ATE167520T1 - Mutierte beta-lactamacylasegene - Google Patents

Mutierte beta-lactamacylasegene

Info

Publication number
ATE167520T1
ATE167520T1 AT91200930T AT91200930T ATE167520T1 AT E167520 T1 ATE167520 T1 AT E167520T1 AT 91200930 T AT91200930 T AT 91200930T AT 91200930 T AT91200930 T AT 91200930T AT E167520 T1 ATE167520 T1 AT E167520T1
Authority
AT
Austria
Prior art keywords
beta
lactamacylase
genes
lactam
mutated beta
Prior art date
Application number
AT91200930T
Other languages
English (en)
Inventor
Wilhelmus Johannes Dr Quax
Der Laan Jan Metske Dr Van
Onno Dr Misset
Herman B M Dr Lenting
Original Assignee
Gist Brocades Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gist Brocades Nv filed Critical Gist Brocades Nv
Application granted granted Critical
Publication of ATE167520T1 publication Critical patent/ATE167520T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C12N9/84—Penicillin amidase (3.5.1.11)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/01—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amides (3.5.1)
    • C12Y305/01011—Penicillin amidase (3.5.1.11), i.e. penicillin-amidohydrolase

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pyrrole Compounds (AREA)
  • Saccharide Compounds (AREA)
AT91200930T 1990-04-18 1991-04-18 Mutierte beta-lactamacylasegene ATE167520T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP90200962 1990-04-18

Publications (1)

Publication Number Publication Date
ATE167520T1 true ATE167520T1 (de) 1998-07-15

Family

ID=8204994

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91200930T ATE167520T1 (de) 1990-04-18 1991-04-18 Mutierte beta-lactamacylasegene

Country Status (10)

Country Link
US (2) US5457032A (de)
EP (1) EP0453048B1 (de)
JP (1) JPH05501806A (de)
KR (1) KR100193802B1 (de)
AT (1) ATE167520T1 (de)
DE (1) DE69129604T2 (de)
ES (1) ES2119756T3 (de)
IE (1) IE911295A1 (de)
PT (1) PT97409B (de)
WO (1) WO1991016435A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT97409B (pt) * 1990-04-18 1998-08-31 Gist Brocades Nv Processo para a preparacao de mutantes beta-lactama-acilases por expressao genetica
DE69421653D1 (de) * 1993-08-05 1999-12-23 Dsm Nv Neue Anwendung von Alcaligenes faecalis Penicillin G Acylase
DE69514923T2 (de) * 1994-08-12 2000-11-02 Dsm N.V., Heerlen Mutierte penicillin-g-acylase gene
ATE402997T1 (de) 1996-11-05 2008-08-15 Bristol Myers Squibb Co Mutierte penicillin g acylasen
US8288322B2 (en) 2000-04-17 2012-10-16 Dyax Corp. Methods of constructing libraries comprising displayed and/or expressed members of a diverse family of peptides, polypeptides or proteins and the novel libraries
DK1276855T3 (da) * 2000-04-17 2012-11-26 Dyax Corp Fremgangsmåde til konstruktion af visningsbiblioteker over genetiske pakker for medlemmer af en diversificeret peptidfamilie
DK1360288T3 (da) 2000-12-18 2011-06-14 Dyax Corp Fokuserede biblioteker af genetiske pakker
US20040067532A1 (en) 2002-08-12 2004-04-08 Genetastix Corporation High throughput generation and affinity maturation of humanized antibody
WO2004111241A1 (en) * 2003-06-12 2004-12-23 Stichting Voor De Technische Wetenschappen Penicillin acylase
KR100530299B1 (ko) * 2003-08-11 2005-11-22 산도즈 게엠베하 변이 세팔로스포린 ｃ 아실라제 및 이를 이용한 7-ａｃａ 제조방법
EP1694835A2 (de) * 2003-12-05 2006-08-30 Stichting Voor De Technische Wetenschappen Glutaryl amidasen und deren verwendung
EP1538205A1 (de) * 2003-12-05 2005-06-08 Stichting Voor De Technische Wetenschappen Glutaryl Amidasen und deren Verwendung
ITMI20040016A1 (it) * 2004-01-12 2004-04-12 Antibiotics S P A Cefalosporina c acilasi
WO2007073947A2 (en) 2005-12-28 2007-07-05 Dsm Ip Assets B.V. Mutant type ii beta- lactam acylases
US12529164B2 (en) 2007-09-14 2026-01-20 Adimab, Llc Rationally designed, synthetic antibody libraries and uses therefor
JP5933894B2 (ja) 2007-09-14 2016-06-15 アディマブ， エルエルシー 合理的に設計された、合成抗体ライブラリおよびその使用
US8877688B2 (en) 2007-09-14 2014-11-04 Adimab, Llc Rationally designed, synthetic antibody libraries and uses therefor
WO2009114815A1 (en) 2008-03-13 2009-09-17 Dyax Corp Libraries of genetic packages comprising novel hc cdr3 designs
WO2009132287A2 (en) 2008-04-24 2009-10-29 Dyax Corp. Libraries of genetic packages comprising novel hc cdr1, cdr2, and cdr3 and novel lc cdr1, cdr2, and cdr3 designs
WO2010054319A2 (en) * 2008-11-10 2010-05-14 Codexis, Inc. Penicillin-g acylases
WO2011032181A2 (en) * 2009-09-14 2011-03-17 Dyax Corp. Libraries of genetic packages comprising novel hc cdr3 designs
KR102810907B1 (ko) 2010-07-16 2025-05-21 아디맵 엘엘씨 항체 라이브러리
AU2013359955B2 (en) 2012-12-14 2017-08-10 Saban Ventures Pty Limited Synergistic disinfection enhancement
AU2013359956B2 (en) 2012-12-14 2017-08-10 Saban Ventures Pty Limited Disinfectant
CN111172142B (zh) * 2020-02-14 2021-09-28 上海陶宇晟生物技术有限责任公司 一种热稳定性高的头孢菌素c酰化酶突变体
CN116144517B (zh) * 2021-11-22 2024-08-30 中国科学院天津工业生物技术研究所 一种7-氨基头孢烷酸生产菌及其制备方法与应用
CN120843489B (zh) * 2025-09-23 2026-01-30 百葵锐(天津)生物科技有限公司 酰化酶的突变体及其在椰油酰甘氨酸钠合成中的应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6121097A (ja) * 1984-07-10 1986-01-29 Asahi Chem Ind Co Ltd ７−アミノセフアロスポラン酸及びその誘導体の製造法
US4981789A (en) * 1987-03-18 1991-01-01 Merck & Co., Inc. One-step enzymatic conversion of cephalosporin C and derivatives to 7-aminocephalosporanic acid and derivatives
EP0322032A3 (de) * 1987-12-21 1991-01-30 Merck & Co. Inc. Enzymatische Umwandlung von Cephalosporin C und Derivaten in 7-Aminocephalosporinsäure und Derivate in einem Schritt
PT97409B (pt) * 1990-04-18 1998-08-31 Gist Brocades Nv Processo para a preparacao de mutantes beta-lactama-acilases por expressao genetica
EP0453047B1 (de) * 1990-04-18 1995-07-05 Gist-Brocades N.V. Penicillin-G-Acylase, dafür kodierendes Gen und Verfahren zur Herstellung von diesem Enzym
GB9019724D0 (en) * 1990-09-10 1990-10-24 Fujisawa Pharmaceutical Co Cephalosporin c acylase
GB9204439D0 (en) * 1992-02-27 1992-04-15 Fujisawa Pharmaceutical Co A new cephalosporin c acylase
TW400384B (en) * 1993-11-01 2000-08-01 Fujisawa Pharmaceutical Co A new cephalosporin C acylase

Also Published As

Publication number Publication date
JPH05501806A (ja) 1993-04-08
US5935831A (en) 1999-08-10
DE69129604T2 (de) 1998-10-15
EP0453048A1 (de) 1991-10-23
US5457032A (en) 1995-10-10
PT97409B (pt) 1998-08-31
WO1991016435A1 (en) 1991-10-31
IE911295A1 (en) 1991-10-23
ES2119756T3 (es) 1998-10-16
KR100193802B1 (ko) 1999-06-15
PT97409A (pt) 1992-01-31
DE69129604D1 (de) 1998-07-23
EP0453048B1 (de) 1998-06-17

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EEIH Change in the person of patent owner
REN Ceased due to non-payment of the annual fee