ATE383325T1 - Verfahren zur herstellung von optisch aktivem alkohol in gegenwart von rhodium, einem chiralen ferrocenyldiphosphin und einem optisch aktivem diamin - Google Patents
Verfahren zur herstellung von optisch aktivem alkohol in gegenwart von rhodium, einem chiralen ferrocenyldiphosphin und einem optisch aktivem diaminInfo
- Publication number
- ATE383325T1 ATE383325T1 AT04717253T AT04717253T ATE383325T1 AT E383325 T1 ATE383325 T1 AT E383325T1 AT 04717253 T AT04717253 T AT 04717253T AT 04717253 T AT04717253 T AT 04717253T AT E383325 T1 ATE383325 T1 AT E383325T1
- Authority
- AT
- Austria
- Prior art keywords
- optically active
- rhodium
- ferrocenyldiphospine
- chiral
- diamine
- Prior art date
Links
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 title abstract 2
- 150000004985 diamines Chemical class 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 229910052703 rhodium Inorganic materials 0.000 title abstract 2
- 239000010948 rhodium Substances 0.000 title abstract 2
- MHOVAHRLVXNVSD-UHFFFAOYSA-N rhodium atom Chemical compound [Rh] MHOVAHRLVXNVSD-UHFFFAOYSA-N 0.000 title abstract 2
- 238000009876 asymmetric hydrogenation reaction Methods 0.000 abstract 2
- VURFVHCLMJOLKN-UHFFFAOYSA-N diphosphane Chemical compound PP VURFVHCLMJOLKN-UHFFFAOYSA-N 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 150000001298 alcohols Chemical class 0.000 abstract 1
- 150000001728 carbonyl compounds Chemical class 0.000 abstract 1
- 230000002349 favourable effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B53/00—Asymmetric syntheses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
- C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
- C07C29/143—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of ketones
- C07C29/145—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of ketones with hydrogen or hydrogen-containing gases
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/31—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of functional groups containing oxygen only in singly bound form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003061843 | 2003-03-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE383325T1 true ATE383325T1 (de) | 2008-01-15 |
Family
ID=32958977
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04717253T ATE383325T1 (de) | 2003-03-07 | 2004-03-04 | Verfahren zur herstellung von optisch aktivem alkohol in gegenwart von rhodium, einem chiralen ferrocenyldiphosphin und einem optisch aktivem diamin |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP1601635B1 (de) |
| AT (1) | ATE383325T1 (de) |
| DE (1) | DE602004011193D1 (de) |
| WO (1) | WO2004078686A1 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4490211B2 (ja) * | 2004-08-27 | 2010-06-23 | 高砂香料工業株式会社 | 光学活性３−キヌクリジノール類の製造方法 |
| JP5172124B2 (ja) | 2006-09-29 | 2013-03-27 | 関東化学株式会社 | ２位に置換基を有する光学活性キヌクリジノール類の製造方法 |
| DE102009030291A1 (de) * | 2009-06-24 | 2011-01-05 | Cu Chemie Uetikon Gmbh | Enantiomerenreine tricyclische Verbindung und Verfahren zur diastereomerenreinen und enantiomerenreinen Herstellung bicyclischer und tricyclischer Verbindungen |
| US10526287B2 (en) | 2015-04-23 | 2020-01-07 | Constellation Pharmaceuticals, Inc. | LSD1 inhibitors and uses thereof |
| TWI753037B (zh) | 2016-10-26 | 2022-01-21 | 美商星座製藥公司 | Lsd1抑制劑及其用途 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0785198T3 (da) * | 1996-01-19 | 2000-11-13 | Lonza Ag | Fremgangsmåde til fremstilling af optisk aktiv 3-quinuclidinol |
-
2004
- 2004-03-04 AT AT04717253T patent/ATE383325T1/de not_active IP Right Cessation
- 2004-03-04 DE DE602004011193T patent/DE602004011193D1/de not_active Expired - Lifetime
- 2004-03-04 WO PCT/JP2004/002776 patent/WO2004078686A1/en not_active Ceased
- 2004-03-04 EP EP04717253A patent/EP1601635B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1601635A1 (de) | 2005-12-07 |
| EP1601635B1 (de) | 2008-01-09 |
| DE602004011193D1 (de) | 2008-02-21 |
| WO2004078686A1 (en) | 2004-09-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |