ATE142334T1 - Hochempfindliche fluoreszierende einzelteilchen, gerät und verfahren zum nachweis einzelner moleküle - Google Patents

Hochempfindliche fluoreszierende einzelteilchen, gerät und verfahren zum nachweis einzelner moleküle

Info

Publication number
ATE142334T1
ATE142334T1 AT90908805T AT90908805T ATE142334T1 AT E142334 T1 ATE142334 T1 AT E142334T1 AT 90908805 T AT90908805 T AT 90908805T AT 90908805 T AT90908805 T AT 90908805T AT E142334 T1 ATE142334 T1 AT E142334T1
Authority
AT
Austria
Prior art keywords
fluorescent particles
particles
fluid
burst
highly sensitive
Prior art date
Application number
AT90908805T
Other languages
English (en)
Inventor
Richard A Mathies
Konan Peck
Lubert Stryer
Original Assignee
Univ Leland Stanford Junior
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Leland Stanford Junior filed Critical Univ Leland Stanford Junior
Application granted granted Critical
Publication of ATE142334T1 publication Critical patent/ATE142334T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1468—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle
    • G01N15/147—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle the analysis being performed on a sample stream
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1429—Signal processing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1429—Signal processing
    • G01N15/1433—Signal processing using image recognition
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution
    • G01N15/0205—Investigating particle size or size distribution by optical means
    • G01N15/0211—Investigating a scatter or diffraction pattern
    • G01N2015/0222—Investigating a scatter or diffraction pattern from dynamic light scattering, e.g. photon correlation spectroscopy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Dispersion Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
AT90908805T 1989-05-26 1990-05-21 Hochempfindliche fluoreszierende einzelteilchen, gerät und verfahren zum nachweis einzelner moleküle ATE142334T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/358,782 US4979824A (en) 1989-05-26 1989-05-26 High sensitivity fluorescent single particle and single molecule detection apparatus and method

Publications (1)

Publication Number Publication Date
ATE142334T1 true ATE142334T1 (de) 1996-09-15

Family

ID=23411024

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90908805T ATE142334T1 (de) 1989-05-26 1990-05-21 Hochempfindliche fluoreszierende einzelteilchen, gerät und verfahren zum nachweis einzelner moleküle

Country Status (7)

Country Link
US (1) US4979824A (de)
EP (1) EP0426829B1 (de)
JP (1) JPH04500274A (de)
AT (1) ATE142334T1 (de)
AU (1) AU624047B2 (de)
DE (1) DE69028370T2 (de)
WO (1) WO1990014589A1 (de)

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Also Published As

Publication number Publication date
EP0426829A4 (en) 1992-05-06
US4979824A (en) 1990-12-25
AU5677690A (en) 1990-12-18
AU624047B2 (en) 1992-05-28
JPH04500274A (ja) 1992-01-16
WO1990014589A1 (en) 1990-11-29
DE69028370T2 (de) 1997-03-13
DE69028370D1 (de) 1996-10-10
EP0426829B1 (de) 1996-09-04
EP0426829A1 (de) 1991-05-15

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