ATE147749T1 - Verfahren zur herstellung von azt(3'-azido-3'- desoxythymidin) und diebezüglichen verbindungen - Google Patents

Verfahren zur herstellung von azt(3'-azido-3'- desoxythymidin) und diebezüglichen verbindungen

Info

Publication number: ATE147749T1
Authority: AT; Austria
Prior art keywords: deoxythymidine; azt; azido; producing; related compounds
Prior art date: 1989-10-27

Application number

AT90403010T

Other languages

English (en)

Inventor

Stanislas Czernecki

Jean-Marc Valery

Original Assignee

Univ Paris Curie

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-10-27

Filing date

1990-10-25

Publication date

1997-02-15

1990-10-25 Application filed by Univ Paris Curie filed Critical Univ Paris Curie

1997-02-15 Application granted granted Critical

1997-02-15 Publication of ATE147749T1 publication Critical patent/ATE147749T1/de

Links

150000001875 compounds Chemical class 0.000 title abstract 5
HBOMLICNUCNMMY-XLPZGREQSA-N zidovudine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](N=[N+]=[N-])C1 HBOMLICNUCNMMY-XLPZGREQSA-N 0.000 title 2
238000004519 manufacturing process Methods 0.000 title 1
238000000034 method Methods 0.000 abstract 1
LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Virology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Oncology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Communicable Diseases (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT90403010T 1989-10-27 1990-10-25 Verfahren zur herstellung von azt(3'-azido-3'- desoxythymidin) und diebezüglichen verbindungen ATE147749T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR8914132A FR2653771B1 (fr)	1989-10-27	1989-10-27	Procede de preparation de l'azt (azido-3'-desoxy-3'-thymidine) et de composes apparentes.

Publications (1)

Publication Number	Publication Date
ATE147749T1 true ATE147749T1 (de)	1997-02-15

Family

ID=9386862

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90403010T ATE147749T1 (de)	1989-10-27	1990-10-25	Verfahren zur herstellung von azt(3'-azido-3'- desoxythymidin) und diebezüglichen verbindungen

Country Status (8)

Country	Link
US (1)	US5124442A (de)
EP (1)	EP0427587B1 (de)
JP (1)	JPH03209393A (de)
KR (1)	KR910007919A (de)
AT (1)	ATE147749T1 (de)
CA (1)	CA2028648A1 (de)
DE (1)	DE69029708D1 (de)
FR (1)	FR2653771B1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5545629A (en) *	1994-04-12	1996-08-13	Montefiore Medical Center	5-ethoxy-2'-deoxyuridines
WO2000075154A2 (en) *	1999-06-04	2000-12-14	Alliedsignal Inc.	Protected nucleosides
CN101190934B (zh) *	2006-11-27	2010-12-15	上海迪赛诺化学制药有限公司	相转移法制备齐多夫定叠氮中间体的方法
CN101376667B (zh) *	2007-08-27	2011-01-12	上海迪赛诺医药发展有限公司	一种合成齐多夫定的中间体及其制备方法和该中间体在合成齐多夫定中的应用
WO2013067669A1 (zh) *	2011-11-07	2013-05-16	上海迪赛诺药业有限公司	制备齐多夫定及其中间体的方法
WO2013067666A1 (zh) *	2011-11-07	2013-05-16	上海迪赛诺药业有限公司	制备齐多夫定及其中间体的方法
CN103864870A (zh) *	2013-11-28	2014-06-18	安徽一帆香料有限公司	一种齐多夫定的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5914040B2 (ja) *	1976-04-05	1984-04-02	ヤマサ醤油株式会社	Ｏ↑２，３′−サイクロピリミジンヌクレオシド類の製造法
EP0199451B1 (de) *	1985-03-16	1996-03-06	The Wellcome Foundation Limited	Therapeutische Nukleoside
US4916122A (en) *	1987-01-28	1990-04-10	University Of Georgia Research Foundation, Inc.	3'-Azido-2',3'-dideoxyuridine anti-retroviral composition
US4681933A (en) *	1986-05-01	1987-07-21	University Of Georgia Research Foundation, Inc.	2',3'-dideoxy-5-substituted uridines and related compounds as antiviral agents
CA1327801C (en) *	1986-07-09	1994-03-15	Kenji Arai	Cyclohexane herbicides
FR2640267B2 (fr) *	1988-01-19	1992-02-14	Univ Paris Curie	Procede de synthese de l'azido-3(prime)-desoxy-3(prime)-thymidine et analogues

1989
- 1989-10-27 FR FR8914132A patent/FR2653771B1/fr not_active Expired - Fee Related
1990
- 1990-10-25 US US07/603,010 patent/US5124442A/en not_active Expired - Fee Related
- 1990-10-25 AT AT90403010T patent/ATE147749T1/de not_active IP Right Cessation
- 1990-10-25 EP EP90403010A patent/EP0427587B1/de not_active Expired - Lifetime
- 1990-10-25 DE DE69029708T patent/DE69029708D1/de not_active Expired - Lifetime
- 1990-10-26 KR KR1019900017263A patent/KR910007919A/ko not_active Abandoned
- 1990-10-26 CA CA002028648A patent/CA2028648A1/fr not_active Abandoned
- 1990-10-29 JP JP2291669A patent/JPH03209393A/ja active Pending

Also Published As

Publication number	Publication date
CA2028648A1 (fr)	1991-04-28
EP0427587B1 (de)	1997-01-15
US5124442A (en)	1992-06-23
JPH03209393A (ja)	1991-09-12
DE69029708D1 (de)	1997-02-27
KR910007919A (ko)	1991-05-30
FR2653771B1 (fr)	1994-09-23
FR2653771A1 (fr)	1991-05-03
EP0427587A1 (de)	1991-05-15

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Legal Events

Date	Code	Title	Description
1997-07-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties