ATE141262T1 - N-cyano-n'-pyridylguanidine als serotoninantagonisten - Google Patents
N-cyano-n'-pyridylguanidine als serotoninantagonistenInfo
- Publication number
- ATE141262T1 ATE141262T1 AT93919045T AT93919045T ATE141262T1 AT E141262 T1 ATE141262 T1 AT E141262T1 AT 93919045 T AT93919045 T AT 93919045T AT 93919045 T AT93919045 T AT 93919045T AT E141262 T1 ATE141262 T1 AT E141262T1
- Authority
- AT
- Austria
- Prior art keywords
- pct
- stands
- hydroxy
- halogen
- alkyl
- Prior art date
Links
- OHCLQPVKNNTOCP-UHFFFAOYSA-N 1-cyano-2-pyridin-2-ylguanidine Chemical compound N#CNC(=N)NC1=CC=CC=N1 OHCLQPVKNNTOCP-UHFFFAOYSA-N 0.000 title 1
- 229940082988 antihypertensives serotonin antagonists Drugs 0.000 title 1
- 239000003420 antiserotonin agent Substances 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000005518 carboxamido group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229940121356 serotonin receptor antagonist Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB929219472A GB9219472D0 (en) | 1992-09-15 | 1992-09-15 | Chemical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE141262T1 true ATE141262T1 (de) | 1996-08-15 |
Family
ID=10721912
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT93919045T ATE141262T1 (de) | 1992-09-15 | 1993-09-13 | N-cyano-n'-pyridylguanidine als serotoninantagonisten |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5563160A (de) |
| EP (1) | EP0660823B1 (de) |
| JP (1) | JP3485567B2 (de) |
| KR (1) | KR100292592B1 (de) |
| AT (1) | ATE141262T1 (de) |
| AU (1) | AU670816B2 (de) |
| CA (1) | CA2143756C (de) |
| DE (1) | DE69304076T2 (de) |
| DK (1) | DK0660823T3 (de) |
| ES (1) | ES2092835T3 (de) |
| FI (1) | FI109118B (de) |
| GB (1) | GB9219472D0 (de) |
| GR (1) | GR3021015T3 (de) |
| NZ (1) | NZ255330A (de) |
| RU (1) | RU2141951C1 (de) |
| WO (1) | WO1994006770A1 (de) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5696140A (en) * | 1992-09-15 | 1997-12-09 | Leo Pharmaceutical Products Ltd. | N-cyano-N'-pyridylguanidines as serotonin antagonists |
| EP0795328A1 (de) * | 1996-03-15 | 1997-09-17 | Pfizer Inc. | Verwendung von Naphthalenderivate zur Behandlung von Lungenkrebs |
| US5869497A (en) * | 1996-03-15 | 1999-02-09 | Eli Lilly And Company | Method of treating or ameliorating the symptoms of common cold or allergic rhinitis |
| GB9711125D0 (en) * | 1997-05-29 | 1997-07-23 | Leo Pharm Prod Ltd | Novel cyanoguanidines |
| GB9711123D0 (en) * | 1997-05-29 | 1997-07-23 | Leo Pharm Prod Ltd | Novel cyanoguanidines |
| GB9711122D0 (en) * | 1997-05-29 | 1997-07-23 | Leo Pharm Prod Ltd | Novel cyanoguanidines |
| GB9711127D0 (en) * | 1997-05-29 | 1997-07-23 | Leo Pharm Prod Ltd | Novel cyanoguanidines |
| GB9711126D0 (en) * | 1997-05-29 | 1997-07-23 | Leo Pharm Prod Ltd | Cyanoamidines |
| GB9711119D0 (en) * | 1997-05-29 | 1997-07-23 | Leo Pharm Prod Ltd | Novel cyanoguanidines |
| GB9711124D0 (en) | 1997-05-29 | 1997-07-23 | Leo Pharm Prod Ltd | Novel cyanoguanidines |
| AU762615B2 (en) * | 1998-06-15 | 2003-07-03 | Arch Development Corporation | Combination of radiotherapy and anti-angiogenic factors |
| WO2000061561A1 (en) * | 1999-04-09 | 2000-10-19 | Shionogi Bioresearch Corp. | Cyanoguanidine compounds |
| US6417207B1 (en) | 1999-05-12 | 2002-07-09 | Nitromed, Inc. | Nitrosated and nitrosylated potassium channel activators, compositions and methods of use |
| AU1494702A (en) | 2000-11-21 | 2002-06-03 | Leo Pharma As | Cyanoguanidine prodrugs |
| ATE442362T1 (de) * | 2001-05-24 | 2009-09-15 | Leo Pharma As | Pyridylcyanoguanidin verbindungen |
| US20030045515A1 (en) * | 2001-05-24 | 2003-03-06 | Lise Binderup | Combination medicament for treatment of neoplastic diseases |
| GB0217920D0 (en) * | 2002-04-23 | 2002-09-11 | Aventis Pharm Prod Inc | Interleukin-4 Gene Expression inhibitors |
| CA2485351C (en) * | 2002-05-17 | 2011-12-06 | Leo Pharma A/S | Cyanoguanidine prodrugs |
| US7253193B2 (en) | 2002-05-17 | 2007-08-07 | Leo Pharma A/S | Cyanoguanidine prodrugs |
| JP4935073B2 (ja) * | 2003-10-14 | 2012-05-23 | 味の素株式会社 | エーテル誘導体 |
| DE102004008141A1 (de) * | 2004-02-19 | 2005-09-01 | Abbott Gmbh & Co. Kg | Guanidinverbindungen und ihre Verwendung als Bindungspartner für 5-HT5-Rezeptoren |
| ES2572777T3 (es) | 2004-12-22 | 2016-06-02 | Leo Pharma A/S | Compuestos novedosos de cianoguanidina |
| EP1917244A2 (de) | 2005-08-24 | 2008-05-07 | Abbott GmbH & Co. KG | Hetaryl substituierte guanidinverbindungen und ihre verwendung als bindungspartner für 5-ht5-rezeptoren |
| WO2009072004A2 (en) * | 2007-09-26 | 2009-06-11 | Gemin X Pharmaceuticals Canada, Inc. | Compositions and methods for effecting nad+ levels using a nicotinamide phosphoribosyl transferase inhibitor |
| US8173677B2 (en) | 2007-09-26 | 2012-05-08 | Gemin X Pharmaceuticals Canada Inc. | Compositions and methods for effecting NAD+ levels using a nicotinamide phosphoribosyl transferase inhibitor |
| CA2751495C (en) | 2009-02-06 | 2013-08-20 | Tianjin Hemay Bio-Tech Co., Ltd. | Pharmaceutical compositions comprising a pyridyl cyanoguanidine and cyclodextrin and/or derivatives thereof |
| US8912184B1 (en) | 2010-03-01 | 2014-12-16 | Alzheimer's Institute Of America, Inc. | Therapeutic and diagnostic methods |
| JP2013540781A (ja) | 2010-10-26 | 2013-11-07 | ティエンジン ホーメイ バイオ−テック カンパニー， リミテッド | Ｎ−（６−（４−クロロフェノキシ）ヘキシル）−ｎ’−シアノ−ｎ’’−（４−ピリジル）グアニジンの結晶多形とその製造及び使用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1489879A (en) * | 1974-12-20 | 1977-10-26 | Leo Pharm Prod Ltd | N'-cyano-n'-3-pyridylguanidines |
| CA2009074C (en) * | 1989-02-03 | 1999-07-27 | David Wayne Robertson | Improvements in and relating to guanidine derivatives |
| GB2242628A (en) * | 1990-04-06 | 1991-10-09 | Sandoz Ltd | Asthma prophylactic use of K+ channel activators |
-
1992
- 1992-09-15 GB GB929219472A patent/GB9219472D0/en active Pending
-
1993
- 1993-09-13 WO PCT/DK1993/000291 patent/WO1994006770A1/en not_active Ceased
- 1993-09-13 AU AU49456/93A patent/AU670816B2/en not_active Expired
- 1993-09-13 DK DK93919045.0T patent/DK0660823T3/da active
- 1993-09-13 RU RU95105437A patent/RU2141951C1/ru active
- 1993-09-13 DE DE69304076T patent/DE69304076T2/de not_active Expired - Lifetime
- 1993-09-13 EP EP93919045A patent/EP0660823B1/de not_active Expired - Lifetime
- 1993-09-13 NZ NZ255330A patent/NZ255330A/en not_active IP Right Cessation
- 1993-09-13 JP JP50770994A patent/JP3485567B2/ja not_active Expired - Lifetime
- 1993-09-13 ES ES93919045T patent/ES2092835T3/es not_active Expired - Lifetime
- 1993-09-13 KR KR1019950700625A patent/KR100292592B1/ko not_active Expired - Lifetime
- 1993-09-13 AT AT93919045T patent/ATE141262T1/de active
- 1993-09-13 US US08/397,266 patent/US5563160A/en not_active Expired - Lifetime
- 1993-09-13 CA CA002143756A patent/CA2143756C/en not_active Expired - Lifetime
-
1995
- 1995-03-14 FI FI951189A patent/FI109118B/fi not_active IP Right Cessation
-
1996
- 1996-09-12 GR GR960402367T patent/GR3021015T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2143756A1 (en) | 1994-03-31 |
| US5563160A (en) | 1996-10-08 |
| NZ255330A (en) | 1997-06-24 |
| CA2143756C (en) | 2003-11-11 |
| DE69304076D1 (de) | 1996-09-19 |
| RU2141951C1 (ru) | 1999-11-27 |
| AU4945693A (en) | 1994-04-12 |
| ES2092835T3 (es) | 1996-12-01 |
| WO1994006770A1 (en) | 1994-03-31 |
| DE69304076T2 (de) | 1997-04-03 |
| GB9219472D0 (en) | 1992-10-28 |
| FI951189L (fi) | 1995-03-14 |
| FI951189A0 (fi) | 1995-03-14 |
| KR100292592B1 (ko) | 2001-09-17 |
| AU670816B2 (en) | 1996-08-01 |
| GR3021015T3 (en) | 1996-12-31 |
| EP0660823B1 (de) | 1996-08-14 |
| JPH08501539A (ja) | 1996-02-20 |
| DK0660823T3 (da) | 1996-09-23 |
| EP0660823A1 (de) | 1995-07-05 |
| KR950702964A (ko) | 1995-08-23 |
| FI109118B (fi) | 2002-05-31 |
| RU95105437A (ru) | 1996-10-27 |
| JP3485567B2 (ja) | 2004-01-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |