ATE141597T1 - 4-aryl-thiazole oder imidazolederivate - Google Patents

4-aryl-thiazole oder imidazolederivate

Info

Publication number: ATE141597T1
Authority: AT; Austria
Prior art keywords: lower alkyl; hydrogen; aryl; alk; thiazole
Prior art date: 1991-03-25

Application number

AT92200825T

Other languages

English (en)

Inventor

John Henry Pick

Robert Thomas Logan

Original Assignee

Akzo Nobel Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-03-25

Filing date

1992-03-23

Publication date

1996-09-15

1992-03-23 Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv

1996-09-15 Application granted granted Critical

1996-09-15 Publication of ATE141597T1 publication Critical patent/ATE141597T1/de

Links

RAXXELZNTBOGNW-UHFFFAOYSA-N 1H-imidazole Chemical class C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 title 1
229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 abstract 2
IQGSYVPGKNJALP-UHFFFAOYSA-N 4-(4-chlorophenyl)-1,3-thiazole-2-carboxamide Chemical compound S1C(C(=O)N)=NC(C=2C=CC(Cl)=CC=2)=C1 IQGSYVPGKNJALP-UHFFFAOYSA-N 0.000 abstract 1
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
206010019280 Heart failures Diseases 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
102000004861 Phosphoric Diester Hydrolases Human genes 0.000 abstract 1
108090001050 Phosphoric Diester Hydrolases Proteins 0.000 abstract 1
125000001931 aliphatic group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
208000006673 asthma Diseases 0.000 abstract 1
235000010290 biphenyl Nutrition 0.000 abstract 1
239000004305 biphenyl Substances 0.000 abstract 1
229940124630 bronchodilator Drugs 0.000 abstract 1
229910052791 calcium Inorganic materials 0.000 abstract 1
239000011575 calcium Substances 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
230000000747 cardiac effect Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
150000002460 imidazoles Chemical class 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
210000003365 myofibril Anatomy 0.000 abstract 1
125000001624 naphthyl group Chemical group 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
230000035945 sensitivity Effects 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 abstract 1
125000004001 thioalkyl group Chemical group 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Paints Or Removers (AREA)
Polyurethanes Or Polyureas (AREA)

AT92200825T 1991-03-25 1992-03-23 4-aryl-thiazole oder imidazolederivate ATE141597T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP91302573		1991-03-25

Publications (1)

Publication Number	Publication Date
ATE141597T1 true ATE141597T1 (de)	1996-09-15

Family

ID=8208225

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92200825T ATE141597T1 (de)	1991-03-25	1992-03-23	4-aryl-thiazole oder imidazolederivate

Country Status (17)

Country	Link
US (2)	US5254575A (de)
EP (1)	EP0506194B1 (de)
JP (1)	JPH0597816A (de)
KR (1)	KR920018037A (de)
AT (1)	ATE141597T1 (de)
AU (1)	AU648394B2 (de)
CA (1)	CA2063172A1 (de)
DE (1)	DE69212870T2 (de)
DK (1)	DK0506194T3 (de)
ES (1)	ES2093765T3 (de)
FI (1)	FI921262L (de)
GR (1)	GR3021260T3 (de)
IE (1)	IE73235B1 (de)
MX (1)	MX9203810A (de)
NO (1)	NO301929B1 (de)
NZ (1)	NZ242095A (de)
ZA (1)	ZA921781B (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5922751A (en) *	1994-06-24	1999-07-13	Euro-Celtique, S.A.	Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same
US5874437A (en) *	1996-11-01	1999-02-23	Nitromed, Inc.	Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
US6331543B1 (en)	1996-11-01	2001-12-18	Nitromed, Inc.	Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use
USRE37234E1 (en)	1996-11-01	2001-06-19	Nitromed, Inc.	Nitrosated and nitrosylated phosphodiestrase inhibitor compounds, compositions and their uses
WO1998019672A1 (en) *	1996-11-01	1998-05-14	Nitromed Inc.	Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
US5958926A (en)	1996-11-01	1999-09-28	Nitromed, Inc.	Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
AU6030098A (en) *	1997-01-16	1998-08-07	Neorx Corporation	Phalloidin derivatives and analogs to treat congestive heart failure
US6472425B1 (en)	1997-10-31	2002-10-29	Nitromed, Inc.	Methods for treating female sexual dysfunctions
CA2715683A1 (en)	1999-08-21	2001-03-01	Nycomed Gmbh	Synergistic combination
US7772188B2 (en)	2003-01-28	2010-08-10	Ironwood Pharmaceuticals, Inc.	Methods and compositions for the treatment of gastrointestinal disorders
US7153824B2 (en)	2003-04-01	2006-12-26	Applied Research Systems Ars Holding N.V.	Inhibitors of phosphodiesterases in infertility
CA2522476A1 (en) *	2003-04-18	2004-11-04	Merck & Co., Inc.	Biaryl substituted thiazoles, oxazoles and imidazoles as sodium channel blockers
TWI336697B (en) *	2003-09-19	2011-02-01	Solvay Pharm Bv	Thiazole derivatives as cannabinoid receptor modulators
TW200732314A (en) *	2005-10-26	2007-09-01	Smithkline Beecham Corp	Substituted thiazoles and their use
US8969514B2 (en)	2007-06-04	2015-03-03	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
MX354786B (es)	2007-06-04	2018-03-21	Synergy Pharmaceuticals Inc	Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos.
ES2522968T3 (es)	2008-06-04	2014-11-19	Synergy Pharmaceuticals Inc.	Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
AU2009270833B2 (en)	2008-07-16	2015-02-19	Bausch Health Ireland Limited	Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US9616097B2 (en)	2010-09-15	2017-04-11	Synergy Pharmaceuticals, Inc.	Formulations of guanylate cyclase C agonists and methods of use
DK2681236T3 (en)	2011-03-01	2018-04-16	Synergy Pharmaceuticals Inc	PROCEDURE FOR MANUFACTURING GUANYLATE CYCLASE-C-AGONISTS
WO2014131024A2 (en)	2013-02-25	2014-08-28	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase and their uses
AU2014235215A1 (en)	2013-03-15	2015-10-01	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase and their uses
AU2014235209B2 (en)	2013-03-15	2018-06-14	Bausch Health Ireland Limited	Guanylate cyclase receptor agonists combined with other drugs
BR112015030326A2 (pt)	2013-06-05	2017-08-29	Synergy Pharmaceuticals Inc	Agonistas ultrapuros de guanilato ciclase c, método de fabricar e usar os mesmos
AU2014305843B2 (en)	2013-08-09	2019-08-29	Ardelyx, Inc.	Compounds and methods for inhibiting phosphate transport
EP4706758A3 (de)	2019-05-21	2026-05-06	Ardelyx, Inc.	Verfahren zur hemmung des phosphattransports

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU168036B (de) *	1973-11-09	1976-02-28
FR2261756A1 (en) *	1974-02-27	1975-09-19	Roussel Uclaf	2-Thiazole-N-(Piperazino or piperidino) alkyl carboxamides - as hypotensive and anti-hypertensive agents of low toxicity
EP0199968B1 (de) *	1985-03-27	1990-02-28	Zenyaku Kogyo Kabushiki Kaisha	Thiazolderivate
JPH02262562A (ja) *	1988-10-20	1990-10-25	Ishihara Sangyo Kaisha Ltd	イミダゾール系化合物

1992
- 1992-03-06 IE IE920734A patent/IE73235B1/en not_active IP Right Cessation
- 1992-03-10 ZA ZA921781A patent/ZA921781B/xx unknown
- 1992-03-13 AU AU12915/92A patent/AU648394B2/en not_active Ceased
- 1992-03-17 CA CA002063172A patent/CA2063172A1/en not_active Abandoned
- 1992-03-23 NZ NZ242095A patent/NZ242095A/en unknown
- 1992-03-23 AT AT92200825T patent/ATE141597T1/de not_active IP Right Cessation
- 1992-03-23 DK DK92200825.5T patent/DK0506194T3/da active
- 1992-03-23 DE DE69212870T patent/DE69212870T2/de not_active Expired - Fee Related
- 1992-03-23 ES ES92200825T patent/ES2093765T3/es not_active Expired - Lifetime
- 1992-03-23 EP EP92200825A patent/EP0506194B1/de not_active Expired - Lifetime
- 1992-03-23 KR KR1019920004745A patent/KR920018037A/ko not_active Ceased
- 1992-03-24 NO NO921156A patent/NO301929B1/no unknown
- 1992-03-24 FI FI921262A patent/FI921262L/fi not_active Application Discontinuation
- 1992-03-25 US US07/857,526 patent/US5254575A/en not_active Expired - Fee Related
- 1992-03-25 JP JP4067491A patent/JPH0597816A/ja active Pending
- 1992-06-29 MX MX9203810A patent/MX9203810A/es unknown
1993
- 1993-10-14 US US08/136,530 patent/US5462959A/en not_active Expired - Fee Related
1996
- 1996-10-04 GR GR960402611T patent/GR3021260T3/el unknown

Also Published As

Publication number	Publication date
KR920018037A (ko)	1992-10-21
ES2093765T3 (es)	1997-01-01
EP0506194A1 (de)	1992-09-30
US5254575A (en)	1993-10-19
FI921262A7 (fi)	1992-09-26
JPH0597816A (ja)	1993-04-20
MX9203810A (es)	1992-07-31
AU648394B2 (en)	1994-04-21
DK0506194T3 (da)	1996-12-23
NO921156D0 (no)	1992-03-24
DE69212870T2 (de)	1997-01-16
EP0506194B1 (de)	1996-08-21
AU1291592A (en)	1992-10-01
NO921156L (no)	1992-09-28
FI921262L (fi)	1992-09-26
US5462959A (en)	1995-10-31
FI921262A0 (fi)	1992-03-24
IE920734A1 (en)	1992-10-07
CA2063172A1 (en)	1992-09-26
NZ242095A (en)	1994-04-27
DE69212870D1 (de)	1996-09-26
GR3021260T3 (en)	1997-01-31
ZA921781B (en)	1992-11-25
NO301929B1 (no)	1997-12-29
IE73235B1 (en)	1997-05-21

Legal Events

Date	Code	Title	Description
1997-01-15	UEP	Publication of translation of european patent specification
1998-12-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE141597T1 (de)	1996-09-15	4-aryl-thiazole oder imidazolederivate
NO20004485D0 (no)	2000-09-08	Sykloalkenderivater, deres fremstilling og anvendelse
ATE122355T1 (de)	1995-05-15	2-substituierte adenosinderivate und pharmazeutische zusammensetzungen zur verwendung gegen infektionskrankheiten.
DK1533292T3 (da)	2007-06-04	Dibenzylaminforbindelse og medicinsk anvendelse deraf
NO170084C (no)	1992-09-09	Analogifremgangsmaate til fremstilling av terapeutisk aktive dihydropyridinderivater
EA200300265A1 (ru)	2003-12-25	Производные хиназолина в качестве ингибиторов киназы
ATE169914T1 (de)	1998-09-15	Piperazin-derivate und ihre verwendung als calmodulin-inhibitoren
DE3781080D1 (de)	1992-09-17	2-substituierte-e-kondensierte(1,2,4)triazolo-(1,5-c)pyrimidine, pharmazeutische zubereitungen und ihre verwendung.
ATE117295T1 (de)	1995-02-15	4-oxochinolin-3-carbonsäure-derivate, ihre herstellung und ihre verwendung.
BG89519A (bg)	1993-12-24	Триазолови фунгицидни съединения и метод за получаването им
DK535789A (da)	1990-04-30	Pyrimidindionderivater, fremgangsmaade til fremstilling heraf og antiarytmika omfattende samme
ATE71090T1 (de)	1992-01-15	Heterocyclische verbindungen und deren herstellung und verwendung.
WO2004004730A3 (en)	2004-04-29	2-aminopyrazine derivatives as inhibitors of cyclin dependent kinases for the treatment of proliferative disorders
DK275483D0 (da)	1983-06-15	1,2,4-triazolderivater eller deres farmaceutisk acceptable salte, fremgangsmade til fremstilling deraf og landbrugsfungicider indeholdende disse forbindelser
EP0603887A3 (de)	1995-04-26	Bicyclische Aminderivate.
RU2008119994A (ru)	2009-12-10	Ингибиторы калиевых каналов
DK224981A (da)	1981-11-23	Aminopropanol-derivater og deres syreadditionssalte fremgangsmaader til deres fremstilling og deres anvendelse som fungicider
DE69406763D1 (de)	1997-12-18	Pyridazinon Derivate, Herstellungsverfahren und Verwendung
DE69102389D1 (de)	1994-07-14	Verwendung eines benzo[b]thiophen-2-carboximidamid-Derivates gegen Herzinsuffizienz.