ATE135401T1 - Cephalosporin c acylase - Google Patents

Cephalosporin c acylase

Info

Publication number: ATE135401T1
Authority: AT; Austria
Prior art keywords: ala; cephalosporin; acylase; aca; leu
Prior art date: 1990-09-10

Application number

AT91308024T

Other languages

English (en)

Inventor

Morita Iwami

Ichiro Aramori

Masao Fukagawa

Takao Isogai

Hitoshi Kojo

Original Assignee

Fujisawa Pharmaceutical Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-09-10

Filing date

1991-09-02

Publication date

1996-03-15

1991-09-02 Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co

1996-03-15 Application granted granted Critical

1996-03-15 Publication of ATE135401T1 publication Critical patent/ATE135401T1/de

Links

HOKIDJSKDBPKTQ-GLXFQSAKSA-N cephalosporin C Chemical compound S1CC(COC(=O)C)=C(C(O)=O)N2C(=O)[C@@H](NC(=O)CCC[C@@H](N)C(O)=O)[C@@H]12 HOKIDJSKDBPKTQ-GLXFQSAKSA-N 0.000 title abstract 10
HSHGZXNAXBPPDL-HZGVNTEJSA-N 7beta-aminocephalosporanic acid Chemical compound S1CC(COC(=O)C)=C(C([O-])=O)N2C(=O)[C@@H]([NH3+])[C@@H]12 HSHGZXNAXBPPDL-HZGVNTEJSA-N 0.000 abstract 2
239000013604 expression vector Substances 0.000 abstract 2
238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 abstract 2
IXUSDMGLUJZNFO-BXUZGUMPSA-N (7R)-7-(4-carboxybutanamido)cephalosporanic acid Chemical compound S1CC(COC(=O)C)=C(C(O)=O)N2C(=O)[C@@H](NC(=O)CCCC(O)=O)[C@@H]12 IXUSDMGLUJZNFO-BXUZGUMPSA-N 0.000 abstract 1
125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 abstract 1
229960000603 cefalotin Drugs 0.000 abstract 1
XIURVHNZVLADCM-IUODEOHRSA-N cefalotin Chemical compound N([C@H]1[C@@H]2N(C1=O)C(=C(CS2)COC(=O)C)C(O)=O)C(=O)CC1=CC=CS1 XIURVHNZVLADCM-IUODEOHRSA-N 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
238000012258 culturing Methods 0.000 abstract 1
230000002255 enzymatic effect Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
244000005700 microbiome Species 0.000 abstract 1
235000015097 nutrients Nutrition 0.000 abstract 1
-1 succinyl 7-ACA Chemical compound 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
- C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
- C12P35/04—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by acylation of the substituent in the 7 position

Landscapes

Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Biomedical Technology (AREA)
Microbiology (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Physics & Mathematics (AREA)
Biophysics (AREA)
Plant Pathology (AREA)
Enzymes And Modification Thereof (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Cephalosporin Compounds (AREA)
Peptides Or Proteins (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT91308024T 1990-09-10 1991-09-02 Cephalosporin c acylase ATE135401T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB909019724A GB9019724D0 (en)	1990-09-10	1990-09-10	Cephalosporin c acylase

Publications (1)

Publication Number	Publication Date
ATE135401T1 true ATE135401T1 (de)	1996-03-15

Family

ID=10681943

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91308024T ATE135401T1 (de)	1990-09-10	1991-09-02	Cephalosporin c acylase

Country Status (14)

Country	Link
US (2)	US5192678A (de)
EP (1)	EP0475652B1 (de)
JP (1)	JP3016449B2 (de)
KR (1)	KR100188163B1 (de)
AT (1)	ATE135401T1 (de)
CA (1)	CA2051090C (de)
DE (1)	DE69117843T2 (de)
DK (1)	DK0475652T3 (de)
ES (1)	ES2084117T3 (de)
GB (1)	GB9019724D0 (de)
GR (1)	GR3019317T3 (de)
HU (1)	HU212321B (de)
IE (1)	IE913163A1 (de)
TR (1)	TR25462A (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE167520T1 (de) *	1990-04-18	1998-07-15	Gist Brocades Nv	Mutierte beta-lactamacylasegene
IT1250698B (it) *	1991-07-24	1995-04-21	Mini Ricerca Scient Tecnolog	Processo per la preparazione enzimatica di acidi 7-ammino-cefalosporanici.
GB9204439D0 (en) *	1992-02-27	1992-04-15	Fujisawa Pharmaceutical Co	A new cephalosporin c acylase
US5449619A (en) *	1992-04-16	1995-09-12	Sybron Chemical Holdings, Inc.	Drain opener formulation
TW400384B (en) *	1993-11-01	2000-08-01	Fujisawa Pharmaceutical Co	A new cephalosporin C acylase
AU3346295A (en) *	1994-08-12	1996-03-07	Gist-Brocades B.V.	Mutated penicillin g acylase genes
DE4437420A1 (de) *	1994-10-19	1996-04-25	Hoechst Ag	Verbessertes, induktionsfreies Verfahren zur gentechnischen Herstellung von Glutarylamidase
GB9423212D0 (en) *	1994-11-17	1995-01-04	Glaxo Group Ltd	Industrial enzymes
KR19990077318A (ko) *	1996-01-16	1999-10-25	에드워드 제이. 존스	세제 및 소독제 제조물
CN1232496A (zh) *	1996-08-12	1999-10-20	藤泽药品工业株式会社	制备生物反应器的方法
WO1998020120A1 (en)	1996-11-05	1998-05-14	Bristol-Myers Squibb Company	Mutant penicillin g acylases
US5766871A (en) *	1996-11-27	1998-06-16	Food Industry Research And Development Institute	Screening and characterization of glutaryl-7-aminocephalosporanic acid acylase
KR100481138B1 (ko) *	1997-09-09	2005-04-11	바이오케미 게젤샤프트 엠베하	효소 활성을 갖는 미생물을 함유하는 구형 입자 및 구형 입자의 제조방법
HUP0301202A2 (hu)	2000-09-22	2003-09-29	Bristol-Myers Squibb Company	Glutaril-cefalosporin amidáz Pseudomonas diminuta BS-203-ból
KR100530299B1 (ko) *	2003-08-11	2005-11-22	산도즈 게엠베하	변이 세팔로스포린 ｃ 아실라제 및 이를 이용한 7-ａｃａ 제조방법
ITMI20040016A1 (it) *	2004-01-12	2004-04-12	Antibiotics S P A	Cefalosporina c acilasi
AU2009288234B2 (en) *	2008-09-02	2014-08-21	Merck Millipore Ltd.	Chromatography membranes, devices containing them, and methods of use thereof
ES2968249T3 (es)	2011-05-17	2024-05-08	Merck Millipore Ltd	Dispositivo con membranas tubulares en capas para cromatografía
CN102321721B (zh) *	2011-10-25	2013-09-11	石药集团中诺药业（石家庄）有限公司	一种制备3-去乙酰基-7-氨基头孢烷酸的工艺
CN105624257B (zh) *	2014-11-04	2019-11-08	北京科技大学	7-氨基头孢烷酸的制备方法及用途
CN111849946A (zh) *	2020-06-30	2020-10-30	深圳大学	透明颤菌血红蛋白在提高头孢菌素c酰化酶表达量中的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS61152286A (ja) *	1984-12-27	1986-07-10	Asahi Chem Ind Co Ltd	セフアロスポリンｃアシラ−ゼ産生遺伝情報を担うｄｎａ断片
KR0171897B1 (ko) *	1989-12-27	1999-02-01	후지사와 도모끼찌로	7-아미노세펨 화합물 또는 그 염류의 제조 방법

1990
- 1990-09-10 GB GB909019724A patent/GB9019724D0/en active Pending
1991
- 1991-08-20 US US07/747,901 patent/US5192678A/en not_active Expired - Fee Related
- 1991-09-02 EP EP91308024A patent/EP0475652B1/de not_active Expired - Lifetime
- 1991-09-02 DE DE69117843T patent/DE69117843T2/de not_active Expired - Fee Related
- 1991-09-02 ES ES91308024T patent/ES2084117T3/es not_active Expired - Lifetime
- 1991-09-02 AT AT91308024T patent/ATE135401T1/de not_active IP Right Cessation
- 1991-09-02 DK DK91308024.8T patent/DK0475652T3/da active
- 1991-09-04 TR TR91/0865A patent/TR25462A/xx unknown
- 1991-09-09 HU HU912906A patent/HU212321B/hu not_active IP Right Cessation
- 1991-09-09 IE IE316391A patent/IE913163A1/en not_active IP Right Cessation
- 1991-09-09 KR KR1019910015672A patent/KR100188163B1/ko not_active Expired - Fee Related
- 1991-09-10 JP JP3308574A patent/JP3016449B2/ja not_active Expired - Fee Related
- 1991-09-10 CA CA002051090A patent/CA2051090C/en not_active Expired - Fee Related
1992
- 1992-08-26 US US07/935,312 patent/US5320948A/en not_active Expired - Fee Related
1996
- 1996-03-14 GR GR960400565T patent/GR3019317T3/el unknown

Also Published As

Publication number	Publication date
EP0475652A3 (en)	1992-11-19
US5192678A (en)	1993-03-09
EP0475652A2 (de)	1992-03-18
GB9019724D0 (en)	1990-10-24
ES2084117T3 (es)	1996-05-01
JP3016449B2 (ja)	2000-03-06
KR100188163B1 (ko)	1999-06-01
HU912906D0 (en)	1992-01-28
US5320948A (en)	1994-06-14
EP0475652B1 (de)	1996-03-13
HU212321B (en)	1996-05-28
CA2051090C (en)	2000-11-21
HUT61586A (en)	1993-01-28
GR3019317T3 (en)	1996-06-30
DE69117843T2 (de)	1996-07-25
TR25462A (tr)	1993-05-01
DK0475652T3 (da)	1996-04-01
JPH0584078A (ja)	1993-04-06
DE69117843D1 (de)	1996-04-18
IE913163A1 (en)	1992-03-11
CA2051090A1 (en)	1992-03-11
KR920006502A (ko)	1992-04-27

Legal Events

Date	Code	Title	Description
1996-09-15	UEP	Publication of translation of european patent specification
2003-06-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DK0475652T3 (da)	1996-04-01	Cephalosporin C-acylase
CA2085292A1 (en)	1994-06-15	Enzyme of Use in Chitosan Hydrolysis
KR850001279A (ko)	1985-03-18	α-아밀라제의 제법
TW274565B (de)	1996-04-21
DE69026921D1 (de)	1996-06-13	Verfahren zur Herstellung von 7-Aminocephem-Verbindungen oder deren Salzen
KR890002391A (ko)	1989-04-10	산성 우레아제 및 그의 제조방법
EP0482844A3 (en)	1993-01-13	Gl-7aca acylase
CA2044911A1 (en)	1991-12-22	Process for producing ascorbic acid-2-phosphate
EP0149915A3 (de)	1986-12-30	Stärkeverwendung durch gram-negative Mikroorganismen
Aleksieva et al.	1991	Acid proteinases production by Humicola lutea cells immobilized in polyhydroxyethylmethacrylate gel
CA2174117A1 (en)	1995-04-20	Alpha-1,4-glucan lyase from a fungus, its purification gene cloning and expression in microorganisms
US5824522A (en)	1998-10-20	Recombinant decarbamylases for producing D-α-amino acids
GB1347665A (en)	1974-02-20	Process for the production of cephalexin
KR930006148A (ko)	1993-04-20	신균주 슈도모나스속 y-132 및 이로부터 생산되는 글루타릴-7-아미노세팔로스포린산 아실라아제
Bhalla et al.	1992	Purification and Characterization of Nitrilase Catalyzing Asymmetric Hydrolysis of Aminonitriles from Rhodococcus rhodochrous PA-34
EP0543021A1 (de)	1993-05-26	Immobilisierte enzympreparation und herstellung von d-alpha-aminosäure