ATE139120T1 - Verwendung von rapamycin zur behandlung des diabetes - Google Patents

Verwendung von rapamycin zur behandlung des diabetes

Info

Publication number: ATE139120T1
Authority: AT; Austria
Prior art keywords: rapamycin; treat diabetes; insulin; arresting; retarding
Prior art date: 1991-04-03

Application number

AT92302842T

Other languages

English (en)

Inventor

William Lee Baeder

Surendra Nath Sehgal

Laurel Moore Adams

Thomas Joseph Caggiano

Original Assignee

American Home Prod

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-04-03

Filing date

1992-03-31

Publication date

1996-06-15

1991-11-14 Priority claimed from US07/792,105 external-priority patent/US5321009A/en

1992-03-31 Application filed by American Home Prod filed Critical American Home Prod

1996-06-15 Application granted granted Critical

1996-06-15 Publication of ATE139120T1 publication Critical patent/ATE139120T1/de

Links

ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 title abstract 2
QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 title abstract 2
229960002930 sirolimus Drugs 0.000 title abstract 2
206010012601 diabetes mellitus Diseases 0.000 title 1
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
102000004877 Insulin Human genes 0.000 abstract 1
108090001061 Insulin Proteins 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
206010067584 Type 1 diabetes mellitus Diseases 0.000 abstract 1
229940125396 insulin Drugs 0.000 abstract 1
230000000979 retarding effect Effects 0.000 abstract 1
208000035408 type 1 diabetes mellitus 1 Diseases 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Diabetes (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Endocrinology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Emergency Medicine (AREA)
Hematology (AREA)
Obesity (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Zoology (AREA)
Immunology (AREA)
Gastroenterology & Hepatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Compounds Of Unknown Constitution (AREA)
Medicines Containing Plant Substances (AREA)
Saccharide Compounds (AREA)
Steroid Compounds (AREA)

AT92302842T 1991-04-03 1992-03-31 Verwendung von rapamycin zur behandlung des diabetes ATE139120T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US67970691A	1991-04-03	1991-04-03
US07/792,105 US5321009A (en)	1991-04-03	1991-11-14	Method of treating diabetes

Publications (1)

Publication Number	Publication Date
ATE139120T1 true ATE139120T1 (de)	1996-06-15

Family

ID=27102296

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92302842T ATE139120T1 (de)	1991-04-03	1992-03-31	Verwendung von rapamycin zur behandlung des diabetes

Country Status (19)

Country	Link
EP (1)	EP0507555B1 (de)
JP (1)	JP2535119B2 (de)
AT (1)	ATE139120T1 (de)
AU (1)	AU652037B2 (de)
CA (1)	CA2064678A1 (de)
CZ (1)	CZ282733B6 (de)
DE (1)	DE69211406T2 (de)
DK (1)	DK0507555T3 (de)
ES (1)	ES2089395T3 (de)
GR (1)	GR3020316T3 (de)
HK (1)	HK108797A (de)
HU (1)	HUT60626A (de)
IE (1)	IE74884B1 (de)
IL (1)	IL101353A0 (de)
MX (1)	MX9201513A (de)
NO (1)	NO921279L (de)
NZ (1)	NZ242190A (de)
SG (1)	SG43075A1 (de)
SK (1)	SK279180B6 (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5378696A (en) *	1990-09-19	1995-01-03	American Home Products Corporation	Rapamycin esters
US5177203A (en) *	1992-03-05	1993-01-05	American Home Products Corporation	Rapamycin 42-sulfonates and 42-(N-carboalkoxy) sulfamates useful as immunosuppressive agents
US5256790A (en) *	1992-08-13	1993-10-26	American Home Products Corporation	27-hydroxyrapamycin and derivatives thereof
CA2106034A1 (en) *	1992-09-24	1994-03-25	Ralph J. Russo	21-norrapamycin
US5480989A (en) *	1992-10-13	1996-01-02	American Home Products Corporation	Carbamates of rapamycin
US5480988A (en) *	1992-10-13	1996-01-02	American Home Products Corporation	Carbamates of rapamycin
US5302584A (en) *	1992-10-13	1994-04-12	American Home Products Corporation	Carbamates of rapamycin
US5434260A (en) *	1992-10-13	1995-07-18	American Home Products Corporation	Carbamates of rapamycin
US5489680A (en) *	1992-10-13	1996-02-06	American Home Products Corporation	Carbamates of rapamycin
US5349060A (en) *	1993-01-07	1994-09-20	American Home Products Corporation	Rapamycin 31-ester with N,N-dimethylglycine derivatives useful as immunosuppressive agents
US5252579A (en) *	1993-02-16	1993-10-12	American Home Products Corporation	Macrocyclic immunomodulators
US7279561B1 (en)	1993-04-23	2007-10-09	Wyeth	Anti-rapamycin monoclonal antibodies
US5504091A (en) *	1993-04-23	1996-04-02	American Home Products Corporation	Biotin esters of rapamycin
AU686629B2 (en)	1993-04-23	1998-02-12	Wyeth	Rapamycin Conjugates and Antibodies
US5387680A (en) *	1993-08-10	1995-02-07	American Home Products Corporation	C-22 ring stabilized rapamycin derivatives
US5391730A (en) *	1993-10-08	1995-02-21	American Home Products Corporation	Phosphorylcarbamates of rapamycin and oxime derivatives thereof
US5373014A (en) *	1993-10-08	1994-12-13	American Home Products Corporation	Rapamycin oximes
US5378836A (en) *	1993-10-08	1995-01-03	American Home Products Corporation	Rapamycin oximes and hydrazones
US5385910A (en) *	1993-11-22	1995-01-31	American Home Products Corporation	Gem-distributed esters of rapamycin
US5385908A (en) *	1993-11-22	1995-01-31	American Home Products Corporation	Hindered esters of rapamycin
US5385909A (en) *	1993-11-22	1995-01-31	American Home Products Corporation	Heterocyclic esters of rapamycin
US5389639A (en) *	1993-12-29	1995-02-14	American Home Products Company	Amino alkanoic esters of rapamycin
US5525610A (en) *	1994-03-31	1996-06-11	American Home Products Corporation	42-Epi-rapamycin and pharmaceutical compositions thereof
US5362718A (en)	1994-04-18	1994-11-08	American Home Products Corporation	Rapamycin hydroxyesters
US5496831A (en) *	1994-05-13	1996-03-05	The General Hospital Corporation	Inhibition of insulin-induced adiposis
US5463048A (en) *	1994-06-14	1995-10-31	American Home Products Corporation	Rapamycin amidino carbamates
US5491231A (en) *	1994-11-28	1996-02-13	American Home Products Corporation	Hindered N-oxide esters of rapamycin
US5563145A (en) *	1994-12-07	1996-10-08	American Home Products Corporation	Rapamycin 42-oximes and hydroxylamines
US5561138A (en) *	1994-12-13	1996-10-01	American Home Products Corporation	Method of treating anemia
US5496832A (en) *	1995-03-09	1996-03-05	American Home Products Corporation	Method of treating cardiac inflammatory disease
FR2736550B1 (fr)	1995-07-14	1998-07-24	Sandoz Sa	Composition pharmaceutique sous la forme d'une dispersion solide comprenant un macrolide et un vehicule
TW427904B (en) *	1995-12-07	2001-04-01	American Home Prod	Neuroprotective agents
US5780462A (en) *	1995-12-27	1998-07-14	American Home Products Corporation	Water soluble rapamycin esters
US5922730A (en) *	1996-09-09	1999-07-13	American Home Products Corporation	Alkylated rapamycin derivatives
US6015809A (en) *	1998-08-17	2000-01-18	American Home Products Corporation	Photocyclized rapamycin
WO2002022805A2 (en) *	2000-09-14	2002-03-21	Beth Israel Deaconess Medical Center, Inc.	Modulation of il-2- and il-15-mediated t cell responses
US20040023885A1 (en)	2002-06-07	2004-02-05	Brand Stephen J	Compositions and methods for treating diabetes

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5100899A (en) *	1989-06-06	1992-03-31	Roy Calne	Methods of inhibiting transplant rejection in mammals using rapamycin and derivatives and prodrugs thereof
US5023263A (en) *	1990-08-09	1991-06-11	American Home Products Corporation	42-oxorapamycin

1992
- 1992-03-24 IL IL101353A patent/IL101353A0/xx unknown
- 1992-03-31 EP EP92302842A patent/EP0507555B1/de not_active Expired - Lifetime
- 1992-03-31 SG SG1996003300A patent/SG43075A1/en unknown
- 1992-03-31 ES ES92302842T patent/ES2089395T3/es not_active Expired - Lifetime
- 1992-03-31 JP JP4076664A patent/JP2535119B2/ja not_active Expired - Fee Related
- 1992-03-31 AT AT92302842T patent/ATE139120T1/de not_active IP Right Cessation
- 1992-03-31 DK DK92302842.7T patent/DK0507555T3/da active
- 1992-03-31 DE DE69211406T patent/DE69211406T2/de not_active Expired - Fee Related
- 1992-04-01 CA CA002064678A patent/CA2064678A1/en not_active Abandoned
- 1992-04-01 SK SK972-92A patent/SK279180B6/sk unknown
- 1992-04-01 AU AU13957/92A patent/AU652037B2/en not_active Ceased
- 1992-04-01 CZ CS92972A patent/CZ282733B6/cs not_active IP Right Cessation
- 1992-04-01 NZ NZ242190A patent/NZ242190A/en not_active IP Right Cessation
- 1992-04-02 MX MX9201513A patent/MX9201513A/es not_active IP Right Cessation
- 1992-04-02 NO NO92921279A patent/NO921279L/no unknown
- 1992-04-02 HU HU9201113A patent/HUT60626A/hu unknown
- 1992-04-02 IE IE921055A patent/IE74884B1/en not_active IP Right Cessation
1996
- 1996-06-20 GR GR960401686T patent/GR3020316T3/el unknown
1997
- 1997-06-26 HK HK108797A patent/HK108797A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE69211406T2 (de)	1996-11-28
SK97292A3 (en)	1994-11-09
JPH0597688A (ja)	1993-04-20
AU1395792A (en)	1992-10-08
SK279180B6 (sk)	1998-07-08
AU652037B2 (en)	1994-08-11
HK108797A (en)	1997-08-22
HUT60626A (en)	1992-10-28
CZ282733B6 (cs)	1997-09-17
CA2064678A1 (en)	1992-10-04
GR3020316T3 (en)	1996-09-30
ES2089395T3 (es)	1996-10-01
EP0507555A1 (de)	1992-10-07
SG43075A1 (en)	1997-10-17
JP2535119B2 (ja)	1996-09-18
IE921055A1 (en)	1992-10-07
MX9201513A (es)	1993-04-01
HU9201113D0 (en)	1992-06-29
DK0507555T3 (da)	1996-07-01
NZ242190A (en)	1997-06-24
EP0507555B1 (de)	1996-06-12
NO921279D0 (no)	1992-04-02
NO921279L (no)	1992-10-05
IL101353A0 (en)	1992-11-15
DE69211406D1 (de)	1996-07-18
CZ97292A3 (en)	1993-09-15
IE74884B1 (en)	1997-08-13

Legal Events

Date	Code	Title	Description
1996-12-15	UEP	Publication of translation of european patent specification
2006-12-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE139120T1 (de)	1996-06-15	Verwendung von rapamycin zur behandlung des diabetes
NO902840L (no)	1990-06-26	Middel for transdermal applikasjon som inneholder gestoden
MX9102226A (es)	1992-06-01	Pañal o articulo absorbente con accesorio tensionante.
DE69428357D1 (de)	2001-10-25	Vorrichtung zur behandlung des diabetes mellitus
DE59107331D1 (de)	1996-03-14	Flupirtin in Kombination mit Antiparkinsonika zur Bekämpfung von Muskelverspannungen
DE3876081D1 (de)	1992-12-24	Sicherheitsgurt mit spannvorrichtung.
DE68910799D1 (de)	1993-12-23	Faserbehandlungszusammensetzung.
FI925466L (fi)	1993-06-03	Skivbroms foer driftblockhjul i en hiss
DE69325029D1 (de)	1999-06-24	Verwendung der il-10 zur verhinderung des insulin-abhängigen diabetes mellitus
DE68913162D1 (de)	1994-03-24	Kautschukmischungen.
DE3873468D1 (de)	1992-09-10	Sicherheitsgurthaltevorrichtung mit manueller lageverstellung.
DE68913088D1 (de)	1994-03-24	Faserbehandlungszusammensetzung.
DE69100250D1 (de)	1993-09-16	Spannzangenentkorker mit aussparung fuer den daumen.
IE891122L (en)	1989-10-08	Improvements in or relating to propanamine derivatives
DE59201740D1 (de)	1995-05-04	Polarisationsinterferometer mit Schmalbandfilter.
DE3862486D1 (de)	1991-05-29	Fungizide mischungen mit prochloraz.
DK44184A (da)	1984-08-03	Deodorant med silaniserede adsorbenter
NO891649D0 (no)	1989-04-21	Anordning med tannstangsheis.
FI920281L (fi)	1992-08-07	Drivhjul med utbytbar hjultandkrans foer motorfordon foersett med gummikedja.
NO885008D0 (no)	1988-11-10	Edelbeskytter for respirator.
ATE84417T1 (de)	1993-01-15	Prostaglandinanaloge zur verwendung in der medizin.
NO891035D0 (no)	1989-03-10	Vekstregulerende substanser.
KR920019218U (ko)	1992-11-16	산소통을 교체할 수 있는 수경