IE74884B1 - Use of rapamycin for treating diabetes - Google Patents

Use of rapamycin for treating diabetes

Info

Publication number
IE74884B1
IE74884B1 IE921055A IE921055A IE74884B1 IE 74884 B1 IE74884 B1 IE 74884B1 IE 921055 A IE921055 A IE 921055A IE 921055 A IE921055 A IE 921055A IE 74884 B1 IE74884 B1 IE 74884B1
Authority
IE
Ireland
Prior art keywords
rapamycin
iddm
days
mice
insulin
Prior art date
Application number
IE921055A
Other languages
English (en)
Other versions
IE921055A1 (en
Inventor
William Lee Baeder
Surendra Nath Sehgal
Laurel Moore Adams
Thomas Joseph Caggiano
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/792,105 external-priority patent/US5321009A/en
Application filed by American Home Prod filed Critical American Home Prod
Publication of IE921055A1 publication Critical patent/IE921055A1/en
Publication of IE74884B1 publication Critical patent/IE74884B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
IE921055A 1991-04-03 1992-04-02 Use of rapamycin for treating diabetes IE74884B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67970691A 1991-04-03 1991-04-03
US07/792,105 US5321009A (en) 1991-04-03 1991-11-14 Method of treating diabetes

Publications (2)

Publication Number Publication Date
IE921055A1 IE921055A1 (en) 1992-10-07
IE74884B1 true IE74884B1 (en) 1997-08-13

Family

ID=27102296

Family Applications (1)

Application Number Title Priority Date Filing Date
IE921055A IE74884B1 (en) 1991-04-03 1992-04-02 Use of rapamycin for treating diabetes

Country Status (19)

Country Link
EP (1) EP0507555B1 (de)
JP (1) JP2535119B2 (de)
AT (1) ATE139120T1 (de)
AU (1) AU652037B2 (de)
CA (1) CA2064678A1 (de)
CZ (1) CZ282733B6 (de)
DE (1) DE69211406T2 (de)
DK (1) DK0507555T3 (de)
ES (1) ES2089395T3 (de)
GR (1) GR3020316T3 (de)
HK (1) HK108797A (de)
HU (1) HUT60626A (de)
IE (1) IE74884B1 (de)
IL (1) IL101353A0 (de)
MX (1) MX9201513A (de)
NO (1) NO921279L (de)
NZ (1) NZ242190A (de)
SG (1) SG43075A1 (de)
SK (1) SK279180B6 (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5378696A (en) * 1990-09-19 1995-01-03 American Home Products Corporation Rapamycin esters
US5177203A (en) * 1992-03-05 1993-01-05 American Home Products Corporation Rapamycin 42-sulfonates and 42-(N-carboalkoxy) sulfamates useful as immunosuppressive agents
US5256790A (en) * 1992-08-13 1993-10-26 American Home Products Corporation 27-hydroxyrapamycin and derivatives thereof
CA2106034A1 (en) * 1992-09-24 1994-03-25 Ralph J. Russo 21-norrapamycin
US5480989A (en) * 1992-10-13 1996-01-02 American Home Products Corporation Carbamates of rapamycin
US5434260A (en) * 1992-10-13 1995-07-18 American Home Products Corporation Carbamates of rapamycin
US5302584A (en) * 1992-10-13 1994-04-12 American Home Products Corporation Carbamates of rapamycin
US5480988A (en) * 1992-10-13 1996-01-02 American Home Products Corporation Carbamates of rapamycin
US5489680A (en) * 1992-10-13 1996-02-06 American Home Products Corporation Carbamates of rapamycin
US5349060A (en) * 1993-01-07 1994-09-20 American Home Products Corporation Rapamycin 31-ester with N,N-dimethylglycine derivatives useful as immunosuppressive agents
US5252579A (en) * 1993-02-16 1993-10-12 American Home Products Corporation Macrocyclic immunomodulators
US7279561B1 (en) 1993-04-23 2007-10-09 Wyeth Anti-rapamycin monoclonal antibodies
ES2295093T3 (es) 1993-04-23 2008-04-16 Wyeth Conjugados y anticuerpos de rapamicina.
US5504091A (en) * 1993-04-23 1996-04-02 American Home Products Corporation Biotin esters of rapamycin
US5387680A (en) * 1993-08-10 1995-02-07 American Home Products Corporation C-22 ring stabilized rapamycin derivatives
US5378836A (en) * 1993-10-08 1995-01-03 American Home Products Corporation Rapamycin oximes and hydrazones
US5373014A (en) * 1993-10-08 1994-12-13 American Home Products Corporation Rapamycin oximes
US5391730A (en) * 1993-10-08 1995-02-21 American Home Products Corporation Phosphorylcarbamates of rapamycin and oxime derivatives thereof
US5385910A (en) * 1993-11-22 1995-01-31 American Home Products Corporation Gem-distributed esters of rapamycin
US5385908A (en) * 1993-11-22 1995-01-31 American Home Products Corporation Hindered esters of rapamycin
US5385909A (en) * 1993-11-22 1995-01-31 American Home Products Corporation Heterocyclic esters of rapamycin
US5389639A (en) * 1993-12-29 1995-02-14 American Home Products Company Amino alkanoic esters of rapamycin
US5525610A (en) * 1994-03-31 1996-06-11 American Home Products Corporation 42-Epi-rapamycin and pharmaceutical compositions thereof
US5362718A (en) 1994-04-18 1994-11-08 American Home Products Corporation Rapamycin hydroxyesters
US5496831A (en) * 1994-05-13 1996-03-05 The General Hospital Corporation Inhibition of insulin-induced adiposis
US5463048A (en) * 1994-06-14 1995-10-31 American Home Products Corporation Rapamycin amidino carbamates
US5491231A (en) * 1994-11-28 1996-02-13 American Home Products Corporation Hindered N-oxide esters of rapamycin
US5563145A (en) * 1994-12-07 1996-10-08 American Home Products Corporation Rapamycin 42-oximes and hydroxylamines
US5561138A (en) * 1994-12-13 1996-10-01 American Home Products Corporation Method of treating anemia
US5496832A (en) * 1995-03-09 1996-03-05 American Home Products Corporation Method of treating cardiac inflammatory disease
FR2736550B1 (fr) 1995-07-14 1998-07-24 Sandoz Sa Composition pharmaceutique sous la forme d'une dispersion solide comprenant un macrolide et un vehicule
TW427904B (en) * 1995-12-07 2001-04-01 American Home Prod Neuroprotective agents
US5780462A (en) * 1995-12-27 1998-07-14 American Home Products Corporation Water soluble rapamycin esters
US5922730A (en) * 1996-09-09 1999-07-13 American Home Products Corporation Alkylated rapamycin derivatives
US6015809A (en) * 1998-08-17 2000-01-18 American Home Products Corporation Photocyclized rapamycin
EP1349873B1 (de) * 2000-09-14 2009-04-01 Beth Israel Deaconess Medical Center, Inc. Modulierung von il-2 und il-15 vermittelten t zellantworten
DE60329724D1 (de) 2002-06-07 2009-11-26 Waratah Pharmaceuticals Inc Methoden und Kompositionen um Diabetes zu behandeln

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5100899A (en) * 1989-06-06 1992-03-31 Roy Calne Methods of inhibiting transplant rejection in mammals using rapamycin and derivatives and prodrugs thereof
US5023263A (en) * 1990-08-09 1991-06-11 American Home Products Corporation 42-oxorapamycin

Also Published As

Publication number Publication date
SG43075A1 (en) 1997-10-17
JP2535119B2 (ja) 1996-09-18
HU9201113D0 (en) 1992-06-29
SK279180B6 (sk) 1998-07-08
IL101353A0 (en) 1992-11-15
DE69211406T2 (de) 1996-11-28
AU1395792A (en) 1992-10-08
NO921279L (no) 1992-10-05
ATE139120T1 (de) 1996-06-15
CZ97292A3 (en) 1993-09-15
JPH0597688A (ja) 1993-04-20
ES2089395T3 (es) 1996-10-01
AU652037B2 (en) 1994-08-11
MX9201513A (es) 1993-04-01
EP0507555A1 (de) 1992-10-07
SK97292A3 (en) 1994-11-09
NO921279D0 (no) 1992-04-02
GR3020316T3 (en) 1996-09-30
IE921055A1 (en) 1992-10-07
HUT60626A (en) 1992-10-28
DK0507555T3 (da) 1996-07-01
HK108797A (en) 1997-08-22
DE69211406D1 (de) 1996-07-18
EP0507555B1 (de) 1996-06-12
NZ242190A (en) 1997-06-24
CZ282733B6 (cs) 1997-09-17
CA2064678A1 (en) 1992-10-04

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US5321009A (en) Method of treating diabetes
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Legal Events

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