ATE140457T1 - PYRROLO(2,3-D>PYRIMIDINE DERIVATIVES, METHOD FOR THE PRODUCTION AND MEDICINAL COMPOSITIONS CONTAINING SAME - Google Patents
PYRROLO(2,3-D>PYRIMIDINE DERIVATIVES, METHOD FOR THE PRODUCTION AND MEDICINAL COMPOSITIONS CONTAINING SAMEInfo
- Publication number
- ATE140457T1 ATE140457T1 AT90913731T AT90913731T ATE140457T1 AT E140457 T1 ATE140457 T1 AT E140457T1 AT 90913731 T AT90913731 T AT 90913731T AT 90913731 T AT90913731 T AT 90913731T AT E140457 T1 ATE140457 T1 AT E140457T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- pyrrolo
- production
- hydrocarbon residue
- compositions containing
- Prior art date
Links
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical class C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 title 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 3
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000003277 amino group Chemical group 0.000 abstract 2
- 125000004122 cyclic group Chemical group 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000004666 alkoxyiminoalkyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
- 150000004943 pyrrolo[2,3-d]pyrimidines Chemical class 0.000 abstract 1
- 125000005505 thiomorpholino group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
A pyrrolo[2,3-d]pyrimidine derivative represented by general formula (1), wherein R<1> represents H or a hydrocarbon residue; R<2> and R<3> each independently represent H a hydrocarbon residue or an acyl group, provided that R<2> and R<3> may combine with a neighboring N atom to form a cyclic amino group; R<4> and R<5> each independently represent H, a halogen atom or an alkyl group; Y represents a linear or cyclic amino group bonding through an N atom with the pyrimidine ring: Z represents H, a hydrocarbon residue, an acyl group, a carboxyl group, a hydroxyl group, an alkoxycarbonyl group, an acyloxy group, an alkoxy group, an alkoxyiminoalkyl group or an amino group, provided that Z may form in cooperation with Z a morpholino group or a thiomorpholino group. <CHEM>
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP24293389 | 1989-09-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE140457T1 true ATE140457T1 (en) | 1996-08-15 |
Family
ID=17096378
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90913731T ATE140457T1 (en) | 1989-09-19 | 1990-09-19 | PYRROLO(2,3-D>PYRIMIDINE DERIVATIVES, METHOD FOR THE PRODUCTION AND MEDICINAL COMPOSITIONS CONTAINING SAME |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0514540B1 (en) |
| KR (1) | KR970009225B1 (en) |
| AT (1) | ATE140457T1 (en) |
| AU (1) | AU641183B2 (en) |
| CA (1) | CA2065434C (en) |
| DE (1) | DE69027862T2 (en) |
| WO (1) | WO1991004254A1 (en) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0495982B1 (en) * | 1989-10-11 | 1996-06-12 | Teijin Limited | Bicyclic pyrimidine derivative, method of producing the same, and pharmaceutical preparation containing the same as active ingredient |
| US5196424A (en) * | 1992-03-24 | 1993-03-23 | Eli Lilly And Company | N-[2-amino-4-substituted[[(pyrrollo or pyrido)[2,3-d]pyrimidinyl]-alkyl]benzoyl]-L-glutamic acids |
| PT633886E (en) * | 1992-04-03 | 2001-03-30 | Upjohn Co | PHARMACEUTICALLY ACTIVE BICYLIC ACID-HETEROCYCLIC AMINTS |
| US5502187A (en) * | 1992-04-03 | 1996-03-26 | The Upjohn Company | Pharmaceutically active bicyclic-heterocyclic amines |
| FR2699176B1 (en) * | 1992-12-11 | 1995-03-03 | Adir | New bicyclic pyrimidine compounds, process for their preparation and pharmaceutical compositions containing them. |
| NZ304519A (en) * | 1995-03-02 | 2000-01-28 | Upjohn Co | Pydrimido[4,5-b]indoles |
| AU1441497A (en) * | 1996-01-23 | 1997-08-20 | Novartis Ag | Pyrrolopyrimidines and processes for their preparation |
| AU1794697A (en) * | 1996-03-06 | 1997-09-22 | Novartis Ag | 7-alkyl-pyrrolo{2,3-d}pyrimidines |
| US6339089B2 (en) | 1997-08-13 | 2002-01-15 | Fujirebio Inc. | Pyrimidine nucleus-containing compound and a medicament containing the same for a blood oxygen partial pressure amelioration, and a method for preparing the same |
| US6686366B1 (en) | 1998-06-02 | 2004-02-03 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A3 receptor and uses thereof |
| IL139787A0 (en) | 1998-06-02 | 2002-02-10 | Osi Pharm Inc | PYRROLO [2, 3d] PYRIMIDINE COMPOSITIONS AND THEIR USE |
| US6878716B1 (en) | 1998-06-02 | 2005-04-12 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A1 receptor and uses thereof |
| US7160890B2 (en) | 1999-12-02 | 2007-01-09 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A3 receptor and uses thereof |
| US6664252B2 (en) | 1999-12-02 | 2003-12-16 | Osi Pharmaceuticals, Inc. | 4-aminopyrrolo[2,3-d]pyrimidine compounds specific to adenosine A2a receptor and uses thereof |
| US6680322B2 (en) | 1999-12-02 | 2004-01-20 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A1 receptors and uses thereof |
| US6680324B2 (en) | 2000-12-01 | 2004-01-20 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A1 receptors and uses thereof |
| US6673802B2 (en) | 2000-12-01 | 2004-01-06 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A3 receptor and uses thereof |
| DE10148883A1 (en) * | 2001-10-04 | 2003-04-10 | Merck Patent Gmbh | New fused bi- or tricyclic pyrimidine derivatives, are phosphodiesterase V inhibitors useful e.g. for treating impotence, cardiovascular disorders, inflammation or tumors |
| DE60234118D1 (en) | 2001-11-30 | 2009-12-03 | Osi Pharm Inc | Compounds specific for adenosine A1 and A3 receptors and their applications |
| US20030229067A1 (en) | 2001-12-20 | 2003-12-11 | Arlindo Castelhano | Pyrrolopyrimidine A2b selective antagonist compounds, their synthesis and use |
| BR0215202A (en) | 2001-12-20 | 2004-10-13 | Osi Pharm Inc | A2b selective pyrimidine antagonist compounds, their synthesis and use |
| WO2005117909A2 (en) | 2004-04-23 | 2005-12-15 | Exelixis, Inc. | Kinase modulators and methods of use |
| JP5927201B2 (en) | 2010-12-16 | 2016-06-01 | カルチャン リミテッド | ASK1-inhibited pyrrolopyrimidine derivatives |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3739366A1 (en) * | 1987-04-10 | 1988-10-27 | Boehringer Mannheim Gmbh | DESAZA-PURIN-NUCLEOSIDE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE IN NUCLEIC ACID SEQUENCING AND AS AN ANTIVIRAL AGENT |
| EP0495982B1 (en) * | 1989-10-11 | 1996-06-12 | Teijin Limited | Bicyclic pyrimidine derivative, method of producing the same, and pharmaceutical preparation containing the same as active ingredient |
-
1990
- 1990-09-19 KR KR1019920700630A patent/KR970009225B1/en not_active Expired - Lifetime
- 1990-09-19 WO PCT/JP1990/001200 patent/WO1991004254A1/en not_active Ceased
- 1990-09-19 AT AT90913731T patent/ATE140457T1/en not_active IP Right Cessation
- 1990-09-19 AU AU64001/90A patent/AU641183B2/en not_active Ceased
- 1990-09-19 EP EP90913731A patent/EP0514540B1/en not_active Expired - Lifetime
- 1990-09-19 CA CA002065434A patent/CA2065434C/en not_active Expired - Fee Related
- 1990-09-19 DE DE69027862T patent/DE69027862T2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| KR970009225B1 (en) | 1997-06-09 |
| AU6400190A (en) | 1991-04-18 |
| CA2065434A1 (en) | 1991-03-20 |
| CA2065434C (en) | 1999-11-30 |
| DE69027862T2 (en) | 1997-03-06 |
| DE69027862D1 (en) | 1996-08-22 |
| WO1991004254A1 (en) | 1991-04-04 |
| EP0514540A1 (en) | 1992-11-25 |
| KR927003591A (en) | 1992-12-18 |
| EP0514540B1 (en) | 1996-07-17 |
| EP0514540A4 (en) | 1994-07-20 |
| AU641183B2 (en) | 1993-09-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |