ATE140237T1 - Oktapeptidanaloge von somatostatin mit threonin in position 6 - Google Patents

Oktapeptidanaloge von somatostatin mit threonin in position 6

Info

Publication number: ATE140237T1
Authority: AT; Austria
Prior art keywords: alkyl; somatostatin; threonine; phenylalkyl; r2oco
Prior art date: 1989-12-08

Application number

AT91901181T

Other languages

English (en)

Inventor

David H Coy

William A Murphy

Original Assignee

Univ Tulane

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-12-08

Filing date

1990-12-04

Publication date

1996-07-15

1990-12-04 Application filed by Univ Tulane filed Critical Univ Tulane

1996-07-15 Application granted granted Critical

1996-07-15 Publication of ATE140237T1 publication Critical patent/ATE140237T1/de

Links

AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 title 1
239000004473 Threonine Substances 0.000 title 1
NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical class C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 title 1
125000003884 phenylalkyl group Chemical group 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 2
125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 1
125000004400 (C1-C12) alkyl group Chemical group 0.000 abstract 1
125000003837 (C1-C20) alkyl group Chemical group 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000006193 alkinyl group Chemical group 0.000 abstract 1
125000001624 naphthyl group Chemical group 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C07K14/6555—Somatostatins at least 1 amino acid in D-form
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/16—Somatostatin; related peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/26—Containing cys-cys disulfide bridge between nonadjacent cysteine residues

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Endocrinology (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Gastroenterology & Hepatology (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Toxicology (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Medicinal Preparation (AREA)

AT91901181T 1989-12-08 1990-12-04 Oktapeptidanaloge von somatostatin mit threonin in position 6 ATE140237T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US44787689A	1989-12-08	1989-12-08

Publications (1)

Publication Number	Publication Date
ATE140237T1 true ATE140237T1 (de)	1996-07-15

Family

ID=23778103

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91901181T ATE140237T1 (de)	1989-12-08	1990-12-04	Oktapeptidanaloge von somatostatin mit threonin in position 6

Country Status (14)

Country	Link
US (1)	US5506339A (de)
EP (1)	EP0457888B1 (de)
JP (1)	JP2925321B2 (de)
KR (1)	KR920702854A (de)
AT (1)	ATE140237T1 (de)
CA (1)	CA2046594A1 (de)
DE (1)	DE69027767T2 (de)
DK (1)	DK0457888T3 (de)
ES (1)	ES2091907T3 (de)
GR (1)	GR3020513T3 (de)
HU (1)	HUT59166A (de)
PT (1)	PT96135B (de)
WO (1)	WO1991009056A1 (de)
ZA (1)	ZA909896B (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU207104B (en) *	1991-01-25	1993-03-01	Biosignal Kutato Fejlesztoe Kf	Process for producing new somatostatin analogs inhibiting tumour growth and pharmaceutical compositions comprising such compounds
CA2079896A1 (en) *	1991-02-08	1992-08-09	Arthur E. Bogden	Method of treating benign and malignant proliferative skin disease
US7238340B1 (en) *	1991-11-27	2007-07-03	Cis Bio International	Monoamine, diamide, thiol-containing metal chelating agents
US5411943A (en) *	1992-02-25	1995-05-02	Biomeasure, Inc.	Hepatoma treatment with somatostatin analogs
US5871711A (en) *	1992-06-23	1999-02-16	Diatide, Inc.	Radioactively-labeled somatostatin-derived peptides for imaging and therapeutic uses
US5716596A (en) *	1992-06-23	1998-02-10	Diatide, Inc.	Radioactively labeled somatostatin-derived peptides for imaging and therapeutic uses
WO1994002163A1 (en) *	1992-07-27	1994-02-03	The Administrators Of The Tulane Educational Fund	Neuromedin b receptor antagonists
US5569741A (en) *	1992-07-27	1996-10-29	Biomeasure, Inc.	Cyclic octapeptide neuromedin B receptor antagonists
US5462926A (en) *	1992-07-27	1995-10-31	Biomeasure, Inc.	Neuromedin B receptor antagonists which demonstrate selectivity
US5932189A (en) *	1994-07-29	1999-08-03	Diatech, Inc.	Cyclic peptide somatostatin analogs
US5597894A (en) *	1995-06-05	1997-01-28	The Louisiana State University Medical Center Foundation	Multi-tyrosinated somatostatin analogs
US5708135A (en) *	1995-09-29	1998-01-13	Biomeasure Incorporated	Cyclic peptide analogs of somatostatin
US6262229B1 (en)	1996-12-04	2001-07-17	Biomeasure Incorporated	Somatostatin antagonists
US6004928A (en) *	1997-05-13	1999-12-21	Biomeasure, Incorporated	Method of treating hyperlipidemia
PT980253E (pt) *	1997-05-13	2004-08-31	Conseils De Rec Appl Scient S	Somatostatina e agonistas de somatostatina para tratar a insensibilidade a insulina e a sindrome x
AU7655098A (en)	1997-05-13	1998-12-08	Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.)	Somatostatin and somatostatin agonists for decreasing body weight
EP0981364B1 (de)	1997-05-13	2006-03-01	Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S.	Methoden und zusammensetzungen zur behandlung der hyperlipidämie
IL140837A0 (en) *	1998-07-30	2002-02-10	Sod Conseils Rech Applic	Method of using lanreotide, a somatostatin analogue
EP1291022A1 (de) *	1998-07-30	2003-03-12	Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S.	Anwendungsverfahren für lanreotid, ein somatostatin analogon
DK1372688T3 (da) *	2001-03-08	2008-08-25	Univ Tulane	Somatostatin-antagonister
CN1541102A (zh) *	2001-04-09	2004-10-27		生长激素抑制素激动剂
AU2002305845B2 (en)	2001-06-08	2006-03-30	Ipsen Pharma S.A.S.	Somatostatin-dopamine chimeric analogs
US8709998B2 (en)	2003-04-22	2014-04-29	Ipsen Pharma S.A.S.	Peptide vectors
JP5728380B2 (ja)	2008-06-12	2015-06-03	シンタクシンリミテッドＳｙｎｔａｘｉｎＬｉｍｉｔｅｄ	神経内分泌疾患の抑制
BRPI0915142A8 (pt)	2008-06-12	2018-01-02	Syntaxin Ltd	Polipeptídeos, ácido nucleico e usos dos mesmos
GB0820970D0 (en)	2008-11-17	2008-12-24	Syntaxin Ltd	Suppression of cancer
DK3007704T3 (da)	2013-06-13	2021-03-29	Antisense Therapeutics Ltd	Kombinationsterapi til akromegali

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4291022A (en) *	1975-03-11	1981-09-22	Sandoz Ltd.	Organic compounds
CY1327A (en) *	1979-11-27	1986-06-27	Sandoz Ag	Novel polypeptides,processes for their production,pharmaceutical compositions comprising said polypeptides and their use
US4328105A (en) *	1980-02-06	1982-05-04	Linde Aktiengesellschaft	Treatment of suspended solids--and adsorbable contaminant--containing liquid
US4282143A (en) *	1980-06-13	1981-08-04	American Home Products Corporation	Octapeptides lowering growth hormone
US4328135A (en) *	1980-06-13	1982-05-04	American Home Products Corporation	Octapeptides lowering growth hormone
DK81082A (da) *	1981-03-06	1982-09-07	Sandoz Ag	Fremgangsmaade til fremstilling af polypeptider
US4485101A (en) *	1983-10-11	1984-11-27	Administrators Of The Tulane Educational Fund	Peptides
US4684620A (en) *	1984-09-04	1987-08-04	Gibson-Stephens Neuropharmaceuticals, Inc.	Cyclic polypeptides having mu-receptor specificity
US4725577A (en) *	1985-04-25	1988-02-16	Administrators Of The Tulane Educational Fund	Biologically active lysine containing octapeptides
US4650787A (en) *	1985-04-25	1987-03-17	Schally Andrew Victor	Biologically active octapeptides
US4904642A (en) *	1985-09-12	1990-02-27	The Administrators Of The Tulane Educational Fund	Therapeutic somatostatin analogs
US4853371A (en) *	1986-06-17	1989-08-01	The Administrators Of The Tulane Educational Fund	Therapeutic somatostatin analogs
JP2568228B2 (ja) *	1987-02-03	1996-12-25	ジ・アドミニストレーターズ・オブ・ザ・ツーレイン・エデュケイショナル・ファンド	治療用ソマトスタチンアナログ
JP2809403B2 (ja) *	1987-07-07	1998-10-08	ジ・アドミニストレーターズ・オブ・ザ・ツーレイン・エデュケイショナル・ファンド	治療用ソマトスタチンアナログ化合物
GB8813160D0 (en) *	1988-06-03	1988-07-06	Soc D Etudes Prod Chimique	Therapeutic methods

1990
- 1990-12-04 WO PCT/US1990/007074 patent/WO1991009056A1/en not_active Ceased
- 1990-12-04 DK DK91901181.7T patent/DK0457888T3/da active
- 1990-12-04 KR KR1019910700860A patent/KR920702854A/ko not_active Ceased
- 1990-12-04 JP JP3501584A patent/JP2925321B2/ja not_active Expired - Lifetime
- 1990-12-04 HU HU912648A patent/HUT59166A/hu unknown
- 1990-12-04 DE DE69027767T patent/DE69027767T2/de not_active Expired - Fee Related
- 1990-12-04 EP EP91901181A patent/EP0457888B1/de not_active Expired - Lifetime
- 1990-12-04 AT AT91901181T patent/ATE140237T1/de not_active IP Right Cessation
- 1990-12-04 CA CA002046594A patent/CA2046594A1/en not_active Abandoned
- 1990-12-04 ES ES91901181T patent/ES2091907T3/es not_active Expired - Lifetime
- 1990-12-07 PT PT96135A patent/PT96135B/pt not_active IP Right Cessation
- 1990-12-10 ZA ZA909896A patent/ZA909896B/xx unknown
1992
- 1992-02-21 US US07/840,621 patent/US5506339A/en not_active Expired - Lifetime
1996
- 1996-07-11 GR GR960401779T patent/GR3020513T3/el unknown

Also Published As

Publication number	Publication date
DE69027767T2 (de)	1997-01-02
ES2091907T3 (es)	1996-11-16
PT96135A (pt)	1991-09-30
HUT59166A (en)	1992-04-28
KR920702854A (ko)	1992-10-28
JP2925321B2 (ja)	1999-07-28
PT96135B (pt)	1998-04-30
CA2046594A1 (en)	1991-06-09
US5506339A (en)	1996-04-09
EP0457888A1 (de)	1991-11-27
ZA909896B (en)	1991-09-25
WO1991009056A1 (en)	1991-06-27
EP0457888A4 (en)	1992-01-02
DK0457888T3 (da)	1996-08-12
GR3020513T3 (en)	1996-10-31
EP0457888B1 (de)	1996-07-10
DE69027767D1 (de)	1996-08-14
JPH04505456A (ja)	1992-09-24

Legal Events

Date	Code	Title	Description
1996-12-15	UEP	Publication of translation of european patent specification
2006-09-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69027767D1 (de)	1996-08-14	Oktapeptidanaloge von somatostatin mit threonin in position 6
DK0565549T3 (da)	1995-07-03	Anvendelse af 1,3-oxathiolannucleosidanaloger til fremstilling af et præparat til behandling af hepatitis B
GR69233B (de)	1982-05-10
EP0235692A3 (en)	1988-09-07	Oligopeptidyl nitrile derivatives, the agents containing them, process for their preparation and their use
JPS53119844A (en)	1978-10-19	Optically active amino acid-mandelic acid complexes and theire preparation
EP0307880A3 (en)	1990-03-21	Ferroelectric liquid-crystal mixtures
PT93488A (pt)	1990-11-07	Processo de preparacao de composicoes farmaceuticas a base de (7 alfa, 17 alfa)-17-hidroxi-7-metil-19-nor-17-pregn-5(10)-en-20-in-3-ona e destes compostos numa forma pura e cristalina
DE69022593D1 (de)	1995-10-26	Neue methylenbisphosphonsäurederivate.
JPS52136118A (en)	1977-11-14	Modification of bestatin and analogous compounds and their preparation
ATE188217T1 (de)	2000-01-15	1,2,3,4,10,14b-hexahydrodibenzo-c,f)pyrazino-1, - a)azepino-derivate
GB8829593D0 (en)	1989-02-08	Novel compounds
NO176018C (no)	1995-01-18	Analogifremgangsmåte for fremstilling av terapeutisk aktive S-enantiomerer av substituerte 2-aminotetraliner
MY111439A (en)	2000-05-31	Thymosin alpha 1 derivatives
ES2046923A1 (es)	1994-02-01	Procedimiento para la estabilizacion de elastomeros.
JPS5358506A (en)	1978-05-26	Detergent composition
GB2135997B (en)	1986-02-19	N-(m-trifluoromethylphenyl)-n'-propargylpiperazine
NZ216125A (en)	1988-10-28	Isoxazoles and pharmaceutical compositions
CA2051460A1 (en)	1992-03-19	Pharmaceutical compounds
FI841992A0 (fi)	1984-05-17	Substituerade isokinolinderivat.
SE8302452D0 (sv)	1983-04-29	Method for treatment of senile dementia
ES8307712A1 (es)	1983-07-16	"procedimiento para la preparacion de n-(2,6-diclorofenil)-acetamidina".
NO914074D0 (no)	1991-10-17	Polyvinylkloridsammensetninger med forbedret bearbeidelses stabilite
DK551487A (da)	1988-04-28	1-hydroxyalkylxanthiner samt farmaceutiske praeparater med indhold af saadanne forbindelser
ATE89551T1 (de)	1993-06-15	Verfahren zur herstellung von optisch aktiven acyloxyazetidinonen.
JPS57108050A (en)	1982-07-05	Novel peptide and its preparation