ATE140457T1 - Pyrrolo(2,3-d>pyrimidinderivate, verfahren zur herstellung und arzneimittelzusammensetzungen die diese enthalten - Google Patents

Pyrrolo(2,3-d>pyrimidinderivate, verfahren zur herstellung und arzneimittelzusammensetzungen die diese enthalten

Info

Publication number: ATE140457T1
Authority: AT; Austria
Prior art keywords: group; pyrrolo; production; hydrocarbon residue; compositions containing
Prior art date: 1989-09-19

Application number

AT90913731T

Other languages

English (en)

Inventor

Yasuji Sakuma

Masaichi Hasegawa

Kenichiro Kataoka

Kenji Hoshina

Noboru Yamazaki

Takashi Kadota

Hisao Yamaguchi

Original Assignee

Teijin Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-09-19

Filing date

1990-09-19

Publication date

1996-08-15

1990-09-19 Application filed by Teijin Ltd filed Critical Teijin Ltd

1996-08-15 Application granted granted Critical

1996-08-15 Publication of ATE140457T1 publication Critical patent/ATE140457T1/de

Links

CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical class C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title 1
239000000203 mixture Substances 0.000 title 1
229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 title 1
125000001183 hydrocarbyl group Chemical group 0.000 abstract 3
125000002252 acyl group Chemical group 0.000 abstract 2
125000003277 amino group Chemical group 0.000 abstract 2
125000004122 cyclic group Chemical group 0.000 abstract 2
125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
125000004423 acyloxy group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000004666 alkoxyiminoalkyl group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
150000004943 pyrrolo[2,3-d]pyrimidines Chemical class 0.000 abstract 1
125000005505 thiomorpholino group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT90913731T 1989-09-19 1990-09-19 Pyrrolo(2,3-d>pyrimidinderivate, verfahren zur herstellung und arzneimittelzusammensetzungen die diese enthalten ATE140457T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP24293389		1989-09-19

Publications (1)

Publication Number	Publication Date
ATE140457T1 true ATE140457T1 (de)	1996-08-15

Family

ID=17096378

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90913731T ATE140457T1 (de)	1989-09-19	1990-09-19	Pyrrolo(2,3-d>pyrimidinderivate, verfahren zur herstellung und arzneimittelzusammensetzungen die diese enthalten

Country Status (7)

Country	Link
EP (1)	EP0514540B1 (de)
KR (1)	KR970009225B1 (de)
AT (1)	ATE140457T1 (de)
AU (1)	AU641183B2 (de)
CA (1)	CA2065434C (de)
DE (1)	DE69027862T2 (de)
WO (1)	WO1991004254A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2067221C (en) *	1989-10-11	1997-04-15	Yasuji Sakuma	Fused pyrimidine derivative, process for preparation of same and pharmaceutical preparation comprising same as active ingredient
US5196424A (en) *	1992-03-24	1993-03-23	Eli Lilly And Company	N-[2-amino-4-substituted[[(pyrrollo or pyrido)[2,3-d]pyrimidinyl]-alkyl]benzoyl]-L-glutamic acids
ES2150941T3 (es) *	1992-04-03	2000-12-16	Upjohn Co	Aminas biciclicas-heterociclicas eficaces farmaceuticamente.
US5502187A (en) *	1992-04-03	1996-03-26	The Upjohn Company	Pharmaceutically active bicyclic-heterocyclic amines
FR2699176B1 (fr) *	1992-12-11	1995-03-03	Adir	Nouveaux composés bicycliques de pyrimidine, leur procédé de préparation et les compositions pharmaceutiques les renfermant.
NZ304519A (en) *	1995-03-02	2000-01-28	Upjohn Co	Pydrimido[4,5-b]indoles
AU1441497A (en) *	1996-01-23	1997-08-20	Novartis Ag	Pyrrolopyrimidines and processes for their preparation
AU1794697A (en) *	1996-03-06	1997-09-22	Novartis Ag	7-alkyl-pyrrolo{2,3-d}pyrimidines
US6339089B2 (en)	1997-08-13	2002-01-15	Fujirebio Inc.	Pyrimidine nucleus-containing compound and a medicament containing the same for a blood oxygen partial pressure amelioration, and a method for preparing the same
US6878716B1 (en)	1998-06-02	2005-04-12	Osi Pharmaceuticals, Inc.	Compounds specific to adenosine A1 receptor and uses thereof
US6686366B1 (en)	1998-06-02	2004-02-03	Osi Pharmaceuticals, Inc.	Compounds specific to adenosine A3 receptor and uses thereof
JP4611524B2 (ja) *	1998-06-02	2011-01-12	オーエスアイ・ファーマスーティカルズ・インコーポレーテッド	ピロロ［２，３ｄ］ピリミジン組成物およびその使用
US6664252B2 (en)	1999-12-02	2003-12-16	Osi Pharmaceuticals, Inc.	4-aminopyrrolo[2,3-d]pyrimidine compounds specific to adenosine A2a receptor and uses thereof
US7160890B2 (en)	1999-12-02	2007-01-09	Osi Pharmaceuticals, Inc.	Compounds specific to adenosine A3 receptor and uses thereof
US6680322B2 (en)	1999-12-02	2004-01-20	Osi Pharmaceuticals, Inc.	Compounds specific to adenosine A1 receptors and uses thereof
US6673802B2 (en)	2000-12-01	2004-01-06	Osi Pharmaceuticals, Inc.	Compounds specific to adenosine A3 receptor and uses thereof
US6680324B2 (en)	2000-12-01	2004-01-20	Osi Pharmaceuticals, Inc.	Compounds specific to adenosine A1 receptors and uses thereof
DE10148883A1 (de) *	2001-10-04	2003-04-10	Merck Patent Gmbh	Pyrimidinderivate
DK1450811T3 (da)	2001-11-30	2010-02-15	Osi Pharm Inc	Forbindelser specifikke af adenosin A1- og A3-receptorer og anvendelser heraf
US20030229067A1 (en)	2001-12-20	2003-12-11	Arlindo Castelhano	Pyrrolopyrimidine A2b selective antagonist compounds, their synthesis and use
CN1620294A (zh)	2001-12-20	2005-05-25	Osi药物公司	嘧啶a2b选择性拮抗剂化合物,它们的合成及用途
WO2005117909A2 (en)	2004-04-23	2005-12-15	Exelixis, Inc.	Kinase modulators and methods of use
ES2617339T3 (es)	2010-12-16	2017-06-16	Calchan Limited	Derivados de pirrolopirimidina inhibidores de ASK1

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3739366A1 (de) *	1987-04-10	1988-10-27	Boehringer Mannheim Gmbh	Desaza-purin-nucleosid-derivate, verfahren zu deren herstellung sowie deren verwendung bei der nucleinsaeure-sequenzierung sowie als antivirale mittel
CA2067221C (en) *	1989-10-11	1997-04-15	Yasuji Sakuma	Fused pyrimidine derivative, process for preparation of same and pharmaceutical preparation comprising same as active ingredient

1990
- 1990-09-19 CA CA002065434A patent/CA2065434C/en not_active Expired - Fee Related
- 1990-09-19 WO PCT/JP1990/001200 patent/WO1991004254A1/ja not_active Ceased
- 1990-09-19 EP EP90913731A patent/EP0514540B1/de not_active Expired - Lifetime
- 1990-09-19 AT AT90913731T patent/ATE140457T1/de not_active IP Right Cessation
- 1990-09-19 DE DE69027862T patent/DE69027862T2/de not_active Expired - Fee Related
- 1990-09-19 KR KR1019920700630A patent/KR970009225B1/ko not_active Expired - Lifetime
- 1990-09-19 AU AU64001/90A patent/AU641183B2/en not_active Ceased

Also Published As

Publication number	Publication date
CA2065434A1 (en)	1991-03-20
EP0514540A4 (en)	1994-07-20
KR927003591A (ko)	1992-12-18
WO1991004254A1 (en)	1991-04-04
EP0514540A1 (de)	1992-11-25
EP0514540B1 (de)	1996-07-17
CA2065434C (en)	1999-11-30
AU6400190A (en)	1991-04-18
DE69027862T2 (de)	1997-03-06
AU641183B2 (en)	1993-09-16
DE69027862D1 (de)	1996-08-22
KR970009225B1 (ko)	1997-06-09

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Legal Events

Date	Code	Title	Description
1997-01-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties