ATE142639T1 - 2-beta,19-ethylen-überbrückte steroide als aromatase-inhibitoren - Google Patents

2-beta,19-ethylen-überbrückte steroide als aromatase-inhibitoren

Info

Publication number: ATE142639T1
Authority: AT; Austria
Prior art keywords: aromatase inhibitors; ethylene; beta; bridged steroids; steroids
Prior art date: 1990-11-30

Application number

AT91120560T

Other languages

English (en)

Inventor

J O'neal Johnston

Norton P Peet

Joseph P Burkhart

Original Assignee

Merrell Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-11-30

Filing date

1991-11-29

Publication date

1996-09-15

1991-11-29 Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc

1996-09-15 Application granted granted Critical

1996-09-15 Publication of ATE142639T1 publication Critical patent/ATE142639T1/de

Links

239000003886 aromatase inhibitor Substances 0.000 title abstract 2
229940046844 aromatase inhibitors Drugs 0.000 title abstract 2
150000003431 steroids Chemical class 0.000 title 1
ORBBRLNBGBWXEF-OQWKOXFXSA-N 3-[(8r,9s,10r,13s,14s)-13-methyl-3,17-dioxo-2,6,7,8,9,11,12,14,15,16-decahydro-1h-cyclopenta[a]phenanthren-10-yl]propyl 4-methylbenzenesulfonate Chemical compound C1=CC(C)=CC=C1S(=O)(=O)OCCC[C@@]1([C@H]2CC[C@]3(C)C(=O)CC[C@H]3[C@@H]2CC2)C2=CC(=O)CC1 ORBBRLNBGBWXEF-OQWKOXFXSA-N 0.000 abstract 1
VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical group C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 abstract 1
150000001441 androstanes Chemical class 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
238000007363 ring formation reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
- C07J53/002—Carbocyclic rings fused
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Diabetes (AREA)
Gynecology & Obstetrics (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Bakery Products And Manufacturing Methods Therefor (AREA)

AT91120560T 1990-11-30 1991-11-29 2-beta,19-ethylen-überbrückte steroide als aromatase-inhibitoren ATE142639T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/621,184 US5166201A (en)	1990-11-30	1990-11-30	2β,19-ethylene bridged steroids as aromatase inhibitors

Publications (1)

Publication Number	Publication Date
ATE142639T1 true ATE142639T1 (de)	1996-09-15

Family

ID=24489093

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91120560T ATE142639T1 (de)	1990-11-30	1991-11-29	2-beta,19-ethylen-überbrückte steroide als aromatase-inhibitoren

Country Status (20)

Country	Link
US (1)	US5166201A (de)
EP (1)	EP0488383B1 (de)
JP (1)	JP3143876B2 (de)
KR (1)	KR100190776B1 (de)
CN (1)	CN1033975C (de)
AT (1)	ATE142639T1 (de)
AU (1)	AU635444B2 (de)
CA (1)	CA2056638C (de)
DE (1)	DE69122048T2 (de)
DK (1)	DK0488383T3 (de)
ES (1)	ES2094183T3 (de)
FI (1)	FI102073B1 (de)
GR (1)	GR3021981T3 (de)
HU (1)	HU210830B (de)
IE (1)	IE914168A1 (de)
IL (1)	IL100196A (de)
NO (1)	NO180304C (de)
NZ (1)	NZ240738A (de)
PT (1)	PT99661B (de)
ZA (1)	ZA919296B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19510862A1 (de) *	1995-03-16	1996-09-19	Schering Ag	Verwendung von Antiestrogenen zur männlichen Fertilitätskontrolle
US6372712B1 (en)	1998-05-22	2002-04-16	The Board Of Trustees Of The Leland Stanford Jr. University	Synthetic bifunctional molecules containing a drug moiety and presenter protein ligand
EP2671508B1 (de)	2005-04-28	2020-09-16	Proteus Digital Health, Inc.	Pharma-Informatiksystem
US9062126B2 (en)	2005-09-16	2015-06-23	Raptor Pharmaceuticals Inc.	Compositions comprising receptor-associated protein (RAP) variants specific for CR-containing proteins and uses thereof
ES2919563T3 (es)	2009-02-20	2022-07-27	Enhanx Biopharm Inc	Sistema de administración de medicamentos a base de glutatión
KR20180114970A (ko)	2009-05-06	2018-10-19	라보라토리 스킨 케어, 인크.	활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3627756A (en) *	1970-04-23	1971-12-14	Searle & Co	N-dialkylaminoalkyl-n-(2{62 ,19-epoxy-5{60 -androstan-17{62 -yl)amines/formamides and 3{60 -halo derivatives thereof
US4322416A (en) *	1980-06-27	1982-03-30	Merrell Dow Pharmaceuticals Inc.	10-Alkynyl steroids
GB8501035D0 (en) *	1985-01-16	1985-02-20	Senior J	Prostaglandins
US4882322A (en) *	1988-10-27	1989-11-21	Merrell Dow Pharmaceuticals Inc.	3β,17β-hydroxy-substituted steroids and related steroidal compounds

1990
- 1990-11-30 US US07/621,184 patent/US5166201A/en not_active Expired - Fee Related
1991
- 1991-11-25 AU AU88128/91A patent/AU635444B2/en not_active Ceased
- 1991-11-25 ZA ZA919296A patent/ZA919296B/xx unknown
- 1991-11-26 NZ NZ240738A patent/NZ240738A/xx unknown
- 1991-11-28 FI FI915623A patent/FI102073B1/fi active IP Right Grant
- 1991-11-28 IL IL10019691A patent/IL100196A/en not_active IP Right Cessation
- 1991-11-29 JP JP03339535A patent/JP3143876B2/ja not_active Expired - Fee Related
- 1991-11-29 ES ES91120560T patent/ES2094183T3/es not_active Expired - Lifetime
- 1991-11-29 DE DE69122048T patent/DE69122048T2/de not_active Expired - Fee Related
- 1991-11-29 PT PT99661A patent/PT99661B/pt not_active IP Right Cessation
- 1991-11-29 EP EP91120560A patent/EP0488383B1/de not_active Expired - Lifetime
- 1991-11-29 IE IE416891A patent/IE914168A1/en not_active Application Discontinuation
- 1991-11-29 HU HU913739A patent/HU210830B/hu not_active IP Right Cessation
- 1991-11-29 NO NO914710A patent/NO180304C/no not_active IP Right Cessation
- 1991-11-29 CA CA002056638A patent/CA2056638C/en not_active Expired - Fee Related
- 1991-11-29 DK DK91120560.7T patent/DK0488383T3/da active
- 1991-11-29 AT AT91120560T patent/ATE142639T1/de not_active IP Right Cessation
- 1991-11-30 KR KR1019910021920A patent/KR100190776B1/ko not_active Expired - Fee Related
- 1991-11-30 CN CN91111251A patent/CN1033975C/zh not_active Expired - Fee Related
1996
- 1996-12-11 GR GR960403414T patent/GR3021981T3/el unknown

Also Published As

Publication number	Publication date
PT99661B (pt)	1999-05-31
AU635444B2 (en)	1993-03-18
NO180304C (no)	1997-04-02
IE914168A1 (en)	1992-06-03
US5166201A (en)	1992-11-24
DE69122048D1 (de)	1996-10-17
EP0488383B1 (de)	1996-09-11
FI102073B (fi)	1998-10-15
FI915623L (fi)	1992-05-31
IL100196A (en)	1996-03-31
DK0488383T3 (da)	1996-09-30
NO180304B (no)	1996-12-16
CA2056638C (en)	2002-03-05
FI915623A0 (fi)	1991-11-28
NO914710D0 (no)	1991-11-29
KR920009842A (ko)	1992-06-25
AU8812891A (en)	1992-06-04
HU913739D0 (en)	1992-02-28
CN1033975C (zh)	1997-02-05
DE69122048T2 (de)	1997-02-20
JPH04290898A (ja)	1992-10-15
HU210830B (en)	1995-08-28
CA2056638A1 (en)	1992-05-31
ZA919296B (en)	1992-08-26
HUT59937A (en)	1992-07-28
FI102073B1 (fi)	1998-10-15
JP3143876B2 (ja)	2001-03-07
EP0488383A1 (de)	1992-06-03
ES2094183T3 (es)	1997-01-16
KR100190776B1 (ko)	1999-06-01
GR3021981T3 (en)	1997-03-31
NZ240738A (en)	1993-11-25
CN1061974A (zh)	1992-06-17
PT99661A (pt)	1992-10-30
IL100196A0 (en)	1992-08-18
NO914710L (no)	1992-06-01

Legal Events

Date	Code	Title	Description
1997-02-15	UEP	Publication of translation of european patent specification
2006-08-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
BR9714510A (pt)	2000-11-28	Processo e preparo de esteróides de 9,11-époxi e intermediários úteis dos mesmos
NO20002676D0 (no)	2000-05-25	Androgene steroidforbindelser og en fremgangsmÕte for fremstilling og anvendelse av samme
AU635444B2 (en)	1993-03-18	2beta,19-ethylene bridged steroids as aromatase inhibitors
ES2096941T3 (es)	1997-03-16	27-hidroxirrapamicina y derivados de la misma.
DK1051177T3 (da)	2006-07-24	Steroide 3-O-Sulfamatderivater som inhibitorer af östronsulfatase
DE69841374D1 (de)	2010-01-21	3-o-sulfamatsteroidderivate als hemmer von estronsulfatase
DE69215125D1 (de)	1996-12-19	Kardioaktive Steroide
ES2104174T3 (es)	1997-10-01	Derivados de bencilamino, bencilamido y bencilimido ciclicos utilizados como agentes antipsicoticos.
DE69126622D1 (de)	1997-07-24	2beta,19-methylenamin überbrückte steroide als aromatasehemmer
PT1196428E (pt)	2005-02-28	Esteroides substituidos com 11 beta-aril-17, 17-espirotiolano
PT1165595E (pt)	2003-08-29	Derivados de acidos biliares especificos do figado provenientes do antagonista do glicocorticoide ru486
NO911236D0 (no)	1991-03-26	Fremgangsmaate for fremstilling av haloethyl-substituerte steroidale enzyminhibitorer.
CA2032311A1 (en)	1991-06-21	2,19-methyleneoxy and 2,19-methylenethio bridged steroids as aromatase and 19-hydroxylase inhibitors