ATE141519T1 - Kontrastmittel enthaltend einen nicht-ionischen kontrast wirkstoff und sodium und kalzium sälze - Google Patents

Kontrastmittel enthaltend einen nicht-ionischen kontrast wirkstoff und sodium und kalzium sälze

Info

Publication number: ATE141519T1
Authority: AT; Austria
Prior art keywords: sodium; concn; contrast; active substance; calcium salts
Prior art date: 1990-03-09

Application number

AT91905048T

Other languages

English (en)

Inventor

Torsten Almen

Lars Baath

Audun Nesheim Oksendal

Per Jynge

Original Assignee

Nycomed Imaging As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-03-09

Filing date

1991-03-07

Publication date

1996-09-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10682193&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE141519(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1990-03-09 Priority claimed from EP90200580A external-priority patent/EP0390242B1/de

1991-03-07 Application filed by Nycomed Imaging As filed Critical Nycomed Imaging As

1996-09-15 Application granted granted Critical

1996-09-15 Publication of ATE141519T1 publication Critical patent/ATE141519T1/de

Links

239000002872 contrast media Substances 0.000 title abstract 4
239000011734 sodium Substances 0.000 title abstract 3
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 title abstract 2
159000000007 calcium salts Chemical class 0.000 title abstract 2
229910052708 sodium Inorganic materials 0.000 title abstract 2
239000013543 active substance Substances 0.000 title 1
BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 abstract 3
239000011575 calcium Substances 0.000 abstract 2
229910001415 sodium ion Inorganic materials 0.000 abstract 2
XUHXFSYUBXNTHU-UHFFFAOYSA-N Iotrolan Chemical compound IC=1C(C(=O)NC(CO)C(O)CO)=C(I)C(C(=O)NC(CO)C(O)CO)=C(I)C=1N(C)C(=O)CC(=O)N(C)C1=C(I)C(C(=O)NC(CO)C(O)CO)=C(I)C(C(=O)NC(CO)C(O)CO)=C1I XUHXFSYUBXNTHU-UHFFFAOYSA-N 0.000 abstract 1
AMDBBAQNWSUWGN-UHFFFAOYSA-N Ioversol Chemical compound OCCN(C(=O)CO)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I AMDBBAQNWSUWGN-UHFFFAOYSA-N 0.000 abstract 1
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 abstract 1
FKNQFGJONOIPTF-UHFFFAOYSA-N Sodium cation Chemical compound [Na+] FKNQFGJONOIPTF-UHFFFAOYSA-N 0.000 abstract 1
229910001424 calcium ion Inorganic materials 0.000 abstract 1
229960004359 iodixanol Drugs 0.000 abstract 1
NBQNWMBBSKPBAY-UHFFFAOYSA-N iodixanol Chemical compound IC=1C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C(I)C=1N(C(=O)C)CC(O)CN(C(C)=O)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I NBQNWMBBSKPBAY-UHFFFAOYSA-N 0.000 abstract 1
229960001025 iohexol Drugs 0.000 abstract 1
NTHXOOBQLCIOLC-UHFFFAOYSA-N iohexol Chemical compound OCC(O)CN(C(=O)C)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I NTHXOOBQLCIOLC-UHFFFAOYSA-N 0.000 abstract 1
229960004647 iopamidol Drugs 0.000 abstract 1
XQZXYNRDCRIARQ-LURJTMIESA-N iopamidol Chemical compound C[C@H](O)C(=O)NC1=C(I)C(C(=O)NC(CO)CO)=C(I)C(C(=O)NC(CO)CO)=C1I XQZXYNRDCRIARQ-LURJTMIESA-N 0.000 abstract 1
229960003182 iotrolan Drugs 0.000 abstract 1
229960004537 ioversol Drugs 0.000 abstract 1
229940029407 ioxaglate Drugs 0.000 abstract 1
TYYBFXNZMFNZJT-UHFFFAOYSA-N ioxaglic acid Chemical compound CNC(=O)C1=C(I)C(N(C)C(C)=O)=C(I)C(C(=O)NCC(=O)NC=2C(=C(C(=O)NCCO)C(I)=C(C(O)=O)C=2I)I)=C1I TYYBFXNZMFNZJT-UHFFFAOYSA-N 0.000 abstract 1
239000011777 magnesium Substances 0.000 abstract 1
159000000003 magnesium salts Chemical class 0.000 abstract 1
239000011591 potassium Substances 0.000 abstract 1
229910052700 potassium Inorganic materials 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0409—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is not a halogenated organic compound
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
- A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
- A61K49/0452—Solutions, e.g. for injection

Landscapes

Health & Medical Sciences (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Liquid Crystal (AREA)
Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
Devices For Indicating Variable Information By Combining Individual Elements (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
Silicates, Zeolites, And Molecular Sieves (AREA)
Diaphragms For Electromechanical Transducers (AREA)
Ultra Sonic Daignosis Equipment (AREA)
Lubricants (AREA)
Paints Or Removers (AREA)
Treatments Of Macromolecular Shaped Articles (AREA)
Compositions Of Macromolecular Compounds (AREA)

AT91905048T 1990-03-09 1991-03-07 Kontrastmittel enthaltend einen nicht-ionischen kontrast wirkstoff und sodium und kalzium sälze ATE141519T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP90200580A EP0390242B1 (de)	1989-03-17	1990-03-09	Kontrastmittel
GB909020091A GB9020091D0 (en)	1990-09-14	1990-09-14	Contrast media

Publications (1)

Publication Number	Publication Date
ATE141519T1 true ATE141519T1 (de)	1996-09-15

Family

ID=10682193

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91905048T ATE141519T1 (de)	1990-03-09	1991-03-07	Kontrastmittel enthaltend einen nicht-ionischen kontrast wirkstoff und sodium und kalzium sälze

Country Status (32)

Country	Link
US (2)	US5328680A (de)
EP (1)	EP0521880B2 (de)
JP (1)	JP3215703B2 (de)
KR (1)	KR100189271B1 (de)
CN (1)	CN1055864C (de)
AT (1)	ATE141519T1 (de)
CA (1)	CA2076861A1 (de)
CZ (1)	CZ285071B6 (de)
DE (1)	DE69121562T3 (de)
DK (1)	DK0521880T4 (de)
DZ (1)	DZ1506A1 (de)
EG (1)	EG19889A (de)
ES (1)	ES2090315T5 (de)
FI (1)	FI100698B (de)
GB (1)	GB9020091D0 (de)
GE (1)	GEP19971155B (de)
GR (2)	GR3020842T3 (de)
HK (1)	HK1003563A1 (de)
HR (1)	HRP930773B1 (de)
HU (1)	HU217075B (de)
IE (1)	IE76916B1 (de)
IL (1)	IL97455A (de)
LV (1)	LV10058B (de)
MY (1)	MY105493A (de)
NO (1)	NO304352B1 (de)
OA (1)	OA09667A (de)
PT (1)	PT96978B (de)
RO (1)	RO111543B1 (de)
SK (1)	SK278621B6 (de)
TR (1)	TR25738A (de)
WO (1)	WO1991013636A1 (de)
YU (1)	YU48683B (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1256248B (it) *	1992-12-24	1995-11-29	Bracco Spa	Formulazioni iniettabili acquose per radiodiagnostica comprendenti miscele di composti aromatici iodurati utili come agenti opacizzanti ai raggi x
GB9419203D0 (en) *	1994-09-23	1994-11-09	Nycomed Innovation Ab	Contrast media
GB9419206D0 (en) *	1994-09-23	1994-11-09	Nycomed Innovation Ab	Contrast media
DK0876140T3 (da) *	1996-01-25	2003-12-15	Schering Ag	Forbedrede kontrastmiddelopløsninger til intravasal anvendelse
DE19648650C2 (de) *	1996-01-29	1998-07-02	Schering Ag	Puffersysteme und deren Verwendung zur Stabilisierung pharmazeutischer Zubereitung
DE10126405A1 (de) *	2001-05-22	2003-02-27	Trommsdorff Gmbh & Co	Physiologisch verträgliche Kalium- und Magnesiumsalze enthaltendes pharmazeutisches Präparat sowie dessen Verwendung zur Prophylaxe und/oder Therapie von QT-Zeitverlängerungen
US7498018B2 (en) *	2003-10-03	2009-03-03	Bracco Diagnostics Inc.	Contrast media for use in medical and diagnostic procedures and methods of using the same
DE102005028882A1 (de) *	2005-06-22	2007-01-04	Siemens Ag	Lösung und Verfahren zum Unterstützen der Bildgebung an einem Patienten
WO2007094683A1 (en)	2006-02-15	2007-08-23	Ge Healthcare As	Contrast agents
JP2009531422A (ja) *	2006-03-29	2009-09-03	ジーイー・ヘルスケア・アクスイェ・セルスカプ	過分極カルボン酸塩及びスルホン酸塩の製造方法
FR2899581B1 (fr) *	2006-04-07	2008-06-27	Guerbet Sa	Procede d'atomisation du ioxilan
US7662859B2 (en)	2007-02-16	2010-02-16	Ge Healthcare As	Contrast agents
EP2178568B1 (de)	2007-07-12	2014-07-02	Ge Healthcare As	Kontrastmittel
EP2200656B1 (de)	2007-10-12	2012-12-05	GE Healthcare AS	Kontrastmittel
ES2413160T3 (es)	2007-10-12	2013-07-15	Ge Healthcare As	Agentes de contraste
CN101820924A (zh)	2007-10-12	2010-09-01	通用电气医疗集团股份有限公司	造影剂
WO2009047318A1 (en)	2007-10-12	2009-04-16	Ge Healthcare As	Contrast agents
CN102271715A (zh)	2009-01-09	2011-12-07	通用电气医疗集团股份有限公司	对比剂组合物
EP2243767A1 (de)	2009-04-21	2010-10-27	Bracco Imaging S.p.A	Verfahren zur Iodierung aromatischer Verbindungen
PT2493511E (pt) *	2009-10-29	2013-11-18	Ge Healthcare As	Composição de diagnóstico que compreende catiões do plasma com perfil de segurança superior
CN102114249B (zh) *	2009-12-30	2013-01-30	四川大学华西医院	一种携氧冠脉造影剂及其制备方法
US20140065076A1 (en) *	2012-08-30	2014-03-06	Otsuka Pharmaceutical Co. Ltd.	Container with concentrated substance and method of using the same
MX2015013658A (es)	2013-03-27	2016-02-18	Ge Healthcare As	Metodo y reactivo para preparar una composicion diagnostica.
BR112016012912A8 (pt) *	2013-12-04	2018-01-30	Hovione Scientia Ltd	formulações de meios de contraste com dissimulação de sabor

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US1858142A (en) *	1928-01-21	1932-05-10	Nat Aniline & Chem Co Inc	Colloidal mono-sodium tetraiodophenolphthalein
NL127881C (de) *	1963-03-25
US3175952A (en) *	1963-05-29	1965-03-30	Sterling Drug Inc	Aqueous radiopaque solutions containing sodium and calcium ions
GB1069437A (en) *	1963-10-23	1967-05-17	Nyegaard & Co As	Injectable x-ray contrast media
DE2909439A1 (de) *	1979-03-08	1980-09-18	Schering Ag	Neue nichtionische roentgenkontrastmittel
DE2928417A1 (de) *	1979-07-12	1981-01-29	Schering Ag	Trijodierte basen
DE3038853A1 (de) *	1980-10-10	1982-05-27	Schering Ag, 1000 Berlin Und 4619 Bergkamen	Neue n-hydroxy-alkylierte dicarbonsaeure-bis-(3,5-dicarbamoyl-2,4,6-trijodanilide), deren herstellung und diese enthaltende roentgenkonstrastmittel (ii)
US4957939A (en) *	1981-07-24	1990-09-18	Schering Aktiengesellschaft	Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging
JPS61502943A (ja) *	1984-06-22	1986-12-18	ビ−チ、リチャ−ド・エル	電解質溶液およびその生体内における使用
AU4500085A (en) *	1984-06-22	1986-01-24	R.L. Veech	Electrolyte solutions containing polyanionic materials
US4863714A (en) *	1987-02-05	1989-09-05	Cook Imaging Corporation	Sterilization of compositions of limited stability
WO1989008101A1 (en) *	1988-03-01	1989-09-08	Mallinckrodt, Inc.	Nonionic x-ray contrast agents, compositions and methods
US5011925A (en) *	1989-03-09	1991-04-30	Mallinckrodt, Inc.	Morpholinoamido EDTA derivatives
GB8906130D0 (en) *	1989-03-17	1989-05-04	Nycomed As	Compositions

1990
- 1990-09-14 GB GB909020091A patent/GB9020091D0/en active Pending
1991
- 1991-03-06 DZ DZ910035A patent/DZ1506A1/fr active
- 1991-03-06 IL IL9745591A patent/IL97455A/en not_active IP Right Cessation
- 1991-03-07 CA CA002076861A patent/CA2076861A1/en not_active Abandoned
- 1991-03-07 HK HK98102624A patent/HK1003563A1/en not_active IP Right Cessation
- 1991-03-07 YU YU40891A patent/YU48683B/sh unknown
- 1991-03-07 US US07/923,926 patent/US5328680A/en not_active Ceased
- 1991-03-07 ES ES91905048T patent/ES2090315T5/es not_active Expired - Lifetime
- 1991-03-07 HU HU9202870A patent/HU217075B/hu unknown
- 1991-03-07 DK DK91905048T patent/DK0521880T4/da active
- 1991-03-07 AT AT91905048T patent/ATE141519T1/de not_active IP Right Cessation
- 1991-03-07 RO RO92-01165A patent/RO111543B1/ro unknown
- 1991-03-07 WO PCT/EP1991/000425 patent/WO1991013636A1/en not_active Ceased
- 1991-03-07 EP EP91905048A patent/EP0521880B2/de not_active Expired - Lifetime
- 1991-03-07 DE DE69121562T patent/DE69121562T3/de not_active Expired - Lifetime
- 1991-03-07 JP JP50518691A patent/JP3215703B2/ja not_active Expired - Lifetime
- 1991-03-08 SK SK619-91A patent/SK278621B6/sk not_active IP Right Cessation
- 1991-03-08 PT PT96978A patent/PT96978B/pt not_active IP Right Cessation
- 1991-03-08 IE IE77591A patent/IE76916B1/en not_active IP Right Cessation
- 1991-03-08 CZ CS91619A patent/CZ285071B6/cs not_active IP Right Cessation
- 1991-03-09 CN CN91101421A patent/CN1055864C/zh not_active Expired - Lifetime
- 1991-03-09 MY MYPI91000386A patent/MY105493A/en unknown
- 1991-03-09 EG EG13791A patent/EG19889A/xx active
- 1991-03-11 TR TR91/0237A patent/TR25738A/xx unknown
1992
- 1992-08-24 OA OA60263A patent/OA09667A/en unknown
- 1992-09-04 FI FI923962A patent/FI100698B/fi active
- 1992-09-08 NO NO923485A patent/NO304352B1/no not_active IP Right Cessation
- 1992-09-09 KR KR1019920702186A patent/KR100189271B1/ko not_active Ceased
- 1992-12-30 LV LVP-92-595A patent/LV10058B/lv unknown
1993
- 1993-04-02 HR HR930773A patent/HRP930773B1/xx not_active IP Right Cessation
- 1993-07-26 GE GEAP19931164A patent/GEP19971155B/en unknown
1996
- 1996-03-15 US US08/616,245 patent/USRE36418E/en not_active Expired - Lifetime
- 1996-08-22 GR GR960402066T patent/GR3020842T3/el unknown
2000
- 2000-07-05 GR GR20000401583T patent/GR3033898T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
HRP930773B1 (en)	2000-10-31
ES2090315T5 (es)	2000-08-01
GR3020842T3 (en)	1996-11-30
PT96978B (pt)	2001-07-31
JP3215703B2 (ja)	2001-10-09
KR100189271B1 (ko)	1999-06-01
WO1991013636A1 (en)	1991-09-19
FI100698B (fi)	1998-02-13
YU40891A (sh)	1994-04-05
OA09667A (en)	1993-05-15
EP0521880B2 (de)	2000-05-31
LV10058B (en)	1994-10-20
HUT62490A (en)	1993-05-28
PT96978A (pt)	1991-10-31
IL97455A0 (en)	1992-06-21
HU217075B (hu)	1999-11-29
DE69121562T2 (de)	1997-01-16
EP0521880B1 (de)	1996-08-21
CA2076861A1 (en)	1991-09-10
US5328680A (en)	1994-07-12
USRE36418E (en)	1999-11-30
CN1056058A (zh)	1991-11-13
GEP19971155B (en)	1997-08-11
AU7345191A (en)	1991-10-10
NO923485D0 (no)	1992-09-08
DK0521880T4 (da)	2000-09-04
EG19889A (en)	1996-03-31
CS9100619A2 (en)	1991-09-15
DE69121562D1 (de)	1996-09-26
RO111543B1 (ro)	1996-11-29
FI923962A0 (fi)	1992-09-04
IE76916B1 (en)	1997-11-05
IL97455A (en)	1995-11-27
FI923962L (fi)	1992-09-04
JPH05504953A (ja)	1993-07-29
CN1055864C (zh)	2000-08-30
IE910775A1 (en)	1991-09-11
EP0521880A1 (de)	1993-01-13
HK1003563A1 (en)	1998-10-30
DZ1506A1 (fr)	2004-09-13
CZ285071B6 (cs)	1999-05-12
DE69121562T3 (de)	2000-11-23
MY105493A (en)	1994-10-31
HU9202870D0 (en)	1992-11-30
DK0521880T3 (da)	1996-09-09
ES2090315T3 (es)	1996-10-16
GB9020091D0 (en)	1990-10-24
YU48683B (sh)	1999-06-15
LV10058A (lv)	1994-05-10
NO923485L (no)	1992-11-05
NO304352B1 (no)	1998-12-07
SK278621B6 (en)	1997-11-05
TR25738A (tr)	1993-09-01
AU645544B2 (en)	1994-01-20
HRP930773A2 (en)	1997-10-31
GR3033898T3 (en)	2000-11-30

Legal Events

Date	Code	Title
1997-02-15	UEP	Publication of translation of european patent specification
2001-01-15	UEP	Publication of translation of european patent specification
2007-04-15	EEFA	Change of the company name
2011-06-15	EELA	Cancelled due to lapse of time

Publication	Publication Date	Title
ATE141519T1 (de)	1996-09-15	Kontrastmittel enthaltend einen nicht-ionischen kontrast wirkstoff und sodium und kalzium sälze
IS4114A (is)	1994-06-25	Vatnskenndar sprautanlegar efnasamsetningar nytsamlegar við geislagreiningu og sem samanstanda af joðuðum hringtengdum efnasamböndum sem notuð eru sem skuggaefni við röntgenmyndatöku
KR930021248A (ko)	1993-11-22	정수용재, 이의 제조 방법 및 정수방법
Koulourides	1990	Summary of Session II: Fluoride and the Caries Process.
GR3019922T3 (en)	1996-08-31	Disinfecting and cleaning composition for contact lenses
BG95330A (bg)	1993-12-24	Контрастни средства
US3325370A (en)	1967-06-13	Aqueous x-ray contrast composition containing a sodium salt of an iodinated organic acid and magnesium ions
US6572842B1 (en)	2003-06-03	Preparation for dental treatment
Sem	2024	PIC Sem-I
Hoff et al.	1990	Concerns with Using Chlorine-Dioxide Disinfection in the USA
JPS63235400A (ja)	1988-09-30	洗浄剤組成物
UA42070C2 (uk)	2001-10-15	Спосіб лікування шлунково-кишкових розладів у новонароджених телят