ATE139763T1 - Verfahren zur herstellung von 5-(2',4'- difluorphenyl)-salizylsäure in reiner form ii - Google Patents
Verfahren zur herstellung von 5-(2',4'- difluorphenyl)-salizylsäure in reiner form iiInfo
- Publication number
- ATE139763T1 ATE139763T1 AT92112205T AT92112205T ATE139763T1 AT E139763 T1 ATE139763 T1 AT E139763T1 AT 92112205 T AT92112205 T AT 92112205T AT 92112205 T AT92112205 T AT 92112205T AT E139763 T1 ATE139763 T1 AT E139763T1
- Authority
- AT
- Austria
- Prior art keywords
- salicylic acid
- difluorophenyl
- producing
- pure form
- diflurophenyl
- Prior art date
Links
- HUPFGZXOMWLGNK-UHFFFAOYSA-N diflunisal Chemical compound C1=C(O)C(C(=O)O)=CC(C=2C(=CC(F)=CC=2)F)=C1 HUPFGZXOMWLGNK-UHFFFAOYSA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000004945 aromatic hydrocarbons Chemical class 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- RXKJFZQQPQGTFL-UHFFFAOYSA-N dihydroxyacetone Chemical compound OCC(=O)CO RXKJFZQQPQGTFL-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229960004889 salicylic acid Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
- C07C51/43—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI912152A IT1250736B (it) | 1991-08-01 | 1991-08-01 | Processo per la preparazione dell'acido 5-(2',4'-difluorofenil) salicilico in forma ii pura |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE139763T1 true ATE139763T1 (de) | 1996-07-15 |
Family
ID=11360489
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92112205T ATE139763T1 (de) | 1991-08-01 | 1992-08-01 | Verfahren zur herstellung von 5-(2',4'- difluorphenyl)-salizylsäure in reiner form ii |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5183935A (de) |
| EP (1) | EP0529279B1 (de) |
| JP (1) | JPH07179395A (de) |
| AT (1) | ATE139763T1 (de) |
| DE (1) | DE69211788T2 (de) |
| DK (1) | DK0529279T3 (de) |
| ES (1) | ES2089305T3 (de) |
| GR (1) | GR3020799T3 (de) |
| IT (1) | IT1250736B (de) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL100353A (en) * | 1991-01-08 | 1997-06-10 | Zambon Spa | Preparation of 5-(2, 4-difluorophenyl)-salicylic acid and novel 2,4-difluorophenyl-boronic acid derivatives being intermediates therefor |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1175212A (en) * | 1967-03-09 | 1969-12-23 | Merck & Co Inc | Halo-Substituted 5-Phenylbenzoic Acids and their Derivatives |
| US4131618A (en) * | 1977-12-29 | 1978-12-26 | Merck & Co., Inc. | Preparation of salicylic acid and derivatives |
| US4225730A (en) * | 1978-05-11 | 1980-09-30 | Merck & Co., Inc. | Process for preparing 4-(2,4-difluorophenyl)-salicyclic acid |
| US4237315A (en) * | 1979-11-02 | 1980-12-02 | Merck & Co., Inc. | Preparation of 5(halophenyl)salicylic acid compounds |
| IT1190926B (it) * | 1982-07-22 | 1988-02-24 | Zambon Spa | Procedimento per preparare l'acido 2',4'-difluoro-4-idrossi-(1,1'-difenil)-3-carbossilico |
| IT1196485B (it) * | 1986-07-14 | 1988-11-16 | Zambon Spa | Derivati dell'acido tiazolidin-4-carbossilico ad attivita' farmaceutica |
| US4847442A (en) * | 1988-07-18 | 1989-07-11 | Allied-Signal Inc. | Process for the preparation of difluorobenzenes |
| US4996047A (en) * | 1988-11-02 | 1991-02-26 | Richardson-Vicks, Inc. | Sustained release drug-resin complexes |
| JPH0768234B2 (ja) * | 1989-12-14 | 1995-07-26 | 久光製薬株式会社 | コウジ酸エステル誘導体 |
-
1991
- 1991-08-01 IT ITMI912152A patent/IT1250736B/it active IP Right Grant
-
1992
- 1992-07-29 JP JP4245447A patent/JPH07179395A/ja active Pending
- 1992-07-29 US US07/921,066 patent/US5183935A/en not_active Expired - Fee Related
- 1992-08-01 DE DE69211788T patent/DE69211788T2/de not_active Expired - Fee Related
- 1992-08-01 AT AT92112205T patent/ATE139763T1/de not_active IP Right Cessation
- 1992-08-01 EP EP92112205A patent/EP0529279B1/de not_active Expired - Lifetime
- 1992-08-01 ES ES92112205T patent/ES2089305T3/es not_active Expired - Lifetime
- 1992-08-01 DK DK92112205.7T patent/DK0529279T3/da active
-
1996
- 1996-08-14 GR GR960402179T patent/GR3020799T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IT1250736B (it) | 1995-04-21 |
| EP0529279A1 (de) | 1993-03-03 |
| US5183935A (en) | 1993-02-02 |
| DE69211788T2 (de) | 1996-10-31 |
| ITMI912152A0 (it) | 1991-08-01 |
| GR3020799T3 (en) | 1996-11-30 |
| ITMI912152A1 (it) | 1993-02-01 |
| JPH07179395A (ja) | 1995-07-18 |
| EP0529279B1 (de) | 1996-06-26 |
| DE69211788D1 (de) | 1996-08-01 |
| DK0529279T3 (da) | 1996-07-29 |
| ES2089305T3 (es) | 1996-10-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |