ATE145649T1 - Kardioaktive 17-aryl und 17-heterozyklyl-14 beta- 5alpha-androstane, androstene und androstadiene, ein verfahren zu ihrer herstellung und pharmazeutische präperate davon - Google Patents

Kardioaktive 17-aryl und 17-heterozyklyl-14 beta- 5alpha-androstane, androstene und androstadiene, ein verfahren zu ihrer herstellung und pharmazeutische präperate davon

Info

Publication number: ATE145649T1
Authority: AT; Austria
Prior art keywords: androstane; heterocyclyl; beta; aryl; androstadienes
Prior art date: 1992-09-29

Application number

AT93112408T

Other languages

English (en)

Inventor

Piero Melloni

Luigi Bernardi

Mara Ferrandi

Marco Frigerio

Marina Mauro

Luisa Quadri

Original Assignee

Sigma Tau Ind Farmaceuti

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-09-29

Filing date

1993-08-03

Publication date

1996-12-15

1993-08-03 Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti

1996-12-15 Application granted granted Critical

1996-12-15 Publication of ATE145649T1 publication Critical patent/ATE145649T1/de

Links

150000001439 androstadienes Chemical class 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
150000001443 androstenes Chemical class 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
239000000825 pharmaceutical preparation Substances 0.000 title 1
NXQOQNROJJFYCJ-FZFXZXLVSA-N androst-16-ene Chemical compound C1CCC[C@]2(C)[C@H]3CC[C@](C)(C=CC4)[C@@H]4[C@@H]3CCC21 NXQOQNROJJFYCJ-FZFXZXLVSA-N 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/003—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring the S atom directly linked to a ring carbon atom of the cyclopenta(a)hydrophenanthrene skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J33/002—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0088—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing unsubstituted amino radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Cardiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Heart & Thoracic Surgery (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT93112408T 1992-09-29 1993-08-03 Kardioaktive 17-aryl und 17-heterozyklyl-14 beta- 5alpha-androstane, androstene und androstadiene, ein verfahren zu ihrer herstellung und pharmazeutische präperate davon ATE145649T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE4232681A DE4232681C2 (de)	1992-09-29	1992-09-29	17-Phenyl- und 17-Furyl-14beta,5alpha-androstan- und androsten- Derivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammensetzung

Publications (1)

Publication Number	Publication Date
ATE145649T1 true ATE145649T1 (de)	1996-12-15

Family

ID=6469164

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93112408T ATE145649T1 (de)	1992-09-29	1993-08-03	Kardioaktive 17-aryl und 17-heterozyklyl-14 beta- 5alpha-androstane, androstene und androstadiene, ein verfahren zu ihrer herstellung und pharmazeutische präperate davon

Country Status (12)

Country	Link
US (2)	US5556846A (de)
EP (1)	EP0590271B1 (de)
JP (1)	JPH06192287A (de)
KR (1)	KR940007054A (de)
AT (1)	ATE145649T1 (de)
CA (1)	CA2106916A1 (de)
DE (2)	DE4232681C2 (de)
DK (1)	DK0590271T3 (de)
ES (1)	ES2094974T3 (de)
GR (1)	GR3021789T3 (de)
HK (1)	HK1005880A1 (de)
ZA (1)	ZA937112B (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1279386B1 (it) *	1994-11-07	1997-12-10	Sigma Tau Ind Farmaceuti	1,5 derivati di 7a-metilperidroinden-3a-oli, attivi sul sistema cardiovascolare, procedimenti per la loro preparazione e composizioni
US5847172A (en) *	1995-06-07	1998-12-08	Magainin Pharmaceuticals Inc.	Certain aminosterol compounds and pharmaceutical compositions including these compounds
US5994334A (en) *	1997-02-05	1999-11-30	University Of Maryland	Androgen synthesis inhibitors
US5994335A (en)	1997-10-17	1999-11-30	The University Of Maryland, Baltimore	17-azolyl steroids useful as androgen synthesis inhibitors
US20100048524A1 (en)	2008-03-14	2010-02-25	Angela Brodie	Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens;Synthesis In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity
CA2723689C (en) *	2008-05-05	2016-07-05	Ryan A. Shenvi	Synthesis of (+) cortistatin a and related compounds
EP2393827B1 (de)	2009-02-05	2015-10-07	Tokai Pharmaceuticals, Inc.	Neue prodrugs von steroiden cyp17-inhibitoren/antiandrogenen
BRPI1012240A2 (pt)	2009-03-23	2018-06-12	Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.	derivados de 5-beta, beta-14-androstana úteis para o tratamento de proteinúria, de glomeruloesclerose e de insuficiência renal
AU2010319697B2 (en) *	2009-11-13	2016-05-19	Tokai Pharmaceuticals, Inc.	Mammalian metabolites of steroids
EP4717314A2 (de)	2011-10-14	2026-04-01	Sage Therapeutics, LLC	3,3 disubstituierte 19-nor-pregnanverbindungen, zusammensetzungen und verwendungen davon
CA2904170A1 (en)	2013-03-14	2014-09-25	University Of Maryland, Baltimore	Androgen receptor down-regulating agents and uses thereof
WO2014169836A1 (en)	2013-04-17	2014-10-23	Sage Therapeutics, Inc.	19-nor neuroactive steroids and methods of use thereof
US9725481B2 (en)	2013-04-17	2017-08-08	Sage Therapeutics, Inc.	19-nor C3, 3-disubstituted C21-C-bound heteroaryl steroids and methods of use thereof
SMT202100509T1 (it)	2013-04-17	2021-11-12	Sage Therapeutics Inc	Steroide di c21-n-pirazolile 19-nor c3,3-disostituito per l'uso in terapia
CN117304245A (zh)	2013-04-17	2023-12-29	萨奇治疗股份有限公司	刺激神经活性的19-去甲类固醇及其使用方法
CA2918735C (en)	2013-07-19	2023-08-01	Sage Therapeutics, Inc.	Neuroactive steroids, compositions, and uses thereof
KR20160058774A (ko)	2013-08-12	2016-05-25	토카이 파마슈티컬, 아이엔씨.	안드로겐-표적 치료제를 이용하는 종양 질환 치료를 위한 바이오마커
CN105579043B (zh)	2013-08-23	2021-09-14	萨奇治疗股份有限公司	神经活性类固醇、组合物和其用途
US10246482B2 (en)	2014-06-18	2019-04-02	Sage Therapeutics, Inc.	Neuroactive steroids, compositions, and uses thereof
MY190408A (en)	2014-10-16	2022-04-21	Sage Therapeutics Inc	Compositions and methods for treating cns disorders
US20170233433A1 (en)	2014-10-16	2017-08-17	Sage Therapeutics, Inc.	Compositions and methods for treating cns disorders
WO2016082789A1 (en)	2014-11-27	2016-06-02	Sage Therapeutics, Inc.	Compositions and methods for treating cns disorders
LT3250210T (lt)	2015-01-26	2021-04-12	Sage Therapeutics, Inc.	Kompozicijos ir būdai, skirti gydyti cns sutrikimus
DK3258939T3 (da)	2015-02-20	2022-12-12	Sage Therapeutics Inc	Neuroaktive steroider, sammensætninger og anvendelser heraf
WO2018013613A1 (en)	2016-07-11	2018-01-18	Sage Therapeutics, Inc.	C17, c20, and c21 substituted neuroactive steroids and their methods of use
CA3030420C (en)	2016-07-11	2025-11-18	Sage Therapeutics, Inc.	C7, C12 AND C16 SUBSTITUTED NEUROACTIVE STEROIDS AND ASSOCIATED METHODS OF USE
JP7670626B2 (ja)	2019-05-31	2025-04-30	セージセラピューティクス，インコーポレイテッド	神経刺激性ステロイド及びその組成物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3405127A (en) *	1965-07-13	1968-10-08	Sterling Drug Inc	12, 17-dioxygenated steroids
DE1768800C3 (de) *	1968-07-02	1978-07-06	Hoechst Ag, 6000 Frankfurt	Verfahren zur Herstellung von 14 ß- Hydroxy-3oxo-5 a-card-20(22)- enoliden
DE2614046C2 (de) *	1976-04-01	1984-08-02	Boehringer Mannheim Gmbh, 6800 Mannheim	Neue 17α-Hydroxy-Cardenolid-Glykoside, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
DE3832303A1 (de) *	1988-09-20	1990-04-12	Schering Ag	11ss-phenyl-14ssh-steroide
IT1250410B (it) *	1991-02-14	1995-04-07	Simes	Composti steroidei attivi sul sistema cardiovascolare
DE4232638C2 (de) *	1992-09-29	1994-11-17	Sigma Tau Ind Farmaceuti	17-Phenyl-5beta-14beta-androstanderivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammensetzungen

1992
- 1992-09-29 DE DE4232681A patent/DE4232681C2/de not_active Expired - Fee Related
1993
- 1993-08-03 DE DE69306212T patent/DE69306212T2/de not_active Expired - Fee Related
- 1993-08-03 ES ES93112408T patent/ES2094974T3/es not_active Expired - Lifetime
- 1993-08-03 AT AT93112408T patent/ATE145649T1/de not_active IP Right Cessation
- 1993-08-03 EP EP93112408A patent/EP0590271B1/de not_active Expired - Lifetime
- 1993-08-03 DK DK93112408.5T patent/DK0590271T3/da active
- 1993-09-24 ZA ZA937112A patent/ZA937112B/xx unknown
- 1993-09-24 CA CA002106916A patent/CA2106916A1/en not_active Abandoned
- 1993-09-27 KR KR1019930019823A patent/KR940007054A/ko not_active Ceased
- 1993-09-29 JP JP5243361A patent/JPH06192287A/ja active Pending
- 1993-09-29 US US08/128,116 patent/US5556846A/en not_active Expired - Fee Related
1995
- 1995-11-03 US US08/552,796 patent/US5721227A/en not_active Expired - Fee Related
1996
- 1996-11-28 GR GR960402277T patent/GR3021789T3/el unknown
1998
- 1998-06-05 HK HK98104949A patent/HK1005880A1/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE69306212T2 (de)	1997-04-24
CA2106916A1 (en)	1994-03-30
US5556846A (en)	1996-09-17
US5721227A (en)	1998-02-24
DE4232681C2 (de)	1994-11-24
ES2094974T3 (es)	1997-02-01
EP0590271A2 (de)	1994-04-06
JPH06192287A (ja)	1994-07-12
DK0590271T3 (da)	1996-12-16
HK1005880A1 (en)	1999-01-29
ZA937112B (en)	1995-07-25
KR940007054A (ko)	1994-04-26
GR3021789T3 (en)	1997-02-28
EP0590271A3 (en)	1994-07-06
DE4232681A1 (de)	1994-03-31
EP0590271B1 (de)	1996-11-27
DE69306212D1 (de)	1997-01-09

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Legal Events

Date	Code	Title	Description
1997-07-15	UEP	Publication of translation of european patent specification
2001-05-15	REN	Ceased due to non-payment of the annual fee