ATE135709T1 - Erythromycinderivate, ihr verfahren zur herstellung und ihre verwendung als arzneimitteln - Google Patents

Erythromycinderivate, ihr verfahren zur herstellung und ihre verwendung als arzneimitteln

Info

Publication number: ATE135709T1
Authority: AT; Austria
Prior art keywords: carbon atoms; group; alkyl; optionally substituted; halogen
Prior art date: 1992-11-05

Application number

AT93402703T

Other languages

English (en)

Inventor

Alain Bonnefoy

Jean-Francois Chantot

Constantin Agouridas

Alexis Denis

Martret Odile Le

Original Assignee

Roussel Uclaf

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-11-05

Filing date

1993-11-04

Publication date

1996-04-15

1993-11-04 Application filed by Roussel Uclaf filed Critical Roussel Uclaf

1996-04-15 Application granted granted Critical

1996-04-15 Publication of ATE135709T1 publication Critical patent/ATE135709T1/de

Links

ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical class O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 title 1
229940126601 medicinal product Drugs 0.000 title 1
125000004432 carbon atom Chemical group C* 0.000 abstract 8
125000000217 alkyl group Chemical group 0.000 abstract 3
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 3
229910052736 halogen Inorganic materials 0.000 abstract 3
150000002367 halogens Chemical class 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000005110 aryl thio group Chemical group 0.000 abstract 2
125000004104 aryloxy group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000005842 heteroatom Chemical group 0.000 abstract 2
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
231100000252 nontoxic Toxicity 0.000 abstract 2
230000003000 nontoxic effect Effects 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000003302 alkenyloxy group Chemical group 0.000 abstract 1
125000005108 alkenylthio group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000004414 alkyl thio group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
125000005133 alkynyloxy group Chemical group 0.000 abstract 1
125000005109 alkynylthio group Chemical group 0.000 abstract 1
230000003115 biocidal effect Effects 0.000 abstract 1
-1 carbocyclic aryl Chemical group 0.000 abstract 1
150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT93402703T 1992-11-05 1993-11-04 Erythromycinderivate, ihr verfahren zur herstellung und ihre verwendung als arzneimitteln ATE135709T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9213321A FR2697524B1 (fr)	1992-11-05	1992-11-05	Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.

Publications (1)

Publication Number	Publication Date
ATE135709T1 true ATE135709T1 (de)	1996-04-15

Family

ID=9435255

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93402703T ATE135709T1 (de)	1992-11-05	1993-11-04	Erythromycinderivate, ihr verfahren zur herstellung und ihre verwendung als arzneimitteln

Country Status (15)

Country	Link
US (1)	US5543400A (de)
EP (1)	EP0606024B1 (de)
JP (1)	JP3334980B2 (de)
KR (1)	KR100319358B1 (de)
CN (1)	CN1033273C (de)
AT (1)	ATE135709T1 (de)
AU (1)	AU664122B2 (de)
CA (1)	CA2102454C (de)
DE (1)	DE69301907T2 (de)
DK (1)	DK0606024T3 (de)
ES (1)	ES2085129T3 (de)
FR (1)	FR2697524B1 (de)
GR (1)	GR3019384T3 (de)
HU (1)	HU217977B (de)
RU (1)	RU2114859C1 (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5527780A (en) *	1992-11-05	1996-06-18	Roussel Uclaf	Erythromycin derivatives
HRP931480B1 (en) *	1993-12-08	1997-08-31	Sour Pliva	9a-N-(N'-CARBAMONYL) and 9a-N-(N'-THIOCARBAMONYL) DERIVATES OF 9-DEOXO-9a-HOMOERYTHROMYCIN A
FR2718450B1 (fr) *	1994-04-08	1997-01-10	Roussel Uclaf	Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2719587B1 (fr) *	1994-05-03	1996-07-12	Roussel Uclaf	Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2727969B1 (fr) *	1994-12-09	1997-01-17	Roussel Uclaf	Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2732023B1 (fr) *	1995-03-22	1997-04-30	Roussel Uclaf	Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2732684B1 (fr) *	1995-04-06	1997-04-30	Roussel Uclaf	Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
US5747466A (en) *	1995-11-08	1998-05-05	Abbott Laboratories	3-deoxy-3-descladinose derivatives of erythromycins A and B
FR2751656B1 (fr) *	1996-07-24	1998-10-16	Hoechst Marion Roussel Inc	Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
UA51730C2 (uk) *	1996-09-04	2002-12-16	Ебботт Лабораторіз	6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
SK285534B6 (sk) *	1996-09-04	2007-03-01	Abbott Laboratories	6-O-substituované ketolidy s antibakteriálnou aktivitou, farmaceutická kompozícia s ich obsahom, ich použitie a spôsob ich prípravy
US5922683A (en) *	1997-05-29	1999-07-13	Abbott Laboratories	Multicyclic erythromycin derivatives
US5780604A (en) *	1997-09-26	1998-07-14	Abbott Laboratories	11,12-cyclic phosphite or phosphate derivatives of erythromycin and related macrolides
HRP980189B1 (en) *	1998-04-06	2004-04-30	Pliva Pharm & Chem Works	Novel 15-membered lactams ketolides
FR2781484B1 (fr) *	1998-07-21	2001-08-10	Hoechst Marion Roussel Inc	Nouveaux derives de la 6-deoxy erythromycine, leur procede de preparation et leur application comme medicaments
FR2785612A1 (fr) *	1998-11-10	2000-05-12	Hoechst Marion Roussel Inc	Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
TR200200436T2 (tr) *	1998-11-03	2002-06-21	Pfizer Inc.	Yeni makrolit antibiyotikler
FR2786188B1 (fr) *	1998-11-24	2002-10-31	Hoechst Marion Roussel Inc	Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments
IT1306205B1 (it) *	1999-01-15	2001-05-30	Zambon Spa	Macrolidi ad attivita' antiinfiammatoria.
AP2001002222A0 (en)	1999-01-27	2001-09-30	Pfizer Prod Inc	Ketolide antibiotics.
US6054435A (en) *	1999-03-19	2000-04-25	Abbott Laboratories	6-O-substituted macrolides having antibacterial activity
IL145739A0 (en) *	1999-05-24	2002-07-25	Pfizer Prod Inc	13-methyl-erythromycin derivatives
AR043050A1 (es) *	2002-09-26	2005-07-13	Rib X Pharmaceuticals Inc	Compuestos heterociclicos bifuncionales y metodos para preparar y usar los mismos
HRP20020779A2 (en)	2002-09-27	2005-02-28	Pliva-Istra�iva�ki institut d.o.o.	NEW 3-DECLADINOSYL DERIVATIVES OF 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHROMICIN A 9a, 11-CYCLIC CARBAMATES
BRPI0408117A (pt) *	2003-03-05	2006-03-01	Rib X Pharmaceuticals Inc	compostos heterocìclicos bifuncionais e métodos de produção e uso dos mesmos
EP1638549A4 (de)	2003-03-10	2011-06-15	Optimer Pharmaceuticals Inc	Neue antibakterielle mittel
WO2005007143A2 (en) *	2003-07-14	2005-01-27	The Board Of Trustees Of The University Of Illinois	Use of makrolides and ketolides for the treatment of tuberculosis
WO2005042554A1 (en) *	2003-10-30	2005-05-12	Rib-X Pharmaceuticals, Inc.	Bifunctional macrolide heterocyclic compounds and methods of making and using the same
JP2007512256A (ja) *	2003-11-18	2007-05-17	リブ−エックスファーマシューティカルズ，インコーポレイテッド	二官能性マクロライド複素環化合物ならびにこれらを製造する方法およびこれらを使用する方法
EP2716647A3 (de) *	2004-02-27	2014-08-20	Rib-X Pharmaceuticals, Inc.	Makrocyclische Verbindungen Und Verfahren Zu Deren Herstellung Und Anwendung
EP2233493A1 (de) *	2004-12-21	2010-09-29	Pfizer Products Inc.	Makrolide
EP1841775A2 (de) *	2005-01-12	2007-10-10	Alpharma APS	Erythromycinderivate als antibakterielle wirkstoffe
CA2703475A1 (en) *	2007-10-25	2009-04-30	Cempra Pharmaceuticals, Inc.	Process for the preparation of macrolide antibacterial agents
US8796232B2 (en) *	2008-10-24	2014-08-05	Cempra Pharmaceuticals, Inc.	Methods for treating resistant diseases using triazole containing macrolides
US9937194B1 (en)	2009-06-12	2018-04-10	Cempra Pharmaceuticals, Inc.	Compounds and methods for treating inflammatory diseases
JP5914335B2 (ja)	2009-09-10	2016-05-11	センプラファーマシューティカルズ，インコーポレイテッド	マラリア、結核、及びｍａｃ病の治療方法
CN103080122A (zh)	2010-03-22	2013-05-01	森普拉制药公司	大环内脂的结晶形式及其用途
WO2011146829A1 (en)	2010-05-20	2011-11-24	Cempra Pharmaceuticals, Inc.	Processes for preparing macrolides and ketolides and intermediates therefor
JP6042334B2 (ja)	2010-09-10	2016-12-14	センプラファーマシューティカルズ，インコーポレイテッド	疾患治療のための水素結合形成フルオロケトライド
CN104470527B (zh)	2012-03-27	2019-05-28	森普拉制药公司	用于施用大环内酯抗生素的肠胃外制剂
RU2015138796A (ru)	2013-03-14	2017-04-19	Семпра Фармасьютикалс, Инк.	Способы и составы для лечения респираторных заболеваний
WO2014145210A1 (en)	2013-03-15	2014-09-18	Cempra Pharmaceuticals, Inc.	Convergent processes for preparing macrolide antibacterial agents

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2936865A1 (de) *	1979-09-12	1981-04-02	Bayer Ag, 5090 Leverkusen	Verwendung von pikromycin-derivaten als nutritiva
US5175150A (en) *	1985-08-31	1992-12-29	Kitasato, Kenkyusho	Erythromycin derivative
US4742049A (en) *	1986-06-04	1988-05-03	Abbott Laboratories	Semisynthetic erythromycin antibiotics
US4920102A (en) *	1988-04-18	1990-04-24	Eli Lilly And Company	Method for treating gastrointestinal disorders
IL99995A (en) *	1990-11-21	1997-11-20	Roussel Uclaf	Erythromycin derivatives, their preparation and pharmaceutical compositions containing them
DE69127457T2 (de) *	1990-11-28	1998-01-22	Taisho Pharmaceutical Co., Ltd., Tokio/Tokyo	6-0-methylerythromycin a-derivat

1992
- 1992-11-05 FR FR9213321A patent/FR2697524B1/fr not_active Expired - Fee Related
1993
- 1993-11-01 US US08/146,695 patent/US5543400A/en not_active Expired - Lifetime
- 1993-11-04 EP EP93402703A patent/EP0606024B1/de not_active Expired - Lifetime
- 1993-11-04 DK DK93402703.8T patent/DK0606024T3/da active
- 1993-11-04 RU RU93050124A patent/RU2114859C1/ru not_active IP Right Cessation
- 1993-11-04 ES ES93402703T patent/ES2085129T3/es not_active Expired - Lifetime
- 1993-11-04 AT AT93402703T patent/ATE135709T1/de active
- 1993-11-04 CA CA002102454A patent/CA2102454C/fr not_active Expired - Lifetime
- 1993-11-04 JP JP29760493A patent/JP3334980B2/ja not_active Expired - Lifetime
- 1993-11-04 AU AU50438/93A patent/AU664122B2/en not_active Expired
- 1993-11-04 HU HU9303134A patent/HU217977B/hu not_active IP Right Cessation
- 1993-11-04 DE DE69301907T patent/DE69301907T2/de not_active Expired - Lifetime
- 1993-11-05 KR KR1019930023372A patent/KR100319358B1/ko not_active Expired - Lifetime
- 1993-11-05 CN CN93114446A patent/CN1033273C/zh not_active Expired - Lifetime
1996
- 1996-03-21 GR GR950403174T patent/GR3019384T3/el unknown

Also Published As

Publication number	Publication date
KR940011475A (ko)	1994-06-21
CN1090582A (zh)	1994-08-10
US5543400A (en)	1996-08-06
CN1033273C (zh)	1996-11-13
ES2085129T3 (es)	1996-05-16
CA2102454C (fr)	2001-02-27
JPH06199887A (ja)	1994-07-19
DE69301907D1 (de)	1996-04-25
HU217977B (hu)	2000-05-28
AU5043893A (en)	1994-05-19
AU664122B2 (en)	1995-11-02
KR100319358B1 (ko)	2002-05-13
JP3334980B2 (ja)	2002-10-15
HUT66082A (en)	1994-09-28
RU2114859C1 (ru)	1998-07-10
EP0606024A1 (de)	1994-07-13
FR2697524B1 (fr)	1994-12-23
EP0606024B1 (de)	1996-03-20
DK0606024T3 (da)	1996-06-17
FR2697524A1 (fr)	1994-05-06
DE69301907T2 (de)	1996-09-05
GR3019384T3 (en)	1996-06-30
CA2102454A1 (fr)	1994-05-06

Legal Events

Date	Code	Title	Description
1996-10-15	UEP	Publication of translation of european patent specification
2005-05-15	EEIH	Change in the person of patent owner

Publication	Publication Date	Title
DE69301907D1 (de)	1996-04-25	Erythromycinderivate, ihr Verfahren zur Herstellung und ihre Verwendung als Arzneimitteln
ATE218141T1 (de)	2002-06-15	Erythromycin-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
MX9206939A (es)	1993-06-01	Derivados de piperazina, procedimiento para su preparacion y composicion farmaceutica que los comprende
ES2197160T3 (es)	2004-01-01	Antagonistas fibronogeno bicicliclos.
IS4151A (is)	1994-10-17	Cephalosporinafleiður, aðferð til framleiðslu þeirra og notkunar sem lyfja
ATE205199T1 (de)	2001-09-15	Quinolin- oder quinazolinderivate, deren herstellung und verwendung
HUT59394A (en)	1992-05-28	Process for producing piperazine derivatives and pharmaceutical compositions comprising same
IE780940L (en)	1978-11-17	Pharmacologically active compounds.
ES8107224A1 (es)	1981-10-01	Un procedimiento para la preparacion de derivados acidos penem-carboxilicos
ATE161848T1 (de)	1998-01-15	Glycyrrheticsäurederivate
KR900018065A (ko)	1990-12-20	벤조시클로알칸 유도체 및 그의 제조방법
ATE119518T1 (de)	1995-03-15	3-cycloalkylpropansäureamide, ihre tautomere und salze, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel und sie enthaltende zusammensetzungen.
PT99644A (pt)	1992-10-30	Processo para a preparacao de novos derivados de guanidina
KR910000637A (ko)	1991-01-29	피롤 유도체, 이의 제조 방법 및 약제학적 활성화합물로서의 이의 용도
ES8504180A1 (es)	1985-04-01	Procedimiento para preparar nuevos derivados de piperidina
HUT60261A (en)	1992-08-28	Process for producing piperazine derivatives and pharmaceutical compositions comprising same
BG100704A (en)	1997-09-30	New piperazine derivatives and methods for their preparation as well as of the compounds containing them
ATE125256T1 (de)	1995-08-15	Zwischenprodukte der mureidomycin-gruppe, ihre herstellung und verwendung.
IT1248068B (it)	1995-01-05	Derivati dell'eseridina ad attivita' anticolinesterasi, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono.