ITRM910189A1 - Derivati amminoacilici e oligopeptidici dell'allopurinolo dotati di attivita' immunostimolante e composizioni farmaceutiche che li contengono - Google Patents

Derivati amminoacilici e oligopeptidici dell'allopurinolo dotati di attivita' immunostimolante e composizioni farmaceutiche che li contengono

Info

Publication number: ITRM910189A1
Authority: IT; Italy
Prior art keywords: allopurinol; derivatives; oligopeptidic; pharmaceutical compositions; compositions containing
Prior art date: 1991-03-22

Application number

IT000189A

Other languages

English (en)

Inventor

Piero Foresta

Mauro Marzi

Patrizia Minetti

Maria Ornella Tinti

Original Assignee

Sigma Tau Ind Farmaceuti

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-03-22

Filing date

1991-03-22

Publication date

1992-09-22

1991-03-22 Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti

1991-03-22 Publication of ITRM910189A0 publication Critical patent/ITRM910189A0/it

1991-03-22 Priority to ITRM910189A priority Critical patent/IT1244501B/it

1992-03-20 Priority to ES92830136T priority patent/ES2094335T3/es

1992-03-20 Priority to DK92830136.5T priority patent/DK0506628T3/da

1992-03-20 Priority to AT92830136T priority patent/ATE143024T1/de

1992-03-20 Priority to EP92830136A priority patent/EP0506628B1/en

1992-03-20 Priority to US07/854,916 priority patent/US5272151A/en

1992-03-20 Priority to DE69213794T priority patent/DE69213794T2/de

1992-03-23 Priority to JP4065009A priority patent/JP3067886B2/ja

1992-09-22 Publication of ITRM910189A1 publication Critical patent/ITRM910189A1/it

1994-07-15 Application granted granted Critical

1994-07-15 Publication of IT1244501B publication Critical patent/IT1244501B/it

1996-11-06 Priority to GR960402931T priority patent/GR3021556T3/el

1998-06-18 Priority to HK98105617A priority patent/HK1006462A1/en

Links

OFCNXPDARWKPPY-UHFFFAOYSA-N allopurinol Chemical class OC1=NC=NC2=C1C=NN2 OFCNXPDARWKPPY-UHFFFAOYSA-N 0.000 title abstract 3
-1 AMINO Chemical class 0.000 title 1
230000003308 immunostimulating effect Effects 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
YMAWOPBAYDPSLA-UHFFFAOYSA-N glycylglycine Chemical compound [NH3+]CC(=O)NCC([O-])=O YMAWOPBAYDPSLA-UHFFFAOYSA-N 0.000 abstract 2
SHAVAUDERMUSPN-DVRYWGNFSA-N (2s)-2,6-diamino-n-[(2s)-1-[(2-amino-2-oxoethyl)amino]-3-(4h-imidazol-4-yl)-1-oxopropan-2-yl]hexanamide Chemical compound NCCCC[C@H](N)C(=O)N[C@H](C(=O)NCC(N)=O)CC1C=NC=N1 SHAVAUDERMUSPN-DVRYWGNFSA-N 0.000 abstract 1
AFLBTVGQCQLOFJ-UHFFFAOYSA-N 2-[[1-(2,6-diaminohexanoyl)pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid Chemical compound NCCCCC(N)C(=O)N1CCCC1C(=O)NC(CCCN=C(N)N)C(O)=O AFLBTVGQCQLOFJ-UHFFFAOYSA-N 0.000 abstract 1
NTUPOKHATNSWCY-UHFFFAOYSA-N 2-[[1-(2-amino-3-phenylpropanoyl)pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid Chemical compound C1CCC(C(=O)NC(CCCN=C(N)N)C(O)=O)N1C(=O)C(N)CC1=CC=CC=C1 NTUPOKHATNSWCY-UHFFFAOYSA-N 0.000 abstract 1
UZFHNLYQWMGUHU-UHFFFAOYSA-N 2-[[6-amino-2-[(2-amino-3-carboxypropanoyl)amino]hexanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid Chemical compound OC(=O)CC(N)C(=O)NC(CCCCN)C(=O)NC(CCCN=C(N)N)C(O)=O UZFHNLYQWMGUHU-UHFFFAOYSA-N 0.000 abstract 1
JLMZKEQFMVORMA-UHFFFAOYSA-N 5-(diaminomethylideneamino)-2-[[1-(pyrrolidine-2-carbonyl)pyrrolidine-2-carbonyl]amino]pentanoic acid Chemical compound NC(N)=NCCCC(C(O)=O)NC(=O)C1CCCN1C(=O)C1NCCC1 JLMZKEQFMVORMA-UHFFFAOYSA-N 0.000 abstract 1
239000004475 Arginine Substances 0.000 abstract 1
PSZNHSNIGMJYOZ-UHFFFAOYSA-N Aspartyl-Arginine Chemical compound OC(=O)CC(N)C(=O)NC(C(O)=O)CCCNC(N)=N PSZNHSNIGMJYOZ-UHFFFAOYSA-N 0.000 abstract 1
108010016626 Dipeptides Proteins 0.000 abstract 1
SCCPDJAQCXWPTF-UHFFFAOYSA-N Glycyl-Aspartate Chemical compound NCC(=O)NC(C(O)=O)CC(O)=O SCCPDJAQCXWPTF-UHFFFAOYSA-N 0.000 abstract 1
108010008488 Glycylglycine Proteins 0.000 abstract 1
ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 abstract 1
CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 abstract 1
ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 abstract 1
KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 1
SENJXOPIZNYLHU-IUCAKERBSA-N Leu-Arg Chemical compound CC(C)C[C@H](N)C(=O)N[C@H](C(O)=O)CCCN=C(N)N SENJXOPIZNYLHU-IUCAKERBSA-N 0.000 abstract 1
ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 abstract 1
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
239000004472 Lysine Substances 0.000 abstract 1
LGMBKOAPPTYKLC-JYJNAYRXSA-N Pro-Phe-Arg Chemical compound C([C@@H](C(=O)N[C@@H](CCCNC(=N)N)C(O)=O)NC(=O)[C@H]1NCCC1)C1=CC=CC=C1 LGMBKOAPPTYKLC-JYJNAYRXSA-N 0.000 abstract 1
CXISPYVYMQWFLE-UHFFFAOYSA-N alanylglycine Chemical compound CC(N)C(=O)NCC(O)=O CXISPYVYMQWFLE-UHFFFAOYSA-N 0.000 abstract 1
108010047495 alanylglycine Proteins 0.000 abstract 1
125000000266 alpha-aminoacyl group Chemical group 0.000 abstract 1
235000001014 amino acid Nutrition 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
235000003704 aspartic acid Nutrition 0.000 abstract 1
OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 abstract 1
108010026970 bursopoietin Proteins 0.000 abstract 1
150000001768 cations Chemical class 0.000 abstract 1
229940043257 glycylglycine Drugs 0.000 abstract 1
108010000761 leucylarginine Proteins 0.000 abstract 1
108010089198 phenylalanyl-prolyl-arginine Proteins 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
108010001055 thymocartin Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Biophysics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Immunology (AREA)
General Chemical & Material Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

ITRM910189A 1991-03-22 1991-03-22 Derivati amminoacilici e oligopeptidici dell'allopurinolo dotati di attivita' immunostimolante e composizioni farmaceutiche che li contengono IT1244501B (it)

Priority Applications (10)

Application Number	Priority Date	Filing Date	Title
ITRM910189A IT1244501B (it)	1991-03-22	1991-03-22	Derivati amminoacilici e oligopeptidici dell'allopurinolo dotati di attivita' immunostimolante e composizioni farmaceutiche che li contengono
EP92830136A EP0506628B1 (en)	1991-03-22	1992-03-20	Aminoacyl and oligopeptidyl derivatives of allopurinol exhibiting immunostimulatory activity, and pharmaceutical formulations containing these substances
DK92830136.5T DK0506628T3 (da)	1991-03-22	1992-03-20	Aminoacyl- og oligopeptidylderivater af allopurinol, der udviser immunostimulerende aktivitet, og farmaceutiske formuleringer indeholdende disse stoffer
AT92830136T ATE143024T1 (de)	1991-03-22	1992-03-20	Aminoacyl und oligopeptidylderivate von allopurinol mit immunostimulierender wirkung und diese enthaltende pharmazeutische zubereitungen
ES92830136T ES2094335T3 (es)	1991-03-22	1992-03-20	Derivados de alopurinol aminoacilados y oligopeptidos de actividad inmunoestimuladora y composiciones farmaceuticas que los contienen.
US07/854,916 US5272151A (en)	1991-03-22	1992-03-20	Aminoacyl and oligopeptidyl derivatives of allopurinol exhibiting immunostimulatory activity, and pharmaceutical formulations containing these substances
DE69213794T DE69213794T2 (de)	1991-03-22	1992-03-20	Aminoacyl und Oligopeptidylderivate von Allopurinol mit immunostimulierender Wirkung und diese enthaltende pharmazeutische Zubereitungen
JP4065009A JP3067886B2 (ja)	1991-03-22	1992-03-23	アロプリノール誘導体および医薬製剤
GR960402931T GR3021556T3 (en)	1991-03-22	1996-11-06	Aminoacyl and oligopeptidyl derivatives of allopurinol exhibiting immunostimulatory activity, and pharmaceutical formulations containing these substances
HK98105617A HK1006462A1 (en)	1991-03-22	1998-06-18	Aminoacyl and oligopeptidyl derivatives of allopurinol exhibiting immunostimulatory activity, and pharma-ceutical formulations containing these substances

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
ITRM910189A IT1244501B (it)	1991-03-22	1991-03-22	Derivati amminoacilici e oligopeptidici dell'allopurinolo dotati di attivita' immunostimolante e composizioni farmaceutiche che li contengono

Publications (3)

Publication Number	Publication Date
ITRM910189A0 ITRM910189A0 (it)	1991-03-22
ITRM910189A1 true ITRM910189A1 (it)	1992-09-22
IT1244501B IT1244501B (it)	1994-07-15

Family

ID=11399991

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ITRM910189A IT1244501B (it)	1991-03-22	1991-03-22	Derivati amminoacilici e oligopeptidici dell'allopurinolo dotati di attivita' immunostimolante e composizioni farmaceutiche che li contengono

Country Status (10)

Country	Link
US (1)	US5272151A (it)
EP (1)	EP0506628B1 (it)
JP (1)	JP3067886B2 (it)
AT (1)	ATE143024T1 (it)
DE (1)	DE69213794T2 (it)
DK (1)	DK0506628T3 (it)
ES (1)	ES2094335T3 (it)
GR (1)	GR3021556T3 (it)
HK (1)	HK1006462A1 (it)
IT (1)	IT1244501B (it)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5928191A (en) *	1993-07-30	1999-07-27	E.P. Technologies, Inc.	Variable curve electrophysiology catheter
US5994361A (en) *	1994-06-22	1999-11-30	Biochem Pharma	Substituted purinyl derivatives with immunomodulating activity
WO1999024038A1 (en)	1997-11-07	1999-05-20	Johns Hopkins University	Methods for treatment of disorders of cardiac contractility
JP4249393B2 (ja)	1998-08-12	2009-04-02	トライアングル・ファーマシューティカルズ，インコーポレイテッド	１，３−オキサチオランヌクレオチドの製造方法
PT1574512E (pt)	2001-03-01	2008-03-05	Abbott Lab	Formas polimórficas e outras formas cristalinas de cis-ftc
WO2003051298A2 (en) *	2001-12-14	2003-06-26	Pharmasset Ltd.	Preparation of intermediates useful in the synthesis of antiviral nucleosides
US6855821B2 (en)	2002-08-06	2005-02-15	Pharmasset, Ltd.	Processes for preparing 1,3-dioxolane nucleosides
US6953041B2 (en)	2002-10-09	2005-10-11	Micell Technologies, Inc.	Compositions of transition metal species in dense phase carbon dioxide and methods of use thereof
WO2005066694A2 (en) *	2003-12-29	2005-07-21	Advanced Medical Optics, Inc.	Intraocular lenses having a visible light-selective-transmissive-region
US7067659B2 (en) *	2004-04-23	2006-06-27	Duke University	Reactive oxygen generating enzyme inhibitor with nitric oxide bioactivity and uses thereof
US7278737B2 (en)	2004-04-30	2007-10-09	Advanced Medical Optics, Inc.	Ophthalmic devices having a highly selective violet light transmissive filter and related methods
JP4896036B2 (ja) *	2004-11-22	2012-03-14	アボット・メディカル・オプティクス・インコーポレイテッド	共重合性アゾ化合物およびそれを含有する物品
AU2005309912B2 (en)	2004-11-22	2011-10-06	Johnson & Johnson Surgical Vision, Inc.	Copolymerizable methine and anthraquinone compounds and articles containing them
US8188098B2 (en) *	2008-05-19	2012-05-29	Hoffmann-La Roche Inc.	GPR119 receptor agonists
EP4681719A3 (en) *	2013-03-15	2026-04-15	XORTX Therapeutics Inc.	Xanthine oxidase inhibitor formulations

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3165520A (en) *		1965-01-12		Certificate of correction
AU564576B2 (en) *	1981-09-24	1987-08-20	Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.	Purine derivatives
US4602089A (en) *	1982-03-12	1986-07-22	Newport Pharmaceuticals, Inc.	Process for preparing purine compounds
DK302883D0 (da) *	1983-06-30	1983-06-30	Hans Bundgaard	Allopurinol prodrugs
US4663326A (en) *	1985-04-04	1987-05-05	Warner-Lambert Company	Pyrazolo[4,3-d]pyrimidine-5,7-(4H,6H)dione or -5-thione-7-one analogs
AU611648B2 (en) *	1986-08-11	1991-06-20	Baxter International Inc.	Pivot pin bearing/seal with loose eyelet especially suited for disposable continuous flow blood filtration system cartridges
IT1213495B (it) *	1986-09-17	1989-12-20	Sigma Tau Ind Farmaceuti	Processo per la preparazione dell'alfa-n-[(ipoxatin-9-il)pentilossicarbonil-]arginina

1991
- 1991-03-22 IT ITRM910189A patent/IT1244501B/it active IP Right Grant
1992
- 1992-03-20 DK DK92830136.5T patent/DK0506628T3/da active
- 1992-03-20 AT AT92830136T patent/ATE143024T1/de not_active IP Right Cessation
- 1992-03-20 DE DE69213794T patent/DE69213794T2/de not_active Expired - Fee Related
- 1992-03-20 EP EP92830136A patent/EP0506628B1/en not_active Expired - Lifetime
- 1992-03-20 ES ES92830136T patent/ES2094335T3/es not_active Expired - Lifetime
- 1992-03-20 US US07/854,916 patent/US5272151A/en not_active Expired - Fee Related
- 1992-03-23 JP JP4065009A patent/JP3067886B2/ja not_active Expired - Fee Related
1996
- 1996-11-06 GR GR960402931T patent/GR3021556T3/el unknown
1998
- 1998-06-18 HK HK98105617A patent/HK1006462A1/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
GR3021556T3 (en)	1997-02-28
EP0506628A2 (en)	1992-09-30
ES2094335T3 (es)	1997-01-16
JPH05117275A (ja)	1993-05-14
DE69213794D1 (de)	1996-10-24
EP0506628B1 (en)	1996-09-18
US5272151A (en)	1993-12-21
DK0506628T3 (da)	1996-11-11
EP0506628A3 (en)	1992-10-21
ITRM910189A0 (it)	1991-03-22
DE69213794T2 (de)	1997-02-06
JP3067886B2 (ja)	2000-07-24
HK1006462A1 (en)	1999-02-26
IT1244501B (it)	1994-07-15
ATE143024T1 (de)	1996-10-15

Legal Events

Date	Code	Title	Description
1994-07-15	0001	Granted
1999-10-27	TA	Fee payment date (situation as of event date), data collected since 19931001	Effective date: 19950131

Publication	Publication Date	Title
DK0506628T3 (da)	1996-11-11	Aminoacyl- og oligopeptidylderivater af allopurinol, der udviser immunostimulerende aktivitet, og farmaceutiske formuleringer indeholdende disse stoffer
EP0254080A3 (en)	1989-05-31	Malonic acid derivatives and methods for their synthesis
TW377350B (en)	1999-12-21	Peptidic ketones as interleukin-1beta-converting enzyme inhibitors
NO911787D0 (no)	1991-05-07	Peptidaminer samt fremgangsmaate for fremstilling derav.
DK1310558T3 (da)	2007-10-08	Stabile produkter af det baktericide/permeabilitetsforögende protein og farmaceutiske sammensætninger, der indeholder disse
RU94015842A (ru)	1996-01-10	Пептидные кетоны, фармацевтическая композиция и способ ингибирования интерлейкин-1 протеазы
ATE102629T1 (de)	1994-03-15	Peptidderivate des blutplaettchen-aggregationsinhibitors.
ATE102949T1 (de)	1994-04-15	Verfahren zur herstellung von retro-inversopeptiden und dessen zwischenprodukte.
DK0437563T3 (da)	1995-05-29	Bioligiske aktive lægemiddelpolymerderivater
EP1323730A4 (en)	2005-01-05	NEW POLYPEPTIDES AND ANTI-HIV DRUGS CONTAINING THEM
DK0482879T3 (da)	1996-02-05	Protease fra bacillus licheniformis
ES2012720A6 (es)	1990-04-01	Procedimiento para la obtencion de sales de adicion de acido de taurina o glicina amidada.
BG97123A (bg)	1993-12-24	Производни на човешка, стимулирана от жлъчните соли, липаза и фармацевтични състави на тяхна основа
DE3751398D1 (de)	1995-08-17	Substrat-Peptide.
DE3782880D1 (de)	1993-01-14	Hemmende peptide.
DK0464009T3 (da)	1999-03-08	Oligopeptidderivater af ipoxantin udstyret med immunomodulerende aktivitet, og farmaceutiske præparater indeholdende samme
ATE46173T1 (de)	1989-09-15	Pharmakologisch aktive peptide.
DE453719T1 (de)	1992-04-30	Bakteriozin-peptid.
DE59206226D1 (de)	1996-06-13	Aminosäurederivate zur Peptidsynthese
EP1221964A4 (en)	2004-12-15	ANTIGENIC MODIFICATION OF POLYPEPTIDES
IT1196502B (it)	1988-11-16	Analoghi parzialmente retro invertiti della tuftsina
TH27915B (th)	1998-02-16	การปรับปรุงความสามารถที่จะทนทานได้ของกรด(สูตร)- อะมิโนที่ออกฤทธิ์ทางเภสัชกรรม