DK0484094T3 - Azasteroide forbindelser til behandling af prostatahypertrofi, deres fremstilling og anvendelse - Google Patents

Azasteroide forbindelser til behandling af prostatahypertrofi, deres fremstilling og anvendelse

Info

Publication number
DK0484094T3
DK0484094T3 DK91309967.7T DK91309967T DK0484094T3 DK 0484094 T3 DK0484094 T3 DK 0484094T3 DK 91309967 T DK91309967 T DK 91309967T DK 0484094 T3 DK0484094 T3 DK 0484094T3
Authority
DK
Denmark
Prior art keywords
alkyl group
substituted alkyl
carbon
preparation
treatment
Prior art date
Application number
DK91309967.7T
Other languages
English (en)
Inventor
Koichi Kojima
Hitoshi Kurata
Hiroyoshi Horikoshi
Takakazu Hamada
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Application granted granted Critical
Publication of DK0484094T3 publication Critical patent/DK0484094T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK91309967.7T 1990-10-29 1991-10-29 Azasteroide forbindelser til behandling af prostatahypertrofi, deres fremstilling og anvendelse DK0484094T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP29140190 1990-10-29

Publications (1)

Publication Number Publication Date
DK0484094T3 true DK0484094T3 (da) 1996-10-28

Family

ID=17768420

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91309967.7T DK0484094T3 (da) 1990-10-29 1991-10-29 Azasteroide forbindelser til behandling af prostatahypertrofi, deres fremstilling og anvendelse

Country Status (20)

Country Link
US (1) US5302621A (da)
EP (1) EP0484094B1 (da)
JP (1) JPH0819151B2 (da)
KR (1) KR0134570B1 (da)
CN (2) CN1053672C (da)
AT (1) ATE139783T1 (da)
AU (1) AU640279B2 (da)
CA (1) CA2054368C (da)
CZ (1) CZ279312B6 (da)
DE (1) DE69120500T2 (da)
DK (1) DK0484094T3 (da)
ES (1) ES2091299T3 (da)
GR (1) GR3020483T3 (da)
HK (1) HK1005456A1 (da)
HU (2) HU218667B (da)
IE (1) IE76452B1 (da)
IL (1) IL99889A (da)
PT (1) PT99371B (da)
RU (1) RU2070204C1 (da)
ZA (1) ZA918570B (da)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5304562A (en) * 1991-10-09 1994-04-19 Ciba-Geigy Corporation 17β-substituted Aza-androstane derivatives
CA2084799C (en) 1991-12-17 2003-01-28 Glenn J. Gormley Method of prevention of prostatic carcinoma with 17 beta-n-monosubstituted-carbamoyl-4-aza-5 alpha-androst-1 -en-3-ones
WO1993013124A1 (en) * 1991-12-20 1993-07-08 Glaxo Inc. Inhibitors of 5-alpha-testosterone reductase
DK0567271T3 (da) * 1992-04-20 1998-02-16 Sankyo Co Steroidderivater til behandling af prostatahypertrofi, fremgangsmåde til fremstilling heraf og anvendelser heraf
US5698720A (en) * 1992-04-20 1997-12-16 Sankyo Company, Limited Steroid derivatives
WO1993023420A1 (en) * 1992-05-20 1993-11-25 Merck & Co., Inc. NEW 7β-SUBSTITUTED-4-AZA-5α-ANDROSTAN-3-ONES AS 5α-REDUCTASE INHIBITORS
AU674145B2 (en) * 1992-05-20 1996-12-12 Merck & Co., Inc. New 17-ester, amide, and ketone derivatives of 3-oxo-4-azasteroids as 5a-reductase inhibitors
GB9216329D0 (en) * 1992-07-31 1992-09-16 Erba Carlo Spa 17beta-substituted 4-aza-5alpha-androstan-3-one derivatives
GB9216284D0 (en) * 1992-07-31 1992-09-16 Erba Carlo Spa Fluorinated 17beta-substituted 4-aza-5alpha-androstane-3-one derivatives
US5302589A (en) * 1992-08-07 1994-04-12 Glaxo, Inc. Heterocyclic inhibitors of 5-α-testosterone reductase
HU212459B (en) * 1992-10-02 1996-06-28 Richter Gedeon Vegyeszet Process for producing new 17-beta-substituted 4-aza-androstane-derivatives and pharmaceutical compositions containing them
DE69329933T2 (de) * 1992-10-06 2001-07-19 Merck & Co., Inc. 17-beta-carboxanilid derivate von 4-aza-5-alpha-androstan-3-one als 5-alpha-reduktase-hemmende arzneimittel
WO1994022900A1 (en) * 1993-04-02 1994-10-13 Ciba-Geigy Ag AZA-ANDROSTANE-17β-CARBOXAMIDES
TW408127B (en) * 1993-09-17 2000-10-11 Glaxo Inc Androstenones
TW369521B (en) * 1993-09-17 1999-09-11 Smithkline Beecham Corp Androstenone derivative
EP0748221B1 (en) * 1993-11-04 1999-04-14 Merck & Co. Inc. 7-substituted-4-aza-steroid derivatives as 5-alpha- reductase inhibitors
US5817818A (en) * 1994-09-16 1998-10-06 Glaxo Wellcome Inc. Androstenones
US5578724A (en) * 1994-09-20 1996-11-26 Eli Lilly And Company Process for preparation of benzo[f]quinolinones
US5541322A (en) * 1994-10-14 1996-07-30 Glaxo Wellcome Inc. Synthesis of 6-azaandrostenones
US5543417A (en) * 1994-10-21 1996-08-06 Merck & Co., Inc. Combination method of treating acne using 4-AZA-5α-cholestan-ones and 4-AZA-5α-androstan-ones as selective 5α-reductase inhibitors with anti-bacterial, keratolytic, or anti-inflammatory agents
IT1271325B (it) * 1994-12-23 1997-05-27 Poli Ind Chimica Spa Composti diastereomericamente puri derivati da 3-oxo e 3-tioxo-4-azaandrostani e loro uso come antiandrogeni
US5656613A (en) * 1995-01-04 1997-08-12 Merck & Co., Inc. Treatment of hyperandrogenic conditions
CN1072679C (zh) * 1995-07-30 2001-10-10 重庆医科大学 一种氮杂甾体化合物、制备及其用途
JPH11512434A (ja) * 1995-09-15 1999-10-26 メルク エンド カンパニー インコーポレーテッド アンドロゲン過剰状態治療用の４−アザステロイド
USRE39056E1 (en) * 1995-09-15 2006-04-04 Merck & Co, Inc. 4-Azasteroids for treatment of hyperandrogenic conditions
RU2154467C2 (ru) * 1996-02-05 2000-08-20 Санкио Компани Лимитед СОСТАВ ИНГИБИТОРА 5α-РЕДУКТАЗЫ ДЛЯ ОРАЛЬНОГО ВВЕДЕНИЯ, СПОСОБ ЕГО ПОЛУЧЕНИЯ И ЕГО ИСПОЛЬЗОВАНИЕ
NZ337048A (en) * 1997-02-26 2000-10-27 Sankyo Co Use of N-[1-methyl-(substituted phenyl)ethyl]-3-oxo-4-aza-5alpha-androst-1-ene-17beta-carboxamide derivatives to treat prostate cancer
US6093722A (en) * 1997-02-26 2000-07-25 Sankyo Company, Limited Method for treating prostate cancer
ES2218840T3 (es) * 1997-07-29 2004-11-16 Sankyo Company Limited Composicion azasteroide para ael tratamiento de la alopecia, el hirsutismo femenino y la seborrea.
US6187925B1 (en) * 1997-12-23 2001-02-13 Merck & Co., Inc. Intermediates and process for the synthesis of azasteroids
US5998427A (en) * 1998-05-14 1999-12-07 Glaxo Wellcome Inc. Androstenones
US6645974B2 (en) 2001-07-31 2003-11-11 Merck & Co., Inc. Androgen receptor modulators and methods for use thereof
PL372920A1 (en) * 2002-03-13 2005-08-08 Merck & Co,Inc. Fluorinated 4-azasteroid derivatives as androgen receptor modulators
CA2524409C (en) * 2003-05-07 2011-12-20 Merck & Co., Inc. Androgen receptor modulators and methods of use thereof
CA2530182A1 (en) * 2003-06-30 2005-01-20 Merck & Co., Inc. 17-acetamido-4-azasteroid derivatives as androgen receptor modulators
CA2530047A1 (en) * 2003-06-30 2005-02-03 Merck & Co., Inc. 17-acetamido-4-azasteroid derivatives as androgen receptor modulators
US7696217B2 (en) * 2003-06-30 2010-04-13 Merck Sharp & Dohme Corp. 17-acetamido-4-azasteroid derivatives as androgen receptor modulators
EP1734963A4 (en) * 2004-04-02 2008-06-18 Merck & Co Inc METHOD FOR TREATING PEOPLE WITH METABOLIC AND ANTHROPOMETRIC DISORDER
CA2602386A1 (en) * 2005-03-25 2006-10-05 Merck & Co., Inc. Method of treating men with testosterone supplement and 5alpha-reductase inhibitor
CN116621913B (zh) * 2022-08-12 2026-03-27 湖南科益新生物医药有限公司 一种4-氮杂甾体化合物及其制备方法、用途及药物组合物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4377584A (en) * 1978-04-13 1983-03-22 Merck & Co., Inc. 4-Aza-17β-substituted-5α-androstan-3-one-reductase inhibitors
AU527030B2 (en) * 1978-04-13 1983-02-10 Merck & Co., Inc. 4-aza-17-substituted-5a-androstan-3-ones
US4179453A (en) 1978-04-13 1979-12-18 Merck & Co., Inc. Process for preparing 17β-carboxy-5-androsten-3-ones
US4220775A (en) * 1979-03-15 1980-09-02 Merck & Co., Inc. Preparation of 4-aza-17-substituted-5α-androstan-3-ones useful as 5α-reductase inhibitors
NZ211145A (en) * 1984-02-27 1988-10-28 Merck & Co Inc 4-aza-5-alpha-androst-1-en-3-ones and pharmaceutical compositions
US4760071A (en) * 1984-02-27 1988-07-26 Merck & Co., Inc. 17β-N-monosubstituted carbamoyl-4-aza-5α-androst-1-en-3-ones which are active as testosterone 5α-reductase inhibitors
GB8505862D0 (en) * 1985-03-07 1985-04-11 Erba Farmitalia Steroidic 5alpha-reductase inhibitors
US5021575A (en) * 1989-11-13 1991-06-04 Merck & Co., Inc. Method for introducing a 1,2 double bond into azasteroids

Also Published As

Publication number Publication date
DE69120500D1 (de) 1996-08-01
ZA918570B (en) 1992-08-26
AU8682191A (en) 1992-04-30
HUT59417A (en) 1992-05-28
JPH0532693A (ja) 1993-02-09
HU218667B (hu) 2000-10-28
CS326991A3 (en) 1992-05-13
CN1209319A (zh) 1999-03-03
US5302621A (en) 1994-04-12
CN1072935C (zh) 2001-10-17
EP0484094B1 (en) 1996-06-26
RU2070204C1 (ru) 1996-12-10
HK1017274A1 (en) 1999-11-19
AU640279B2 (en) 1993-08-19
IL99889A0 (en) 1992-08-18
JPH0819151B2 (ja) 1996-02-28
EP0484094A2 (en) 1992-05-06
ATE139783T1 (de) 1996-07-15
CA2054368C (en) 2001-10-02
IL99889A (en) 1995-06-29
HK1005456A1 (en) 1999-01-08
GR3020483T3 (en) 1996-10-31
CA2054368A1 (en) 1992-04-30
HU913396D0 (en) 1992-01-28
EP0484094A3 (en) 1993-07-14
IE76452B1 (en) 1997-10-22
ES2091299T3 (es) 1996-11-01
HU211642A9 (en) 1995-12-28
DE69120500T2 (de) 1997-02-27
CZ279312B6 (cs) 1995-04-12
PT99371B (pt) 1999-04-30
IE913747A1 (en) 1992-05-22
CN1053672C (zh) 2000-06-21
CN1062145A (zh) 1992-06-24
PT99371A (pt) 1992-09-30
KR0134570B1 (ko) 1998-04-14
KR920008063A (ko) 1992-05-27

Similar Documents

Publication Publication Date Title
DK0484094T3 (da) Azasteroide forbindelser til behandling af prostatahypertrofi, deres fremstilling og anvendelse
DK0567271T3 (da) Steroidderivater til behandling af prostatahypertrofi, fremgangsmåde til fremstilling heraf og anvendelser heraf
DK98787A (da) 1,2,5,6-tetrahydropyridin-3-carboxaldehydoximderivater og praeparater med indhold deraf samt fremgangsmaade til deres fremstilling
ATE114465T1 (de) Pharmazeutische zusammensetzung zur inhibierung der knochenresorption.
EP0347815A3 (en) Cleaner for thermostatic water bath
FI103887B (fi) Menetelmä terapeuttisesti käyttökelpoisten imidatsolyylimetyyli-pyridiinien valmistamiseksi
ATE131061T1 (de) Förderung der osteogenese durch verwendung von vitamin d-derivaten.
DK397487D0 (da) 3-aryl-3-cycloalkyl-piperidin-2,6-dion-derivater, deres fremstilling og anvendelse
SE8505369D0 (sv) New thienopyridine derivatives, a process of preparation thereof and therapeutic compositions containing the same
TW225989B (da)
EP0802179A4 (en) DERIVATE SUBSTITUTED AMIDINONAPHTHYLESTER
DK0764443T3 (da) Midler tl behandling af med tumorer forbundet kakeksi
DK401779A (da) Fremgangsmaade til isomerisering af 3-azabicyclo-(3.1.0) hexanderivater
DK0627419T3 (da) Optisk aktive derivater af 1-phenylpyrrolidon og fremgangsmåde til fremstilling deraf
TH919A (th) การเตรียมอนุพันธ์ 1-แอลคิล-2-อะมิโน-เททราลิน