ATE135704T1 - 4-heterocyclyl-piperidin derivate, deren herstellung und deren verwendung als hemmstoffe der calcium-akkumulation in hirnzellen - Google Patents

4-heterocyclyl-piperidin derivate, deren herstellung und deren verwendung als hemmstoffe der calcium-akkumulation in hirnzellen

Info

Publication number
ATE135704T1
ATE135704T1 AT91901483T AT91901483T ATE135704T1 AT E135704 T1 ATE135704 T1 AT E135704T1 AT 91901483 T AT91901483 T AT 91901483T AT 91901483 T AT91901483 T AT 91901483T AT E135704 T1 ATE135704 T1 AT E135704T1
Authority
AT
Austria
Prior art keywords
alkyl
hydrogen
heterocyclyl
inhibitors
production
Prior art date
Application number
AT91901483T
Other languages
English (en)
Inventor
Palle Jakobsen
Ursula Sonnewald
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Application granted granted Critical
Publication of ATE135704T1 publication Critical patent/ATE135704T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT91901483T 1989-12-18 1990-12-11 4-heterocyclyl-piperidin derivate, deren herstellung und deren verwendung als hemmstoffe der calcium-akkumulation in hirnzellen ATE135704T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK640289A DK640289D0 (da) 1989-12-18 1989-12-18 Ny heterocyklisk kemi

Publications (1)

Publication Number Publication Date
ATE135704T1 true ATE135704T1 (de) 1996-04-15

Family

ID=8148694

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91901483T ATE135704T1 (de) 1989-12-18 1990-12-11 4-heterocyclyl-piperidin derivate, deren herstellung und deren verwendung als hemmstoffe der calcium-akkumulation in hirnzellen

Country Status (18)

Country Link
US (1) US5102894A (de)
EP (1) EP0505465B1 (de)
JP (1) JPH05502867A (de)
CN (1) CN1052674A (de)
AT (1) ATE135704T1 (de)
AU (1) AU645722B2 (de)
CA (1) CA2071480A1 (de)
DE (1) DE69026110T2 (de)
DK (2) DK640289D0 (de)
ES (1) ES2084151T3 (de)
FI (1) FI922826L (de)
IE (1) IE904435A1 (de)
IL (2) IL96592A (de)
NO (2) NO922313D0 (de)
PT (1) PT96235B (de)
WO (1) WO1991009032A1 (de)
ZA (1) ZA9010183B (de)
ZW (1) ZW19190A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2763589B1 (fr) 1997-05-22 2001-01-05 Centre Nat Rech Scient Composes pour la preparation de medicaments destines au traitement de pathologies impliquant le glutamate extracellulaire, et leurs procedes d'obtention
US7294637B2 (en) 2000-09-11 2007-11-13 Sepracor, Inc. Method of treating addiction or dependence using a ligand for a monamine receptor or transporter
EP1318988A2 (de) * 2000-09-11 2003-06-18 Sepracor, Inc. Liganden für monoamin rezeptoren und transporter, und verwendungsmethoden dafür (neurotransmission)
WO2005032479A2 (en) 2003-10-01 2005-04-14 Unviversity Of Florida Research Foundation, Inc. Compositions and methods for selective inhibition of nicotine acetylcholine receptors
CN101163477A (zh) * 2005-02-23 2008-04-16 普雷萨药品公司 多介质多巴胺转运抑制剂，以及其相关应用
CN101163676A (zh) 2005-02-23 2008-04-16 普雷萨药品公司 用于治疗运动障碍及其它cns适应症的多巴胺转运蛋白抑制剂

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2895965A (en) * 1959-07-21 Process for the production of
GB1422263A (en) * 1973-01-30 1976-01-21 Ferrosan As 4-phenyl-piperidine compounds
DK231088D0 (da) * 1988-04-28 1988-04-28 Ferrosan As Piperidinforbindelser, deres fremstilling og anvendelse
IE66332B1 (en) * 1986-11-03 1995-12-27 Novo Nordisk As Piperidine compounds and their preparation and use
US5017585A (en) * 1986-11-03 1991-05-21 Novo Nordisk A/S Method of treating calcium overload
DK588289D0 (da) * 1989-11-22 1989-11-22 Ferrosan As Ny heterocyklisk kemi

Also Published As

Publication number Publication date
ZA9010183B (en) 1991-10-30
WO1991009032A1 (en) 1991-06-27
EP0505465B1 (de) 1996-03-20
PT96235B (pt) 1998-06-30
IL96592A (en) 1995-06-29
IE904435A1 (en) 1991-06-19
CA2071480A1 (en) 1991-06-19
DK0505465T3 (da) 1996-08-05
DK640289D0 (da) 1989-12-18
IL96592A0 (en) 1991-09-16
PT96235A (pt) 1991-09-30
AU645722B2 (en) 1994-01-20
ES2084151T3 (es) 1996-05-01
DE69026110T2 (de) 1996-10-02
FI922826A0 (fi) 1992-06-17
EP0505465A1 (de) 1992-09-30
FI922826A7 (fi) 1992-06-17
NO1994003I1 (no) 1994-07-01
NO922313L (no) 1992-06-12
CN1052674A (zh) 1991-07-03
FI922826L (fi) 1992-06-17
DE69026110D1 (de) 1996-04-25
NO922313D0 (no) 1992-06-12
AU6971691A (en) 1991-07-18
ZW19190A1 (en) 1991-06-05
US5102894A (en) 1992-04-07
JPH05502867A (ja) 1993-05-20

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties