ATE135367T1 - Antithrombotische peptide und pseudopeptide - Google Patents

Antithrombotische peptide und pseudopeptide

Info

Publication number
ATE135367T1
ATE135367T1 AT91900107T AT91900107T ATE135367T1 AT E135367 T1 ATE135367 T1 AT E135367T1 AT 91900107 T AT91900107 T AT 91900107T AT 91900107 T AT91900107 T AT 91900107T AT E135367 T1 ATE135367 T1 AT E135367T1
Authority
AT
Austria
Prior art keywords
image
antithrbotic
pseudopeptides
peptides
aralkyl
Prior art date
Application number
AT91900107T
Other languages
English (en)
Inventor
Scott I Klein
Bruce F Molino
Original Assignee
Rhone Poulenc Rorer Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Int filed Critical Rhone Poulenc Rorer Int
Application granted granted Critical
Publication of ATE135367T1 publication Critical patent/ATE135367T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1019—Tetrapeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT91900107T 1989-12-01 1990-11-28 Antithrombotische peptide und pseudopeptide ATE135367T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/444,484 US5053392A (en) 1989-12-01 1989-12-01 Novel arginine, glycine, aspartic acid derivatives as platelet-aggregation inhibitors

Publications (1)

Publication Number Publication Date
ATE135367T1 true ATE135367T1 (de) 1996-03-15

Family

ID=23765095

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91900107T ATE135367T1 (de) 1989-12-01 1990-11-28 Antithrombotische peptide und pseudopeptide

Country Status (8)

Country Link
US (1) US5053392A (de)
EP (1) EP0502926B1 (de)
JP (1) JPH05504762A (de)
AT (1) ATE135367T1 (de)
AU (1) AU636426B2 (de)
CA (1) CA2069754A1 (de)
DE (1) DE69025952T2 (de)
WO (1) WO1991007976A1 (de)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5395609A (en) * 1989-06-19 1995-03-07 Antisoma Limited Synthetic peptides for use in tumor detection
US5332726A (en) * 1989-09-29 1994-07-26 Rhone-Poulenc Rorer Pharmaceuticals Inc. Antithrombotic peptides and pseudopeptides
US6017877A (en) * 1990-04-06 2000-01-25 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5672585A (en) * 1990-04-06 1997-09-30 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5780303A (en) * 1990-04-06 1998-07-14 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US6521594B1 (en) 1990-04-06 2003-02-18 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5260277A (en) * 1990-09-10 1993-11-09 Tanabe Seiyaku Co., Ltd. Guanidinyl and related cell adhesion modulation compounds
US5391705A (en) * 1991-03-15 1995-02-21 Merrell Dow Pharmaceuticals Inc. Polyfluorinated tripeptide thrombin inhibitors
CA2075154A1 (en) * 1991-08-06 1993-02-07 Neelakantan Balasubramanian Peptide aldehydes as antithrombotic agents
US5250679A (en) * 1991-10-18 1993-10-05 Genentech, Inc. Nonpeptidyl platelet aggregation inhibitors having specificity for the GPIIb III.sub. receptor
US5565449A (en) * 1991-10-18 1996-10-15 Genentech, Inc. Nonpeptidyl integrin inhibitors having specificity for the GPIIb IIIa receptor
WO1993008823A1 (en) * 1991-11-06 1993-05-13 Tanabe Seiyaku Co., Ltd. Guanidinyl and related cell adhesion modulation compounds
US5416093A (en) * 1991-11-12 1995-05-16 Eli Lilly And Company Antithrombotic agents
US5252566A (en) * 1991-11-12 1993-10-12 Eli Lilly And Company Antithrombotic agents
JPH07503944A (ja) * 1991-11-22 1995-04-27 イエダ　リサーチ　アンド　デベロツプメント　カンパニー　リミテツド Ａｒｇ−ｇｌｙ−ａｓｐ配列の非ペプチド代替物およびそれらからなる医薬組成物
WO1993018058A1 (en) * 1992-03-06 1993-09-16 G.D. Searle & Co. Peptides mimics useful as platelet aggregation inhibitors
US5728802A (en) * 1992-05-06 1998-03-17 Affymax Technologies N.V. Peptides and compounds that bind selectins including endothelium leukocyte adhesion molecule 1 (ELAM-1)
US5648458A (en) * 1992-05-06 1997-07-15 Affymax Technologies N.V. Peptides and compounds that bind to ELAM-1
US5643873A (en) * 1992-05-06 1997-07-01 Affymax Technologies N.V. Peptides and compounds that bind selectins including endothelial leukocyte adhesion molecule 1
AU653232B2 (en) * 1992-06-04 1994-09-22 Merrell Pharmaceuticals Inc. Novel thrombin inhibitors
US5338725A (en) * 1992-06-30 1994-08-16 The Research Foundation Of The State University Of New York Anti-aggregatory agents for platelets
WO1994017828A2 (en) * 1993-02-09 1994-08-18 Biogen, Inc. Treatment for insulin dependent diabetes
US6268380B1 (en) * 1993-02-19 2001-07-31 G. D. Searle & Co. Urea derivatives useful as platelet aggregation inhibitors
US5656600A (en) * 1993-03-25 1997-08-12 Corvas International, Inc. α-ketoamide derivatives as inhibitors of thrombosis
DE4309867A1 (de) * 1993-03-26 1994-09-29 Cassella Ag Neue Harnstoffderivate, ihre Herstellung und Verwendung
US5780590A (en) * 1993-10-15 1998-07-14 Rhone-Poulenc Rorer Pharmaceuticals Inc. Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides
US5488037A (en) * 1994-03-04 1996-01-30 Eli Lilly And Company Antithrombotic agents
US5436229A (en) * 1994-03-04 1995-07-25 Eli Lilly And Company Bisulfite adducts of arginine aldehydes
US5885967A (en) * 1994-03-04 1999-03-23 Eli Lilly And Company Antithrombotic agents
US5707966A (en) * 1994-03-04 1998-01-13 Eli Lilly And Company Antithrombotic agents
US5705487A (en) * 1994-03-04 1998-01-06 Eli Lilly And Company Antithrombotic agents
US5484772A (en) * 1994-03-04 1996-01-16 Eli Lilly And Company Antithrombotic agents
ZA951618B (en) * 1994-03-04 1996-08-27 Lilly Co Eli Antithrombotic agents
US5602101A (en) * 1994-03-04 1997-02-11 Eli Lilly And Company Antithrombotic agents
US5726159A (en) * 1994-03-04 1998-03-10 Eli Lilly And Company Antithrombotic agents
US5439888A (en) * 1994-03-04 1995-08-08 Eli Lilly And Company Antithrombotic agents
CA2143533A1 (en) * 1994-03-04 1995-09-05 Kenneth D. Kurz Antithrombotic agents
US5637599A (en) * 1994-06-17 1997-06-10 Corvas International, Inc. Arginine mimic derivatives as enzyme inhibitors
SE9404196D0 (sv) * 1994-12-02 1994-12-02 Astra Ab New antithrombotic formulation
US5914319A (en) * 1995-02-27 1999-06-22 Eli Lilly And Company Antithrombotic agents
US5710130A (en) * 1995-02-27 1998-01-20 Eli Lilly And Company Antithrombotic agents
AU4954296A (en) * 1995-03-17 1996-10-08 Fujisawa Pharmaceutical Co., Ltd. N-acylpiperidinylcarbonylaminocarboxylic acids and their use as glycoprotein iib/iia antagonists and fibrinogen-blood platelets binding inhibitors
US6069232A (en) * 1995-10-02 2000-05-30 Hoechst Marion Roussel, Inc. Polyfluoroalkyl tryptophan tripeptide thrombin inhibitors
US5739354A (en) * 1996-03-26 1998-04-14 Hoechst Marion Roussel, Inc. Process for the preparation of N-methyl-D-phenylalanyl-N- 1- 3- (aminoiminomethyl)amino!propyl!-3,3-difluoro-2-oxohexyl!-L-prolinamide
SI0946185T2 (sl) * 1996-11-27 2010-08-31 Aventis Pharma Inc Farmacevtski sestavek, ki obsega spojino z anti-Xa-aktivnostjo in antagonistično spojino za agregacijo ploščic
DE60103959T2 (de) * 2000-04-19 2005-07-07 Kaneka Corp. Neue azetidin-derivate und ein verfahren zur herstellung derselben
EP1853246A1 (de) * 2005-02-17 2007-11-14 Instituto del Metabolismo Celular, S.L. L-aspartsäure zur behandlung von problemen in verbindung mit dem fett- oder glucosestoffwechsel

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4547489A (en) * 1984-06-11 1985-10-15 Ortho Pharmaceutical Corporation Conformationally restricted thymopentin-like compounds
US4683291A (en) * 1985-10-28 1987-07-28 Scripps Clinic And Research Foundation Platelet binding inhibitors
FR2608160B1 (fr) * 1986-12-15 1989-03-31 Inst Nat Sante Rech Med Nouveaux derives peptidiques et leur application notamment en therapeutique
US4857508A (en) * 1987-12-03 1989-08-15 Monsanto Company Novel platelet-aggregation inhibitor peptide derivatives
NZ229004A (en) * 1988-05-19 1993-09-27 Immunobiology Res Inst Inc Tetrapeptides having t cell helper acitivity
US4952562A (en) * 1989-09-29 1990-08-28 Rorer Pharmaceutical Corporation Anti-thrombotic peptides and pseudopeptides

Also Published As

Publication number Publication date
EP0502926A4 (de) 1992-07-13
EP0502926A1 (de) 1992-09-16
CA2069754A1 (en) 1991-06-02
AU6890091A (en) 1991-06-26
EP0502926B1 (de) 1996-03-13
DE69025952T2 (de) 1996-09-12
DE69025952D1 (en) 1996-04-18
JPH05504762A (ja) 1993-07-22
AU636426B2 (en) 1993-04-29
US5053392A (en) 1991-10-01
WO1991007976A1 (en) 1991-06-13

Similar Documents

Publication Publication Date Title
DE69025952D1 (en) Antithrombotische peptide und pseudopeptide
NO911787D0 (no) Peptidaminer samt fremgangsmaate for fremstilling derav.
ATE129409T1 (de) Neue verwendung von peptidderivat.
ES2131811T3 (es) Metodos y composiciones de proteinas modificadas n-terminalmente de forma quimica.
HUT52527A (en) Process for producing bradiquinine-antagonistic peptides and pharmaceutical compositions containing them as active components
EP0591355A4 (de) Porphycenverbindungen zur photodynamischen therapie.
DK0422937T3 (da) Fibrinogenreceptorantagonister
HU9200134D0 (en) Process for the production of /6s/- and /6r/-tetrahydropholic acid
ATE165808T1 (de) Biaromatische verbindungen mit acetylenischer dreifachbindung und adamantylgruppe, sie enthaltende pharmazeutische und kosmetische zusammensetzungen und verwendungen
ES480299A1 (es) Procedimiento de preparacion de nuevos acidos alfa-(hidroxi-alcohil)-lactama-n-aceticos y de sus amidas.
HU9301520D0 (en) Methods for producing cyclopeptides promoting absorption of peptides and albumins through mucous membrane as well as pharmaceutical preparations containing said compounds as auxiliary agents
ATE130312T1 (de) Polypeptid mit sich wiederholenden zelladhäsiven hauptsequenzen.
DE69013742D1 (de) Peptide und diese Peptide enthaltende Wirkstoffe gegen Dementia.
ITRM910189A1 (it) Derivati amminoacilici e oligopeptidici dell'allopurinolo dotati di attivita' immunostimolante e composizioni farmaceutiche che li contengono
EP0310887A3 (en) Vasoconstrictor peptide
DK215289A (da) N-(5,6,7,8-tetrahydropyrido(2,3-d)pyrimidin-6-yl-alkanoyl)-glutaminsyrederivater
DE3883055D1 (de) Enkastine: neue glycopeptide mit enkephalinase-hemmender wirkung, verfahren zu ihrer herstellung und ihre verwendung als pharmazeutische praeparate.
HUT65453A (en) Process for producing 6-oxo-azepinoindole derivatives and pharmaceutical preparations containing them
IE42785L (en) Peptides
SE8406554L (sv) Nya gonadoliberinderivat och forfarande for deras framstellning
DE69224613D1 (de) Peptide, Herstellung und deren Verwendung
KR960703612A (ko) 면역계 및 중추 신경계 치료용 신규의 트리펩티드(novel tripeptides useful in immune and cns therapy)
ATE147268T1 (de) Hypoglycemische peptide
SE8605573D0 (sv) Novel compounds
ATE46347T1 (de) Immunostimulierende peptide.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties