ATE136031T1 - Azabizyklische verbindungen, verfahren und zwischenprodukte zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen - Google Patents

Azabizyklische verbindungen, verfahren und zwischenprodukte zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen

Info

Publication number: ATE136031T1
Authority: AT; Austria
Prior art keywords: hydrogen; processes; production; pharmaceutical preparations; intermediate products
Prior art date: 1989-10-07

Application number

AT90310632T

Other languages

English (en)

Inventor

Sarah Margaret Smithkl Jenkins

Pinnacles The

Harry John Smithklin Wadsworth

Pinnacles

Sidney Barry Smithkline Orlek

Steven Mark Smithklin Bromidge

Original Assignee

Beecham Group Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-10-07

Filing date

1990-09-28

Publication date

1996-04-15

1989-10-07 Priority claimed from GB898922620A external-priority patent/GB8922620D0/en

1990-07-21 Priority claimed from GB909016069A external-priority patent/GB9016069D0/en

1990-09-28 Application filed by Beecham Group Plc filed Critical Beecham Group Plc

1996-04-15 Application granted granted Critical

1996-04-15 Publication of ATE136031T1 publication Critical patent/ATE136031T1/de

Links

150000001875 compounds Chemical class 0.000 title abstract 2
239000013067 intermediate product Substances 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
238000000034 method Methods 0.000 title 1
239000000825 pharmaceutical preparation Substances 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 5
239000001257 hydrogen Substances 0.000 abstract 5
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
150000002431 hydrogen Chemical group 0.000 abstract 2
125000006656 (C2-C4) alkenyl group Chemical group 0.000 abstract 1
125000006650 (C2-C4) alkynyl group Chemical group 0.000 abstract 1
101150047265 COR2 gene Proteins 0.000 abstract 1
101100294102 Caenorhabditis elegans nhr-2 gene Proteins 0.000 abstract 1
101100295738 Gallus gallus COR3 gene Proteins 0.000 abstract 1
101100467189 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) QCR2 gene Proteins 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000000717 hydrazino group Chemical group [H]N([*])N([H])[H] 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
General Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Psychiatry (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Hospice & Palliative Care (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT90310632T 1989-10-07 1990-09-28 Azabizyklische verbindungen, verfahren und zwischenprodukte zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen ATE136031T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB898922620A GB8922620D0 (en)	1989-10-07	1989-10-07	Novel compounds
GB909016069A GB9016069D0 (en)	1990-07-21	1990-07-21	Novel compounds

Publications (1)

Publication Number	Publication Date
ATE136031T1 true ATE136031T1 (de)	1996-04-15

Family

ID=26296014

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90310632T ATE136031T1 (de)	1989-10-07	1990-09-28	Azabizyklische verbindungen, verfahren und zwischenprodukte zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen

Country Status (10)

Country	Link
US (1)	US5981545A (de)
EP (1)	EP0427390B1 (de)
JP (1)	JPH03145491A (de)
KR (1)	KR910007929A (de)
AT (1)	ATE136031T1 (de)
AU (1)	AU639493B2 (de)
CA (1)	CA2027093A1 (de)
DE (1)	DE69026197T2 (de)
IE (1)	IE903576A1 (de)
PT (1)	PT95520A (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IE922270A1 (en) *	1991-07-26	1993-01-27	Akzo Nv	Pyrazole derivatives
SE9201478D0 (sv) *	1992-05-11	1992-05-11	Kabi Pharmacia Ab	Heteroaromatic quinuclidinenes, their use and preparation
US5393767A (en) *	1993-08-26	1995-02-28	Dowelanco	Insect control with substituted triazole and tetrazole compounds
US5733912A (en) *	1997-02-19	1998-03-31	Abbott Laboratories	7A-heterocycle substituted hexahydro-1H-pyrrolizine compounds useful in controlling chemical synaptic transmission
FR2862647B1 (fr) *	2003-11-25	2008-07-04	Aventis Pharma Sa	Derives de pyrazolyle, procede de preparation et intermediaires de ce procede a titre de medicaments et de compositions pharmaceutiques les renfermant
EP2258357A3 (de)	2005-08-26	2011-04-06	Braincells, Inc.	Neurogenese mit Acetylcholinesterasehemmer
EP2275096A3 (de)	2005-08-26	2011-07-13	Braincells, Inc.	Neurogenese durch modulation des Muscarinrezeptors
WO2008030651A1 (en) *	2006-09-08	2008-03-13	Braincells, Inc.	Combinations containing a 4-acylaminopyridine derivative
US8987315B2 (en)	2009-12-31	2015-03-24	Innocrin Pharmaceuticals, Inc.	Metalloenzyme inhibitor compounds
US20130225583A1 (en) *	2010-10-21	2013-08-29	Gerald W. Shipps, Jr.	Substituted amino-triazolyl pde10 inhibitors

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3813384A (en) *	1972-01-17	1974-05-28	Asta Werke Ag Chem Fab	Basically substituted benzyl phthalazone derivatives,acid salts thereof and process for the production thereof
FR2414044A1 (fr) *	1978-01-10	1979-08-03	Pharmindustrie	Nouveaux derives d'aza-1 bicyclo(2,2,2) octane, utilisables comme medicaments
NZ219646A (en) *	1986-03-27	1990-10-26	Merck Sharp & Dohme	Oxadiazole derivatives of azacyclics for treating cns disorders
EP0261763B1 (de) *	1986-06-27	1994-02-09	Beecham Group Plc	Verbrückte bicyclische N-heterocyclische Verbindungen
ATE133415T1 (de) *	1987-04-15	1996-02-15	Beecham Group Plc	Am brückenkopf substituierte azabicyclenderivate
GB8714789D0 (en) *	1987-06-24	1987-07-29	Lundbeck & Co As H	Heterocyclic compounds
GB8717446D0 (en) *	1987-07-23	1987-08-26	Merck Sharp & Dohme	Chemical compounds
NZ225999A (en) *	1987-09-10	1992-04-28	Merck Sharp & Dohme	Azacyclic- or azabicyclic-substituted thiadiazole derivatives and pharmaceutical compositions
NZ226000A (en) *	1987-09-10	1991-06-25	Merck Sharp & Dohme	Oxadiazolyl-azabicycloheptanes and pharmaceutical compositions
DE3877470T2 (de) *	1987-09-10	1993-06-24	Merck Sharp & Dohme	Oxazole und thiazole zur behandlung seniler demenz.
IL88156A (en) *	1987-11-13	1997-02-18	Novo Nordisk As	Azacyclic compounds their preparation and pharmaceutical compositions containing them
EP0322182A3 (de) *	1987-12-22	1992-01-02	Beecham Group Plc	Azabicyclische-Verbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen
IL88846A0 (en) *	1988-01-08	1989-07-31	Merck Sharp & Dohme	Lipophilic oxadiazoles,their preparation and pharmaceutical compositions containing them
GB8808926D0 (en) *	1988-04-15	1988-05-18	Beecham Group Plc	Novel compounds
EP0363085A3 (de) *	1988-10-03	1991-03-27	Beecham Group Plc	Chemische Verbindungen
CA2000041A1 (en) *	1988-10-13	1990-04-13	Barry S. Orlek	Compounds
GB8830226D0 (en) *	1988-12-23	1989-02-22	Beecham Group Plc	Novel compounds
EP0402056A3 (de) *	1989-06-06	1991-09-04	Beecham Group p.l.c.	Azabicyclische Verbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen
US5200419A (en) *	1990-05-21	1993-04-06	Warner-Lambert Company	Substituted tetrazoles and derivatives thereof acting at muscarinic receptors

1990
- 1990-09-28 AT AT90310632T patent/ATE136031T1/de not_active IP Right Cessation
- 1990-09-28 DE DE69026197T patent/DE69026197T2/de not_active Expired - Fee Related
- 1990-09-28 EP EP90310632A patent/EP0427390B1/de not_active Expired - Lifetime
- 1990-10-04 US US07/594,034 patent/US5981545A/en not_active Expired - Fee Related
- 1990-10-04 PT PT95520A patent/PT95520A/pt not_active Application Discontinuation
- 1990-10-05 AU AU63823/90A patent/AU639493B2/en not_active Ceased
- 1990-10-05 IE IE357690A patent/IE903576A1/en unknown
- 1990-10-05 CA CA002027093A patent/CA2027093A1/en not_active Abandoned
- 1990-10-06 KR KR1019900015906A patent/KR910007929A/ko not_active Withdrawn
- 1990-10-08 JP JP2268562A patent/JPH03145491A/ja active Pending

Also Published As

Publication number	Publication date
AU6382390A (en)	1991-04-11
DE69026197D1 (de)	1996-05-02
DE69026197T2 (de)	1997-01-09
KR910007929A (ko)	1991-05-30
JPH03145491A (ja)	1991-06-20
CA2027093A1 (en)	1991-04-08
EP0427390A3 (en)	1992-02-12
IE903576A1 (en)	1991-04-10
PT95520A (pt)	1991-08-14
EP0427390A2 (de)	1991-05-15
AU639493B2 (en)	1993-07-29
EP0427390B1 (de)	1996-03-27
US5981545A (en)	1999-11-09

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Legal Events

Date	Code	Title	Description
1996-09-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties