ATE138930T1 - 4-substitutiertes 17-beta-(cyclopropyloxy)androst-5-en-3-beta-ol und seine derivate, verwendbar als inhibitoren der c17-20-lyase - Google Patents

4-substitutiertes 17-beta-(cyclopropyloxy)androst-5-en-3-beta-ol und seine derivate, verwendbar als inhibitoren der c17-20-lyase

Info

Publication number: ATE138930T1
Authority: AT; Austria
Prior art keywords: beta; androst; cyclopropyloxy; substituted; lyase
Prior art date: 1989-08-15

Application number

AT90115390T

Other languages

English (en)

Inventor

Michael R Angelastro

Thomas R Blohm

Original Assignee

Merrell Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-08-15

Filing date

1990-08-10

Publication date

1996-06-15

1990-08-10 Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc

1996-06-15 Application granted granted Critical

1996-06-15 Publication of ATE138930T1 publication Critical patent/ATE138930T1/de

Links

LYFPAZBMEUSVNA-UHFFFAOYSA-N (10R)-3c-Hydroxy-10r.13c-dimethyl-(8cH.9tH.14tH)-Delta5-tetradecahydro-1H-cyclopenta[a]phenanthren Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCCC1(C)CC2 LYFPAZBMEUSVNA-UHFFFAOYSA-N 0.000 title 1
LYFPAZBMEUSVNA-DYKIIFRCSA-N (3s,8s,9s,10r,13s,14s)-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-3-ol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CCC[C@@]1(C)CC2 LYFPAZBMEUSVNA-DYKIIFRCSA-N 0.000 title 1
102000004317 Lyases Human genes 0.000 title 1
108090000856 Lyases Proteins 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
238000006932 Simmons-Smith cyclopropanation reaction Methods 0.000 abstract 1
QYKIQEUNHZKYBP-UHFFFAOYSA-N Vinyl ether Chemical compound C=COC=C QYKIQEUNHZKYBP-UHFFFAOYSA-N 0.000 abstract 1
239000003098 androgen Substances 0.000 abstract 1
230000001419 dependent effect Effects 0.000 abstract 1
150000002170 ethers Chemical class 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
- C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
- C07J1/0029—Ethers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
- C07J1/0037—Androstane derivatives substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being a saturated hydrocarbon group

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)

AT90115390T 1989-08-15 1990-08-10 4-substitutiertes 17-beta-(cyclopropyloxy)androst-5-en-3-beta-ol und seine derivate, verwendbar als inhibitoren der c17-20-lyase ATE138930T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/394,026 US4966897A (en)	1989-08-15	1989-08-15	4-substituted 17β-(cyclopropyloxy)androst-5-en-3β-ol and related compounds useful as C17-20 lyase inhibitors

Publications (1)

Publication Number	Publication Date
ATE138930T1 true ATE138930T1 (de)	1996-06-15

Family

ID=23557245

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90115390T ATE138930T1 (de)	1989-08-15	1990-08-10	4-substitutiertes 17-beta-(cyclopropyloxy)androst-5-en-3-beta-ol und seine derivate, verwendbar als inhibitoren der c17-20-lyase

Country Status (22)

Country	Link
US (1)	US4966897A (de)
EP (1)	EP0413269B1 (de)
JP (1)	JP2879702B2 (de)
KR (1)	KR910004650A (de)
CN (1)	CN1050195A (de)
AT (1)	ATE138930T1 (de)
AU (1)	AU628210B2 (de)
CA (1)	CA2023008C (de)
DD (1)	DD298106A5 (de)
DE (1)	DE69027262T2 (de)
DK (1)	DK0413269T3 (de)
ES (1)	ES2090064T3 (de)
FI (1)	FI95711C (de)
GR (1)	GR3020797T3 (de)
HU (1)	HUT55030A (de)
IE (1)	IE902941A1 (de)
IL (1)	IL95359A (de)
NO (1)	NO903565L (de)
NZ (1)	NZ234855A (de)
PH (1)	PH27549A (de)
PT (1)	PT94994B (de)
ZA (1)	ZA906307B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4966898A (en) *	1989-08-15	1990-10-30	Merrell Dow Pharmaceuticals Inc.	4-substituted 17β-(cyclopropylamino)androst-5-en-3β-ol and related compounds useful as C17-20 lyase inhibitors
WO1994020520A1 (en) *	1993-03-10	1994-09-15	Magainin Pharmaceuticals Inc.	Steroid derivatives, pharmaceutical compositions containing them, and their use as antibiotics or disinfectants
US5486511A (en) *	1993-05-25	1996-01-23	Merrell Dow Pharmaceuticals Inc.	4-amino-17β-(cyclopropyloxy)androst-4-en-3-one, 4-amino-17β-(cyclopropylamino)androst-4-en-3-one and related compounds as C17-20 lyase and 5α-reductase
TW369521B (en) *	1993-09-17	1999-09-11	Smithkline Beecham Corp	Androstenone derivative
US5856535A (en) *	1994-08-18	1999-01-05	Magainin Pharmaceuticals, Inc.	Aminosterol ester compounds
US5840740A (en) *	1995-06-07	1998-11-24	Magainin Pharmaceuticals Inc.	Aminosterol compounds and a method of treating infection using the aminosterol compounds
US5541322A (en) *	1994-10-14	1996-07-30	Glaxo Wellcome Inc.	Synthesis of 6-azaandrostenones
US5661141A (en) *	1995-03-27	1997-08-26	Petrow; Vladimir	19-oxygenated steroids as therapeutic agents
US5874597A (en) *	1995-06-07	1999-02-23	Magainin Pharmaceuticals, Inc.	Certain aminosterol compounds and pharmaceutical compositions including these compounds
US5840936A (en) *	1995-06-07	1998-11-24	Magainin Pharmaceuticals Inc.	Aminosterol compounds useful as inhibitors of the sodium/proton exchanger (NHE)
US5994336A (en) *	1995-06-07	1999-11-30	Magainin Pharmaceuticals Inc.	Method of inhibiting proliferation of cells by administering an aminosterol compound
US6143738A (en) *	1995-06-07	2000-11-07	Magainin Pharmaceuticals, Inc.	Therapeutic uses for an aminosterol compound
US5792635A (en) *	1995-06-07	1998-08-11	Magainin Pharmaceuticals, Inc.	Method of inhibiting the sodium/proton exchanger NHE3 and method of inhibiting growth by administering squalamine
US5763430A (en) *	1995-06-07	1998-06-09	Magainin Pharmaceuticals Inc.	Method of treating a viral infection by administering a steroid compound
US5795885A (en) *	1995-06-07	1998-08-18	Magainin Pharmaceuticals Inc.	Method of inhibiting profileration of cells by administering an aminosterol compound
US5847172A (en) *	1995-06-07	1998-12-08	Magainin Pharmaceuticals Inc.	Certain aminosterol compounds and pharmaceutical compositions including these compounds
US6365597B1 (en)	1996-02-14	2002-04-02	Aventis Pharmaceuticals Inc.	4-aza steroids
PT910382E (pt) *	1996-04-26	2003-10-31	Genaera Corp	Esqualamina em combinacao com outros agentes anti-cancro para o tratamento de tumores
US6596712B2 (en)	1996-04-26	2003-07-22	Genaera Corporation	Treatment of carcinomas using squalamine in combination with other anti-cancer agents or modalities
US6262283B1 (en)	1996-12-06	2001-07-17	Magainin Pharmaceuticals Inc.	Stereoselective synthesis of 24-hydroxylated compounds useful for the preparation of aminosterols, vitamin D analogs, and other compounds
DK1274718T3 (da) *	2000-04-12	2007-02-12	Genaera Corp	En fremgangsmåde til forberedelse af 7.alpha.-hydroxy 3-aminosubstituerede steroler vee en ubeskyttet 7.alpha.-hydroxy gruppe
JP2007297879A (ja) *	2006-05-02	2007-11-15	Central Glass Co Ltd	電磁波吸収板

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3475464A (en) *	1966-11-07	1969-10-28	Syntex Corp	Process for the preparation of steroids and novel intermediates thereof
US4139617A (en) *	1974-05-13	1979-02-13	Richardson-Merrell Inc.	19-Oxygenated-androst-5-enes for the enhancement of libido
US4891367A (en) *	1987-04-22	1990-01-02	Merrell Dow Pharmaceuticals Inc.	17β-(cyclopropyloxy)androst-5-en-3β-ol and related compounds useful as C17-20 lyase inhibitors
US4966898A (en) *	1989-08-15	1990-10-30	Merrell Dow Pharmaceuticals Inc.	4-substituted 17β-(cyclopropylamino)androst-5-en-3β-ol and related compounds useful as C17-20 lyase inhibitors

1989
- 1989-08-15 US US07/394,026 patent/US4966897A/en not_active Expired - Fee Related
1990
- 1990-08-09 JP JP2209388A patent/JP2879702B2/ja not_active Expired - Fee Related
- 1990-08-09 ZA ZA906307A patent/ZA906307B/xx unknown
- 1990-08-09 AU AU60878/90A patent/AU628210B2/en not_active Ceased
- 1990-08-09 CA CA002023008A patent/CA2023008C/en not_active Expired - Fee Related
- 1990-08-10 DE DE69027262T patent/DE69027262T2/de not_active Expired - Fee Related
- 1990-08-10 NZ NZ234855A patent/NZ234855A/xx unknown
- 1990-08-10 DK DK90115390.8T patent/DK0413269T3/da active
- 1990-08-10 EP EP90115390A patent/EP0413269B1/de not_active Expired - Lifetime
- 1990-08-10 ES ES90115390T patent/ES2090064T3/es not_active Expired - Lifetime
- 1990-08-10 AT AT90115390T patent/ATE138930T1/de not_active IP Right Cessation
- 1990-08-13 IL IL9535990A patent/IL95359A/en not_active IP Right Cessation
- 1990-08-14 KR KR1019900012534A patent/KR910004650A/ko not_active Ceased
- 1990-08-14 NO NO90903565A patent/NO903565L/no unknown
- 1990-08-14 IE IE294190A patent/IE902941A1/en not_active IP Right Cessation
- 1990-08-14 PT PT94994A patent/PT94994B/pt not_active IP Right Cessation
- 1990-08-14 HU HU905005A patent/HUT55030A/hu unknown
- 1990-08-15 PH PH41035A patent/PH27549A/en unknown
- 1990-08-15 FI FI904036A patent/FI95711C/fi not_active IP Right Cessation
- 1990-08-15 DD DD90343475A patent/DD298106A5/de unknown
- 1990-08-15 CN CN90107578A patent/CN1050195A/zh active Pending
1996
- 1996-08-14 GR GR960402177T patent/GR3020797T3/el unknown

Also Published As

Publication number	Publication date
DE69027262D1 (de)	1996-07-11
AU6087890A (en)	1991-02-21
HUT55030A (en)	1991-04-29
IL95359A (en)	1995-08-31
NZ234855A (en)	1992-11-25
DK0413269T3 (da)	1996-06-24
FI95711B (fi)	1995-11-30
PT94994B (pt)	1997-05-28
DD298106A5 (de)	1992-02-06
US4966897A (en)	1990-10-30
EP0413269A3 (en)	1992-05-20
FI95711C (fi)	1996-03-11
AU628210B2 (en)	1992-09-10
PT94994A (pt)	1991-04-18
HU905005D0 (en)	1991-01-28
FI904036A0 (fi)	1990-08-15
JPH0383996A (ja)	1991-04-09
KR910004650A (ko)	1991-03-29
CA2023008C (en)	2001-05-15
NO903565D0 (no)	1990-08-14
ES2090064T3 (es)	1996-10-16
CA2023008A1 (en)	1991-02-16
PH27549A (en)	1993-08-18
EP0413269A2 (de)	1991-02-20
IE902941A1 (en)	1991-02-27
IL95359A0 (en)	1991-06-30
ZA906307B (en)	1991-06-26
GR3020797T3 (en)	1996-11-30
NO903565L (no)	1991-02-18
DE69027262T2 (de)	1996-10-02
JP2879702B2 (ja)	1999-04-05
CN1050195A (zh)	1991-03-27
EP0413269B1 (de)	1996-06-05

Legal Events

Date	Code	Title	Description
1997-01-15	UEP	Publication of translation of european patent specification
2004-05-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69027262D1 (de)	1996-07-11	4-Substitutiertes 17-beta-(Cyclopropyloxy)androst-5-en-3-beta-ol und seine Derivate, verwendbar als Inhibitoren der C17-20-Lyase
ATE137761T1 (de)	1996-05-15	4-substituiertes 17-beta-(cyclopropyl-amino)- androst-5-en-3-beta-ol und seine derivate, verwendbar als inhibitoren der c17-20-lyase
ATE91684T1 (de)	1993-08-15	1,2-cyclohexylaminoarylamide zu verwendung als analgetika.
DK0721455T3 (da)	2003-04-07	Tetrahydropyridin-(eller 4-hydroxypiperidin)alkylazoler med en affinitet for sigma og/eller 5-HT1A-receptorer
DE3864725D1 (de)	1991-10-17	C17-20-lyase-inhibitoren.
HU9203761D0 (en)	1993-03-29	Method for producing substituted pyridine derivatives
DE3872938D1 (de)	1992-08-27	17-beta-(cyclopropyloxy)androst-5-en-3-beta-ol-derivate und verwandte verbindungen als c17-20 lyase-inhibitoren.
ATE131061T1 (de)	1995-12-15	Förderung der osteogenese durch verwendung von vitamin d-derivaten.
NO842345L (no)	1984-12-27	Heksahydropyrrolo(2,1-a)isoquinolin-derivater.
FR2552429B1 (fr)	1986-07-18	Procede de preparation de quinolinones-4