ATE139783T1 - Azasteroide zur behandlung prostatischer hypertrophie, ihre herstellung und verwendung - Google Patents

Azasteroide zur behandlung prostatischer hypertrophie, ihre herstellung und verwendung

Info

Publication number
ATE139783T1
ATE139783T1 AT91309967T AT91309967T ATE139783T1 AT E139783 T1 ATE139783 T1 AT E139783T1 AT 91309967 T AT91309967 T AT 91309967T AT 91309967 T AT91309967 T AT 91309967T AT E139783 T1 ATE139783 T1 AT E139783T1
Authority
AT
Austria
Prior art keywords
alkyl group
substituted alkyl
carbon
aryl
preparation
Prior art date
Application number
AT91309967T
Other languages
English (en)
Inventor
Koichi Kojima
Hitoshi Kurata
Hiroyoshi Horikoshi
Takakazu Hamada
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Application granted granted Critical
Publication of ATE139783T1 publication Critical patent/ATE139783T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT91309967T 1990-10-29 1991-10-29 Azasteroide zur behandlung prostatischer hypertrophie, ihre herstellung und verwendung ATE139783T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP29140190 1990-10-29

Publications (1)

Publication Number Publication Date
ATE139783T1 true ATE139783T1 (de) 1996-07-15

Family

ID=17768420

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91309967T ATE139783T1 (de) 1990-10-29 1991-10-29 Azasteroide zur behandlung prostatischer hypertrophie, ihre herstellung und verwendung

Country Status (20)

Country Link
US (1) US5302621A (de)
EP (1) EP0484094B1 (de)
JP (1) JPH0819151B2 (de)
KR (1) KR0134570B1 (de)
CN (2) CN1053672C (de)
AT (1) ATE139783T1 (de)
AU (1) AU640279B2 (de)
CA (1) CA2054368C (de)
CZ (1) CZ279312B6 (de)
DE (1) DE69120500T2 (de)
DK (1) DK0484094T3 (de)
ES (1) ES2091299T3 (de)
GR (1) GR3020483T3 (de)
HK (1) HK1005456A1 (de)
HU (2) HU218667B (de)
IE (1) IE76452B1 (de)
IL (1) IL99889A (de)
PT (1) PT99371B (de)
RU (1) RU2070204C1 (de)
ZA (1) ZA918570B (de)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5304562A (en) * 1991-10-09 1994-04-19 Ciba-Geigy Corporation 17β-substituted Aza-androstane derivatives
CA2084799C (en) 1991-12-17 2003-01-28 Glenn J. Gormley Method of prevention of prostatic carcinoma with 17 beta-n-monosubstituted-carbamoyl-4-aza-5 alpha-androst-1 -en-3-ones
JPH07502511A (ja) * 1991-12-20 1995-03-16 グラクソ、インコーポレーテッド ５‐α‐テストステロンレダクターゼ阻害剤
DK0567271T3 (da) * 1992-04-20 1998-02-16 Sankyo Co Steroidderivater til behandling af prostatahypertrofi, fremgangsmåde til fremstilling heraf og anvendelser heraf
US5698720A (en) * 1992-04-20 1997-12-16 Sankyo Company, Limited Steroid derivatives
CA2135167A1 (en) * 1992-05-20 1993-11-25 Donald W. Graham New 17-ester, amide, and ketone derivatives of 3-oxo-4- azasteroids as 5a-reductase inhibitors
WO1993023420A1 (en) * 1992-05-20 1993-11-25 Merck & Co., Inc. NEW 7β-SUBSTITUTED-4-AZA-5α-ANDROSTAN-3-ONES AS 5α-REDUCTASE INHIBITORS
GB9216284D0 (en) * 1992-07-31 1992-09-16 Erba Carlo Spa Fluorinated 17beta-substituted 4-aza-5alpha-androstane-3-one derivatives
GB9216329D0 (en) * 1992-07-31 1992-09-16 Erba Carlo Spa 17beta-substituted 4-aza-5alpha-androstan-3-one derivatives
US5302589A (en) * 1992-08-07 1994-04-12 Glaxo, Inc. Heterocyclic inhibitors of 5-α-testosterone reductase
HU212459B (en) * 1992-10-02 1996-06-28 Richter Gedeon Vegyeszet Process for producing new 17-beta-substituted 4-aza-androstane-derivatives and pharmaceutical compositions containing them
EP0663924B1 (de) * 1992-10-06 2001-02-14 Merck & Co. Inc. 17-beta-carboxanilid derivate von 4-aza-5-alpha-androstan-3-one als 5-alpha-reduktase-hemmende arzneimittel
AU6427194A (en) * 1993-04-02 1994-10-24 Ciba-Geigy Ag Aza-androstane-17beta -carboxamides
TW369521B (en) * 1993-09-17 1999-09-11 Smithkline Beecham Corp Androstenone derivative
TW408127B (en) * 1993-09-17 2000-10-11 Glaxo Inc Androstenones
ATE178795T1 (de) * 1993-11-04 1999-04-15 Merck & Co Inc 7-substituierte-4-aza-steroid-derivate als 5- alpha-reductase-hemmer
US5817818A (en) * 1994-09-16 1998-10-06 Glaxo Wellcome Inc. Androstenones
US5578724A (en) * 1994-09-20 1996-11-26 Eli Lilly And Company Process for preparation of benzo[f]quinolinones
US5541322A (en) * 1994-10-14 1996-07-30 Glaxo Wellcome Inc. Synthesis of 6-azaandrostenones
US5543417A (en) * 1994-10-21 1996-08-06 Merck & Co., Inc. Combination method of treating acne using 4-AZA-5α-cholestan-ones and 4-AZA-5α-androstan-ones as selective 5α-reductase inhibitors with anti-bacterial, keratolytic, or anti-inflammatory agents
IT1271325B (it) * 1994-12-23 1997-05-27 Poli Ind Chimica Spa Composti diastereomericamente puri derivati da 3-oxo e 3-tioxo-4-azaandrostani e loro uso come antiandrogeni
US5656613A (en) * 1995-01-04 1997-08-12 Merck & Co., Inc. Treatment of hyperandrogenic conditions
CN1072679C (zh) * 1995-07-30 2001-10-10 重庆医科大学 一种氮杂甾体化合物、制备及其用途
US6001844A (en) * 1995-09-15 1999-12-14 Merck & Co., Inc. 4-Azasteroids for treatment of hyperandrogenic conditions
EP0859761A4 (de) * 1995-09-15 2000-01-26 Merck & Co Inc 4-azasteroide zur behandlung von hyperandrogenen zuständen
CZ289856B6 (cs) * 1996-02-05 2002-04-17 Sankyo Company Limited Farmaceutický prostředek na bázi inhibitoru 5alfa-reduktázy
US6093722A (en) 1997-02-26 2000-07-25 Sankyo Company, Limited Method for treating prostate cancer
ES2221703T3 (es) * 1997-02-26 2005-01-01 Sankyo Company Limited Compuesto azasteroide para el tratamiento o la prevencion del cancer de prostata.
CA2298851A1 (en) * 1997-07-29 1999-02-11 Sankyo Company Limited Remedial agent for baldness and other diseases
US6187925B1 (en) * 1997-12-23 2001-02-13 Merck & Co., Inc. Intermediates and process for the synthesis of azasteroids
US5998427A (en) * 1998-05-14 1999-12-07 Glaxo Wellcome Inc. Androstenones
US6645974B2 (en) * 2001-07-31 2003-11-11 Merck & Co., Inc. Androgen receptor modulators and methods for use thereof
NZ534946A (en) * 2002-03-13 2007-05-31 Merck & Co Inc Fluorinated 4-azasteroid derivatives as androgen receptor modulators
EP1622567B1 (de) * 2003-05-07 2013-07-24 Merck Sharp & Dohme Corp. Androgen-rezeptor-modulatoren und verfahren zu ihrer verwendung
EP1641535A4 (de) * 2003-06-30 2008-05-14 Merck & Co Inc 17-acetamido-4-azasteroidderivate als androgenrezeptormodulatoren
AU2004255749B2 (en) * 2003-06-30 2008-12-18 Merck Sharp & Dohme Corp. 17-acetamido-4-azasteroid derivatives as androgen receptor modulators
WO2005009949A2 (en) * 2003-06-30 2005-02-03 Merck & Co., Inc. 17-acetamido-4-azasteroid derivatives as androgen receptor modulators
US20080125403A1 (en) * 2004-04-02 2008-05-29 Merck & Co., Inc. Method of Treating Men with Metabolic and Anthropometric Disorders
AU2006229840B2 (en) * 2005-03-25 2010-12-23 Merck Sharp & Dohme Corp. Method of treating men with testosterone supplement and 5alpha-reductase inhibitor
CN116621913B (zh) * 2022-08-12 2026-03-27 湖南科益新生物医药有限公司 一种4-氮杂甾体化合物及其制备方法、用途及药物组合物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179453A (en) 1978-04-13 1979-12-18 Merck & Co., Inc. Process for preparing 17β-carboxy-5-androsten-3-ones
US4377584A (en) * 1978-04-13 1983-03-22 Merck & Co., Inc. 4-Aza-17β-substituted-5α-androstan-3-one-reductase inhibitors
AU527030B2 (en) * 1978-04-13 1983-02-10 Merck & Co., Inc. 4-aza-17-substituted-5a-androstan-3-ones
US4220775A (en) * 1979-03-15 1980-09-02 Merck & Co., Inc. Preparation of 4-aza-17-substituted-5α-androstan-3-ones useful as 5α-reductase inhibitors
NZ211145A (en) * 1984-02-27 1988-10-28 Merck & Co Inc 4-aza-5-alpha-androst-1-en-3-ones and pharmaceutical compositions
US4760071A (en) * 1984-02-27 1988-07-26 Merck & Co., Inc. 17β-N-monosubstituted carbamoyl-4-aza-5α-androst-1-en-3-ones which are active as testosterone 5α-reductase inhibitors
GB8505862D0 (en) * 1985-03-07 1985-04-11 Erba Farmitalia Steroidic 5alpha-reductase inhibitors
US5021575A (en) * 1989-11-13 1991-06-04 Merck & Co., Inc. Method for introducing a 1,2 double bond into azasteroids

Also Published As

Publication number Publication date
HUT59417A (en) 1992-05-28
JPH0532693A (ja) 1993-02-09
GR3020483T3 (en) 1996-10-31
JPH0819151B2 (ja) 1996-02-28
IL99889A (en) 1995-06-29
US5302621A (en) 1994-04-12
HU913396D0 (en) 1992-01-28
CN1062145A (zh) 1992-06-24
RU2070204C1 (ru) 1996-12-10
CZ279312B6 (cs) 1995-04-12
DE69120500D1 (de) 1996-08-01
PT99371A (pt) 1992-09-30
IE76452B1 (en) 1997-10-22
EP0484094B1 (de) 1996-06-26
KR0134570B1 (ko) 1998-04-14
CN1209319A (zh) 1999-03-03
AU8682191A (en) 1992-04-30
EP0484094A2 (de) 1992-05-06
EP0484094A3 (en) 1993-07-14
IL99889A0 (en) 1992-08-18
CN1072935C (zh) 2001-10-17
ZA918570B (en) 1992-08-26
PT99371B (pt) 1999-04-30
CA2054368A1 (en) 1992-04-30
HK1005456A1 (en) 1999-01-08
CN1053672C (zh) 2000-06-21
CA2054368C (en) 2001-10-02
DK0484094T3 (da) 1996-10-28
CS326991A3 (en) 1992-05-13
DE69120500T2 (de) 1997-02-27
HK1017274A1 (en) 1999-11-19
HU211642A9 (en) 1995-12-28
HU218667B (hu) 2000-10-28
ES2091299T3 (es) 1996-11-01
AU640279B2 (en) 1993-08-19
IE913747A1 (en) 1992-05-22
KR920008063A (ko) 1992-05-27

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Legal Events

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