ATE139784T1 - Hybrid-rezeptoren, diese kodierende nukleinsäure, ihre herstellung und ihre verwendung zur bestimmung von liganden sowie deren antagonisten oder agonisten - Google Patents

Hybrid-rezeptoren, diese kodierende nukleinsäure, ihre herstellung und ihre verwendung zur bestimmung von liganden sowie deren antagonisten oder agonisten

Info

Publication number
ATE139784T1
ATE139784T1 AT87303801T AT87303801T ATE139784T1 AT E139784 T1 ATE139784 T1 AT E139784T1 AT 87303801 T AT87303801 T AT 87303801T AT 87303801 T AT87303801 T AT 87303801T AT E139784 T1 ATE139784 T1 AT E139784T1
Authority
AT
Austria
Prior art keywords
agonists
antagonists
hybrid receptors
production
nucleic acids
Prior art date
Application number
AT87303801T
Other languages
English (en)
Inventor
Thomas Joseph Dull
Heimo Riedel
Axel Ullrich
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of ATE139784T1 publication Critical patent/ATE139784T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/033—Fusion polypeptide containing a localisation/targetting motif containing a motif for targeting to the internal surface of the plasma membrane, e.g. containing a myristoylation motif
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/90—Fusion polypeptide containing a motif for post-translational modification
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/968—High energy substrates, e.g. fluorescent, chemiluminescent, radioactive
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/806—Antigenic peptides or proteins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT87303801T 1986-04-30 1987-04-29 Hybrid-rezeptoren, diese kodierende nukleinsäure, ihre herstellung und ihre verwendung zur bestimmung von liganden sowie deren antagonisten oder agonisten ATE139784T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/857,899 US4859609A (en) 1986-04-30 1986-04-30 Novel receptors for efficient determination of ligands and their antagonists or agonists

Publications (1)

Publication Number Publication Date
ATE139784T1 true ATE139784T1 (de) 1996-07-15

Family

ID=25326982

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87303801T ATE139784T1 (de) 1986-04-30 1987-04-29 Hybrid-rezeptoren, diese kodierende nukleinsäure, ihre herstellung und ihre verwendung zur bestimmung von liganden sowie deren antagonisten oder agonisten

Country Status (8)

Country Link
US (1) US4859609A (de)
EP (1) EP0244221B1 (de)
JP (2) JP2592063B2 (de)
AT (1) ATE139784T1 (de)
CA (1) CA1328419C (de)
DE (1) DE3751846T2 (de)
ES (1) ES2090007T3 (de)
GR (1) GR3021017T3 (de)

Families Citing this family (149)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6861511B1 (en) 1986-06-04 2005-03-01 Bayer Corporation Detection and quantification of neu related proteins in the biological fluids of humans
US6794160B1 (en) 1986-10-24 2004-09-21 Salk Inst For Biological Studi Hormone receptor compositions and methods
US5071773A (en) * 1986-10-24 1991-12-10 The Salk Institute For Biological Studies Hormone receptor-related bioassays
US6994988B1 (en) 1987-02-12 2006-02-07 Genetech, Inc. Methods and deoxyribonucleic acid for the preparation of tissue factor protein
US7084251B1 (en) 1987-02-12 2006-08-01 Genentech, Inc. Methods and Deoxyribonucleic acid for the preparation of tissue factor protein
US6710169B2 (en) 1987-10-02 2004-03-23 Genentech, Inc. Adheson variants
US5336603A (en) * 1987-10-02 1994-08-09 Genentech, Inc. CD4 adheson variants
US4981784A (en) * 1987-12-02 1991-01-01 The Salk Institute For Biological Studies Retinoic acid receptor method
US5571692A (en) * 1987-12-02 1996-11-05 The Salk Institute For Biological Studies Retinoic acid receptor α, vectors and cells comprising the same DNA encoding
US5223606A (en) * 1987-12-16 1993-06-29 Institut Pasteur Steroid/thyroid hormone receptor-related protein inappropriately expressed in human hepatocellular carcinoma
US5317090A (en) * 1987-12-16 1994-05-31 Institut Pasteur Steroid/thyroid hormone receptor-related gene, which is inappropriately expressed in human hepatocellular carcinoma, and which is a retinoic acid receptor
EP0321362B1 (de) * 1987-12-16 1996-09-25 Institut Pasteur Retinoesäurerezeptor und Derivate davon, beide Substanzen codierende DNS und die Verwendung der Proteine und der DNS
US5149781A (en) * 1987-12-16 1992-09-22 Institut Pasteur Steroid/thyroid hormone receptor-related gene inappropriately expressed in human hepatocellular carcinoma
US6018026A (en) * 1988-01-22 2000-01-25 Zymogenetics, Inc. Biologically active dimerized and multimerized polypeptide fusions
US5750375A (en) * 1988-01-22 1998-05-12 Zymogenetics, Inc. Methods of producing secreted receptor analogs and biologically active dimerized polypeptide fusions
DE68926888T2 (de) * 1988-01-22 1997-01-09 Zymogenetics Inc Verfahren zur Herstellung von sekretierten Rezeptoranalogen
US5567584A (en) * 1988-01-22 1996-10-22 Zymogenetics, Inc. Methods of using biologically active dimerized polypeptide fusions to detect PDGF
FR2628750B1 (fr) * 1988-03-21 1991-11-08 Pasteur Institut Vecteur modifie par une sequence codant pour une sequence d'acides amines contenue dans une proteine de mammifere ayant une activite biologique de recepteur membranaire
SE8802939D0 (sv) * 1988-08-19 1988-08-19 Kabigen Ab A method for the production and isolation of a fusion protein in eukaryotic cells
US5217867A (en) * 1988-11-30 1993-06-08 The Salk Institute For Biological Studies Receptors: their identification, characterization, preparation and use
EP1201757A3 (de) * 1988-12-22 2002-09-11 Genentech, Inc. Verfahren zur Herstellung von wasserlöslichen Polypeptiden
WO1990012877A1 (en) * 1989-04-19 1990-11-01 Cetus Corporation Multifunctional m-csf proteins and genes encoding therefor
JP3039802B2 (ja) 1989-07-06 2000-05-08 ザ リージェンツ オブザ ユニバーシティ オブ カリフォルニア 繊維芽細胞成長因子のための受容体
FR2650598B1 (fr) * 1989-08-03 1994-06-03 Rhone Poulenc Sante Derives de l'albumine a fonction therapeutique
US5284746A (en) * 1990-02-08 1994-02-08 Zymogenetics, Inc. Methods of producing hybrid G protein-coupled receptors
US5498538A (en) * 1990-02-15 1996-03-12 The University Of North Carolina At Chapel Hill Totally synthetic affinity reagents
ATE212059T1 (de) * 1990-02-15 2002-02-15 Methoden zur identifizierung heterofunktionaler fusionsproteine
US5747334A (en) * 1990-02-15 1998-05-05 The University Of North Carolina At Chapel Hill Random peptide library
AU655417B2 (en) 1990-03-22 1994-12-22 Salk Institute For Biological Studies, The Insect retinoid receptor compositions and methods
US5861274A (en) * 1990-03-22 1999-01-19 The Salk Institute For Biological Studies Nucleic acids encoding peroxisome proliferator-activated receptor
US5369028A (en) * 1990-04-03 1994-11-29 The Salk Institute Biotechnology/Industrial Associates, Inc. DNA and mRNA encoding human neuronal nicotinic acetylcholine receptor compositions and cells transformed with same
US6440681B1 (en) 1990-04-03 2002-08-27 Merck & Co., Inc. Methods for identifying agonists and antagonists for human neuronal nicotinic acetylcholine receptors
IL97996A0 (en) * 1990-04-30 1992-06-21 Novo Nordisk As Hybrid cellular receptor
DK106490D0 (da) * 1990-04-30 1990-04-30 Novo Nordisk As Celle
US5578482A (en) * 1990-05-25 1996-11-26 Georgetown University Ligand growth factors that bind to the erbB-2 receptor protein and induce cellular responses
US5218090A (en) * 1990-06-12 1993-06-08 Warner-Lambert Company EGF receptor truncates
US5401629A (en) * 1990-08-07 1995-03-28 The Salk Institute Biotechnology/Industrial Associates, Inc. Assay methods and compositions useful for measuring the transduction of an intracellular signal
US5453491A (en) * 1990-09-11 1995-09-26 Kiyoshi Takatsu Murine interleukin-5 receptor
IE20020110A1 (en) 1990-09-13 2003-05-28 Univ Duke Expression of G Protein Coupled Receptors in Yeast
WO1992006220A1 (en) * 1990-10-05 1992-04-16 President And Fellows Of Harvard College Detection and isolation of ligands
DE4037837A1 (de) * 1990-11-28 1992-06-04 Behringwerke Ag Zellfreie rezeptorbindungsteste, ihre herstellung und verwendung
US5385831A (en) * 1990-12-12 1995-01-31 Zymogenetics, Inc. Method for producing a mammalian G protein coupled glutamate receptor
NZ240921A (en) * 1990-12-12 1994-06-27 Zymogenetics Inc G protein coupled glutamate receptor (neurotransmitters), recombinant production
US5869609A (en) * 1990-12-12 1999-02-09 Zymogenetics, Inc. G protein coupled glutamate receptors
DE69123241T2 (de) * 1990-12-14 1997-04-17 Cell Genesys Inc Chimärische ketten zur transduktion von rezeptorverbundenen signalwegen
EP0492179A3 (en) * 1990-12-28 1992-12-09 American Cyanamid Company Avian growth hormone receptor and binding protein
US5264565A (en) * 1991-01-22 1993-11-23 Affymax Technologies, N.V. Nucleic acid encoding the D2 /Ml chimeric receptor
US5688768A (en) * 1991-02-19 1997-11-18 Cor Therapeutics, Inc. Recombinant thrombin receptor and related pharmaceuticals
US7119182B1 (en) 1991-02-19 2006-10-10 The Regents Of The University Of California Recombinant thrombin receptor and related pharmaceuticals
US5256766A (en) * 1991-02-19 1993-10-26 The Regents Of The University Of California Recombinant thrombin receptor and related pharmaceuticals
CA2106061C (en) * 1991-03-15 2008-10-07 Christie A. Kelton Human follicle stimulating hormone receptor
US5212075A (en) * 1991-04-15 1993-05-18 The Regents Of The University Of California Compositions and methods for introducing effectors to pathogens and cells
US5215915A (en) * 1991-04-16 1993-06-01 Duke University Cloned gene encoding rat d1b dopamine receptor
US5245011A (en) * 1991-04-16 1993-09-14 Duke University Aqueous solution containing D1B dopamine receptor
SE9101433D0 (sv) * 1991-05-13 1991-05-13 Marianne Hansson Recombinant dna sequence and its use
AU2179192A (en) * 1991-06-05 1993-01-08 United States Of America, Represented By The Secretary, Department Of Health And Human Services, The Transfected mammalian cell lines expressing the a1 adenosine receptor
ATE173295T1 (de) * 1991-08-08 1998-11-15 Genentech Inc Ecdysteroid-abhängige gen regulierung in säugetier-zellen
IL100219A0 (en) * 1991-12-02 1992-09-06 Yeda Res & Dev Variable region within fibroblast growth factor receptors that confers ligand specificity
US5436155A (en) * 1991-12-31 1995-07-25 Arch Development Corporation Isolated DNA encoding a somatostatin receptor
FR2686899B1 (fr) 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
CA2131389A1 (en) * 1992-03-02 1993-09-16 John M. Maraganore Thrombin receptor antagonists
NZ252486A (en) * 1992-04-29 1997-08-22 Univ Georgetown Blocking peptides capable of binding to ligands of the epidermal growth factor receptor (erbb-2) and their use in detecting such ligands
WO1994001558A2 (en) * 1992-07-02 1994-01-20 The Salk Institute For Biological Studies Multimeric forms of members of the steroid/thyroid superfamily of receptors with the ultraspiracle receptor
IL106197A (en) * 1992-07-30 1999-11-30 Cor Therapeutics Inc Agagonists for the rhombin receptors and pharmaceutical preparations containing them
EP0682710B1 (de) * 1993-02-10 2003-10-29 Unilever Plc Isolierungsverfahren verwendend immobilisierte proteine mit spezifischen bindungskapazitäten
CA2155330C (en) 1993-03-08 2002-01-29 Kathryn J. Elliott Human neuronal nicotinic acetylcholine receptor compositions and methods employing same
FR2703935B1 (fr) * 1993-04-14 1995-07-21 Usinor Sacilor Dispositif de changement rapide et de maintien d'une paroi laterale d'une machine de coulee continue d'un produit metallique entre cylindres.
EP0705341A1 (de) * 1993-06-07 1996-04-10 Amgen Inc. Hybride rezeptormoleküle
US6562333B1 (en) 1993-06-14 2003-05-13 Schering Corporation Purified mammalian CTLA-8 antigens and related reagents
US5679582A (en) * 1993-06-21 1997-10-21 Scriptgen Pharmaceuticals, Inc. Screening method for identifying ligands for target proteins
IL110298A (en) * 1993-07-13 1999-04-11 Brann Mark Robert Identification of ligands by selective amplification of cells transfected with receptors
AU7844894A (en) * 1993-09-27 1995-04-18 University Of Massachusetts Medical Center Receptor-activated reporter systems
US5989893A (en) * 1993-09-27 1999-11-23 University Of Massachusetts Medical Center Receptor-activated reporter systems
WO1995013299A1 (en) * 1993-11-08 1995-05-18 The Salk Institute Biotechnology/Industrial Associates, Inc. Human neuronal nicotinic acetylcholine receptor compositions and methods employing same
WO1995014930A1 (en) * 1993-11-23 1995-06-01 Genentech, Inc. Kinase receptor activation assay
AU697142B2 (en) * 1993-11-23 1998-10-01 Genentech Inc. Protein tyrosine kinases named Rse
US6287784B1 (en) 1993-11-23 2001-09-11 Genentech, Inc. Kinase receptor activation assay
US5523227A (en) * 1994-06-17 1996-06-04 The Board Of Trustees Of The Leland Stanford Junior Univ. DNA encoding calcium-signal modulating cyclophilin ligand
US6010861A (en) * 1994-08-03 2000-01-04 Dgi Biotechnologies, Llc Target specific screens and their use for discovering small organic molecular pharmacophores
WO1996024063A1 (en) * 1995-01-30 1996-08-08 The General Hospital Corporation Methods for identifying integrin antagonists
US5665873A (en) * 1995-02-09 1997-09-09 Dana Farber Cancer Institute Glucocorticoid response elements
US6485967B1 (en) 1995-06-07 2002-11-26 Merck & Co., Inc. Human neuronal nicotinic acetylcholine receptor α6 and β3 nucleic acid
DE69637587D1 (de) * 1995-07-26 2008-08-21 Astrazeneca Ab Chimäre rezeptoren und verfahren zur identifizieren verbindungen mit einem aktivität als metabotropischen glutamatrezeptoren sowie verwendung solcher verbindungen in der behandlung von neurologischer erkrankungen und neurologischenstörrungen
JPH10509053A (ja) 1995-09-08 1998-09-08 スクリプトジェン・ファーマスーティカルズ，インコーポレイテッド Ｒｎａに対する親和性を有する化合物のためのスクリーン
CA2184195C (en) * 1995-10-25 2002-04-16 Andrew Pakula Screening method for identifying ligands for target proteins
GB9526733D0 (en) 1995-12-30 1996-02-28 Delta Biotechnology Ltd Fusion proteins
US5981199A (en) 1996-06-14 1999-11-09 Boehringer Mannheim Corporation Method for measuring antigen concentration
ES2308787T3 (es) 1996-08-16 2008-12-01 Schering Corporation Antigenos de superficie de celular de mamiferos; reactivos relacionados.
US6544523B1 (en) * 1996-11-13 2003-04-08 Chiron Corporation Mutant forms of Fas ligand and uses thereof
EP1803816A3 (de) 1996-12-13 2007-09-26 Schering Corporation Zelloberflächen-Antigene aus Säugetieren und verwandte Reagenzien
JP2001514511A (ja) * 1997-03-05 2001-09-11 スクリプトゲン ファーマシューティカルズ インク 核酸への親和性を持つ化合物同定のための蛍光異方性を用いたスクリーニング
ATE458053T1 (de) 1997-05-07 2010-03-15 Schering Corp Menschliche toll-like-rezeptorproteine, zugehörige reagenzien und verfahren
AR014891A1 (es) 1997-07-09 2001-04-11 Schering Corp Genes aislados de proteinas de membranas de mamiferos; reactivos relacionados
AU8101698A (en) 1997-07-18 1999-02-10 Novo Nordisk A/S Use of fviia or fviiai for the treatment of adverse conditions related to the fviia mediated intracellular signalling pathway
US6461610B1 (en) 1997-07-18 2002-10-08 Novo Nordisk A/S Methods for modifying cell motility using factor VIIa or inactivated factor VIIa
PE20000183A1 (es) 1997-07-25 2000-03-11 Schering Corp Citoquinas de mamiferos y reactivos relacionados
ES2274574T3 (es) 1997-08-01 2007-05-16 Schering Corporation Proteinas de membrana celular de mamifero; reactivos relacionados.
US7632651B2 (en) 1997-09-15 2009-12-15 Mds Analytical Technologies (Us) Inc. Molecular modification assays
US7745142B2 (en) 1997-09-15 2010-06-29 Molecular Devices Corporation Molecular modification assays
US7070921B2 (en) 2000-04-28 2006-07-04 Molecular Devices Corporation Molecular modification assays
PL194483B1 (pl) 1997-11-12 2007-06-29 Dimensional Pharmaceuticals 3 Sposób wyznaczania funkcji biologicznej docelowego białka
AUPP135698A0 (en) * 1998-01-15 1998-02-05 Commonwealth Scientific And Industrial Research Organisation Insectical modalities
US7262280B1 (en) 1998-04-03 2007-08-28 Nps Pharmaceuticals, Inc. G-protein fusion receptors and constructs encoding same
US6692696B1 (en) * 1998-06-18 2004-02-17 ARETé ASSOCIATES Biosensor
WO2000017362A1 (en) 1998-09-21 2000-03-30 Schering Corporation Human interleukin-b50, therapeutic uses
EP0997476A3 (de) 1998-09-25 2000-07-19 Schering-Plough Antikörper gegen ein Antigen auf Langerhans Zellen in Säugetieren und deren Verwendungen
US6569631B1 (en) 1998-11-12 2003-05-27 3-Dimensional Pharmaceuticals, Inc. Microplate thermal shift assay for ligand development using 5-(4″dimethylaminophenyl)-2-(4′-phenyl)oxazole derivative fluorescent dyes
DE60043051D1 (de) 1999-01-11 2009-11-12 Schering Corp Dafür kodierende polynukleotide. verwendungen
US6972198B2 (en) 1999-02-26 2005-12-06 Cyclacel, Ltd. Methods and compositions using protein binding partners
EP1942114A3 (de) 1999-03-11 2008-08-27 Schering Corporation Säuger-Zytokine, zugehörige Reagenzien und Verfahren
NZ515382A (en) 1999-05-13 2004-03-26 Medical Res Council OX2 receptor homologs
SI1181366T2 (sl) 1999-06-01 2013-10-30 Merck Sharp & Dohme Corp. Sesalski receptorski proteini; sorodni reagenti in postopki
CN1365391A (zh) 1999-07-30 2002-08-21 先灵公司 哺乳动物细胞因子以及相关试剂
EP1905832A3 (de) 1999-09-09 2009-09-09 Schering Corporation Säuger Interleukin-12 P40 und Interleukin B30, Antikörper, Verwendungen in pharmazeutischen Zusammenstellungen
NZ518374A (en) * 1999-09-13 2006-09-29 Equitech Lab Inc A method for detecting a target analyte in a sample
US20050148018A1 (en) 1999-10-07 2005-07-07 David Weiner Methods of identifying inverse agonists of the serotonin 2A receptor
US20040033600A1 (en) * 2001-03-21 2004-02-19 Palli Subba Reddy Ecdysone receptor-based inducible gene expression system
US6946134B1 (en) 2000-04-12 2005-09-20 Human Genome Sciences, Inc. Albumin fusion proteins
EP2206720A1 (de) 2000-04-12 2010-07-14 Human Genome Sciences, Inc. Albuminfusionsproteine
CA2408571C (en) 2000-05-10 2014-04-29 Schering Corporation Mammalian receptor proteins; related reagents and methods
US7422743B2 (en) 2000-05-10 2008-09-09 Schering Corporation Mammalian receptor protein DCRS5;methods of treatment
NZ522327A (en) 2000-05-25 2004-09-24 Schering Corp Mammalian DNAX Toll-like receptor protein, DTLR 10, antibodies and medicaments made therefrom and use in treating immunological disorders
JP4908721B2 (ja) * 2000-07-17 2012-04-04 中外製薬株式会社 生理活性を有するリガンドのスクリーニング方法
JP2004509617A (ja) 2000-09-08 2004-04-02 シェーリング　コーポレイション 哺乳動物遺伝子；関連試薬および方法
US8105825B2 (en) * 2000-10-03 2012-01-31 Intrexon Corporation Multiple inducible gene regulation system
US6890734B2 (en) 2000-11-10 2005-05-10 Schering Corporation Nucleic acids encoding a cytokine receptor complex
US20060116325A1 (en) * 2001-02-15 2006-06-01 Oleg Chertov Methods and compositions for inhibiting hiv-coreceptor interactions
EP1373470B1 (de) * 2001-02-20 2013-04-24 Intrexon Corporation Neue substitutionsmutantenrezeptoren und ihre verwendung in einem induzierbaren genexpressionssystem auf basis eines nukleären rezeptors
WO2002066613A2 (en) 2001-02-20 2002-08-29 Rheogene Holdings, Inc Novel ecdysone receptor/invertebrate retinoid x receptor-based inducible gene expression system
CA2438133C (en) 2001-02-20 2015-01-27 Rheogene, Inc. Novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system
ES2424812T3 (es) 2001-02-20 2013-10-08 Intrexon Corporation Receptores X retinoides quiméricos y su uso en un sistema inducible de expresión génica basado en receptores de ecdisona novedoso
US7507413B2 (en) 2001-04-12 2009-03-24 Human Genome Sciences, Inc. Albumin fusion proteins
EP1409982A4 (de) * 2001-06-14 2006-05-24 Anadys Pharmaceuticals Inc Verfahren zum screening auf liganden von zielmolekülen
WO2003027289A1 (en) 2001-09-26 2003-04-03 Rheo Gene Holdings, Inc. Leafhopper ecdysone receptor nucleic acids, polypeptides, and uses thereof
CA2459807C (en) * 2001-09-26 2013-09-03 Jianzhong Zhang Whitefly ecdysone receptor nucleic acids, polypeptides, and uses thereof
EP2261250B1 (de) 2001-12-21 2015-07-01 Human Genome Sciences, Inc. GCSF-Albumin Fusionsproteine
JP2006511220A (ja) * 2002-12-23 2006-04-06 グライコフィ， インコーポレイテッド 遺伝子発現のステロイド受容体調節
CA2513213C (en) 2003-01-22 2013-07-30 Human Genome Sciences, Inc. Albumin fusion proteins
US7304161B2 (en) 2003-02-10 2007-12-04 Intrexon Corporation Diaclhydrazine ligands for modulating the expression of exogenous genes in mammalian systems via an ecdysone receptor complex
US7456315B2 (en) 2003-02-28 2008-11-25 Intrexon Corporation Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
US20040185548A1 (en) * 2003-03-17 2004-09-23 Qun-Sheng Ji Hybrid receptors for efficient assay of modulators of receptor protein-tyrosine kinases
US20050186658A1 (en) * 2003-10-17 2005-08-25 Nps Pharmaceuticals, Inc. Chimeric metabotropic glutamate receptors and uses thereof
US7935510B2 (en) * 2004-04-30 2011-05-03 Intrexon Corporation Mutant receptors and their use in a nuclear receptor-based inducible gene expression system
EP1751115A4 (de) 2004-05-23 2010-10-20 Gerard M Housey Theramuteinmodulatoren
US8431110B2 (en) 2005-05-23 2013-04-30 Hmi Medical Innovations, Llc. Compounds and method of identifying, synthesizing, optimizing and profiling protein modulators
US20090275070A1 (en) * 2005-11-23 2009-11-05 Housey Gerard M Compounds and Methods of Identifying, Synthesizing, Optimizing and Profiling Protein Modulators
AR059193A1 (es) 2006-01-31 2008-03-12 Bayer Schering Pharma Ag Modulacion de la actividad de mdl-1 para el tratamiento de enfermedades inflamatorias
ES2683329T3 (es) 2013-03-15 2018-09-26 Intrexon Corporation Diacilhidrazinas que contienen boro
WO2016044390A1 (en) 2014-09-17 2016-03-24 Intrexon Corporation Boron-containing diacylhydrazine compounds

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3935074A (en) * 1973-12-17 1976-01-27 Syva Company Antibody steric hindrance immunoassay with two antibodies
US4374925A (en) * 1978-11-24 1983-02-22 Syva Company Macromolecular environment control in specific receptor assays
US4446231A (en) * 1979-10-03 1984-05-01 Self Colin H Immunoassay using an amplified cyclic detection system
IT1144705B (it) * 1980-03-17 1986-10-29 Harvard College Produzione ottimale di polipeptidi con impiego di geni fusionati
JPS57106625A (en) * 1980-12-22 1982-07-02 Teijin Ltd Cytotoxic protein complex and its preparation
DE3100061A1 (de) * 1981-01-02 1982-08-05 Hans A. Dipl.-Chem. Dr. 8000 München Thoma Verfahren zur bestimmung von liganden mittels kompetitionsreaktion
DE3209149A1 (de) * 1982-03-13 1983-10-06 Hoechst Ag Verfahren zur gemeinsamen immunologischen bestimmung von prokollagen-peptid (typ iii) und prokollagen-peptid col 1 (typ iii) und verfahren zur herstellung von anti-prokollagen-peptid col 1 (typ iii)-serum
US4544629A (en) * 1982-11-19 1985-10-01 Minnesota Mining And Manufacturing Company Receptor-based histamine assay
US4816567A (en) * 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
GB8314362D0 (en) * 1983-05-24 1983-06-29 Celltech Ltd Polypeptide and protein products
JPS60166699A (ja) * 1984-02-03 1985-08-29 Japan Found Cancer 成人ｔ細胞白血病ウイルス抗原ポリペプチド
EP0173494A3 (de) * 1984-08-27 1987-11-25 The Board Of Trustees Of The Leland Stanford Junior University Chimäre Rezeptoren durch Verbindung und Expression von DNS

Also Published As

Publication number Publication date
HK1008022A1 (en) 1999-04-30
JP2795833B2 (ja) 1998-09-10
GR3021017T3 (en) 1996-12-31
DE3751846T2 (de) 1997-01-09
JPH09117285A (ja) 1997-05-06
ES2090007T3 (es) 1996-10-16
JP2592063B2 (ja) 1997-03-19
US4859609A (en) 1989-08-22
EP0244221B1 (de) 1996-06-26
CA1328419C (en) 1994-04-12
EP0244221A1 (de) 1987-11-04
DE3751846D1 (de) 1996-08-01
JPS62272990A (ja) 1987-11-27

Similar Documents

Publication Publication Date Title
ATE139784T1 (de) Hybrid-rezeptoren, diese kodierende nukleinsäure, ihre herstellung und ihre verwendung zur bestimmung von liganden sowie deren antagonisten oder agonisten
ATE87663T1 (de) Verfahren zur herstellung von faktor-viii:c-typ- proteinen.
ATE16820T1 (de) Testelement zur bestimmung von glukose in hoher konzentration.
DE68911633D1 (de) Verfahren zur Bestimmung von Peroxidase-Aktivität unter Verwendung von Chemilumineszenz.
DE68905633D1 (de) Markierer der t-zelle aktivierung.
DE3773608D1 (de) Mit fasern verstaerkte kautschukmischung, verfahren zu deren herstellung und deren verwendung.
ATE378407T1 (de) Morphogene protein-spezifische zelloberflächenrezeptoren und ihre verwendungen
DE3671640D1 (de) Kationische emulsionen von bitumen-polymerartigen bituminoesen bindemitteln und kationisches emulgiersystem, unter anderem verwendbar zur erhaltung derselben.
DE3581193D1 (de) Dachbedeckungsmaterial mit hoher festigkeit unter verwendung von verbesserten schichtblaettern.
ATE308609T1 (de) Pth rezeptor und testverfahren unter verwendung desselben
ATE142264T1 (de) Rekombinante herstellung von a-ketten- polypeptiden von pdgf
IL143558A0 (en) Method of enhancing the biological activity of ligands
DE3575746D1 (de) Faserstruktur zur verstaerkung von baumaterial.
EP0992584A3 (de) Gereinigte Säugetier FLT3 Liganden und deren Agonisten und Antagonisten
DE3485319D1 (de) Rekombinante dns, diese rekombinante dns enthaltende bakterien, und verfahren zur herstellung von l-threonin oder l-isoleucin unter verwendung dieser bakterien.
DE3582645D1 (de) Verfahren zur herstellung von mischkristallpigmenten auf der basis von perylentetracarbonsaeurediimiden und deren verwendung.
DE3688311D1 (de) Verfahren zum zuechten von rekombinanten zellen.
DE3583709D1 (de) Substrate zur verwendung fuer die bestimmung der konzentration von harnkallikrein.
DE3780938D1 (de) Reagens zur bestimmung von chloridionen.
DE3586999D1 (de) Verfahren zur bestimmung von leucinaminopeptidase (lap).
DE3582464D1 (de) Mischkristallpigmente auf der basis von perylentetracarbonsaeurediimiden, verfahren zu ihrer herstellung und ihre verwendung.
EP0155832A3 (de) Stabile Proteine, Verfahren zu deren Herstellung, dieselben kodierende Plasmide und andere DNS, diese Plasmide enthaltende Zellkulturen
DE3852082D1 (de) Verfahren zur Erhöhung der Expression von Polypeptiden in rekombinanten Zellkulturen.
DE3789456D1 (de) Polyimidschaumvorprodukt und dessen verwendung zur verstärkung von offenzellenmaterialien.
DE3582388D1 (de) Mischkristallpigmente auf der basis von perylentetracarbonsaeurediimiden, verfahren zu ihrer herstellung und ihre verwendung.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time