

Country Status (9)

Country	Link
US (2)	US5387677A (de)
EP (1)	EP0550714B1 (de)
AT (1)	ATE134643T1 (de)
AU (1)	AU2181592A (de)
CA (1)	CA2090026C (de)
DE (2)	DE69208636T2 (de)
ES (1)	ES2085023T3 (de)
HU (1)	HUT63852A (de)
WO (1)	WO1993000351A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RU2111970C1 (ru) *	1996-06-25	1998-05-27	Иван Игоревич Федоров	3'-оксимино-2',3'-дидезоксинуклеозиды
RU2392969C1 (ru) *	2008-11-18	2010-06-27	Общество с ограниченной ответственностью "Базис"	Способ получения биоцидного средства
CN102731600B (zh) *	2012-03-13	2013-06-19	绿洲生物技术（南通）有限公司	齐多夫定及其中间体的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4211773A (en) *	1978-10-02	1980-07-08	Sloan Kettering Institute For Cancer Research	5-Substituted 1-(2'-Deoxy-2'-substituted-β-D-arabinofuranosyl)pyrimidine nucleosides
US4874751A (en) *	1985-03-16	1989-10-17	Burroughs Wellcome Co.	Antibacterial treatment
US4724232A (en) *	1985-03-16	1988-02-09	Burroughs Wellcome Co.	Treatment of human viral infections
US4818750A (en) *	1985-09-17	1989-04-04	Burroughs Wellcome Co.	Treatment of human viral infections
US4847244A (en) *	1985-09-17	1989-07-11	Burroughs Wellcome Co.	Treatment of human viral infections
US4857511A (en) *	1985-09-17	1989-08-15	Burroughs Wellcome Co.	Treatment of human viral infections
DE3650741T2 (de) *	1985-09-17	2000-10-12	The Wellcome Foundation Ltd., Greenford	Kombination therapeutische Nukleoside mit weiteren therapeutisch wirksamen Komponenten.
GB8707421D0 (en) *	1987-03-27	1987-04-29	Wellcome Found	Pharmaceutical formulations
US4837311A (en) *	1987-06-22	1989-06-06	Hoffman-La Roche Inc.	Anti-retroviral compounds
US4904770A (en) *	1988-03-24	1990-02-27	Bristol-Myers Company	Production of 2',3'-dideoxy-2',3'-didehydronucleosides
US4921950A (en) *	1988-06-09	1990-05-01	Burroughs Wellcome Co.	Preparation of 3'azido-3-'-deoxythymidine
US4916218A (en) *	1988-06-09	1990-04-10	Almond Merrick R	1-(β-D-xylofuranosyl)thymine derivatives

1992
- 1992-06-22 ES ES92914161T patent/ES2085023T3/es not_active Expired - Lifetime
- 1992-06-22 WO PCT/CA1992/000269 patent/WO1993000351A1/en not_active Ceased
- 1992-06-22 CA CA002090026A patent/CA2090026C/en not_active Expired - Fee Related
- 1992-06-22 DE DE69208636T patent/DE69208636T2/de not_active Expired - Fee Related
- 1992-06-22 HU HU9300462A patent/HUT63852A/hu unknown
- 1992-06-22 DE DE0550714T patent/DE550714T1/de active Pending
- 1992-06-22 EP EP92914161A patent/EP0550714B1/de not_active Expired - Lifetime
- 1992-06-22 AU AU21815/92A patent/AU2181592A/en not_active Abandoned
- 1992-06-22 AT AT92914161T patent/ATE134643T1/de not_active IP Right Cessation
- 1992-07-16 US US07/914,104 patent/US5387677A/en not_active Expired - Fee Related
1994
- 1994-10-21 US US08/326,854 patent/US5519129A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US5387677A (en)	1995-02-07
WO1993000351A1 (en)	1993-01-07
AU2181592A (en)	1993-01-25
DE69208636T2 (de)	1996-07-11
US5519129A (en)	1996-05-21
DE550714T1 (de)	1995-06-14
EP0550714B1 (de)	1996-02-28
ES2085023T3 (es)	1996-05-16
HU9300462D0 (en)	1993-05-28
CA2090026A1 (en)	1992-12-22
HUT63852A (en)	1993-10-28
DE69208636D1 (de)	1996-04-04
EP0550714A1 (de)	1993-07-14
CA2090026C (en)	1995-09-19

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Legal Events

Date	Code	Title	Description
1996-08-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties