ATE136878T1 - Neue methoden zur katalytischen reduktion organischer substrate - Google Patents

Neue methoden zur katalytischen reduktion organischer substrate

Info

Publication number
ATE136878T1
ATE136878T1 AT92901632T AT92901632T ATE136878T1 AT E136878 T1 ATE136878 T1 AT E136878T1 AT 92901632 T AT92901632 T AT 92901632T AT 92901632 T AT92901632 T AT 92901632T AT E136878 T1 ATE136878 T1 AT E136878T1
Authority
AT
Austria
Prior art keywords
ketones
catalysts
enriched
reduced
catalytic reduction
Prior art date
Application number
AT92901632T
Other languages
English (en)
Inventor
Stephen L Buchwald
Kristina A Kreutzer
Christopher A Willoughby
Robert B Grossman
Scott C Berk
Esther Spaltenstein
Alberto Gutierrez
Original Assignee
Massachusetts Inst Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/616,892 external-priority patent/US5286878A/en
Priority claimed from US07/792,227 external-priority patent/US5227538A/en
Priority claimed from US07/792,233 external-priority patent/US5220020A/en
Priority claimed from US07/792,229 external-priority patent/US5292893A/en
Application filed by Massachusetts Inst Technology filed Critical Massachusetts Inst Technology
Application granted granted Critical
Publication of ATE136878T1 publication Critical patent/ATE136878T1/de

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/023Preparation; Separation; Stabilisation; Use of additives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B41/00Formation or introduction of functional groups containing oxygen
    • C07B41/02Formation or introduction of functional groups containing oxygen of hydroxy or O-metal groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B43/00Formation or introduction of functional groups containing nitrogen
    • C07B43/04Formation or introduction of functional groups containing nitrogen of amino groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/44Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers
    • C07C209/52Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers by reduction of imines or imino-ethers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/143Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of ketones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/147Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/15Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of oxides of carbon exclusively
    • C07C29/151Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of oxides of carbon exclusively with hydrogen or hydrogen-containing gases
    • C07C29/153Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of oxides of carbon exclusively with hydrogen or hydrogen-containing gases characterised by the catalyst used
    • C07C29/156Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of oxides of carbon exclusively with hydrogen or hydrogen-containing gases characterised by the catalyst used containing iron group metals, platinum group metals or compounds thereof
    • C07C29/157Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of oxides of carbon exclusively with hydrogen or hydrogen-containing gases characterised by the catalyst used containing iron group metals, platinum group metals or compounds thereof containing platinum group metals or compounds thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/06Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07Optical isomers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/02Systems containing only non-condensed rings with a three-membered ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT92901632T 1990-11-21 1991-11-21 Neue methoden zur katalytischen reduktion organischer substrate ATE136878T1 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US07/616,892 US5286878A (en) 1990-11-21 1990-11-21 Catalytic reduction of organic carbonyls
US69894091A 1991-05-13 1991-05-13
US69893991A 1991-05-13 1991-05-13
US74911191A 1991-08-23 1991-08-23
US07/792,227 US5227538A (en) 1990-11-21 1991-11-14 Catalytic asymmetric reduction of ketones using metal catalysts
US07/792,233 US5220020A (en) 1990-11-21 1991-11-14 Catalytic reduction of organic carbonyls using metal catalysts
US07/792,229 US5292893A (en) 1990-11-21 1991-11-14 Catalytic asymmetric and non-asymmetric reduction of times and oximes using metal catalysts

Publications (1)

Publication Number Publication Date
ATE136878T1 true ATE136878T1 (de) 1996-05-15

Family

ID=27569855

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92901632T ATE136878T1 (de) 1990-11-21 1991-11-21 Neue methoden zur katalytischen reduktion organischer substrate

Country Status (6)

Country Link
EP (1) EP0558656B1 (de)
JP (1) JPH06502867A (de)
AT (1) ATE136878T1 (de)
CA (1) CA2096747A1 (de)
DE (1) DE69118906T2 (de)
WO (1) WO1992009545A2 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5489682A (en) * 1990-11-21 1996-02-06 Massachusetts Institute Of Technology Catalytic asymmetric reduction of enamines
DE19525184A1 (de) * 1995-07-11 1997-01-16 Basf Ag Verfahren zur Umwandlung der achiralen meso-Form oder des Racemats eines ansa-Metallocenkomplexes oder deren Mischungen in eines seiner Enantiomeren
GB9623685D0 (en) * 1996-11-14 1997-01-08 British Nuclear Fuels Plc Improvements in and relating to compounds and catalysts
GB2335151A (en) * 1996-11-14 1999-09-15 British Nuclear Fuels Plc Improvements in and relating to compounds and catalysts
DE19730880A1 (de) * 1997-07-18 1999-01-21 Basf Ag Verfahren zur selektiven Herstellung von racemischen ansa-Metallocenkomplexen
DE19741876A1 (de) 1997-09-23 1999-03-25 Basf Ag Verfahren zur selektiven Herstellung racemischer Metallocenkomplexe
DE10030638A1 (de) 2000-06-29 2002-01-10 Basell Polyolefine Gmbh Verfahren zur selektiven Herstellung racemischer Metallocenkomplexe
DE60324172D1 (de) 2002-10-25 2008-11-27 Basell Polyolefine Gmbh Razemoselektive herstellung isolierbarer ansa-metallocen-biphenoxid-komplexe
DE10250025A1 (de) 2002-10-25 2004-05-06 Basell Polyolefine Gmbh Verfahren zur Darstellung teilweise hydrierter rac-ansa-Metallocen-Komplexe
DE10250062A1 (de) 2002-10-25 2004-05-06 Basell Polyolefine Gmbh Verfahren zur racemoselektiven Darstellung von verbrückten Metallocenkomplexen mit unsubstituierten oder 2-substituierten Indenylliganden
AU2003294243A1 (en) * 2002-11-06 2004-07-22 Penn State Research Foundation Asymmetric reductive amination of ketones
PL1641740T3 (pl) * 2003-05-23 2009-09-30 Sumitomo Chemical Co Sposób wytwarzania optycznie aktywnego związku nitrowego
FR2869313B1 (fr) * 2004-04-23 2008-09-05 Rhodia Chimie Sa Procede de reduction d'un groupe fonctionnel sous forme oxydee
EP2066601B1 (de) * 2006-09-28 2012-10-24 Agency for Science, Technology And Research Hydrosilylierung
US8975443B2 (en) 2010-07-16 2015-03-10 Abbvie Inc. Phosphine ligands for catalytic reactions
US9255074B2 (en) 2010-07-16 2016-02-09 Abbvie Inc. Process for preparing antiviral compounds
EP3461556A1 (de) 2010-07-16 2019-04-03 AbbVie Ireland Unlimited Company Phosphinliganden für katalytische reaktionen
EP3056486B1 (de) 2010-07-16 2018-07-11 AbbVie Ireland Unlimited Company Verfahren zur herstellung von zwischenverbindungen antiviraler verbindungen
CN115386089B (zh) * 2022-08-29 2023-07-11 万华化学集团股份有限公司 一种硅烷低聚物的制备方法与应用

Also Published As

Publication number Publication date
EP0558656B1 (de) 1996-04-17
CA2096747A1 (en) 1992-05-22
JPH06502867A (ja) 1994-03-31
WO1992009545A3 (en) 1992-10-29
DE69118906D1 (de) 1996-05-23
WO1992009545A2 (en) 1992-06-11
EP0558656A1 (de) 1993-09-08
DE69118906T2 (de) 1996-11-28

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