ES2096941T3 - 27-hidroxirrapamicina y derivados de la misma. - Google Patents

27-hidroxirrapamicina y derivados de la misma.

Info

Publication number
ES2096941T3
ES2096941T3 ES93919994T ES93919994T ES2096941T3 ES 2096941 T3 ES2096941 T3 ES 2096941T3 ES 93919994 T ES93919994 T ES 93919994T ES 93919994 T ES93919994 T ES 93919994T ES 2096941 T3 ES2096941 T3 ES 2096941T3
Authority
ES
Spain
Prior art keywords
derivatives
hydroxirrapamicina
same
hydroxyrapamycin
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93919994T
Other languages
English (en)
Inventor
Frances Christy Nelson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
American Home Products Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/009,605 external-priority patent/US5256790A/en
Application filed by American Home Products Corp filed Critical American Home Products Corp
Application granted granted Critical
Publication of ES2096941T3 publication Critical patent/ES2096941T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Transplantation (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

LA INVENCION SUMINISTRA UN COMPUESTO DE LA FORMULA (I), Y LOS DERIVADOS SUSTITUIDOS EN 27 DE LA MISMA QUE SON UTILES COMO AGENTES INMUNOSUPRESORES, ANTIINFLAMATORIOS, ANTIFUNGALES, ANTITUMORALES, Y ANTIPROLIFERATIVOS. EL COMPUESTO DESCRITO POR LA FORMULA (I) ES NOMBRADO COMO 27-HIDROXIRAPAMICINA, Y TAMBIEN PUEDE SER REFERIDO COMO 27-DEOXO-27-HIDROXIRAPAMICINA.
ES93919994T 1992-08-13 1993-08-12 27-hidroxirrapamicina y derivados de la misma. Expired - Lifetime ES2096941T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93012492A 1992-08-13 1992-08-13
US08/009,605 US5256790A (en) 1992-08-13 1993-01-27 27-hydroxyrapamycin and derivatives thereof

Publications (1)

Publication Number Publication Date
ES2096941T3 true ES2096941T3 (es) 1997-03-16

Family

ID=26679675

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93919994T Expired - Lifetime ES2096941T3 (es) 1992-08-13 1993-08-12 27-hidroxirrapamicina y derivados de la misma.

Country Status (12)

Country Link
EP (1) EP0655065B1 (es)
JP (1) JPH08501084A (es)
AT (1) ATE146179T1 (es)
AU (1) AU5007193A (es)
CA (1) CA2142288A1 (es)
DE (1) DE69306585T2 (es)
DK (1) DK0655065T3 (es)
ES (1) ES2096941T3 (es)
GR (1) GR3022730T3 (es)
HU (1) HU221499B (es)
MX (1) MX9304868A (es)
WO (1) WO1994004540A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5527907A (en) * 1993-11-19 1996-06-18 Abbott Laboratories Macrolide immunomodulators
EP0729471A1 (en) * 1993-11-19 1996-09-04 Abbott Laboratories Semisynthetic analogs of rapamycin (macrolides) being immunomodulators
US6187757B1 (en) 1995-06-07 2001-02-13 Ariad Pharmaceuticals, Inc. Regulation of biological events using novel compounds
DE69624921T2 (de) 1995-06-09 2003-09-11 Novartis Ag, Basel Rapamycinderivate
IL147803A0 (en) 1999-08-24 2002-08-14 Ariad Gene Therapeutics Inc 28-epirapalogs
US7067526B1 (en) 1999-08-24 2006-06-27 Ariad Gene Therapeutics, Inc. 28-epirapalogs
EP1478648B1 (en) 2002-02-01 2014-04-30 ARIAD Pharmaceuticals, Inc. Phosphorus-containing compounds and uses thereof
WO2004060346A2 (en) 2002-12-30 2004-07-22 Angiotech International Ag Drug delivery from rapid gelling polymer composition
EP1768662A2 (en) 2004-06-24 2007-04-04 Novartis Vaccines and Diagnostics, Inc. Small molecule immunopotentiators and assays for their detection
CA2669415A1 (en) 2006-11-14 2008-05-22 Ariad Pharmaceuticals, Inc. Solid dosage form comprising ap23573
EP2245165A4 (en) 2008-01-11 2011-06-01 Massachusetts Eye & Ear Infirm TRANSGENIC CONDITIONAL STOP DIMERICABLE CASPASE ANIMALS
CN105283553B (zh) 2013-06-11 2021-06-25 克隆技术实验室有限公司 蛋白质富集的微泡及其制备和使用方法
PL3788049T3 (pl) 2018-05-01 2023-06-19 Revolution Medicines, Inc. Połączone z C40, C28 i C32 analogi rapamycyny jako inhibitory mTOR
EP3788050B1 (en) 2018-05-01 2024-08-28 Revolution Medicines, Inc. C26-linked rapamycin analogs as mtor inhibitors
AU2022253019A1 (en) * 2021-04-09 2023-11-16 Revolution Medicines, Inc. Synthesis of rapamycin analog compounds
EP4531859A4 (en) 2022-05-25 2026-05-27 Revolution Medicines Inc CANCER TREATMENT METHODS USING AN MTOR INHIBITOR

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04230389A (ja) * 1990-07-16 1992-08-19 American Home Prod Corp ラパマイシン誘導体
US5102876A (en) * 1991-05-07 1992-04-07 American Home Products Corporation Reduction products of rapamycin

Also Published As

Publication number Publication date
GR3022730T3 (en) 1997-06-30
DE69306585D1 (de) 1997-01-23
ATE146179T1 (de) 1996-12-15
WO1994004540A1 (en) 1994-03-03
AU5007193A (en) 1994-03-15
HU221499B (en) 2002-10-28
JPH08501084A (ja) 1996-02-06
CA2142288A1 (en) 1994-03-03
DK0655065T3 (es) 1997-02-24
HUT71614A (en) 1996-01-29
HU9500432D0 (en) 1995-04-28
MX9304868A (es) 1994-05-31
EP0655065A1 (en) 1995-05-31
EP0655065B1 (en) 1996-12-11
DE69306585T2 (de) 1997-04-17

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