ATE167670T1 - N-alkylthiopolyaminderivate als radioprotektive mittel - Google Patents

N-alkylthiopolyaminderivate als radioprotektive mittel

Info

Publication number: ATE167670T1
Authority: AT; Austria
Prior art keywords: alkylthiopolyamine; derivatives; radioprotective agents; radioprotective; agents
Prior art date: 1993-05-26

Application number

AT94917900T

Other languages

English (en)

Inventor

Michael L Edwards

Ronald D Snyder

Original Assignee

Merrell Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-05-26

Filing date

1994-04-28

Publication date

1998-07-15

1994-04-28 Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc

1998-07-15 Application granted granted Critical

1998-07-15 Publication of ATE167670T1 publication Critical patent/ATE167670T1/de

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/16—Esters of thiophosphoric acids or thiophosphorous acids
- C07F9/165—Esters of thiophosphoric acids
- C07F9/1651—Esters of thiophosphoric acids with hydroxyalkyl compounds with further substituents on alkyl

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Steroid Compounds (AREA)
Polyamides (AREA)

AT94917900T 1993-05-26 1994-04-28 N-alkylthiopolyaminderivate als radioprotektive mittel ATE167670T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US6930293A	1993-05-26	1993-05-26

Publications (1)

Publication Number	Publication Date
ATE167670T1 true ATE167670T1 (de)	1998-07-15

Family

ID=22088062

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94917900T ATE167670T1 (de)	1993-05-26	1994-04-28	N-alkylthiopolyaminderivate als radioprotektive mittel

Country Status (19)

Country	Link
US (1)	US5434145A (de)
EP (1)	EP0700380B1 (de)
KR (1)	KR960702830A (de)
CN (1)	CN1124483A (de)
AT (1)	ATE167670T1 (de)
AU (1)	AU679236B2 (de)
CA (1)	CA2161869C (de)
DE (1)	DE69411271T2 (de)
DK (1)	DK0700380T3 (de)
ES (1)	ES2119203T3 (de)
FI (1)	FI955643A7 (de)
GR (1)	GR3027657T3 (de)
HU (1)	HUT73421A (de)
IL (1)	IL109720A (de)
MX (1)	MX9403915A (de)
NO (1)	NO306020B1 (de)
NZ (1)	NZ267211A (de)
WO (1)	WO1994027961A1 (de)
ZA (1)	ZA943520B (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5677351A (en) *	1986-12-02	1997-10-14	University Of Florida Research Foundation, Inc.	Sterically hindered tetraamines and method for their production
US5342945A (en) *	1986-12-02	1994-08-30	University Of Florida Research Foundation, Inc.	Anti-neoplastic, anti-viral or anti-retroviral spermine derivatives
US5393757A (en) *	1986-12-02	1995-02-28	University Of Florida	Polyamines and anti-diarrheal and gastrointestinal anti-spasmodic pharmaceutical compositions and methods of treatment
US5567686A (en) *	1992-03-13	1996-10-22	Arch Development Corporation	Method for protection against genotoxic mutagenesis
US5869338A (en) *	1992-03-13	1999-02-09	Arch Development Corporation	Method for protection against genotoxic mutagenesis
US5994409A (en) *	1997-12-09	1999-11-30	U.S. Bioscience, Inc.	Methods for treatment of neuro--and nephro--disorders and therapeutic toxicities using aminothiol compounds
CN1336015A (zh) *	1998-12-15	2002-02-13	杜拉塞尔公司	电化学电池封装
US7312244B2 (en) *	1999-04-30	2007-12-25	Cellgate, Inc.	Polyamine analog-amino acid conjugates useful as anticancer agents
WO2000066175A2 (en) *	1999-04-30	2000-11-09	Slil Biomedical Corporation	Conjugates as therapies for cancer and prostate diseases
IL146127A0 (en)	1999-04-30	2002-07-25	Slil Biomedical Corp	Conformationally restricted polymine analogs as disease therapies
US6649587B1 (en)	1999-04-30	2003-11-18	Slil Biomedical Corporation	Polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases
US6482943B1 (en)	1999-04-30	2002-11-19	Slil Biomedical Corporation	Quinones as disease therapies
US6489312B1 (en)	1999-06-15	2002-12-03	Medimmune Oncology, Inc.	Pharmaceutical formulations comprising aminoalkyl phosphorothioates
US6160022A (en) *	1999-07-19	2000-12-12	University Of Florida	Chemical resection of pancreas
US7053072B2 (en)	2001-05-11	2006-05-30	Medimmune Oncology, Inc.	Methods for the administration of amifostine and related compounds
WO2003013245A1 (en) *	2001-08-07	2003-02-20	Wisconsin Alumni Research Foundation	Polyamines and analogs for protecting cells during cancer chemotherapy and radiotherapy
US6982351B2 (en) *	2001-12-07	2006-01-03	Cellgate, Inc.	Cycloalkyl substituted polyamines for cancer therapy and methods of synthesis therefor
WO2003066572A1 (en) *	2002-02-07	2003-08-14	Wisconsin Alumni Research Foundation	Polyamine compounds and compositions for use in conjunction with cancer therapy
US7314959B2 (en)	2003-08-07	2008-01-01	Wisconsin Alumni Research Foundation	Amino thiol compounds and compositions for use in conjunction with cancer therapy
US7754463B2 (en) *	2006-06-20	2010-07-13	Dana-Farber Cancer Institute	Inhibitors of USP1 Deubiquitinating Enzyme Complex
US20100049284A1 (en) *	2008-05-15	2010-02-25	The Catholic University Of America	Use of heat to treat biological systems exposed to damaging radiation
US9518032B2 (en)	2010-04-30	2016-12-13	Dana-Farber Cancer Institute, Inc.	Small molecule inhibitors of USP1 deubiquitinating enzyme activity
US9725425B1 (en)	2014-02-25	2017-08-08	Dana-Farber Cancer Institute, Inc.	Compounds and methods for treating cancer

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2653977A (en) *		1953-09-29		Chxnx
US2951092A (en) *	1956-12-13	1960-08-30	Olin Mathieson	Triamine derivatives
US3892824A (en) *	1968-12-16	1975-07-01	Southern Res Inst	S-{107 -({107 -aminoalkylamino)alkyl dihydrogen phosphorothioates
US5091576A (en) *	1986-12-02	1992-02-25	University Of Florida	Anti-neoplastic, anti-viral or anti-retroviral spermine derivatives
US5342945A (en) *	1986-12-02	1994-08-30	University Of Florida Research Foundation, Inc.	Anti-neoplastic, anti-viral or anti-retroviral spermine derivatives
US5109024A (en) *	1987-02-03	1992-04-28	Merrell Dow Pharmaceuticals Inc.	Polyamine derivatives as antineoplastic agents
US5217964A (en) *	1991-01-23	1993-06-08	Merrell Dow Pharmaceuticals Inc.	Polyamine thiols as radioprotective agents
US5488042A (en) *	1992-03-13	1996-01-30	Arch Development Corporation	Method for protection against genotoxic mutagenesis

1994
- 1994-04-28 DE DE69411271T patent/DE69411271T2/de not_active Expired - Fee Related
- 1994-04-28 CN CN94192245A patent/CN1124483A/zh active Pending
- 1994-04-28 NZ NZ267211A patent/NZ267211A/en unknown
- 1994-04-28 FI FI955643A patent/FI955643A7/fi unknown
- 1994-04-28 HU HU9503370A patent/HUT73421A/hu unknown
- 1994-04-28 DK DK94917900T patent/DK0700380T3/da active
- 1994-04-28 CA CA002161869A patent/CA2161869C/en not_active Expired - Fee Related
- 1994-04-28 AU AU69428/94A patent/AU679236B2/en not_active Ceased
- 1994-04-28 ES ES94917900T patent/ES2119203T3/es not_active Expired - Lifetime
- 1994-04-28 AT AT94917900T patent/ATE167670T1/de not_active IP Right Cessation
- 1994-04-28 EP EP94917900A patent/EP0700380B1/de not_active Expired - Lifetime
- 1994-04-28 WO PCT/US1994/004662 patent/WO1994027961A1/en not_active Ceased
- 1994-05-20 ZA ZA943520A patent/ZA943520B/xx unknown
- 1994-05-22 IL IL10972094A patent/IL109720A/xx not_active IP Right Cessation
- 1994-05-25 MX MX9403915A patent/MX9403915A/es not_active IP Right Cessation
- 1994-10-14 US US08/323,472 patent/US5434145A/en not_active Expired - Fee Related
1995
- 1995-11-24 NO NO954768A patent/NO306020B1/no unknown
- 1995-11-25 KR KR1019950705352A patent/KR960702830A/ko not_active Ceased
1998
- 1998-08-14 GR GR980401833T patent/GR3027657T3/el unknown

Also Published As

Publication number	Publication date
WO1994027961A1 (en)	1994-12-08
IL109720A (en)	1999-09-22
US5434145A (en)	1995-07-18
FI955643A0 (fi)	1995-11-23
NO954768L (no)	1996-01-23
ES2119203T3 (es)	1998-10-01
NO306020B1 (no)	1999-09-06
CA2161869C (en)	2001-11-13
NO954768D0 (no)	1995-11-24
AU679236B2 (en)	1997-06-26
CA2161869A1 (en)	1994-12-08
HU9503370D0 (en)	1996-01-29
AU6942894A (en)	1994-12-20
EP0700380A1 (de)	1996-03-13
DK0700380T3 (da)	1998-11-09
NZ267211A (en)	1997-11-24
DE69411271D1 (de)	1998-07-30
CN1124483A (zh)	1996-06-12
IL109720A0 (en)	1994-08-26
DE69411271T2 (de)	1998-11-05
HUT73421A (en)	1996-07-29
FI955643L (fi)	1995-11-23
FI955643A7 (fi)	1995-11-23
MX9403915A (es)	1995-01-31
GR3027657T3 (en)	1998-11-30
EP0700380B1 (de)	1998-06-24
KR960702830A (ko)	1996-05-23
ZA943520B (en)	1995-01-23

Legal Events

Date	Code	Title	Description
1999-02-15	UEP	Publication of translation of european patent specification
2004-01-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
KR960702830A (ko)	1996-05-23	방사선 보호제로서의 N-알킬티오 폴리아민 유도체(N-Alkylthio polyaine derivatives as radioprotective agents)
BR9808491A (pt)	2000-05-23	Compostos calcilìticos
DK1200418T3 (da)	2004-07-26	Nematodicide trifluorbutener
ES2195970T3 (es)	2003-12-16	L-ribavirina y usos de la misma.
NL300304I1 (nl)	2008-01-02	Pleuromutilinderivaten als anti-bacteriele middelen.
IT1271014B (it)	1997-05-26	3-aril-benzofuranoni come agenti stabilizzanti
DK1097173T3 (da)	2008-09-01	Anvendelse af peptider af IL-2 og derivater deraf som terapeutiske midler
BG99177A (bg)	1995-07-28	Нови 7 бета-заместени-4-аза-5 алфа-холестанони като инхибитори на 5 алфа-редуктаза
ATE203519T1 (de)	2001-08-15	Chinolinderivate als antimalariamittel
MXPA94001345A (es)	2010-10-04	Derivados de poliamina como agentes radioprotectores.
FI970448L (fi)	1997-04-03	N-substituoituja 3-atsobisyklo(3.2.0)heptaanijohdannaisia,jotka ovat käyttökelpoisia neuroleptisina aineina
BG100248A (bg)	1996-07-31	Инхибитори на скваленсинтетаза
BG101221A (bg)	1997-08-29	N-заместени азабициклохептанови производни, приложими като невролептици
TR200003203T2 (tr)	2001-03-21	Karboksaldehitin saflaştırılması
ATE238791T1 (de)	2003-05-15	Verwendung von 2-methyl-thiazolidin-2,4- dicarbonsäure als mukolytikum
DK0720597T3 (da)	1998-10-07	Triarylethylenderivater til terapeutisk anvendelse
FI930265A0 (fi)	1993-01-22	Antikoagulantpeptider
DE59803066D1 (de)	2002-03-21	Substituierte benzyloxyimino-verbindungen
ATE136884T1 (de)	1996-05-15	Neue 2-mercaptomethylen-tetrahydronaphthalin- und -indan-2-carboxamide als enkephalinaseinhibitoren
FI945414A0 (fi)	1994-11-17	Menetelmä N,N-disubstituoidun aminofenolin valmistamiseksi
YU48719B (sh)	1999-07-28	Lizin so 6-hloro-5-fluoro-3-(2-tenoil)-2-oksindol-1-karboksamida
FI920186A0 (fi)	1992-01-16	Polyaminfenoler som skyddar mot straolning.
ITMI931785A1 (it)	1995-02-06	Valilamidi di 7alfa-amino-1, 1-dioxo-cefem
TR199801087T2 (xx)	1998-09-21	4,10 �- diasetoksi-2alfa-Benzoiloksi- 5 �, 20 epoksi-1- hidroksi-9- okso-19- norsiklopropa(G) taks-11- en- 13alfa-il
HN1998000014A (es)	1999-11-03	Metodo de purificacion de 1,3,5, trii sopropilbenceno