ATE167520T1 - Mutierte beta-lactamacylasegene - Google Patents

Mutierte beta-lactamacylasegene

Info

Publication number
ATE167520T1
ATE167520T1 AT91200930T AT91200930T ATE167520T1 AT E167520 T1 ATE167520 T1 AT E167520T1 AT 91200930 T AT91200930 T AT 91200930T AT 91200930 T AT91200930 T AT 91200930T AT E167520 T1 ATE167520 T1 AT E167520T1
Authority
AT
Austria
Prior art keywords
beta
lactamacylase
genes
lactam
mutated beta
Prior art date
Application number
AT91200930T
Other languages
English (en)
Inventor
Wilhelmus Johannes Dr Quax
Der Laan Jan Metske Dr Van
Onno Dr Misset
Herman B M Dr Lenting
Original Assignee
Gist Brocades Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gist Brocades Nv filed Critical Gist Brocades Nv
Application granted granted Critical
Publication of ATE167520T1 publication Critical patent/ATE167520T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C12N9/84—Penicillin amidase (3.5.1.11)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/01—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amides (3.5.1)
    • C12Y305/01011—Penicillin amidase (3.5.1.11), i.e. penicillin-amidohydrolase

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pyrrole Compounds (AREA)
  • Saccharide Compounds (AREA)
AT91200930T 1990-04-18 1991-04-18 Mutierte beta-lactamacylasegene ATE167520T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP90200962 1990-04-18

Publications (1)

Publication Number Publication Date
ATE167520T1 true ATE167520T1 (de) 1998-07-15

Family

ID=8204994

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91200930T ATE167520T1 (de) 1990-04-18 1991-04-18 Mutierte beta-lactamacylasegene

Country Status (10)

Country Link
US (2) US5457032A (de)
EP (1) EP0453048B1 (de)
JP (1) JPH05501806A (de)
KR (1) KR100193802B1 (de)
AT (1) ATE167520T1 (de)
DE (1) DE69129604T2 (de)
ES (1) ES2119756T3 (de)
IE (1) IE911295A1 (de)
PT (1) PT97409B (de)
WO (1) WO1991016435A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2119756T3 (es) * 1990-04-18 1998-10-16 Gist Brocades Nv Genes de beta lactama acilasa mutados.
DE69421653D1 (de) * 1993-08-05 1999-12-23 Dsm Nv Neue Anwendung von Alcaligenes faecalis Penicillin G Acylase
ES2144139T3 (es) * 1994-08-12 2000-06-01 Dsm Nv Genes de la penicilina g-acilasa mutados.
ATE402997T1 (de) * 1996-11-05 2008-08-15 Bristol Myers Squibb Co Mutierte penicillin g acylasen
US8288322B2 (en) 2000-04-17 2012-10-16 Dyax Corp. Methods of constructing libraries comprising displayed and/or expressed members of a diverse family of peptides, polypeptides or proteins and the novel libraries
CA2798625C (en) * 2000-04-17 2017-01-24 Dyax Corp. Novel methods of constructing libraries of genetic packages that collectively display the members of a diverse family of peptides, polypeptides or proteins
PT1360288E (pt) 2000-12-18 2011-03-07 Dyax Corp Bibliotecas orientadas de pacotes genéticos
US20040067532A1 (en) 2002-08-12 2004-04-08 Genetastix Corporation High throughput generation and affinity maturation of humanized antibody
WO2004111241A1 (en) * 2003-06-12 2004-12-23 Stichting Voor De Technische Wetenschappen Penicillin acylase
KR100530299B1 (ko) * 2003-08-11 2005-11-22 산도즈 게엠베하 변이 세팔로스포린 ｃ 아실라제 및 이를 이용한 7-ａｃａ 제조방법
EP1538205A1 (de) * 2003-12-05 2005-06-08 Stichting Voor De Technische Wetenschappen Glutaryl Amidasen und deren Verwendung
WO2005054452A2 (en) * 2003-12-05 2005-06-16 Stichting Voor De Technische Wetenschappen Glutaryl amidases and their uses
ITMI20040016A1 (it) * 2004-01-12 2004-04-12 Antibiotics S P A Cefalosporina c acilasi
BRPI0621278A2 (pt) 2005-12-28 2011-12-06 Dsm Ip Assests Bv acilases mutantes
US8877688B2 (en) 2007-09-14 2014-11-04 Adimab, Llc Rationally designed, synthetic antibody libraries and uses therefor
US12529164B2 (en) 2007-09-14 2026-01-20 Adimab, Llc Rationally designed, synthetic antibody libraries and uses therefor
EP3124497B1 (de) 2007-09-14 2020-04-15 Adimab, LLC Synthetische antikörperbibliotheken mit rationalem design und verwendungen davon
WO2009114815A1 (en) 2008-03-13 2009-09-17 Dyax Corp Libraries of genetic packages comprising novel hc cdr3 designs
WO2009132287A2 (en) 2008-04-24 2009-10-29 Dyax Corp. Libraries of genetic packages comprising novel hc cdr1, cdr2, and cdr3 and novel lc cdr1, cdr2, and cdr3 designs
US8247192B2 (en) * 2008-11-10 2012-08-21 Codexis, Inc. Penicillin-G acylases
JP2013504602A (ja) * 2009-09-14 2013-02-07 ダイアックス コーポレーション 新しく設計したｈｃｃｄｒ３を含む遺伝子パッケージライブラリー
KR102024922B1 (ko) 2010-07-16 2019-09-25 아디맵 엘엘씨 항체 라이브러리
JP6239643B2 (ja) 2012-12-14 2017-11-29 サバン ベンチャーズ ピーティーワイ リミテッド 相乗的消毒作用増強
WO2014089633A1 (en) 2012-12-14 2014-06-19 Saban Ventures Pty Limited Disinfectant
CN111172142B (zh) * 2020-02-14 2021-09-28 上海陶宇晟生物技术有限责任公司 一种热稳定性高的头孢菌素c酰化酶突变体
CN116144517B (zh) * 2021-11-22 2024-08-30 中国科学院天津工业生物技术研究所 一种7-氨基头孢烷酸生产菌及其制备方法与应用
CN120843489B (zh) * 2025-09-23 2026-01-30 百葵锐(天津)生物科技有限公司 酰化酶的突变体及其在椰油酰甘氨酸钠合成中的应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6121097A (ja) * 1984-07-10 1986-01-29 Asahi Chem Ind Co Ltd ７−アミノセフアロスポラン酸及びその誘導体の製造法
US4981789A (en) * 1987-03-18 1991-01-01 Merck & Co., Inc. One-step enzymatic conversion of cephalosporin C and derivatives to 7-aminocephalosporanic acid and derivatives
EP0322032A3 (de) * 1987-12-21 1991-01-30 Merck & Co. Inc. Enzymatische Umwandlung von Cephalosporin C und Derivaten in 7-Aminocephalosporinsäure und Derivate in einem Schritt
KR0152667B1 (ko) * 1990-04-18 1998-10-01 한스 월터 라벤 페니실린 g 아실라아제, 이 효소를 코드화한 유전자 및 이 효소의 제조방법
ES2119756T3 (es) * 1990-04-18 1998-10-16 Gist Brocades Nv Genes de beta lactama acilasa mutados.
GB9019724D0 (en) * 1990-09-10 1990-10-24 Fujisawa Pharmaceutical Co Cephalosporin c acylase
GB9204439D0 (en) * 1992-02-27 1992-04-15 Fujisawa Pharmaceutical Co A new cephalosporin c acylase
TW400384B (en) * 1993-11-01 2000-08-01 Fujisawa Pharmaceutical Co A new cephalosporin C acylase

Also Published As

Publication number Publication date
PT97409B (pt) 1998-08-31
PT97409A (pt) 1992-01-31
ES2119756T3 (es) 1998-10-16
EP0453048A1 (de) 1991-10-23
IE911295A1 (en) 1991-10-23
KR100193802B1 (ko) 1999-06-15
EP0453048B1 (de) 1998-06-17
DE69129604D1 (de) 1998-07-23
DE69129604T2 (de) 1998-10-15
JPH05501806A (ja) 1993-04-08
WO1991016435A1 (en) 1991-10-31
US5457032A (en) 1995-10-10
US5935831A (en) 1999-08-10

Similar Documents

Publication Publication Date Title
DE69129604D1 (de) Mutierte beta-Lactamacylasegene
ATE189477T1 (de) Mutierte penicillin-g-acylase gene
ATE402997T1 (de) Mutierte penicillin g acylasen
PT1165763E (pt) Variantes de hidantoinase com propriedades melhoradas e a sua utilizacao para a producao de aminoacidos
DK0652960T3 (da) Cyklisk GMP-bindende, cyklisk GMP-specifikke phosphodiesterasematerialer og fremgangsmåder
DK0699076T3 (da) Vaccine mod mellemørebetændelse
DE69231745D1 (de) Gensequenzen kodierend für Flavonoid-Stoffwechselwegenzyme und deren Verwendung
PL299053A1 (en) Amino acid compound being a nucleic acid, vector, host cell, genomic zyme clone, method of diagnozing the alzheimer disease, method of determining and expressing a nucleic acid sequence
HUP0100094A1 (hu) Új felületi antigén
TR199501134A2 (tr) Memeli ve viral proteinleri asiri ifade edilmesi.
DE69331484D1 (de) N-Acetylglucosaminyl-Transferase, dafür kodierendes Gen, entsprechende Vektoren und transformierte Wirte und Herstellungsverfahren dafür
FI102971B (fi) Enantioselektiivinen polypeptidi, sen valmistus, sitä koodittava DNA j a geeni, sekä sitä ilmentävä mikro-organismi, ja menetelmä stereoisome erin valmistamiseksi
AU8258591A (en) Human mk gene and protein sequence
NO944181D0 (no) Proteaser for sopp
EP0776972A4 (de) FÜR DAS IgG-Fc-BINDENDE PROTEIN KODIERENDES GEN
DK622189A (da) Protein, der er indvolveret i syntesen af beta-lactamforbindelser, og gen, der koder derfor
DE50007747D1 (de) N-Acetylaminosäureracemase
AU1577799A (en) Nucleotide sequences encoding the tomato light hypersensitive phenotype, encodedproteins and uses thereof
FI960951A0 (fi) Akarboosibiosynteesigeenejä Actinoplanes sp:stä, menetelmiä niiden eristämiseksi sekä niiden käyttö
IT1160124B (it) Vettore di espressione di plasmidi relativo procedimento per l'espressione di un gene estraneo e relativi microorganismi
DE69231145D1 (de) Für eine Esterase kodierendes Gen und dieses Gen enthaltender Mikroorganismus
DK251385D0 (da) Kultur af bacillus subtilis mutant og fremgangsmaade til fremstillingderaf samt fremgangsmaade til anvendelse deraf
ATE107694T1 (de) Für a.nidulans-isopenicillin-n-synthetase codierende dns, deren verwendung und dafür codierende vektoren.
DK349787D0 (da) 1,2,3-thiadiazol-4-thiolater samt n3-thioacylsemicarbazider
DK394284D0 (da) Alfa-alleniske alfa-aminosyrer

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EEIH Change in the person of patent owner
REN Ceased due to non-payment of the annual fee