ES2092835T3 - N-ciano-n'-piridilguanidinas como antagonistas de la serotonina. - Google Patents
N-ciano-n'-piridilguanidinas como antagonistas de la serotonina.Info
- Publication number
- ES2092835T3 ES2092835T3 ES93919045T ES93919045T ES2092835T3 ES 2092835 T3 ES2092835 T3 ES 2092835T3 ES 93919045 T ES93919045 T ES 93919045T ES 93919045 T ES93919045 T ES 93919045T ES 2092835 T3 ES2092835 T3 ES 2092835T3
- Authority
- ES
- Spain
- Prior art keywords
- nitro
- halogen
- ciano
- alkyl
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000005557 antagonist Substances 0.000 title 1
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 title 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical class O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 3
- -1 TRIFLUOROMETILE Chemical class 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical class [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- WZKSXHQDXQKIQJ-UHFFFAOYSA-N F[C](F)F Chemical class F[C](F)F WZKSXHQDXQKIQJ-UHFFFAOYSA-N 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 150000003857 carboxamides Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical class [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 150000003254 radicals Chemical class 0.000 abstract 1
- 229940121356 serotonin receptor antagonist Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
LA PRESENTE INVENCION ES RELATIVA A COMPUESTOS DESCONOCIDOS HASTA AHORA DE FORMULA (I) O SUS FORMAS TAUTOMERAS, ESTANDO LA CONEXION AL ANILLO DE PIRIDINA EN LA POSICION 3- O 4-, EN LA QUE R'', R'''' SON IGUALES O DIFERENTES Y REPRESENTAN HIDROGENO, HALOGENO, TRIFLUOROMETILO, HIDROXI, ALQUILO C1-C4, GRUPOS NITRO O CIANO. ALQUILENO REPRESENTA UNA CADENA DE CARBONO LINEAL O RAMIFICADA DE C1 A C8, QUE PUEDE SER SUSTITUIDO POR HIDROXI O HALOGENO, GRUPOS NITRO O CIANO. X REPRESENTA OXIGENO, -S(O)NDONDE N REPRESENTA UN ENTERO DE 0 A 2, O =NR1 DONDE R1 ES HIDROGENO O ALQUILO C1-C4. R REPRESENTA HIDROGENO O UNO O MAS RADICALES ALQUILO C1-C4 O ALCOXILO, HIDROXILO, HALOGENO, TRIFLUOROMETILO, CIANO, CARBOXAMIDO, SULFAMOILO O NITRO. LOS COMPUESTOS PRESENTADOS SON VALIOSOS EN LA PRACTICA HUMANA Y VETERINARIA COMO ANTAGONISTAS DE RECEPTOR DE SEROTONINA SELECTIVA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB929219472A GB9219472D0 (en) | 1992-09-15 | 1992-09-15 | Chemical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2092835T3 true ES2092835T3 (es) | 1996-12-01 |
Family
ID=10721912
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES93919045T Expired - Lifetime ES2092835T3 (es) | 1992-09-15 | 1993-09-13 | N-ciano-n'-piridilguanidinas como antagonistas de la serotonina. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5563160A (es) |
| EP (1) | EP0660823B1 (es) |
| JP (1) | JP3485567B2 (es) |
| KR (1) | KR100292592B1 (es) |
| AT (1) | ATE141262T1 (es) |
| AU (1) | AU670816B2 (es) |
| CA (1) | CA2143756C (es) |
| DE (1) | DE69304076T2 (es) |
| DK (1) | DK0660823T3 (es) |
| ES (1) | ES2092835T3 (es) |
| FI (1) | FI109118B (es) |
| GB (1) | GB9219472D0 (es) |
| GR (1) | GR3021015T3 (es) |
| NZ (1) | NZ255330A (es) |
| RU (1) | RU2141951C1 (es) |
| WO (1) | WO1994006770A1 (es) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5696140A (en) * | 1992-09-15 | 1997-12-09 | Leo Pharmaceutical Products Ltd. | N-cyano-N'-pyridylguanidines as serotonin antagonists |
| EP0795328A1 (en) * | 1996-03-15 | 1997-09-17 | Pfizer Inc. | Use of naphthalene derivatives in treating lung carcinoma |
| US5869497A (en) * | 1996-03-15 | 1999-02-09 | Eli Lilly And Company | Method of treating or ameliorating the symptoms of common cold or allergic rhinitis |
| GB9711125D0 (en) * | 1997-05-29 | 1997-07-23 | Leo Pharm Prod Ltd | Novel cyanoguanidines |
| GB9711123D0 (en) * | 1997-05-29 | 1997-07-23 | Leo Pharm Prod Ltd | Novel cyanoguanidines |
| GB9711122D0 (en) * | 1997-05-29 | 1997-07-23 | Leo Pharm Prod Ltd | Novel cyanoguanidines |
| GB9711127D0 (en) * | 1997-05-29 | 1997-07-23 | Leo Pharm Prod Ltd | Novel cyanoguanidines |
| GB9711126D0 (en) * | 1997-05-29 | 1997-07-23 | Leo Pharm Prod Ltd | Cyanoamidines |
| GB9711119D0 (en) * | 1997-05-29 | 1997-07-23 | Leo Pharm Prod Ltd | Novel cyanoguanidines |
| GB9711124D0 (en) | 1997-05-29 | 1997-07-23 | Leo Pharm Prod Ltd | Novel cyanoguanidines |
| AU762615B2 (en) * | 1998-06-15 | 2003-07-03 | Arch Development Corporation | Combination of radiotherapy and anti-angiogenic factors |
| WO2000061561A1 (en) * | 1999-04-09 | 2000-10-19 | Shionogi Bioresearch Corp. | Cyanoguanidine compounds |
| US6417207B1 (en) | 1999-05-12 | 2002-07-09 | Nitromed, Inc. | Nitrosated and nitrosylated potassium channel activators, compositions and methods of use |
| AU1494702A (en) | 2000-11-21 | 2002-06-03 | Leo Pharma As | Cyanoguanidine prodrugs |
| ATE442362T1 (de) * | 2001-05-24 | 2009-09-15 | Leo Pharma As | Pyridylcyanoguanidin verbindungen |
| US20030045515A1 (en) * | 2001-05-24 | 2003-03-06 | Lise Binderup | Combination medicament for treatment of neoplastic diseases |
| GB0217920D0 (en) * | 2002-04-23 | 2002-09-11 | Aventis Pharm Prod Inc | Interleukin-4 Gene Expression inhibitors |
| CA2485351C (en) * | 2002-05-17 | 2011-12-06 | Leo Pharma A/S | Cyanoguanidine prodrugs |
| US7253193B2 (en) | 2002-05-17 | 2007-08-07 | Leo Pharma A/S | Cyanoguanidine prodrugs |
| JP4935073B2 (ja) * | 2003-10-14 | 2012-05-23 | 味の素株式会社 | エーテル誘導体 |
| DE102004008141A1 (de) * | 2004-02-19 | 2005-09-01 | Abbott Gmbh & Co. Kg | Guanidinverbindungen und ihre Verwendung als Bindungspartner für 5-HT5-Rezeptoren |
| ES2572777T3 (es) | 2004-12-22 | 2016-06-02 | Leo Pharma A/S | Compuestos novedosos de cianoguanidina |
| EP1917244A2 (de) | 2005-08-24 | 2008-05-07 | Abbott GmbH & Co. KG | Hetaryl substituierte guanidinverbindungen und ihre verwendung als bindungspartner für 5-ht5-rezeptoren |
| WO2009072004A2 (en) * | 2007-09-26 | 2009-06-11 | Gemin X Pharmaceuticals Canada, Inc. | Compositions and methods for effecting nad+ levels using a nicotinamide phosphoribosyl transferase inhibitor |
| US8173677B2 (en) | 2007-09-26 | 2012-05-08 | Gemin X Pharmaceuticals Canada Inc. | Compositions and methods for effecting NAD+ levels using a nicotinamide phosphoribosyl transferase inhibitor |
| CA2751495C (en) | 2009-02-06 | 2013-08-20 | Tianjin Hemay Bio-Tech Co., Ltd. | Pharmaceutical compositions comprising a pyridyl cyanoguanidine and cyclodextrin and/or derivatives thereof |
| US8912184B1 (en) | 2010-03-01 | 2014-12-16 | Alzheimer's Institute Of America, Inc. | Therapeutic and diagnostic methods |
| JP2013540781A (ja) | 2010-10-26 | 2013-11-07 | ティエンジン ホーメイ バイオ−テック カンパニー， リミテッド | Ｎ−（６−（４−クロロフェノキシ）ヘキシル）−ｎ’−シアノ−ｎ’’−（４−ピリジル）グアニジンの結晶多形とその製造及び使用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1489879A (en) * | 1974-12-20 | 1977-10-26 | Leo Pharm Prod Ltd | N'-cyano-n'-3-pyridylguanidines |
| CA2009074C (en) * | 1989-02-03 | 1999-07-27 | David Wayne Robertson | Improvements in and relating to guanidine derivatives |
| GB2242628A (en) * | 1990-04-06 | 1991-10-09 | Sandoz Ltd | Asthma prophylactic use of K+ channel activators |
-
1992
- 1992-09-15 GB GB929219472A patent/GB9219472D0/en active Pending
-
1993
- 1993-09-13 WO PCT/DK1993/000291 patent/WO1994006770A1/en not_active Ceased
- 1993-09-13 AU AU49456/93A patent/AU670816B2/en not_active Expired
- 1993-09-13 DK DK93919045.0T patent/DK0660823T3/da active
- 1993-09-13 RU RU95105437A patent/RU2141951C1/ru active
- 1993-09-13 DE DE69304076T patent/DE69304076T2/de not_active Expired - Lifetime
- 1993-09-13 EP EP93919045A patent/EP0660823B1/en not_active Expired - Lifetime
- 1993-09-13 NZ NZ255330A patent/NZ255330A/en not_active IP Right Cessation
- 1993-09-13 JP JP50770994A patent/JP3485567B2/ja not_active Expired - Lifetime
- 1993-09-13 ES ES93919045T patent/ES2092835T3/es not_active Expired - Lifetime
- 1993-09-13 KR KR1019950700625A patent/KR100292592B1/ko not_active Expired - Lifetime
- 1993-09-13 AT AT93919045T patent/ATE141262T1/de active
- 1993-09-13 US US08/397,266 patent/US5563160A/en not_active Expired - Lifetime
- 1993-09-13 CA CA002143756A patent/CA2143756C/en not_active Expired - Lifetime
-
1995
- 1995-03-14 FI FI951189A patent/FI109118B/fi not_active IP Right Cessation
-
1996
- 1996-09-12 GR GR960402367T patent/GR3021015T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2143756A1 (en) | 1994-03-31 |
| US5563160A (en) | 1996-10-08 |
| NZ255330A (en) | 1997-06-24 |
| CA2143756C (en) | 2003-11-11 |
| DE69304076D1 (de) | 1996-09-19 |
| RU2141951C1 (ru) | 1999-11-27 |
| AU4945693A (en) | 1994-04-12 |
| WO1994006770A1 (en) | 1994-03-31 |
| DE69304076T2 (de) | 1997-04-03 |
| GB9219472D0 (en) | 1992-10-28 |
| FI951189L (fi) | 1995-03-14 |
| FI951189A0 (fi) | 1995-03-14 |
| KR100292592B1 (ko) | 2001-09-17 |
| ATE141262T1 (de) | 1996-08-15 |
| AU670816B2 (en) | 1996-08-01 |
| GR3021015T3 (en) | 1996-12-31 |
| EP0660823B1 (en) | 1996-08-14 |
| JPH08501539A (ja) | 1996-02-20 |
| DK0660823T3 (da) | 1996-09-23 |
| EP0660823A1 (en) | 1995-07-05 |
| KR950702964A (ko) | 1995-08-23 |
| FI109118B (fi) | 2002-05-31 |
| RU95105437A (ru) | 1996-10-27 |
| JP3485567B2 (ja) | 2004-01-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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