ATE136035T1 - Steroidderivate, die ein substituiertes thioethylradikal an der stelle 10 des steroids tragen, verfahren zu ihrer herstellung und zwischenprodukte davon, ihre verwendung als arzneimittel und pharmazeutische präparate davon - Google Patents
Steroidderivate, die ein substituiertes thioethylradikal an der stelle 10 des steroids tragen, verfahren zu ihrer herstellung und zwischenprodukte davon, ihre verwendung als arzneimittel und pharmazeutische präparate davonInfo
- Publication number
- ATE136035T1 ATE136035T1 AT90403726T AT90403726T ATE136035T1 AT E136035 T1 ATE136035 T1 AT E136035T1 AT 90403726 T AT90403726 T AT 90403726T AT 90403726 T AT90403726 T AT 90403726T AT E136035 T1 ATE136035 T1 AT E136035T1
- Authority
- AT
- Austria
- Prior art keywords
- steroid
- products
- radical
- production
- place
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 150000003431 steroids Chemical class 0.000 title 2
- 239000013067 intermediate product Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000005110 aryl thio group Chemical group 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000002483 medication Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0038—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an androstane skeleton, including 18- or 19-substituted derivatives, 18-nor derivatives and also derivatives where position 17-beta is substituted by a carbon atom not directly bonded to a further carbon atom and not being part of an amide group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- C07J41/0016—Oximes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8917047A FR2656310B1 (fr) | 1989-12-22 | 1989-12-22 | Nouveaux produits sterouides comportant en position 10, un radical thioethyle substitue, leur procede de preparation et les intermediaires de ce procede, leur application comme medicaments et les compositions pharmaceutiques les renfermant. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE136035T1 true ATE136035T1 (de) | 1996-04-15 |
Family
ID=9388860
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90403726T ATE136035T1 (de) | 1989-12-22 | 1990-12-21 | Steroidderivate, die ein substituiertes thioethylradikal an der stelle 10 des steroids tragen, verfahren zu ihrer herstellung und zwischenprodukte davon, ihre verwendung als arzneimittel und pharmazeutische präparate davon |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5086047A (de) |
| EP (1) | EP0434570B1 (de) |
| JP (1) | JP3065109B2 (de) |
| AT (1) | ATE136035T1 (de) |
| CA (1) | CA2032989A1 (de) |
| DE (1) | DE69026225T2 (de) |
| DK (1) | DK0434570T3 (de) |
| ES (1) | ES2084682T3 (de) |
| FR (1) | FR2656310B1 (de) |
| GR (1) | GR3019442T3 (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2677027B1 (fr) * | 1991-05-27 | 1993-09-10 | Roussel Uclaf | Nouveaux produits sterouides substitues en position 6, et comportant, en position 10, un radical thioethyle, leur procede de preparation leurs intermediaires, leur application comme medicaments. |
| US6407082B1 (en) * | 1996-09-13 | 2002-06-18 | New Life Pharmaceuticals Inc. | Prevention of ovarian cancer by administration of a vitamin D compound |
| US6511970B1 (en) | 1996-09-13 | 2003-01-28 | New Life Pharmaceuticals Inc. | Prevention of ovarian cancer by administration of products that induce transforming growth factor-beta and/or apoptosis in the ovarian epithelium |
| US6765002B2 (en) | 2000-03-21 | 2004-07-20 | Gustavo Rodriguez | Prevention of ovarian cancer by administration of products that induce transforming growth factor-β and/or apoptosis in the ovarian epithelium |
| US6028064A (en) * | 1996-09-13 | 2000-02-22 | New Life Pharmaceuticals Inc. | Prevention of ovarian cancer by administration of progestin products |
| US6034074A (en) | 1996-09-13 | 2000-03-07 | New Life Pharmaceuticals Inc. | Prevention of ovarian cancer by administration of a Vitamin D compound |
| EP0943333A1 (de) * | 1998-03-18 | 1999-09-22 | S.W. Patentverwertungs GmbH | Medikament zur Prophylaxe und/oder Behandlung des Mammakarzinoms enthaltend einen Hemmer der Bildung von Oestrogenen |
| ATE473759T1 (de) | 1998-05-22 | 2010-07-15 | Univ Leland Stanford Junior | Bifunktionelle moleküle sowie darauf basierende therapien. |
| US20010044431A1 (en) * | 2000-03-21 | 2001-11-22 | Rodriguez Gustavo C. | Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium |
| DE10141937A1 (de) * | 2001-08-28 | 2003-03-27 | Alfred Schmidt | Markierung der Aromatase |
| CN102379684B (zh) | 2005-04-28 | 2014-11-19 | 普罗透斯数字保健公司 | 药物信息系统 |
| US9062126B2 (en) | 2005-09-16 | 2015-06-23 | Raptor Pharmaceuticals Inc. | Compositions comprising receptor-associated protein (RAP) variants specific for CR-containing proteins and uses thereof |
| TWI433674B (zh) | 2006-12-28 | 2014-04-11 | Infinity Discovery Inc | 環杷明(cyclopamine)類似物類 |
| CN104059124A (zh) | 2007-12-27 | 2014-09-24 | 无限药品股份有限公司 | 立体选择性还原的方法 |
| EP2398500B1 (de) | 2009-02-20 | 2019-03-13 | 2-BBB Medicines B.V. | Arzneiabgabesystem auf glutathion-basis |
| ES2942923T3 (es) | 2009-05-06 | 2023-06-07 | Laboratory Skin Care Inc | Composiciones de administración dérmica que comprenden complejos de agente activo-partículas de fosfato de calcio y métodos de uso de las mismas |
| JP6141015B2 (ja) | 2009-08-05 | 2017-06-07 | インフィニティ ファーマスーティカルズ、インク. | シクロパミン類似体の酵素によるアミノ基転移 |
| US9376447B2 (en) | 2010-09-14 | 2016-06-28 | Infinity Pharmaceuticals, Inc. | Transfer hydrogenation of cyclopamine analogs |
| HRP20251395T1 (hr) | 2015-06-04 | 2026-02-13 | Sol-Gel Technologies Ltd. | Topikalne formulacije za isporuku spojeva inhibitora hedgehog signalnog puta i njihova uporaba |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4634694A (en) * | 1984-01-14 | 1987-01-06 | Akzo N.V. | Novel Δ4 - and Δ5 -androstene derivatives and pharmaceutical compositions containing these derivatives |
| DE3714964A1 (de) * | 1987-04-30 | 1988-11-10 | Schering Ag | 15-alkyl-19-thio-4-androsten-3,17-dione, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate |
| DE3714965A1 (de) * | 1987-04-30 | 1988-11-10 | Schering Ag | 3-methylen-4-androsten-17-one, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate |
| EP0334425A1 (de) * | 1988-03-24 | 1989-09-27 | Akzo N.V. | Delta-4-Androstenderivate |
-
1989
- 1989-12-22 FR FR8917047A patent/FR2656310B1/fr not_active Expired - Fee Related
-
1990
- 1990-12-21 CA CA002032989A patent/CA2032989A1/fr not_active Abandoned
- 1990-12-21 ES ES90403726T patent/ES2084682T3/es not_active Expired - Lifetime
- 1990-12-21 JP JP2412675A patent/JP3065109B2/ja not_active Expired - Lifetime
- 1990-12-21 AT AT90403726T patent/ATE136035T1/de not_active IP Right Cessation
- 1990-12-21 DE DE69026225T patent/DE69026225T2/de not_active Expired - Lifetime
- 1990-12-21 EP EP90403726A patent/EP0434570B1/de not_active Expired - Lifetime
- 1990-12-21 DK DK90403726.4T patent/DK0434570T3/da active
- 1990-12-24 US US07/633,291 patent/US5086047A/en not_active Expired - Lifetime
-
1996
- 1996-03-28 GR GR950403177T patent/GR3019442T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK0434570T3 (da) | 1996-05-06 |
| JP3065109B2 (ja) | 2000-07-12 |
| EP0434570B1 (de) | 1996-03-27 |
| GR3019442T3 (en) | 1996-06-30 |
| FR2656310A1 (fr) | 1991-06-28 |
| DE69026225D1 (de) | 1996-05-02 |
| CA2032989A1 (fr) | 1991-06-23 |
| ES2084682T3 (es) | 1996-05-16 |
| US5086047A (en) | 1992-02-04 |
| EP0434570A2 (de) | 1991-06-26 |
| JPH04120091A (ja) | 1992-04-21 |
| DE69026225T2 (de) | 1996-11-14 |
| FR2656310B1 (fr) | 1992-05-07 |
| EP0434570A3 (en) | 1991-10-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69026225D1 (de) | Steroidderivate, die ein substituiertes Thioethylradikal an der Stelle 10 des Steroids tragen, Verfahren zu ihrer Herstellung und Zwischenprodukte davon, ihre Verwendung als Arzneimittel und pharmazeutische Präparate davon | |
| CA2174033A1 (fr) | Nouveaux composes pyridiniques, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent | |
| KR950702181A (ko) | 20-위치가 변형된 비타민 D계열의 유도체, 이들의 제조 방법, 이 제조 방법을 위한 중간 생성물, 이들 유도체를 함유하는 제약 제제, 및 약제 제조를 위한 이들의 용도(Derivatives in the Vitamin D Series Modified at the 20 Position a Method of Preparing Such Derivatives, Intermediates Used in This Method, Pharmaceutical Preparations Containing the Derivatives and Their Use in the Preparation of Drugs) | |
| ATE156835T1 (de) | Neue 11-benzaldoximestradien-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel | |
| DE68914488D1 (de) | 2-(2-Hydroxy-3-phenoxypropylamino)ethylphenoxyacetamide, Verfahren und Zwischenprodukte zu deren Herstellung. | |
| ATE145649T1 (de) | Kardioaktive 17-aryl und 17-heterozyklyl-14 beta- 5alpha-androstane, androstene und androstadiene, ein verfahren zu ihrer herstellung und pharmazeutische präperate davon | |
| HUP9603428A2 (en) | Novel crystalmodification of cdch and process for producing it and pharmaceutical composition containing it | |
| HUT48275A (en) | Process for production of steroides being in new, 17-position containing 3,4 or six members of spiro-chain and medical compositions containing such compounds | |
| ATE24488T1 (de) | 3-hydroxypyrrolidin-2-on-derivate, verfahren und zwischenprodukte zu deren herstellung und diese enthaltende arzneimittel. | |
| ATE150466T1 (de) | Neue 19-nor-steroide mit einer 11-beta- phenoxysulfonamid- oder 11-beta- phenoxysulfonylurea-gruppe, verfahren und zwischenprodukte zu ihrer herstellung sowie medikamenten und pharmazeutische präparate davon | |
| ATE149513T1 (de) | Neue 11-benzaldoxim-17beta methoxy-17alpha- methoxymethyl-estradien-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel | |
| NO303715B1 (no) | Stabilt, vandig apparat | |
| GR3020105T3 (en) | New 17-(methylene)-lactone spiro condensed steroids, method and intermediates for their production, their use as medicines and pharmaceutical compositions containing them | |
| ATE42561T1 (de) | In position 10 durch ein eine doppel- bzw. dreifachbindung enthaltendes radikal substituierte neue steroide, verfahren zu ihrer herstellung, ihre anwendung als heilmittel und diese enthaltende pharmazeutische praeparate. | |
| DE69013815D1 (de) | Omega-Phenylaminoalkansäuren, die durch ein 19-nor-Steroidrest am Phenylrest substituiert sind, ihre Salze, ein Verfahren zu ihrer Herstellung, sowie Zwischenprodukte dieses Verfahrens, ihre Verwendung als Arzneimittel und pharmazeutische Präparate davon. | |
| ATE152118T1 (de) | Kardioaktive 17b-(3-furyl) und 17b-(4- pyridazinyl)-5beta, 14beta-androstan derivate, verfahren zu ihrer herstellung und pharmazeutische präparate davon | |
| ATE172976T1 (de) | 3-aminochroman-spiroderivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen | |
| ATE25849T1 (de) | Tricyclophosphazen-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel. | |
| ATE122356T1 (de) | Neue 17-spiro substituierte steroide, verfahren zu deren herstellung und zwischenprodukten davon, ihre verwendung als arzneimittel sowie pharmazeutische präparate davon. | |
| YU51199A (sh) | Novi 4-halogeni steroidi, postupak i međuproizvodi za njihovo pripremanje, njihova primena kao medikamenata i farmaceutske kompozicije koje ih sadrže | |
| DE3863214D1 (de) | Glutaminsaeurederivate, ihre salze, verfahren zu ihrer herstellung, verwendung als arzneimittel und diese enthaltende zusammensetzungen. | |
| ATE194357T1 (de) | 21-(2-oxo-tetrahydrofuran)-thio pregnan derivative, ein verfahren zu ihrer herstellung und pharmazeutische präparate davon | |
| RU93033697A (ru) | Производные 2-амино-n-[[[4-(аминокарбонил) пиримидин-2-ил]амино] алкил] пиримидин-4-карбоксамида, способ их получения и фармацевтическая композиция на их основе | |
| ATE106384T1 (de) | Ungesättigte derivate von der 2,6- aminoheptandisäure, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel. | |
| ATE163424T1 (de) | Neue 17-(3-imino-2-alkyl-propenyl)-5beta-14beta- androstanderivate, zur behandlung von kardiovaskulären erkrankungen, ein verfahren zu ihrer herstellung und pharmazeutische präparate davon |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |